GREMLIN Database
SRR1 - SRR1
PFAM: PF07985 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 55 (53)
Sequences: 882 (734)
Seq/√Len: 100.8
META: 0.338

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_S48_D3.6511.00
9_F48_D2.8841.00
6_L44_F2.3701.00
1_I22_L2.2621.00
2_V5_G2.0461.00
39_A52_L2.0371.00
22_L26_R1.9111.00
3_C22_L1.8351.00
19_L44_F1.7801.00
6_L19_L1.7351.00
46_E49_K1.5301.00
4_L40_Y1.5061.00
1_I26_R1.4471.00
6_L41_D1.4351.00
39_A44_F1.4021.00
50_E53_E1.3861.00
30_G34_S1.3550.99
44_F52_L1.2670.99
8_S45_T1.2510.99
22_L37_V1.2420.99
30_G33_G1.2340.99
10_S47_L1.1620.98
22_L44_F1.1550.98
29_L40_Y1.1340.98
10_S45_T1.0200.96
2_V38_Y1.0110.96
24_L27_E0.9730.95
17_Y21_L0.9340.94
3_C6_L0.9320.94
46_E53_E0.9320.94
21_L40_Y0.9200.93
9_F52_L0.9130.93
23_L27_E0.8950.92
2_V50_E0.8460.90
6_L9_F0.8450.90
31_I35_S0.7980.87
34_S50_E0.7970.87
4_L9_F0.7910.86
47_L53_E0.7880.86
47_L51_F0.7800.86
5_G12_S0.7780.85
4_L38_Y0.7670.85
23_L49_K0.7630.84
12_S15_S0.7630.84
27_E54_S0.7410.83
21_L25_L0.7070.80
3_C19_L0.7060.79
15_S40_Y0.7060.79
34_S46_E0.7010.79
33_G53_E0.6970.79
6_L52_L0.6680.76
41_D44_F0.6680.76
5_G17_Y0.6660.75
43_V48_D0.6630.75
12_S40_Y0.6510.74
27_E35_S0.6490.74
35_S46_E0.6480.73
26_R30_G0.6430.73
44_F48_D0.6410.73
9_F19_L0.6260.71
27_E33_G0.6130.69
28_L47_L0.6110.69
3_C44_F0.6030.68
47_L54_S0.6010.68
22_L43_V0.5820.65
10_S25_L0.5780.65
16_R21_L0.5750.64
46_E54_S0.5570.62
16_R44_F0.5490.61
32_P41_D0.5480.61
28_L31_I0.5300.58
22_L41_D0.5190.57
4_L24_L0.5190.57
30_G53_E0.5170.56
4_L19_L0.5170.56
13_R16_R0.5120.56
5_G11_S0.5120.56
3_C26_R0.5090.55
5_G18_Q0.5030.54
13_R49_K0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2y0cA 4 0.9455 16.3 0.821 Contact Map
4xr9A 2 0.9455 14.4 0.825 Contact Map
1mszA 1 0.6727 14.2 0.826 Contact Map
4a7pA 2 0.9455 14.1 0.826 Contact Map
3vtfA 2 0.9455 12.2 0.831 Contact Map
3ojoA 2 0.9273 11 0.834 Contact Map
2o3jA 4 0.9818 7.7 0.846 Contact Map
3gg2A 3 0.9455 7.7 0.846 Contact Map
3i9v3 1 0.9273 7.6 0.846 Contact Map
2q3eA 5 0.9455 7.4 0.847 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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