GREMLIN Database
DUF1707 - Domain of unknown function (DUF1707)
PFAM: PF08044 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 53 (53)
Sequences: 21854 (11325)
Seq/√Len: 1555.6
META: 0.904

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_F26_L2.4931.00
12_A37_Y2.3001.00
12_A33_L1.9701.00
11_V49_T1.9651.00
19_F29_F1.7931.00
15_L29_F1.7311.00
3_A42_R1.6711.00
32_R51_D1.5521.00
13_E16_R1.5221.00
18_A23_R1.4871.00
48_L51_D1.4521.00
18_A21_E1.4101.00
30_D34_D1.3551.00
16_R29_F1.3261.00
17_E21_E1.3161.00
26_L30_D1.3001.00
18_A49_T1.3001.00
36_A48_L1.2901.00
35_A48_L1.2751.00
14_R18_A1.2471.00
11_V45_L1.2281.00
4_S23_R1.2261.00
34_D38_A1.2071.00
14_R49_T1.1941.00
42_R46_A1.1891.00
17_E20_A1.1801.00
31_E35_A1.1761.00
23_R53_P1.1541.00
9_E37_Y1.1021.00
9_E13_E1.0771.00
16_R20_A1.0621.00
47_A50_A1.0611.00
15_L36_A1.0601.00
12_A36_A1.0281.00
10_R14_R1.0201.00
11_V36_A0.9511.00
5_D22_G0.9261.00
25_T28_E0.8911.00
28_E31_E0.8831.00
9_E12_A0.8781.00
40_R44_E0.8781.00
7_D42_R0.8671.00
41_T44_E0.8151.00
29_F33_L0.7961.00
2_R40_R0.7951.00
19_F30_D0.7771.00
13_E17_E0.7731.00
9_E16_R0.7711.00
35_A47_A0.7651.00
25_T40_R0.7621.00
6_A9_E0.7601.00
4_S7_D0.7581.00
36_A45_L0.7461.00
3_A45_L0.7411.00
29_F41_T0.7381.00
30_D33_L0.7281.00
6_A10_R0.7201.00
18_A52_L0.7191.00
35_A50_A0.7181.00
1_L42_R0.6751.00
18_A28_E0.6671.00
45_L48_L0.6511.00
27_D30_D0.6461.00
28_E32_R0.6271.00
31_E40_R0.6031.00
4_S53_P0.6011.00
12_A16_R0.5891.00
3_A41_T0.5871.00
10_R13_E0.5811.00
39_A44_E0.5731.00
2_R51_D0.5711.00
31_E34_D0.5611.00
44_E47_A0.5601.00
46_A50_A0.5391.00
15_L49_T0.5341.00
3_A47_A0.5241.00
5_D8_R0.5131.00
7_D10_R0.5131.00
35_A38_A0.5091.00
34_D37_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ug3A 1 0.9057 18.9 0.787 Contact Map
3l6aA 1 0.9057 14.9 0.796 Contact Map
1mliA 5 1 13.1 0.801 Contact Map
3znuA 5 0.9245 12.1 0.804 Contact Map
3eiqC 1 0.9057 10.2 0.81 Contact Map
1qsaA 1 1 9.6 0.813 Contact Map
2ionA 1 0.9057 9.2 0.814 Contact Map
4kisA 2 0.9623 8 0.819 Contact Map
2nszA 1 0.9057 7.6 0.821 Contact Map
3hzsA 3 0.6981 7 0.824 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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