GREMLIN Database
SspH - Small acid-soluble spore protein H family
PFAM: PF08141 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 58 (58)
Sequences: 1146 (817)
Seq/√Len: 107.2
META: 0.552

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_E40_H4.3221.00
3_V30_V2.7121.00
27_I37_A2.5621.00
7_K32_E2.5031.00
5_R58_E2.2601.00
38_T48_E2.0381.00
15_M26_W1.9961.00
10_L16_I1.9651.00
28_E48_E1.9601.00
31_D34_N1.9361.00
20_Y39_V1.7931.00
37_A53_V1.7461.00
7_K11_S1.5861.00
3_V53_V1.4951.00
31_D38_T1.4911.00
10_L27_I1.4441.00
15_M42_L1.3150.99
14_E17_N1.3040.99
6_A27_I1.2950.99
28_E38_T1.2600.99
38_T50_E1.2420.99
35_G54_S1.2180.99
40_H48_E1.2100.99
10_L26_W1.2030.99
3_V35_G1.1460.98
18_V27_I1.1450.98
49_Q52_P1.0190.97
12_S16_I0.9920.96
16_I26_W0.9830.96
24_P43_D0.9770.96
3_V7_K0.9600.95
21_N55_E0.9220.94
34_N47_E0.8910.93
29_H38_T0.8890.93
26_W41_P0.8650.92
31_D36_T0.8300.90
6_A53_V0.8110.89
52_P55_E0.7900.88
10_L29_H0.7800.87
13_P17_N0.7770.87
33_D43_D0.7510.85
40_H45_P0.7470.85
8_E12_S0.7290.84
34_N50_E0.7290.84
33_D36_T0.7130.82
28_E42_L0.7020.81
2_D22_G0.6910.80
41_P49_Q0.6900.80
13_P19_T0.6850.80
23_V43_D0.6820.79
21_N45_P0.6610.77
35_G43_D0.6520.76
8_E11_S0.6510.76
14_E43_D0.6510.76
23_V41_P0.6450.75
5_R8_E0.6340.74
25_V41_P0.6330.74
1_M38_T0.6320.74
20_Y47_E0.6120.72
26_W42_L0.6050.71
19_T23_V0.5990.70
6_A29_H0.5940.69
30_V47_E0.5930.69
29_H45_P0.5900.69
34_N54_S0.5780.67
20_Y49_Q0.5740.67
19_T57_E0.5690.66
28_E50_E0.5680.66
39_V51_V0.5670.66
30_V48_E0.5610.65
22_G31_D0.5600.65
44_N47_E0.5530.64
11_S14_E0.5520.64
23_V47_E0.5510.64
36_T50_E0.5500.63
28_E32_E0.5440.63
3_V32_E0.5430.62
5_R9_I0.5430.62
43_D47_E0.5420.62
8_E15_M0.5400.62
5_R34_N0.5400.62
20_Y55_E0.5310.61
20_Y51_V0.5140.58
51_V56_L0.5090.58
11_S48_E0.5020.57
17_N49_Q0.5010.56
6_A30_V0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4anjA 1 0.569 30.4 0.836 Contact Map
3s6wA 1 0.8103 29.3 0.838 Contact Map
1i84S 2 0.9828 26 0.842 Contact Map
2v26A 1 0.5517 25 0.843 Contact Map
4nl7A 1 0.9828 24.1 0.844 Contact Map
2ycuA 1 0.6897 22.4 0.847 Contact Map
4qq6A 1 0.8621 22.3 0.847 Contact Map
1kk8A 1 0.9138 14.9 0.859 Contact Map
3qiiA 2 0.8103 14.8 0.859 Contact Map
4a4fA 1 0.9655 13.8 0.861 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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