GREMLIN Database
DUF1705 - Domain of unknown function (DUF1705)
PFAM: PF08019 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 152 (148)
Sequences: 5234 (4033)
Seq/√Len: 331.5
META: 0.786

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_I83_W4.1181.00
75_G79_A3.1821.00
47_M50_N3.1351.00
23_I79_A2.9411.00
26_L82_L2.6761.00
95_E99_R2.6611.00
6_V106_A2.6421.00
31_A71_L2.2501.00
56_P60_R2.2201.00
81_L85_V2.2001.00
80_L84_R2.1401.00
37_D70_Y2.1231.00
6_V102_L2.0621.00
14_W17_L1.9291.00
32_A140_Y1.8781.00
7_L103_I1.8541.00
70_Y74_L1.8531.00
117_F121_Y1.8511.00
33_S37_D1.8381.00
46_S49_R1.7831.00
32_A43_I1.7711.00
13_S18_L1.7621.00
118_Y122_A1.7511.00
139_N143_S1.7291.00
97_L101_L1.7161.00
29_S140_Y1.6981.00
56_P59_A1.6621.00
34_Y70_Y1.5811.00
36_M136_N1.5721.00
6_V10_S1.5501.00
90_R95_E1.5331.00
72_L76_V1.5141.00
24_L28_V1.5131.00
63_L68_L1.4941.00
23_I82_L1.4451.00
48_I147_Y1.4421.00
33_S70_Y1.4251.00
20_P23_I1.4091.00
49_R53_E1.4091.00
76_V80_L1.4051.00
36_M43_I1.3981.00
101_L105_L1.3881.00
89_Y95_E1.3861.00
30_A75_G1.3821.00
90_R98_R1.3531.00
136_N139_N1.3501.00
54_T58_E1.3451.00
94_R97_L1.3371.00
25_L141_I1.3351.00
45_P146_K1.3141.00
132_R142_Y1.2911.00
67_L71_L1.2881.00
23_I27_L1.2701.00
94_R98_R1.2661.00
27_L75_G1.2641.00
93_K97_L1.2561.00
142_Y146_K1.2551.00
35_F62_L1.2401.00
98_R101_L1.2311.00
145_G149_K1.2241.00
91_P94_R1.2191.00
145_G148_A1.2081.00
42_V134_L1.1781.00
52_L147_Y1.1451.00
69_L73_L1.1231.00
68_L72_L1.1171.00
97_L100_L1.1131.00
112_L116_L1.1081.00
2_F6_V1.0801.00
65_L69_L1.0691.00
71_L76_V1.0651.00
144_L148_A1.0571.00
142_Y145_G1.0501.00
66_K70_Y1.0441.00
123_S127_N1.0441.00
49_R147_Y1.0261.00
135_I138_T1.0021.00
117_F120_D0.9881.00
27_L79_A0.9711.00
100_L104_L0.9521.00
140_Y144_L0.9451.00
38_T66_K0.9451.00
136_N142_Y0.9411.00
44_D47_M0.9081.00
118_Y125_F0.9041.00
18_L22_L0.8981.00
29_S33_S0.8971.00
146_K149_K0.8931.00
98_R102_L0.8921.00
26_L79_A0.8861.00
29_S136_N0.8811.00
35_F67_L0.8711.00
105_L109_V0.8661.00
138_T142_Y0.8631.00
17_L20_P0.8521.00
102_L106_A0.8521.00
11_L14_W0.8461.00
7_L110_I0.8381.00
84_R88_R0.8361.00
90_R94_R0.8331.00
3_A109_V0.8291.00
106_A110_I0.8271.00
113_L116_L0.8271.00
30_A78_P0.8191.00
130_E134_L0.8191.00
28_V140_Y0.8111.00
12_L21_L0.8101.00
136_N140_Y0.8071.00
133_Y138_T0.8011.00
85_V89_Y0.7901.00
109_V113_L0.7881.00
121_Y125_F0.7881.00
3_A110_I0.7871.00
3_A113_L0.7861.00
48_I144_L0.7841.00
3_A6_V0.7811.00
124_F131_L0.7791.00
110_I114_L0.7671.00
19_K87_I0.7661.00
133_Y142_Y0.7651.00
10_S102_L0.7621.00
43_I51_V0.7430.99
79_A82_L0.7300.99
133_Y139_N0.7290.99
36_M39_Y0.7280.99
75_G78_P0.7250.99
109_V112_L0.7250.99
55_D132_R0.7230.99
7_L106_A0.7200.99
47_M62_L0.7170.99
15_R18_L0.7170.99
19_K23_I0.7160.99
5_L138_T0.7150.99
31_A67_L0.7120.99
5_L9_L0.7120.99
141_I145_G0.7020.99
136_N143_S0.7010.99
123_S126_R0.6900.99
55_D61_D0.6850.99
88_R91_P0.6840.99
20_P24_L0.6830.99
122_A125_F0.6670.99
68_L71_L0.6630.99
125_F128_H0.6570.99
34_Y66_K0.6530.99
114_L121_Y0.6530.99
3_A106_A0.6490.99
45_P49_R0.6470.98
81_L84_R0.6450.98
35_F43_I0.6430.98
135_I139_N0.6420.98
22_L26_L0.6400.98
10_S14_W0.6350.98
27_L71_L0.6330.98
28_V32_A0.6320.98
107_L111_V0.6310.98
41_V51_V0.6300.98
50_N62_L0.6290.98
128_H131_L0.6270.98
129_K133_Y0.6270.98
30_A74_L0.6230.98
122_A126_R0.6130.98
120_D124_F0.6130.98
43_I139_N0.6130.98
44_D50_N0.6120.98
43_I48_I0.6110.98
57_A61_D0.6100.98
105_L112_L0.6070.98
55_D58_E0.6060.98
9_L25_L0.6040.98
102_L105_L0.6030.98
10_S13_S0.6020.98
114_L122_A0.6010.98
57_A60_R0.6010.98
51_V59_A0.5880.97
104_L108_L0.5870.97
35_F41_V0.5840.97
134_L139_N0.5820.97
4_L8_L0.5810.97
22_L82_L0.5800.97
4_L7_L0.5780.97
65_L68_L0.5770.97
47_M58_E0.5760.97
15_R89_Y0.5740.97
39_Y62_L0.5700.97
50_N58_E0.5670.97
27_L30_A0.5670.97
125_F135_I0.5650.96
113_L117_F0.5640.96
46_S50_N0.5630.96
45_P143_S0.5620.96
47_M54_T0.5620.96
16_Y20_P0.5620.96
33_S74_L0.5600.96
110_I113_L0.5580.96
52_L144_L0.5580.96
45_P133_Y0.5530.96
64_S67_L0.5530.96
48_I143_S0.5520.96
72_L77_L0.5510.96
59_A63_L0.5470.96
9_L12_L0.5440.96
96_L100_L0.5430.96
66_K69_L0.5360.95
71_L75_G0.5360.95
28_V48_I0.5310.95
8_L12_L0.5290.95
10_S99_R0.5260.95
34_Y38_T0.5260.95
54_T59_A0.5210.94
23_I26_L0.5180.94
119_K122_A0.5170.94
45_P142_Y0.5170.94
120_D123_S0.5150.94
25_L29_S0.5140.94
76_V79_A0.5130.94
27_L31_A0.5120.94
43_I62_L0.5100.94
48_I52_L0.5050.94
32_A36_M0.5030.93
18_L89_Y0.5010.93
7_L99_R0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4av3A 2 0.3487 3.7 0.925 Contact Map
3k6vA 1 0.1579 3.4 0.926 Contact Map
1rz2A 1 0.2171 3.2 0.927 Contact Map
4httA 1 0.875 2.7 0.93 Contact Map
2hi7B 1 0.4737 2.2 0.933 Contact Map
4i0uA 4 0.4737 2 0.935 Contact Map
2w3zA 1 0.1184 1.7 0.937 Contact Map
2zy9A 2 0.4934 1.6 0.938 Contact Map
4ev6A 3 0.5066 1.5 0.939 Contact Map
3owqA 1 0.0658 1.5 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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