GREMLIN Database
NUC130_3NT - NUC130/3NT domain
PFAM: PF08158 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 52 (52)
Sequences: 743 (529)
Seq/√Len: 73.3
META: 0.51

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
2_L13_T2.6641.00
3_A42_A2.6421.00
20_L39_L2.4091.00
18_Q22_D2.2641.00
15_E18_Q1.9361.00
42_A45_L1.9061.00
7_P49_K1.8821.00
22_D26_Q1.7781.00
31_L35_L1.7521.00
15_E19_Q1.7191.00
44_I48_N1.6571.00
5_V8_C1.5610.99
4_H7_P1.5390.99
11_K14_A1.4940.99
32_D35_L1.3570.98
27_H30_V1.2790.97
3_A16_F1.2500.97
37_E41_Q1.2270.96
5_V13_T1.2000.96
37_E40_V1.1800.96
6_A13_T1.1050.94
9_Y43_L1.0840.93
11_K33_P1.0510.92
47_R50_D1.0190.91
1_F52_I0.9980.90
7_P51_L0.9980.90
41_Q50_D0.9890.89
24_L39_L0.9780.89
12_E22_D0.9740.89
4_H36_R0.9720.89
23_L39_L0.9600.88
18_Q21_I0.9520.87
47_R51_L0.9330.86
21_I48_N0.9140.85
45_L48_N0.8750.83
33_P36_R0.8740.83
8_C47_R0.8620.82
26_Q30_V0.8600.82
41_Q51_L0.8430.80
21_I25_E0.8290.79
3_A6_A0.8290.79
13_T51_L0.8260.79
7_P20_L0.7930.76
26_Q50_D0.7650.73
28_H38_K0.7490.72
14_A18_Q0.7460.72
35_L39_L0.7440.71
2_L24_L0.7410.71
13_T19_Q0.7230.69
2_L15_E0.7140.68
13_T16_F0.7050.67
29_A32_D0.6800.64
27_H45_L0.6790.64
9_Y21_I0.6740.64
2_L5_V0.6620.62
26_Q33_P0.6620.62
16_F20_L0.6600.62
16_F19_Q0.6470.61
29_A33_P0.6310.59
21_I37_E0.6270.58
34_E38_K0.6090.56
38_K49_K0.6030.55
9_Y33_P0.5980.55
32_D41_Q0.5970.55
10_P14_A0.5940.54
17_P46_L0.5890.54
12_E17_P0.5600.50
8_C34_E0.5590.50
3_A30_V0.5550.49
2_L37_E0.5490.49
19_Q49_K0.5480.48
16_F30_V0.5430.48
26_Q40_V0.5310.46
4_H25_E0.5280.46
6_A46_L0.5110.44
28_H35_L0.5020.43
4_H35_L0.5010.43
1_F18_Q0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4owtA 1 1 54.3 0.785 Contact Map
2db0A 1 0.9231 33 0.812 Contact Map
3u0rA 1 0.9231 15.9 0.837 Contact Map
2i2oA 2 0.9808 15.9 0.837 Contact Map
4p6zG 1 0.8846 11.7 0.847 Contact Map
3bwgA 2 0.9038 11.6 0.847 Contact Map
2vd5A 2 1 9.7 0.852 Contact Map
2x19B 1 0.9423 9.6 0.853 Contact Map
2vglA 1 0.9231 9.5 0.853 Contact Map
1oyzA 1 0.8654 9 0.855 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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