GREMLIN Database
Swi3 - Replication Fork Protection Component Swi3
PFAM: PF07962 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 81 (80)
Sequences: 592 (446)
Seq/√Len: 49.8
META: 0.343

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_G34_D4.4011.00
54_K57_D2.9471.00
75_L79_R2.8981.00
3_D6_R2.7841.00
16_L20_F2.5901.00
58_F62_V2.4241.00
46_A58_F2.1971.00
13_L66_G1.8430.99
55_F59_L1.8180.99
15_K19_E1.7290.99
26_K30_H1.7080.98
27_G30_H1.6480.98
29_G34_D1.6070.98
32_A36_K1.5740.97
53_A57_D1.5330.97
38_L42_Y1.4540.96
31_E34_D1.3870.95
53_A75_L1.3630.94
27_G31_E1.3250.93
72_Q76_K1.3040.93
35_L47_H1.2540.91
37_R41_F1.2400.91
46_A57_D1.2390.91
61_R75_L1.2300.90
11_R15_K1.1860.88
63_E66_G1.1370.86
30_H34_D1.1240.86
61_R79_R1.1190.85
53_A61_R1.1020.85
65_L69_K1.0950.84
7_L13_L1.0890.84
40_N71_V1.0860.84
32_A54_K1.0830.83
35_L59_L1.0660.82
37_R42_Y1.0610.82
35_L58_F1.0460.81
4_E70_R1.0270.80
34_D45_W1.0240.80
74_Y78_W1.0210.80
4_E65_L1.0110.79
14_P17_R1.0080.79
15_K48_R1.0050.79
20_F48_R0.9820.77
16_L19_E0.9800.77
76_K80_D0.9630.76
35_L55_F0.9520.75
69_K72_Q0.9450.74
47_H52_K0.9450.74
9_S49_L0.9280.73
45_W51_P0.9210.72
19_E41_F0.8990.70
49_L58_F0.8970.70
49_L55_F0.8920.70
69_K73_V0.8730.68
59_L66_G0.8710.68
21_K80_D0.8660.67
26_K34_D0.8580.67
25_F28_K0.8230.63
23_L64_K0.8220.63
77_E80_D0.8190.63
30_H33_S0.8190.63
20_F41_F0.8140.63
22_K42_Y0.8110.62
9_S60_E0.8040.62
30_H55_F0.8030.62
13_L17_R0.7940.61
53_A58_F0.7880.60
23_L37_R0.7800.59
43_Q55_F0.7770.59
51_P55_F0.7750.59
10_P33_S0.7640.58
44_L57_D0.7600.57
1_K10_P0.7580.57
43_Q47_H0.7510.56
2_L10_P0.7420.56
36_K39_L0.7400.55
4_E68_K0.7320.55
2_L64_K0.7300.54
28_K31_E0.7220.53
39_L79_R0.7160.53
16_L41_F0.7050.52
62_V69_K0.6910.50
1_K5_E0.6910.50
10_P18_K0.6810.49
50_Y54_K0.6730.48
61_R64_K0.6700.48
26_K29_G0.6670.48
32_A38_L0.6570.47
2_L58_F0.6560.47
4_E50_Y0.6440.46
6_R14_P0.6340.45
19_E76_K0.6240.44
36_K53_A0.6210.43
5_E59_L0.6180.43
50_Y57_D0.6160.43
47_H58_F0.6130.42
56_D62_V0.6090.42
7_L12_G0.6050.42
66_G75_L0.5960.41
9_S18_K0.5960.41
25_F65_L0.5730.38
21_K24_K0.5720.38
60_E64_K0.5720.38
20_F39_L0.5620.37
76_K79_R0.5610.37
21_K40_N0.5590.37
50_Y68_K0.5520.36
5_E22_K0.5360.35
3_D16_L0.5340.35
68_K73_V0.5320.35
4_E8_L0.5280.34
49_L64_K0.5240.34
23_L53_A0.5230.34
15_K60_E0.5190.33
23_L41_F0.5180.33
26_K31_E0.5170.33
9_S58_F0.5160.33
13_L64_K0.5140.33
25_F34_D0.5130.33
16_L28_K0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2v6eA 2 0.9753 40.1 0.856 Contact Map
2wscF 1 0.6914 14.6 0.883 Contact Map
5chsA 1 0.6296 13.6 0.885 Contact Map
4xk8F 1 0.6914 13.5 0.885 Contact Map
3j7aG 1 0.8025 13.4 0.885 Contact Map
4kt0F 1 0.679 9.6 0.893 Contact Map
1jb0F 1 0.679 9.4 0.893 Contact Map
3us6A 1 0.5926 8.7 0.894 Contact Map
1tohA 3 0.9012 8.2 0.896 Contact Map
4bujB 1 1 7.5 0.898 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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