GREMLIN Database
DUF1699 - Protein of unknown function (DUF1699)
PFAM: PF08004 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 130 (129)
Sequences: 552 (244)
Seq/√Len: 21.4
META: 0.889

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
96_E117_E5.1071.00
113_K117_E3.9011.00
72_L123_D2.6940.99
58_K70_E2.5390.98
117_E120_L2.2720.96
10_E28_P2.2200.96
96_E100_L2.0730.94
121_S124_L2.0150.93
3_I21_I1.9620.92
110_I115_S1.9450.91
79_H82_D1.9230.91
59_S99_E1.8680.89
30_N55_T1.7780.87
119_K124_L1.7430.86
2_K5_V1.7130.85
3_I10_E1.6740.83
24_L36_L1.6740.83
95_E102_A1.6320.82
13_P22_V1.6280.82
43_L115_S1.6260.81
19_E86_Y1.6000.80
77_W83_I1.5820.80
39_T87_Y1.5230.77
78_G82_D1.5060.76
21_I44_R1.4890.75
40_C44_R1.4840.75
54_K66_M1.4650.74
93_V107_A1.4610.74
25_A52_Y1.4500.73
52_Y75_D1.4330.72
119_K128_I1.3900.70
109_D112_E1.3810.69
30_N52_Y1.3780.69
21_I40_C1.3770.69
6_V40_C1.3660.69
100_L105_K1.3580.68
63_F67_Q1.3430.67
58_K65_E1.3280.66
4_R86_Y1.2850.64
60_I69_I1.2700.63
112_E122_P1.2560.62
119_K125_I1.2520.62
53_K56_M1.2350.61
124_L127_Y1.1850.57
59_S66_M1.1830.57
84_N129_L1.1770.57
58_K61_E1.1740.57
21_I37_V1.1730.57
8_S13_P1.1670.56
53_K90_P1.1630.56
29_S66_M1.1600.56
10_E13_P1.1580.56
115_S125_I1.1560.55
30_N57_S1.1460.55
6_V11_E1.1050.52
20_K44_R1.0990.52
39_T94_I1.0990.52
92_S111_A1.0920.51
24_L103_E1.0810.50
87_Y94_I1.0730.50
100_L121_S1.0640.49
53_K123_D1.0450.48
9_R47_Q1.0390.48
2_K60_I1.0390.48
79_H86_Y1.0370.47
6_V45_A1.0270.47
45_A48_V1.0250.47
91_D125_I1.0220.46
77_W85_E1.0180.46
66_M73_E1.0050.45
68_G126_K1.0040.45
28_P38_Q1.0020.45
6_V102_A0.9940.45
21_I45_A0.9900.44
31_K101_K0.9840.44
28_P37_V0.9780.43
83_I119_K0.9700.43
43_L116_R0.9680.43
122_P125_I0.9660.43
63_F81_K0.9590.42
53_K61_E0.9580.42
76_V82_D0.9510.42
34_F67_Q0.9480.42
13_P17_P0.9310.40
26_F32_D0.9240.40
11_E36_L0.9190.40
111_A118_T0.9140.39
10_E88_T0.8920.38
76_V80_R0.8900.38
52_Y81_K0.8830.37
38_Q68_G0.8810.37
89_V93_V0.8740.37
7_S80_R0.8550.36
39_T43_L0.8520.35
65_E103_E0.8520.35
96_E119_K0.8500.35
16_N40_C0.8480.35
114_V117_E0.8410.35
62_M73_E0.8360.34
18_N42_R0.8350.34
51_S57_S0.8300.34
52_Y85_E0.8280.34
35_N128_I0.8240.34
68_G111_A0.8230.34
20_K50_P0.8220.34
31_K34_F0.8150.33
91_D100_L0.8110.33
60_I63_F0.8050.33
26_F29_S0.8050.33
101_K125_I0.7940.32
52_Y55_T0.7890.32
38_Q42_R0.7830.31
90_P107_A0.7770.31
15_L40_C0.7760.31
90_P106_S0.7700.31
112_E128_I0.7600.30
62_M110_I0.7570.30
9_R20_K0.7450.29
93_V129_L0.7430.29
91_D114_V0.7420.29
61_E70_E0.7360.29
91_D121_S0.7350.29
102_A112_E0.7310.28
2_K95_E0.7270.28
36_L124_L0.7090.27
38_Q48_V0.7050.27
16_N39_T0.7030.27
71_L123_D0.7020.27
1_M5_V0.7020.27
20_K47_Q0.6950.26
73_E77_W0.6950.26
31_K39_T0.6930.26
14_T53_K0.6930.26
37_V70_E0.6830.26
22_V120_L0.6780.26
10_E16_N0.6730.25
34_F62_M0.6720.25
69_I97_I0.6650.25
123_D126_K0.6640.25
97_I129_L0.6600.25
70_E103_E0.6580.25
7_S81_K0.6560.24
79_H83_I0.6560.24
44_R70_E0.6540.24
45_A127_Y0.6490.24
19_E30_N0.6440.24
108_E120_L0.6430.24
10_E46_I0.6380.24
31_K100_L0.6330.23
47_Q87_Y0.6270.23
13_P44_R0.6190.23
27_R79_H0.6170.23
102_A122_P0.6130.22
49_P52_Y0.6090.22
13_P16_N0.6090.22
72_L96_E0.6080.22
10_E61_E0.6030.22
8_S36_L0.5900.21
17_P60_I0.5870.21
95_E116_R0.5860.21
47_Q74_G0.5840.21
8_S67_Q0.5820.21
9_R13_P0.5790.21
92_S96_E0.5740.21
52_Y80_R0.5740.21
22_V97_I0.5730.21
76_V83_I0.5650.20
115_S124_L0.5610.20
2_K83_I0.5610.20
9_R45_A0.5610.20
34_F73_E0.5580.20
31_K62_M0.5490.20
125_I129_L0.5450.19
88_T127_Y0.5420.19
88_T128_I0.5420.19
78_G81_K0.5390.19
10_E14_T0.5390.19
106_S112_E0.5380.19
80_R85_E0.5350.19
68_G91_D0.5330.19
118_T121_S0.5260.19
74_G78_G0.5230.18
24_L89_V0.5220.18
71_L116_R0.5220.18
56_M108_E0.5210.18
37_V40_C0.5180.18
41_P79_H0.5130.18
16_N91_D0.5100.18
103_E117_E0.5090.18
106_S123_D0.5090.18
17_P20_K0.5060.18
90_P94_I0.5050.18
93_V98_K0.5010.18
6_V9_R0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bqqA 2 0.8308 44.2 0.939 Contact Map
3eglA 1 0.8231 40.9 0.94 Contact Map
3uj3X 2 0.3308 39.3 0.94 Contact Map
4kisA 2 0.5846 38.9 0.941 Contact Map
1gdtA 2 0.7308 34.7 0.942 Contact Map
1mgpA 1 0.9077 26.4 0.946 Contact Map
4uvkA 1 0.4 21.1 0.948 Contact Map
4u7bA 2 0.3462 20.9 0.948 Contact Map
2cfuA 2 0.9 20.4 0.948 Contact Map
1u78A 1 0.3308 19.9 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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