GREMLIN Database
BING4CT - BING4CT (NUC141) domain
PFAM: PF08149 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 79 (79)
Sequences: 743 (461)
Seq/√Len: 51.9
META: 0.463

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_V35_I5.5361.00
25_G32_F4.7771.00
71_L75_M4.4671.00
54_E62_A3.6701.00
51_N58_Q3.6081.00
25_G34_S2.6381.00
72_Q75_M2.3921.00
3_M37_V2.0071.00
20_F49_E1.9110.99
20_F50_A1.8610.99
57_K60_R1.7720.99
27_G31_G1.7540.99
28_H31_G1.5740.98
10_S30_K1.4460.96
20_F45_F1.3790.95
18_C24_L1.3130.94
25_G33_S1.3100.93
5_H35_I1.2970.93
23_V36_L1.2840.93
11_P29_S1.2700.92
18_C25_G1.2420.91
18_C23_V1.1650.89
56_K60_R1.1450.88
12_V15_V1.1410.88
18_C32_F1.1390.87
47_A51_N1.1220.87
5_H27_G1.0440.82
59_R63_E1.0230.81
7_L12_V1.0220.81
55_T58_Q1.0000.80
50_A69_D0.9950.79
50_A54_E0.9310.75
3_M7_L0.9180.74
18_C71_L0.9120.73
37_V59_R0.9100.73
46_D67_L0.9050.72
15_V33_S0.9040.72
44_N63_E0.8790.70
52_P67_L0.8730.70
36_L49_E0.8650.69
20_F34_S0.8630.69
28_H33_S0.8610.69
24_L45_F0.8510.68
12_V72_Q0.8470.67
46_D49_E0.8250.65
50_A65_K0.8230.65
13_E57_K0.8100.64
47_A53_F0.8080.64
21_E43_P0.7770.61
53_F56_K0.7770.61
11_P53_F0.7670.60
17_F69_D0.7510.58
17_F29_S0.7430.57
54_E59_R0.7390.57
34_S68_L0.7330.56
9_G29_S0.7270.56
27_G55_T0.7270.56
10_S17_F0.7200.55
10_S29_S0.7160.54
20_F58_Q0.7070.53
3_M79_D0.7040.53
7_L26_V0.7020.53
51_N62_A0.6920.52
34_S45_F0.6900.52
62_A65_K0.6860.51
11_P18_C0.6850.51
10_S16_R0.6830.51
10_S36_L0.6830.51
22_D38_P0.6790.51
49_E77_T0.6770.50
35_I40_A0.6740.50
32_F57_K0.6730.50
30_K53_F0.6730.50
40_A75_M0.6720.50
6_G9_G0.6660.49
10_S13_E0.6660.49
14_S27_G0.6600.49
48_L51_N0.6570.48
1_P21_E0.6540.48
6_G10_S0.6540.48
8_P64_V0.6460.47
21_E48_L0.6430.47
71_L77_T0.6310.46
11_P55_T0.6300.45
34_S62_A0.6260.45
7_L10_S0.6250.45
70_K76_I0.6090.43
59_R74_E0.6040.43
71_L76_I0.6000.42
18_C74_E0.6000.42
19_P51_N0.5950.42
65_K69_D0.5910.41
62_A74_E0.5890.41
8_P48_L0.5880.41
69_D77_T0.5830.41
4_T17_F0.5820.41
21_E74_E0.5800.40
8_P49_E0.5800.40
21_E51_N0.5700.39
5_H17_F0.5640.39
19_P54_E0.5630.39
3_M14_S0.5580.38
6_G11_P0.5470.37
47_A58_Q0.5380.36
28_H66_S0.5380.36
4_T8_P0.5370.36
27_G69_D0.5330.36
18_C72_Q0.5330.36
53_F61_E0.5280.35
17_F40_A0.5260.35
48_L63_E0.5190.34
56_K59_R0.5150.34
3_M6_G0.5100.34
65_K77_T0.5090.33
13_E29_S0.5070.33
12_V26_V0.5040.33
17_F32_F0.5030.33
52_P58_Q0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4n7vC 1 0.3924 20.7 0.922 Contact Map
1mukA 1 0.5823 16.1 0.925 Contact Map
1r5mA 1 0.4937 13.3 0.928 Contact Map
1g8mA 2 0.7722 13.1 0.928 Contact Map
1zczA 2 0.7848 12.7 0.929 Contact Map
3zzmA 2 0.7848 10.7 0.931 Contact Map
4ehiA 2 0.7848 10.3 0.931 Contact Map
2xxpA 1 0.8861 10.1 0.932 Contact Map
3d2mA 5 0.9494 9.3 0.933 Contact Map
4bzjA 2 0.8354 8 0.935 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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