GREMLIN Database
TRAUB - Apoptosis-antagonizing transcription factor, C-terminal
PFAM: PF08164 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 83 (82)
Sequences: 608 (448)
Seq/√Len: 49.5
META: 0.365

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_D49_K3.4121.00
40_V45_S3.0591.00
40_V44_A2.9321.00
41_D44_A2.8761.00
75_I78_L2.3861.00
3_Q6_K2.0911.00
56_E59_Q2.0841.00
77_E81_S2.0691.00
70_W74_A2.0391.00
44_A51_R1.9380.99
47_G51_R1.7840.99
44_A47_G1.7600.99
32_K35_K1.6570.98
63_A74_A1.5670.97
61_F71_S1.5540.97
16_S19_A1.5250.97
2_Q7_E1.5020.96
44_A49_K1.4450.96
24_W27_L1.4210.95
42_T49_K1.4130.95
2_Q62_M1.3880.95
31_R38_K1.2970.92
2_Q9_I1.2820.92
28_Q31_R1.2710.91
9_I28_Q1.2700.91
40_V49_K1.2440.91
50_L53_T1.2430.91
24_W29_K1.2220.90
12_R70_W1.2040.89
27_L32_K1.1860.88
2_Q57_K1.1660.87
10_E77_E1.1050.84
80_A83_F1.0760.83
9_I13_S1.0740.83
31_R34_K1.0670.82
45_S48_R1.0430.81
26_A33_K1.0380.81
23_Q28_Q1.0340.80
42_T51_R1.0280.80
55_H62_M1.0110.79
8_L42_T1.0070.78
72_E75_I0.9970.78
55_H65_E0.9800.77
44_A48_R0.9710.76
9_I39_K0.9680.76
15_D19_A0.9650.75
10_E31_R0.9480.74
47_G58_L0.9450.74
29_K32_K0.9240.72
71_S81_S0.9210.72
1_Y4_L0.9200.72
7_E10_E0.8900.69
51_R54_V0.8880.69
41_D51_R0.8760.68
71_S74_A0.8730.68
50_L75_I0.8730.68
62_M78_L0.8650.67
72_E77_E0.8650.67
1_Y5_L0.8350.64
8_L63_A0.8210.63
15_D22_G0.8210.63
68_G76_D0.8000.61
3_Q35_K0.7950.61
24_W28_Q0.7830.59
45_S51_R0.7800.59
50_L55_H0.7750.59
7_E83_F0.7750.59
41_D47_G0.7680.58
45_S56_E0.7620.57
17_S20_G0.7600.57
46_K60_N0.7520.56
7_E52_Y0.7520.56
7_E45_S0.7490.56
4_L75_I0.7430.55
70_W73_E0.7400.55
42_T53_T0.7330.54
49_K60_N0.7280.54
14_S28_Q0.7250.54
74_A78_L0.7080.52
74_A77_E0.7070.52
13_S69_T0.7020.51
57_K61_F0.6990.51
53_T65_E0.6890.50
40_V51_R0.6820.49
71_S75_I0.6780.49
16_S21_S0.6720.48
56_E70_W0.6670.48
18_A50_L0.6610.47
51_R81_S0.6590.47
77_E80_A0.6560.47
11_S70_W0.6490.46
25_L30_L0.6450.45
27_L31_R0.6450.45
6_K9_I0.6350.44
9_I30_L0.6280.44
42_T48_R0.6150.42
9_I72_E0.6130.42
27_L35_K0.6120.42
40_V43_K0.6100.42
27_L30_L0.6090.42
23_Q26_A0.5970.41
19_A22_G0.5920.40
11_S23_Q0.5870.40
13_S83_F0.5850.39
71_S80_A0.5800.39
43_K49_K0.5800.39
23_Q30_L0.5780.39
26_A30_L0.5680.38
15_D18_A0.5650.37
40_V48_R0.5620.37
66_D76_D0.5590.37
63_A81_S0.5490.36
23_Q83_F0.5490.36
35_K39_K0.5480.36
45_S49_K0.5460.36
3_Q22_G0.5460.36
51_R61_F0.5380.35
70_W77_E0.5230.34
48_R51_R0.5220.33
9_I42_T0.5210.33
4_L82_L0.5190.33
55_H63_A0.5070.32
16_S32_K0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xrpB 1 0.506 8.7 0.907 Contact Map
3ww3A 3 0.6506 5.7 0.915 Contact Map
4ywtA 1 0.9759 5.4 0.916 Contact Map
3vlcE 1 0.6988 4.1 0.921 Contact Map
3odnA 1 0.7831 3.7 0.922 Contact Map
4gyvA 4 0.6627 3.3 0.924 Contact Map
3b2eE 1 0.6988 3 0.925 Contact Map
4uf5B 1 0.1325 2.8 0.927 Contact Map
3ziuA 1 0.5181 2.7 0.928 Contact Map
2cjqA 1 0.8795 2.6 0.928 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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