DUF1702 - PFAM28P - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

DUF1702 - Protein of unknown function (DUF1702)

PFAM:	PF08012	Sequences: MLGALRRRLLGPSPAEVTFARRGFPVGDPAARERLETVGRTFLEGYHAALEARDPEELARRLEAVPPELRGFAYEGAAMGLALLDALTPWRRRRLRAFLAGPGAPHIYMVYVGAGWALARLPRPLWRKLLPDLTGARLDPLLRWLALDGYGFHQGYFHTRRYVDRQRRPRRLPWEGPPGYARRAFDQGLGRSLWFVHGADVERVAATIARFPPERRADLWSGVGLAAAYAGGADEAELEALREAAGPHRPQLAQGAAFAAKARQRAGNVPPHTELACRVLCGLSAEEAAALTDEALPDLPADGAEPAYEVWRQRIRARF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	319 (306)
Sequences:	842 (727)
Seq/√Len:	41.5
META:	0.728

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
261_K	293_D	6.358	1.00
155_G	192_S	4.763	1.00
186_D	215_R	4.279	1.00
228_A	256_A	3.797	1.00
155_G	189_L	3.684	1.00
257_A	292_T	3.293	1.00
95_L	114_A	3.276	1.00
227_A	238_L	3.029	1.00
180_Y	184_A	2.974	1.00
235_E	239_E	2.816	1.00
251_Q	316_R	2.670	1.00
93_R	97_A	2.636	1.00
120_R	153_H	2.629	1.00
260_A	277_C	2.624	1.00
223_V	241_L	2.612	1.00
58_L	81_L	2.584	1.00
235_E	275_L	2.574	1.00
63_E	74_Y	2.542	1.00
269_V	285_A	2.535	1.00
274_E	286_E	2.514	1.00
197_H	207_T	2.430	1.00
180_Y	309_E	2.385	1.00
42_F	116_W	2.365	1.00
7_R	51_E	2.332	1.00
185_F	189_L	2.324	1.00
260_A	289_A	2.249	1.00
298_D	314_R	2.242	1.00
242_R	249_R	2.216	1.00
209_A	216_R	2.121	0.99
264_Q	269_V	2.039	0.99
306_P	309_E	2.029	0.99
50_L	84_L	2.005	0.99
256_A	280_L	1.999	0.99
169_P	185_F	1.981	0.99
254_Q	258_F	1.971	0.99
106_H	109_M	1.969	0.99
116_W	258_F	1.945	0.99
202_E	240_A	1.925	0.99
84_L	94_R	1.890	0.99
78_A	110_V	1.886	0.99
183_R	309_E	1.877	0.99
235_E	278_R	1.872	0.98
34_R	68_E	1.773	0.98
26_V	32_R	1.758	0.98
290_A	294_E	1.757	0.98
201_V	205_A	1.737	0.97
261_K	296_L	1.702	0.97
103_G	110_V	1.692	0.97
213_P	216_R	1.660	0.97
17_V	43_L	1.656	0.97
168_R	182_R	1.641	0.96
204_V	223_V	1.640	0.96
6_R	11_G	1.639	0.96
227_A	280_L	1.636	0.96
208_I	223_V	1.634	0.96
154_Q	158_H	1.633	0.96
248_H	251_Q	1.600	0.96
233_A	237_E	1.599	0.96
160_R	165_R	1.586	0.96
154_Q	185_F	1.584	0.96
274_E	284_S	1.579	0.96
261_K	264_Q	1.558	0.95
104_A	265_R	1.539	0.95
144_W	180_Y	1.531	0.95
120_R	154_Q	1.522	0.95
256_A	277_C	1.517	0.94
241_L	252_L	1.498	0.94
86_A	125_L	1.480	0.94
34_R	69_L	1.479	0.94
180_Y	306_P	1.466	0.93
19_F	26_V	1.462	0.93
118_L	150_Y	1.458	0.93
284_S	287_E	1.457	0.93
82_A	95_L	1.434	0.93
306_P	310_V	1.420	0.92
39_G	156_Y	1.416	0.92
274_E	285_A	1.414	0.92
209_A	244_A	1.406	0.92
38_V	69_L	1.402	0.92
160_R	164_D	1.393	0.91
294_E	318_R	1.383	0.91
39_G	108_Y	1.353	0.90
95_L	110_V	1.335	0.90
62_L	73_A	1.320	0.89
51_E	61_R	1.315	0.89
186_D	219_L	1.314	0.89
52_A	58_L	1.311	0.89
81_L	98_F	1.309	0.89
180_Y	183_R	1.298	0.88
39_G	42_F	1.295	0.88
159_T	196_V	1.284	0.88
216_R	248_H	1.279	0.88
92_R	300_P	1.270	0.87
234_D	237_E	1.269	0.87
108_Y	266_A	1.267	0.87
300_P	314_R	1.254	0.86
310_V	314_R	1.252	0.86
116_W	254_Q	1.249	0.86
187_Q	218_D	1.249	0.86
215_R	219_L	1.247	0.86
205_A	244_A	1.246	0.86
299_L	314_R	1.240	0.86
71_G	230_A	1.234	0.86
183_R	218_D	1.232	0.85
258_F	262_A	1.226	0.85
223_V	252_L	1.224	0.85
161_R	167_R	1.206	0.84
221_S	225_L	1.204	0.84
7_R	11_G	1.203	0.84
116_W	225_L	1.201	0.84
34_R	38_V	1.199	0.84
162_Y	189_L	1.198	0.84
228_A	273_T	1.197	0.84
254_Q	262_A	1.181	0.83
300_P	310_V	1.178	0.83
217_A	251_Q	1.172	0.82
285_A	289_A	1.164	0.82
50_L	80_G	1.163	0.82
4_A	7_R	1.151	0.81
42_F	258_F	1.141	0.81
298_D	310_V	1.125	0.80
168_R	214_E	1.124	0.80
155_G	185_F	1.114	0.79
79_M	225_L	1.108	0.79
65_V	73_A	1.102	0.78
213_P	247_P	1.101	0.78
98_F	103_G	1.100	0.78
63_E	70_R	1.096	0.78
252_L	256_A	1.087	0.77
240_A	243_E	1.084	0.77
72_F	230_A	1.075	0.77
112_V	116_W	1.073	0.76
43_L	47_H	1.069	0.76
235_E	279_V	1.066	0.76
221_S	230_A	1.060	0.76
32_R	42_F	1.055	0.75
236_A	239_E	1.042	0.74
19_F	32_R	1.041	0.74
313_Q	316_R	1.028	0.73
116_W	262_A	1.020	0.73
166_Q	211_F	1.020	0.73
108_Y	258_F	1.011	0.72
96_R	100_A	1.010	0.72
145_L	195_F	1.005	0.72
281_C	288_A	0.997	0.71
59_A	74_Y	0.995	0.71
209_A	213_P	0.989	0.70
309_E	313_Q	0.975	0.69
186_D	211_F	0.974	0.69
43_L	116_W	0.972	0.69
98_F	239_E	0.965	0.68
29_P	32_R	0.963	0.68
145_L	254_Q	0.960	0.68
83_L	87_L	0.959	0.68
25_P	197_H	0.945	0.67
102_P	105_P	0.943	0.67
78_A	145_L	0.943	0.67
112_V	230_A	0.943	0.67
139_D	153_H	0.939	0.66
211_F	215_R	0.938	0.66
296_L	315_I	0.937	0.66
109_M	268_N	0.933	0.66
108_Y	139_D	0.932	0.66
230_A	254_Q	0.929	0.66
238_L	276_A	0.916	0.64
283_L	291_L	0.915	0.64
122_P	198_G	0.912	0.64
4_A	8_R	0.908	0.64
19_F	36_E	0.907	0.64
227_A	277_C	0.907	0.64
197_H	203_R	0.907	0.64
256_A	281_C	0.902	0.63
304_A	317_A	0.902	0.63
43_L	114_A	0.901	0.63
17_V	41_T	0.897	0.63
197_H	204_V	0.896	0.63
160_R	236_A	0.892	0.62
39_G	254_Q	0.886	0.62
47_H	50_L	0.884	0.62
99_L	110_V	0.883	0.62
236_A	247_P	0.879	0.61
82_A	114_A	0.877	0.61
108_Y	116_W	0.876	0.61
145_L	230_A	0.876	0.61
195_F	225_L	0.875	0.61
109_M	145_L	0.874	0.61
233_A	284_S	0.872	0.61
78_A	109_M	0.871	0.60
117_A	156_Y	0.870	0.60
72_F	254_Q	0.869	0.60
173_P	184_A	0.868	0.60
294_E	297_P	0.865	0.60
59_A	102_P	0.865	0.60
145_L	262_A	0.861	0.60
106_H	266_A	0.857	0.59
9_L	20_A	0.856	0.59
145_L	266_A	0.853	0.59
42_F	112_V	0.852	0.59
230_A	312_R	0.850	0.59
114_A	162_Y	0.848	0.58
58_L	62_L	0.845	0.58
107_I	111_Y	0.844	0.58
108_Y	141_L	0.843	0.58
17_V	47_H	0.839	0.58
292_T	296_L	0.839	0.58
309_E	312_R	0.837	0.57
165_R	239_E	0.829	0.57
109_M	116_W	0.826	0.56
38_V	41_T	0.825	0.56
299_L	302_D	0.822	0.56
78_A	266_A	0.821	0.56
256_A	260_A	0.815	0.55
308_Y	311_W	0.814	0.55
49_A	80_G	0.809	0.55
162_Y	165_R	0.806	0.55
203_R	206_A	0.806	0.55
22_R	39_G	0.804	0.54
225_L	262_A	0.804	0.54
150_Y	154_Q	0.804	0.54
283_L	288_A	0.794	0.53
213_P	308_Y	0.793	0.53
53_R	57_E	0.793	0.53
253_A	257_A	0.788	0.53
207_T	210_R	0.786	0.53
225_L	230_A	0.781	0.52
109_M	230_A	0.778	0.52
271_P	274_E	0.777	0.52
305_E	313_Q	0.775	0.52
19_F	199_A	0.773	0.51
18_T	21_R	0.770	0.51
150_Y	163_V	0.765	0.51
123_R	127_R	0.765	0.51
202_E	244_A	0.764	0.51
78_A	187_Q	0.762	0.50
22_R	36_E	0.760	0.50
308_Y	315_I	0.756	0.50
121_L	193_L	0.754	0.50
274_E	278_R	0.754	0.50
264_Q	285_A	0.753	0.50
228_A	280_L	0.752	0.49
30_A	33_E	0.749	0.49
156_Y	272_H	0.748	0.49
16_E	22_R	0.745	0.49
224_G	252_L	0.739	0.48
116_W	230_A	0.739	0.48
264_Q	286_E	0.738	0.48
56_E	60_R	0.735	0.48
261_K	265_R	0.735	0.48
21_R	228_A	0.734	0.48
153_H	198_G	0.732	0.48
163_V	232_G	0.731	0.48
80_G	121_L	0.731	0.48
291_L	315_I	0.730	0.47
300_P	305_E	0.727	0.47
293_D	316_R	0.726	0.47
138_L	146_A	0.726	0.47
147_L	150_Y	0.724	0.47
216_R	246_G	0.723	0.47
108_Y	145_L	0.723	0.47
122_P	230_A	0.722	0.47
147_L	189_L	0.721	0.47
70_R	74_Y	0.721	0.47
88_T	93_R	0.716	0.46
161_R	216_R	0.712	0.46
262_A	311_W	0.711	0.46
306_P	313_Q	0.708	0.45
39_G	116_W	0.698	0.44
79_M	156_Y	0.694	0.44
284_S	305_E	0.693	0.44
202_E	209_A	0.692	0.44
153_H	229_Y	0.689	0.44
11_G	14_P	0.689	0.44
91_R	303_G	0.688	0.44
227_A	241_L	0.681	0.43
143_R	200_D	0.676	0.42
71_G	225_L	0.675	0.42
46_Y	50_L	0.674	0.42
221_S	262_A	0.672	0.42
31_A	141_L	0.672	0.42
60_R	64_A	0.671	0.42
189_L	192_S	0.669	0.42
108_Y	153_H	0.669	0.42
116_W	311_W	0.668	0.42
43_L	112_V	0.667	0.42
18_T	248_H	0.667	0.42
228_A	238_L	0.665	0.41
108_Y	225_L	0.662	0.41
60_R	210_R	0.661	0.41
145_L	156_Y	0.658	0.41
118_L	125_L	0.658	0.41
23_G	29_P	0.653	0.40
146_A	199_A	0.648	0.40
16_E	24_F	0.648	0.40
5_L	318_R	0.648	0.40
151_G	187_Q	0.647	0.40
62_L	77_A	0.646	0.40
50_L	94_R	0.644	0.40
183_R	215_R	0.642	0.39
46_Y	88_T	0.642	0.39
45_G	76_G	0.641	0.39
14_P	38_V	0.641	0.39
117_A	231_G	0.639	0.39
164_D	210_R	0.639	0.39
205_A	240_A	0.639	0.39
308_Y	312_R	0.639	0.39
166_Q	210_R	0.638	0.39
116_W	229_Y	0.638	0.39
62_L	74_Y	0.635	0.39
111_Y	116_W	0.634	0.39
76_G	152_F	0.634	0.39
15_A	214_E	0.632	0.38
15_A	30_A	0.631	0.38
66_P	286_E	0.630	0.38
221_S	312_R	0.628	0.38
211_F	219_L	0.627	0.38
15_A	21_R	0.625	0.38
118_L	146_A	0.625	0.38
24_F	36_E	0.623	0.38
39_G	230_A	0.621	0.38
116_W	141_L	0.620	0.37
153_H	215_R	0.619	0.37
291_L	295_A	0.619	0.37
22_R	116_W	0.619	0.37
195_F	254_Q	0.617	0.37
39_G	112_V	0.610	0.37
145_L	225_L	0.608	0.36
80_G	195_F	0.607	0.36
225_L	311_W	0.607	0.36
59_A	63_E	0.606	0.36
240_A	244_A	0.606	0.36
184_A	302_D	0.605	0.36
181_A	245_A	0.605	0.36
195_F	221_S	0.604	0.36
201_V	244_A	0.604	0.36
158_H	161_R	0.603	0.36
58_L	77_A	0.602	0.36
110_V	114_A	0.602	0.36
152_F	195_F	0.600	0.36
305_E	310_V	0.598	0.36
225_L	312_R	0.597	0.35
19_F	80_G	0.597	0.35
35_L	71_G	0.596	0.35
295_A	315_I	0.596	0.35
58_L	63_E	0.594	0.35
67_P	164_D	0.592	0.35
146_A	318_R	0.591	0.35
150_Y	185_F	0.591	0.35
122_P	196_V	0.590	0.35
86_A	124_P	0.588	0.35
257_A	261_K	0.587	0.35
39_G	46_Y	0.586	0.35
261_K	292_T	0.584	0.34
39_G	43_L	0.584	0.34
277_C	285_A	0.584	0.34
72_F	76_G	0.584	0.34
242_R	280_L	0.583	0.34
62_L	223_V	0.583	0.34
225_L	254_Q	0.580	0.34
20_A	125_L	0.579	0.34
43_L	159_T	0.578	0.34
78_A	221_S	0.578	0.34
96_R	249_R	0.578	0.34
184_A	309_E	0.578	0.34
71_G	76_G	0.576	0.34
42_F	45_G	0.574	0.33
42_F	254_Q	0.573	0.33
123_R	126_W	0.571	0.33
42_F	262_A	0.571	0.33
19_F	35_L	0.570	0.33
210_R	310_V	0.570	0.33
206_A	236_A	0.570	0.33
73_A	273_T	0.566	0.33
45_G	258_F	0.564	0.33
47_H	58_L	0.564	0.33
122_P	147_L	0.563	0.33
15_A	107_I	0.563	0.33
300_P	304_A	0.562	0.33
11_G	155_G	0.562	0.33
251_Q	260_A	0.561	0.32
22_R	35_L	0.560	0.32
39_G	139_D	0.560	0.32
293_D	296_L	0.559	0.32
97_A	102_P	0.559	0.32
38_V	278_R	0.558	0.32
84_L	88_T	0.556	0.32
99_L	107_I	0.556	0.32
37_T	41_T	0.556	0.32
67_P	147_L	0.554	0.32
217_A	248_H	0.554	0.32
167_R	170_R	0.552	0.32
39_G	153_H	0.551	0.32
90_W	94_R	0.550	0.32
15_A	18_T	0.550	0.32
17_V	28_D	0.549	0.31
262_A	266_A	0.549	0.31
34_R	46_Y	0.547	0.31
246_G	249_R	0.547	0.31
289_A	292_T	0.546	0.31
180_Y	225_L	0.546	0.31
35_L	119_A	0.545	0.31
109_M	195_F	0.545	0.31
86_A	123_R	0.545	0.31
106_H	268_N	0.545	0.31
163_V	211_F	0.544	0.31
236_A	317_A	0.543	0.31
50_L	139_D	0.542	0.31
44_E	65_V	0.539	0.31
225_L	308_Y	0.537	0.30
169_P	182_R	0.534	0.30
252_L	280_L	0.534	0.30
120_R	150_Y	0.534	0.30
240_A	317_A	0.533	0.30
58_L	280_L	0.532	0.30
58_L	102_P	0.530	0.30
251_Q	254_Q	0.530	0.30
212_P	283_L	0.530	0.30
35_L	42_F	0.530	0.30
11_G	47_H	0.528	0.30
310_V	313_Q	0.528	0.30
256_A	288_A	0.528	0.30
39_G	225_L	0.527	0.30
110_V	236_A	0.526	0.30
95_L	257_A	0.526	0.30
215_R	238_L	0.525	0.30
188_G	191_R	0.524	0.29
115_G	191_R	0.524	0.29
115_G	188_G	0.524	0.29
85_D	94_R	0.524	0.29
19_F	24_F	0.524	0.29
40_R	60_R	0.523	0.29
55_P	143_R	0.521	0.29
19_F	23_G	0.520	0.29
109_M	262_A	0.520	0.29
16_E	21_R	0.519	0.29
42_F	153_H	0.518	0.29
74_Y	101_G	0.517	0.29
39_G	145_L	0.516	0.29
111_Y	150_Y	0.513	0.29
172_L	185_F	0.513	0.29
36_E	230_A	0.512	0.29
39_G	195_F	0.512	0.29
299_L	305_E	0.512	0.29
208_I	241_L	0.511	0.28
52_A	310_V	0.510	0.28
85_D	220_W	0.509	0.28
41_T	156_Y	0.507	0.28
225_L	258_F	0.506	0.28
179_G	203_R	0.505	0.28
32_R	35_L	0.505	0.28
107_I	142_L	0.504	0.28
165_R	216_R	0.504	0.28
35_L	45_G	0.504	0.28
301_A	304_A	0.503	0.28
185_F	277_C	0.503	0.28
25_P	203_R	0.503	0.28
193_L	207_T	0.502	0.28
71_G	195_F	0.502	0.28
145_L	258_F	0.500	0.28
201_V	239_E	0.500	0.28

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3l0zA	2	0.3072	16.2	0.973	Contact Map
3ll7A	1	0.1944	8	0.977	Contact Map
2e18A	2	0.348	5.5	0.978	Contact Map
3u4gA	2	0.3166	3.8	0.98	Contact Map
2kmfA	1	0.1599	3.5	0.98	Contact Map
2higA	3	0.1317	3.2	0.981	Contact Map
4hfxA	2	0.1348	2.9	0.981	Contact Map
3kyzA	2	0.1285	2.9	0.981	Contact Map
4wv4B	1	0.2853	2.8	0.981	Contact Map
3d2yA	3	0.279	2.8	0.981	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0094 seconds.