GREMLIN Database
DUF1720 - Domain of unknown function (DUF1720)
PFAM: PF08226 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 75 (74)
Sequences: 537 (466)
Seq/√Len: 54.1
META: 0.419

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_P43_P2.9511.00
40_Q54_Q2.2311.00
43_P57_P2.0811.00
42_Q56_Q2.0431.00
46_P50_Q2.0221.00
25_Q42_Q1.9871.00
60_F75_F1.9621.00
43_P72_P1.9581.00
39_L53_L1.9521.00
41_P55_P1.9211.00
56_Q71_Q1.8940.99
57_P72_P1.8080.99
53_L68_L1.7620.99
42_Q71_Q1.7460.99
31_P34_T1.7260.99
54_Q69_Q1.7010.99
25_Q56_Q1.6940.99
63_Q66_Q1.6890.99
11_P14_Q1.6630.99
8_F29_F1.5540.98
32_Q35_G1.5520.98
26_P57_P1.5510.98
5_P26_P1.5090.97
22_L53_L1.5080.97
4_Q42_Q1.4330.96
40_Q69_Q1.4070.96
4_Q25_Q1.3610.95
24_P41_P1.2320.92
3_P70_P1.2310.92
26_P72_P1.1700.90
23_Q54_Q1.1510.89
72_P75_F1.1230.88
4_Q71_Q1.0750.86
12_Q17_Q1.0640.85
44_T58_T1.0340.83
5_P43_P0.9920.81
32_Q37_Q0.9540.78
38_G67_P0.9450.77
46_P49_F0.9450.77
6_T58_T0.9430.77
39_L68_L0.9380.77
32_Q42_Q0.9290.76
57_P60_F0.9120.75
22_L39_L0.9070.74
30_Q46_P0.8980.74
49_F53_L0.8920.73
53_L56_Q0.8840.72
3_P41_P0.8800.72
32_Q36_G0.8740.72
65_Q71_Q0.8730.71
16_P19_Q0.8470.69
45_G74_G0.8440.69
31_P35_G0.8310.68
11_P32_Q0.8040.65
68_L73_T0.7950.64
64_Q69_Q0.7920.64
62_Q70_P0.7850.63
29_F60_F0.7740.62
62_Q66_Q0.7680.61
41_P70_P0.7650.61
64_Q71_Q0.7530.60
15_Q19_Q0.7470.59
63_Q67_P0.7440.59
25_Q71_Q0.7410.59
65_Q72_P0.7250.57
9_Q30_Q0.7230.57
3_P6_T0.7090.55
10_Q51_P0.7080.55
55_P58_T0.7010.55
29_F34_T0.6930.54
27_T44_T0.6880.53
4_Q7_G0.6870.53
9_Q12_Q0.6760.52
13_Q29_F0.6710.51
10_Q13_Q0.6650.51
45_G59_G0.6650.51
12_Q15_Q0.6640.51
31_P47_G0.6620.50
28_G59_G0.6600.50
61_Q64_Q0.6590.50
11_P19_Q0.6460.49
37_Q51_P0.6460.49
55_P70_P0.6370.48
47_G51_P0.6340.47
12_Q18_Q0.6310.47
5_P57_P0.6260.47
7_G28_G0.6260.47
14_Q17_Q0.6120.45
23_Q40_Q0.5910.43
10_Q31_P0.5860.42
8_F60_F0.5830.42
64_Q67_P0.5790.42
20_Q26_P0.5780.42
9_Q15_Q0.5670.40
52_G67_P0.5610.40
11_P15_Q0.5490.39
28_G45_G0.5490.39
11_P16_P0.5450.38
16_P20_Q0.5430.38
10_Q14_Q0.5430.38
61_Q69_Q0.5400.38
61_Q65_Q0.5360.37
3_P35_G0.5310.37
6_T73_T0.5280.36
44_T73_T0.5270.36
38_G52_G0.5170.35
53_L58_T0.5160.35
62_Q67_P0.5100.35
4_Q56_Q0.5030.34
49_F56_Q0.5020.34
33_Q36_G0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2lq1A 1 0.3333 1.1 0.893 Contact Map
2jx3A 1 0.0533 0.5 0.915 Contact Map
3g9hA 1 0.0267 0.4 0.922 Contact Map
3lvgA 3 0.0267 0.3 0.928 Contact Map
1k0hA 1 0.3333 0.3 0.93 Contact Map
3zh5A 1 0.32 0.2 0.94 Contact Map
2c7nA 1 0.12 0.2 0.941 Contact Map
3afhA 1 0.1733 0.2 0.942 Contact Map
4g6zA 1 0.1867 0.2 0.944 Contact Map
2qiyA 2 0.28 0.2 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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