GREMLIN Database
DBP10CT - DBP10CT (NUC160) domain
PFAM: PF08147 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 65 (62)
Sequences: 634 (446)
Seq/√Len: 56.7
META: 0.44

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_D38_G2.6631.00
41_K49_K2.6451.00
43_R49_K2.6311.00
42_I52_A2.4981.00
60_D64_K2.3951.00
60_D63_K2.3031.00
23_K28_Y2.1181.00
51_P54_Y1.6570.99
17_M30_K1.6380.99
58_R61_K1.6080.99
22_D26_K1.5870.98
57_G60_D1.5070.98
4_G7_G1.4980.98
40_K53_S1.4330.97
44_T48_A1.4090.97
13_Q17_M1.3650.96
6_D28_Y1.3500.96
59_Y62_W1.3440.96
14_K17_M1.2920.94
4_G9_G1.2310.93
3_T27_K1.2270.93
9_G12_K1.1890.92
44_T50_I1.1220.89
10_L13_Q1.1190.89
36_E40_K1.1150.89
28_Y41_K1.1090.88
23_K59_Y1.0890.88
53_S56_S1.0820.87
17_M28_Y1.0750.87
44_T51_P1.0310.85
4_G11_R1.0290.84
8_E11_R1.0270.84
7_G14_K1.0090.83
46_S49_K1.0070.83
15_R57_G0.9990.83
14_K18_K0.9300.78
6_D34_G0.9110.76
33_N36_E0.8980.75
37_D49_K0.8910.75
31_R37_D0.8850.74
12_K15_R0.8840.74
6_D9_G0.8750.73
44_T54_Y0.8740.73
23_K26_K0.8230.69
25_K48_A0.8090.67
55_K60_D0.8070.67
28_Y50_I0.7960.66
16_V30_K0.7930.66
13_Q16_V0.7900.66
7_G18_K0.7870.65
28_Y31_R0.7840.65
44_T52_A0.7650.63
18_K32_T0.7620.63
24_K42_I0.7540.62
6_D22_D0.7530.62
4_G13_Q0.7450.61
22_D43_R0.7380.60
35_D39_S0.7260.59
9_G39_S0.7220.59
12_K16_V0.7070.57
44_T56_S0.7020.56
14_K30_K0.7000.56
32_T41_K0.6940.56
6_D40_K0.6920.55
7_G11_R0.6860.55
23_K61_K0.6840.55
15_R26_K0.6750.54
15_R32_T0.6740.53
12_K60_D0.6680.53
55_K61_K0.6610.52
23_K29_V0.6610.52
24_K28_Y0.6610.52
37_D40_K0.6560.51
24_K54_Y0.6510.51
41_K44_T0.6490.51
28_Y63_K0.6480.51
26_K33_N0.6350.49
39_S46_S0.6140.47
6_D46_S0.6120.47
28_Y61_K0.6100.46
4_G12_K0.6050.46
57_G63_K0.6030.46
42_I51_P0.5960.45
29_V42_I0.5780.43
52_A56_S0.5770.43
2_L9_G0.5620.41
15_R30_K0.5530.40
14_K43_R0.5320.38
31_R34_G0.5190.37
33_N50_I0.5170.37
9_G29_V0.5110.36
21_W47_G0.5090.36
27_K31_R0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2cs2A 1 0.6769 11.6 0.866 Contact Map
3j60B 1 0.7538 3.5 0.896 Contact Map
4ujpC 1 0.7538 3.4 0.896 Contact Map
1ynxA 1 0.9231 3.4 0.896 Contact Map
3j20A 1 0.7538 3.1 0.897 Contact Map
3j7aB 1 0.7538 2.7 0.901 Contact Map
3j38B 1 0.7846 2.5 0.903 Contact Map
1jmcA 1 0.9231 1.9 0.908 Contact Map
4gnxC 1 0.9231 1.9 0.909 Contact Map
4bpe4 1 0.7538 1.6 0.913 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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