GREMLIN Database
DUF1702 - Protein of unknown function (DUF1702)
PFAM: PF08012 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 319 (306)
Sequences: 842 (727)
Seq/√Len: 41.5
META: 0.728

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
261_K293_D6.3581.00
155_G192_S4.7631.00
186_D215_R4.2791.00
228_A256_A3.7971.00
155_G189_L3.6841.00
257_A292_T3.2931.00
95_L114_A3.2761.00
227_A238_L3.0291.00
180_Y184_A2.9741.00
235_E239_E2.8161.00
251_Q316_R2.6701.00
93_R97_A2.6361.00
120_R153_H2.6291.00
260_A277_C2.6241.00
223_V241_L2.6121.00
58_L81_L2.5841.00
235_E275_L2.5741.00
63_E74_Y2.5421.00
269_V285_A2.5351.00
274_E286_E2.5141.00
197_H207_T2.4301.00
180_Y309_E2.3851.00
42_F116_W2.3651.00
7_R51_E2.3321.00
185_F189_L2.3241.00
260_A289_A2.2491.00
298_D314_R2.2421.00
242_R249_R2.2161.00
209_A216_R2.1210.99
264_Q269_V2.0390.99
306_P309_E2.0290.99
50_L84_L2.0050.99
256_A280_L1.9990.99
169_P185_F1.9810.99
254_Q258_F1.9710.99
106_H109_M1.9690.99
116_W258_F1.9450.99
202_E240_A1.9250.99
84_L94_R1.8900.99
78_A110_V1.8860.99
183_R309_E1.8770.99
235_E278_R1.8720.98
34_R68_E1.7730.98
26_V32_R1.7580.98
290_A294_E1.7570.98
201_V205_A1.7370.97
261_K296_L1.7020.97
103_G110_V1.6920.97
213_P216_R1.6600.97
17_V43_L1.6560.97
168_R182_R1.6410.96
204_V223_V1.6400.96
6_R11_G1.6390.96
227_A280_L1.6360.96
208_I223_V1.6340.96
154_Q158_H1.6330.96
248_H251_Q1.6000.96
233_A237_E1.5990.96
160_R165_R1.5860.96
154_Q185_F1.5840.96
274_E284_S1.5790.96
261_K264_Q1.5580.95
104_A265_R1.5390.95
144_W180_Y1.5310.95
120_R154_Q1.5220.95
256_A277_C1.5170.94
241_L252_L1.4980.94
86_A125_L1.4800.94
34_R69_L1.4790.94
180_Y306_P1.4660.93
19_F26_V1.4620.93
118_L150_Y1.4580.93
284_S287_E1.4570.93
82_A95_L1.4340.93
306_P310_V1.4200.92
39_G156_Y1.4160.92
274_E285_A1.4140.92
209_A244_A1.4060.92
38_V69_L1.4020.92
160_R164_D1.3930.91
294_E318_R1.3830.91
39_G108_Y1.3530.90
95_L110_V1.3350.90
62_L73_A1.3200.89
51_E61_R1.3150.89
186_D219_L1.3140.89
52_A58_L1.3110.89
81_L98_F1.3090.89
180_Y183_R1.2980.88
39_G42_F1.2950.88
159_T196_V1.2840.88
216_R248_H1.2790.88
92_R300_P1.2700.87
234_D237_E1.2690.87
108_Y266_A1.2670.87
300_P314_R1.2540.86
310_V314_R1.2520.86
116_W254_Q1.2490.86
187_Q218_D1.2490.86
215_R219_L1.2470.86
205_A244_A1.2460.86
299_L314_R1.2400.86
71_G230_A1.2340.86
183_R218_D1.2320.85
258_F262_A1.2260.85
223_V252_L1.2240.85
161_R167_R1.2060.84
221_S225_L1.2040.84
7_R11_G1.2030.84
116_W225_L1.2010.84
34_R38_V1.1990.84
162_Y189_L1.1980.84
228_A273_T1.1970.84
254_Q262_A1.1810.83
300_P310_V1.1780.83
217_A251_Q1.1720.82
285_A289_A1.1640.82
50_L80_G1.1630.82
4_A7_R1.1510.81
42_F258_F1.1410.81
298_D310_V1.1250.80
168_R214_E1.1240.80
155_G185_F1.1140.79
79_M225_L1.1080.79
65_V73_A1.1020.78
213_P247_P1.1010.78
98_F103_G1.1000.78
63_E70_R1.0960.78
252_L256_A1.0870.77
240_A243_E1.0840.77
72_F230_A1.0750.77
112_V116_W1.0730.76
43_L47_H1.0690.76
235_E279_V1.0660.76
221_S230_A1.0600.76
32_R42_F1.0550.75
236_A239_E1.0420.74
19_F32_R1.0410.74
313_Q316_R1.0280.73
116_W262_A1.0200.73
166_Q211_F1.0200.73
108_Y258_F1.0110.72
96_R100_A1.0100.72
145_L195_F1.0050.72
281_C288_A0.9970.71
59_A74_Y0.9950.71
209_A213_P0.9890.70
309_E313_Q0.9750.69
186_D211_F0.9740.69
43_L116_W0.9720.69
98_F239_E0.9650.68
29_P32_R0.9630.68
145_L254_Q0.9600.68
83_L87_L0.9590.68
25_P197_H0.9450.67
102_P105_P0.9430.67
78_A145_L0.9430.67
112_V230_A0.9430.67
139_D153_H0.9390.66
211_F215_R0.9380.66
296_L315_I0.9370.66
109_M268_N0.9330.66
108_Y139_D0.9320.66
230_A254_Q0.9290.66
238_L276_A0.9160.64
283_L291_L0.9150.64
122_P198_G0.9120.64
4_A8_R0.9080.64
19_F36_E0.9070.64
227_A277_C0.9070.64
197_H203_R0.9070.64
256_A281_C0.9020.63
304_A317_A0.9020.63
43_L114_A0.9010.63
17_V41_T0.8970.63
197_H204_V0.8960.63
160_R236_A0.8920.62
39_G254_Q0.8860.62
47_H50_L0.8840.62
99_L110_V0.8830.62
236_A247_P0.8790.61
82_A114_A0.8770.61
108_Y116_W0.8760.61
145_L230_A0.8760.61
195_F225_L0.8750.61
109_M145_L0.8740.61
233_A284_S0.8720.61
78_A109_M0.8710.60
117_A156_Y0.8700.60
72_F254_Q0.8690.60
173_P184_A0.8680.60
294_E297_P0.8650.60
59_A102_P0.8650.60
145_L262_A0.8610.60
106_H266_A0.8570.59
9_L20_A0.8560.59
145_L266_A0.8530.59
42_F112_V0.8520.59
230_A312_R0.8500.59
114_A162_Y0.8480.58
58_L62_L0.8450.58
107_I111_Y0.8440.58
108_Y141_L0.8430.58
17_V47_H0.8390.58
292_T296_L0.8390.58
309_E312_R0.8370.57
165_R239_E0.8290.57
109_M116_W0.8260.56
38_V41_T0.8250.56
299_L302_D0.8220.56
78_A266_A0.8210.56
256_A260_A0.8150.55
308_Y311_W0.8140.55
49_A80_G0.8090.55
162_Y165_R0.8060.55
203_R206_A0.8060.55
22_R39_G0.8040.54
225_L262_A0.8040.54
150_Y154_Q0.8040.54
283_L288_A0.7940.53
213_P308_Y0.7930.53
53_R57_E0.7930.53
253_A257_A0.7880.53
207_T210_R0.7860.53
225_L230_A0.7810.52
109_M230_A0.7780.52
271_P274_E0.7770.52
305_E313_Q0.7750.52
19_F199_A0.7730.51
18_T21_R0.7700.51
150_Y163_V0.7650.51
123_R127_R0.7650.51
202_E244_A0.7640.51
78_A187_Q0.7620.50
22_R36_E0.7600.50
308_Y315_I0.7560.50
121_L193_L0.7540.50
274_E278_R0.7540.50
264_Q285_A0.7530.50
228_A280_L0.7520.49
30_A33_E0.7490.49
156_Y272_H0.7480.49
16_E22_R0.7450.49
224_G252_L0.7390.48
116_W230_A0.7390.48
264_Q286_E0.7380.48
56_E60_R0.7350.48
261_K265_R0.7350.48
21_R228_A0.7340.48
153_H198_G0.7320.48
163_V232_G0.7310.48
80_G121_L0.7310.48
291_L315_I0.7300.47
300_P305_E0.7270.47
293_D316_R0.7260.47
138_L146_A0.7260.47
147_L150_Y0.7240.47
216_R246_G0.7230.47
108_Y145_L0.7230.47
122_P230_A0.7220.47
147_L189_L0.7210.47
70_R74_Y0.7210.47
88_T93_R0.7160.46
161_R216_R0.7120.46
262_A311_W0.7110.46
306_P313_Q0.7080.45
39_G116_W0.6980.44
79_M156_Y0.6940.44
284_S305_E0.6930.44
202_E209_A0.6920.44
153_H229_Y0.6890.44
11_G14_P0.6890.44
91_R303_G0.6880.44
227_A241_L0.6810.43
143_R200_D0.6760.42
71_G225_L0.6750.42
46_Y50_L0.6740.42
221_S262_A0.6720.42
31_A141_L0.6720.42
60_R64_A0.6710.42
189_L192_S0.6690.42
108_Y153_H0.6690.42
116_W311_W0.6680.42
43_L112_V0.6670.42
18_T248_H0.6670.42
228_A238_L0.6650.41
108_Y225_L0.6620.41
60_R210_R0.6610.41
145_L156_Y0.6580.41
118_L125_L0.6580.41
23_G29_P0.6530.40
146_A199_A0.6480.40
16_E24_F0.6480.40
5_L318_R0.6480.40
151_G187_Q0.6470.40
62_L77_A0.6460.40
50_L94_R0.6440.40
183_R215_R0.6420.39
46_Y88_T0.6420.39
45_G76_G0.6410.39
14_P38_V0.6410.39
117_A231_G0.6390.39
164_D210_R0.6390.39
205_A240_A0.6390.39
308_Y312_R0.6390.39
166_Q210_R0.6380.39
116_W229_Y0.6380.39
62_L74_Y0.6350.39
111_Y116_W0.6340.39
76_G152_F0.6340.39
15_A214_E0.6320.38
15_A30_A0.6310.38
66_P286_E0.6300.38
221_S312_R0.6280.38
211_F219_L0.6270.38
15_A21_R0.6250.38
118_L146_A0.6250.38
24_F36_E0.6230.38
39_G230_A0.6210.38
116_W141_L0.6200.37
153_H215_R0.6190.37
291_L295_A0.6190.37
22_R116_W0.6190.37
195_F254_Q0.6170.37
39_G112_V0.6100.37
145_L225_L0.6080.36
80_G195_F0.6070.36
225_L311_W0.6070.36
59_A63_E0.6060.36
240_A244_A0.6060.36
184_A302_D0.6050.36
181_A245_A0.6050.36
195_F221_S0.6040.36
201_V244_A0.6040.36
158_H161_R0.6030.36
58_L77_A0.6020.36
110_V114_A0.6020.36
152_F195_F0.6000.36
305_E310_V0.5980.36
225_L312_R0.5970.35
19_F80_G0.5970.35
35_L71_G0.5960.35
295_A315_I0.5960.35
58_L63_E0.5940.35
67_P164_D0.5920.35
146_A318_R0.5910.35
150_Y185_F0.5910.35
122_P196_V0.5900.35
86_A124_P0.5880.35
257_A261_K0.5870.35
39_G46_Y0.5860.35
261_K292_T0.5840.34
39_G43_L0.5840.34
277_C285_A0.5840.34
72_F76_G0.5840.34
242_R280_L0.5830.34
62_L223_V0.5830.34
225_L254_Q0.5800.34
20_A125_L0.5790.34
43_L159_T0.5780.34
78_A221_S0.5780.34
96_R249_R0.5780.34
184_A309_E0.5780.34
71_G76_G0.5760.34
42_F45_G0.5740.33
42_F254_Q0.5730.33
123_R126_W0.5710.33
42_F262_A0.5710.33
19_F35_L0.5700.33
210_R310_V0.5700.33
206_A236_A0.5700.33
73_A273_T0.5660.33
45_G258_F0.5640.33
47_H58_L0.5640.33
122_P147_L0.5630.33
15_A107_I0.5630.33
300_P304_A0.5620.33
11_G155_G0.5620.33
251_Q260_A0.5610.32
22_R35_L0.5600.32
39_G139_D0.5600.32
293_D296_L0.5590.32
97_A102_P0.5590.32
38_V278_R0.5580.32
84_L88_T0.5560.32
99_L107_I0.5560.32
37_T41_T0.5560.32
67_P147_L0.5540.32
217_A248_H0.5540.32
167_R170_R0.5520.32
39_G153_H0.5510.32
90_W94_R0.5500.32
15_A18_T0.5500.32
17_V28_D0.5490.31
262_A266_A0.5490.31
34_R46_Y0.5470.31
246_G249_R0.5470.31
289_A292_T0.5460.31
180_Y225_L0.5460.31
35_L119_A0.5450.31
109_M195_F0.5450.31
86_A123_R0.5450.31
106_H268_N0.5450.31
163_V211_F0.5440.31
236_A317_A0.5430.31
50_L139_D0.5420.31
44_E65_V0.5390.31
225_L308_Y0.5370.30
169_P182_R0.5340.30
252_L280_L0.5340.30
120_R150_Y0.5340.30
240_A317_A0.5330.30
58_L280_L0.5320.30
58_L102_P0.5300.30
251_Q254_Q0.5300.30
212_P283_L0.5300.30
35_L42_F0.5300.30
11_G47_H0.5280.30
310_V313_Q0.5280.30
256_A288_A0.5280.30
39_G225_L0.5270.30
110_V236_A0.5260.30
95_L257_A0.5260.30
215_R238_L0.5250.30
188_G191_R0.5240.29
115_G191_R0.5240.29
115_G188_G0.5240.29
85_D94_R0.5240.29
19_F24_F0.5240.29
40_R60_R0.5230.29
55_P143_R0.5210.29
19_F23_G0.5200.29
109_M262_A0.5200.29
16_E21_R0.5190.29
42_F153_H0.5180.29
74_Y101_G0.5170.29
39_G145_L0.5160.29
111_Y150_Y0.5130.29
172_L185_F0.5130.29
36_E230_A0.5120.29
39_G195_F0.5120.29
299_L305_E0.5120.29
208_I241_L0.5110.28
52_A310_V0.5100.28
85_D220_W0.5090.28
41_T156_Y0.5070.28
225_L258_F0.5060.28
179_G203_R0.5050.28
32_R35_L0.5050.28
107_I142_L0.5040.28
165_R216_R0.5040.28
35_L45_G0.5040.28
301_A304_A0.5030.28
185_F277_C0.5030.28
25_P203_R0.5030.28
193_L207_T0.5020.28
71_G195_F0.5020.28
145_L258_F0.5000.28
201_V239_E0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l0zA 2 0.3072 16.2 0.973 Contact Map
3ll7A 1 0.1944 8 0.977 Contact Map
2e18A 2 0.348 5.5 0.978 Contact Map
3u4gA 2 0.3166 3.8 0.98 Contact Map
2kmfA 1 0.1599 3.5 0.98 Contact Map
2higA 3 0.1317 3.2 0.981 Contact Map
4hfxA 2 0.1348 2.9 0.981 Contact Map
3kyzA 2 0.1285 2.9 0.981 Contact Map
4wv4B 1 0.2853 2.8 0.981 Contact Map
3d2yA 3 0.279 2.8 0.981 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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