GREMLIN Database
AARP2CN - AARP2CN (NUC121) domain
PFAM: PF08142 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 86 (84)
Sequences: 1439 (973)
Seq/√Len: 106.2
META: 0.418

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_D48_R4.2281.00
7_R11_V3.6971.00
68_H74_D3.4681.00
66_L76_Q3.1731.00
4_N8_F2.3441.00
30_R53_Y2.3391.00
39_D46_C1.9701.00
34_L51_V1.8871.00
49_T78_S1.8321.00
36_D39_D1.7181.00
33_D50_V1.6971.00
24_P61_L1.6731.00
40_I46_C1.6571.00
35_T48_R1.5881.00
31_V52_L1.5481.00
8_F11_V1.5461.00
68_H71_G1.5151.00
69_I72_V1.5151.00
61_L67_V1.4411.00
24_P59_T1.4101.00
39_D43_N1.3881.00
43_N46_C1.3641.00
65_R77_I1.3240.99
31_V56_V1.2350.99
17_L20_R1.2290.99
56_V61_L1.2140.99
61_L77_I1.2040.99
24_P60_P1.2040.99
5_L13_K1.1830.99
29_D57_R1.1730.99
71_G85_D1.1290.98
71_G74_D1.1200.98
39_D44_P1.1170.98
7_R14_P1.0930.98
23_R53_Y1.0560.97
4_N7_R1.0450.97
46_C84_P1.0350.97
53_Y83_L1.0260.97
9_I14_P0.9950.96
37_P40_I0.9870.96
28_A31_V0.9680.95
28_A52_L0.9460.95
66_L75_F0.9400.95
18_R59_T0.9330.94
40_I47_D0.9320.94
62_K65_R0.9220.94
63_A66_L0.9210.94
20_R25_Y0.9180.94
29_D72_V0.9020.93
52_L77_I0.8980.93
14_P19_W0.8960.93
5_L74_D0.8680.92
40_I43_N0.8630.92
47_D69_I0.8580.91
18_R21_N0.8550.91
9_I69_I0.8490.91
44_P47_D0.8380.91
1_E13_K0.8370.90
39_D45_K0.8280.90
19_W22_S0.8260.90
36_D40_I0.8130.89
13_K55_Y0.8080.89
14_P17_L0.8050.89
77_I80_I0.7990.88
72_V75_F0.7910.88
21_N59_T0.7800.87
50_V66_L0.7740.87
58_G69_I0.7690.86
65_R76_Q0.7670.86
26_L70_P0.7650.86
22_S57_R0.7590.86
3_L7_R0.7570.85
24_P55_Y0.7440.84
19_W37_P0.7270.83
24_P56_V0.7230.83
43_N69_I0.7130.82
15_R18_R0.7100.82
66_L80_I0.7060.81
32_E51_V0.7000.81
32_E35_T0.6980.81
56_V60_P0.6930.80
21_N71_G0.6920.80
28_A57_R0.6910.80
8_F23_R0.6890.80
10_S13_K0.6820.79
5_L35_T0.6730.78
23_R63_A0.6700.78
15_R30_R0.6560.76
62_K77_I0.6520.76
51_V64_N0.6430.75
29_D58_G0.6420.75
26_L56_V0.6420.75
67_V70_P0.6420.75
25_Y58_G0.6350.74
24_P74_D0.6340.74
18_R22_S0.6330.74
65_R84_P0.6320.74
64_N78_S0.6300.73
60_P64_N0.6280.73
35_T47_D0.6270.73
16_P32_E0.6260.73
12_M62_K0.6240.73
40_I44_P0.6230.73
18_R24_P0.6180.72
43_N63_A0.6110.71
26_L51_V0.6080.71
3_L12_M0.5980.69
55_Y85_D0.5980.69
33_D55_Y0.5920.69
67_V77_I0.5890.68
55_Y86_P0.5680.66
16_P20_R0.5680.66
2_I25_Y0.5600.64
13_K16_P0.5460.62
24_P80_I0.5450.62
46_C56_V0.5430.62
63_A77_I0.5420.62
5_L34_L0.5410.62
11_V23_R0.5380.61
52_L75_F0.5370.61
61_L80_I0.5180.58
45_K50_V0.5160.58
1_E25_Y0.5130.58
9_I34_L0.5110.57
2_I9_I0.5060.57
5_L8_F0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rd4A 1 0.9535 36.8 0.881 Contact Map
4tmxA 1 0.8721 34.4 0.883 Contact Map
1d2eA 3 0.8721 26.5 0.889 Contact Map
3avxA 1 0.8721 26 0.89 Contact Map
4upyB 1 0.8721 21.1 0.895 Contact Map
2c78A 1 0.8605 16.8 0.899 Contact Map
1s0uA 1 0.9651 16.5 0.899 Contact Map
3j81k 1 0.7326 15.8 0.9 Contact Map
3wbiA 1 0.8605 14.7 0.902 Contact Map
4zciA 1 0.8721 13.6 0.903 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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