GREMLIN Database
DUF1688 - Protein of unknown function (DUF1688)
PFAM: PF07958 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 417 (399)
Sequences: 1587 (1074)
Seq/√Len: 53.8
META: 0.686

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
234_L283_T3.7851.00
324_L330_A3.5071.00
19_A24_L3.5061.00
317_V408_I3.4921.00
374_D377_E3.3101.00
306_G360_L3.2601.00
47_R394_E3.0841.00
161_A180_E3.0731.00
58_F291_E2.9901.00
324_L348_L2.9781.00
39_D370_R2.9651.00
37_A319_T2.8181.00
95_D206_P2.8101.00
261_P347_E2.7471.00
147_D150_R2.7151.00
135_M167_G2.6681.00
30_D323_V2.6541.00
91_R211_D2.6321.00
35_D366_L2.6101.00
4_S7_A2.6071.00
112_R121_T2.6001.00
183_A187_R2.5281.00
342_H348_L2.4881.00
329_D348_L2.4661.00
385_E390_A2.4041.00
99_V151_V2.3871.00
42_A367_V2.3731.00
257_C272_L2.3211.00
316_F321_V2.2891.00
16_L358_A2.2711.00
199_V237_G2.2591.00
287_I301_L2.2441.00
38_A366_L2.2051.00
161_A183_A2.2031.00
40_Y398_E2.1971.00
234_L279_S2.1731.00
93_L292_W2.1401.00
373_L377_E2.1061.00
140_A167_G2.0961.00
40_Y319_T2.0751.00
5_A8_V2.0261.00
342_H346_S1.9781.00
135_M141_F1.9551.00
300_G303_G1.9551.00
12_A273_V1.9491.00
275_F308_P1.9040.99
87_A210_F1.8820.99
265_G270_D1.8780.99
378_L383_V1.8610.99
363_L383_V1.8580.99
20_L31_L1.8330.99
38_A42_A1.8310.99
364_A368_R1.8290.99
15_V18_L1.8280.99
264_G270_D1.7900.99
247_L272_L1.7830.99
3_L239_G1.7760.99
20_L29_V1.7730.99
395_I399_L1.7600.99
122_F130_V1.7600.99
18_L24_L1.7570.99
364_A383_V1.7480.99
210_F294_A1.7450.99
73_W77_A1.7230.99
159_L183_A1.7160.99
326_D329_D1.7090.99
224_R297_T1.7030.99
18_L23_R1.6990.99
233_A237_G1.6920.99
88_E147_D1.6910.99
115_E134_R1.6810.99
98_I193_L1.6810.99
226_P300_G1.6670.99
114_R121_T1.6490.99
141_F167_G1.6450.99
319_T395_I1.6400.98
16_L29_V1.6240.98
134_R137_A1.6220.98
123_G130_V1.5990.98
45_T48_R1.5900.98
63_R66_E1.5810.98
8_V257_C1.5640.98
228_P300_G1.5630.98
94_I210_F1.5600.98
66_E71_D1.5560.98
324_L408_I1.5530.98
379_P382_K1.5520.98
160_T163_D1.5370.98
40_Y395_I1.5340.98
72_R115_E1.4980.97
88_E92_A1.4840.97
316_F359_L1.4790.97
18_L263_L1.4610.97
16_L31_L1.4570.97
344_V416_V1.4510.97
143_S155_A1.4470.97
44_V49_Y1.4430.97
188_R191_E1.4410.97
98_I206_P1.4400.96
341_A411_I1.4380.96
48_R385_E1.4230.96
200_F237_G1.4170.96
40_Y45_T1.4130.96
75_E134_R1.4040.96
168_F176_L1.4040.96
193_L206_P1.3950.96
17_A20_L1.3830.96
39_D43_A1.3810.96
129_A177_V1.3680.95
95_D136_F1.3660.95
228_P303_G1.3610.95
20_L362_R1.3600.95
68_G130_V1.3510.95
212_Y233_A1.3500.95
306_G316_F1.3460.95
397_A403_D1.3360.95
13_H16_L1.3340.95
68_G72_R1.3300.95
329_D342_H1.3220.94
366_L370_R1.3180.94
150_R155_A1.2990.94
99_V141_F1.2920.94
117_E134_R1.2920.94
165_A179_L1.2780.93
87_A214_A1.2770.93
287_I298_V1.2700.93
142_S148_P1.2690.93
63_R288_E1.2670.93
196_R236_D1.2650.93
343_E346_S1.2460.92
42_A365_P1.2400.92
31_L362_R1.2390.92
187_R190_G1.2380.92
273_V354_A1.2370.92
151_V206_P1.2350.92
48_R390_A1.2340.92
33_R36_A1.2210.92
94_I98_I1.2140.91
28_R323_V1.2110.91
196_R199_V1.2110.91
230_I287_I1.2030.91
157_A194_A1.2020.91
192_A240_P1.2020.91
14_R263_L1.1920.91
36_A39_D1.1870.90
329_D340_R1.1820.90
37_A321_V1.1730.90
373_L378_L1.1710.90
343_E411_I1.1670.90
192_A237_G1.1650.90
225_L298_V1.1530.89
56_I378_L1.1460.89
130_V133_L1.1450.89
22_G28_R1.1440.89
67_A129_A1.1420.89
363_L388_T1.1280.88
367_V371_L1.1270.88
263_L270_D1.1260.88
38_A383_V1.1240.88
13_H362_R1.1200.88
362_R365_P1.1130.87
91_R207_G1.1100.87
197_P200_F1.1020.87
27_F351_E1.1000.87
212_Y216_R1.0990.87
68_G120_Q1.0960.86
347_E350_V1.0960.86
157_A191_E1.0910.86
113_Y134_R1.0900.86
143_S150_R1.0870.86
77_A93_L1.0860.86
37_A41_V1.0690.85
67_A130_V1.0660.85
28_R325_R1.0580.84
75_E78_A1.0540.84
217_A223_G1.0540.84
95_D193_L1.0540.84
71_D74_A1.0500.84
90_A210_F1.0500.84
267_D270_D1.0500.84
366_L369_A1.0470.84
73_W93_L1.0460.84
229_A233_A1.0410.83
12_A16_L1.0380.83
200_F208_G1.0370.83
58_F381_A1.0370.83
118_T122_F1.0370.83
98_I238_L1.0360.83
56_I382_K1.0350.83
46_R53_L1.0330.83
308_P357_V1.0320.83
72_R134_R1.0260.83
245_S253_P1.0240.82
28_R322_L1.0210.82
230_I283_T1.0210.82
326_D340_R1.0190.82
80_L83_W1.0150.82
66_E115_E1.0120.82
144_D147_D1.0110.82
308_P316_F1.0090.81
5_A231_L1.0080.81
143_S152_D1.0030.81
62_W97_A1.0030.81
246_R258_W1.0010.81
3_L257_C1.0000.81
40_Y394_E0.9980.81
201_G208_G0.9950.81
133_L137_A0.9940.81
227_A231_L0.9910.80
316_F388_T0.9830.80
25_P347_E0.9820.80
192_A196_R0.9780.79
414_G417_F0.9740.79
199_V212_Y0.9650.78
216_R229_A0.9620.78
68_G115_E0.9600.78
128_L176_L0.9540.78
3_L7_A0.9480.77
3_L236_D0.9440.77
37_A45_T0.9430.77
44_V394_E0.9430.77
391_A395_I0.9410.77
142_S150_R0.9380.76
70_V115_E0.9370.76
324_L329_D0.9370.76
209_L238_L0.9370.76
155_A163_D0.9360.76
341_A409_K0.9360.76
383_V388_T0.9350.76
43_A47_R0.9350.76
38_A367_V0.9230.75
58_F97_A0.9220.75
72_R76_L0.9190.75
216_R225_L0.9140.75
37_A40_Y0.9140.75
40_Y43_A0.9110.74
6_A10_E0.9100.74
5_A228_P0.9090.74
115_E118_T0.9080.74
35_D370_R0.9040.74
58_F301_L0.9020.74
67_A72_R0.9010.74
277_K310_Y0.9000.73
19_A322_L0.8980.73
413_D416_V0.8970.73
12_A358_A0.8960.73
43_A398_E0.8960.73
154_A158_R0.8960.73
161_A165_A0.8940.73
70_V75_E0.8930.73
13_H358_A0.8920.73
373_L383_V0.8910.73
161_A179_L0.8910.73
17_A21_A0.8910.73
19_A29_V0.8910.73
394_E398_E0.8880.72
387_G391_A0.8870.72
247_L259_R0.8860.72
85_D91_R0.8830.72
12_A15_V0.8820.72
351_E354_A0.8790.72
226_P299_T0.8790.72
14_R265_G0.8720.71
227_A304_L0.8720.71
395_I404_G0.8680.71
122_F133_L0.8670.71
231_L235_L0.8640.70
11_R274_P0.8630.70
89_R93_L0.8600.70
397_A402_P0.8590.70
224_R299_T0.8570.70
164_L179_L0.8560.70
317_V324_L0.8550.70
330_A348_L0.8530.69
395_I405_G0.8500.69
226_P229_A0.8490.69
216_R233_A0.8470.69
42_A370_R0.8450.69
14_R18_L0.8440.69
393_R396_A0.8440.69
129_A134_R0.8430.68
264_G267_D0.8420.68
201_G204_P0.8410.68
44_V47_R0.8380.68
54_D382_K0.8230.67
7_A10_E0.8210.66
344_V348_L0.8200.66
159_L162_A0.8190.66
291_E297_T0.8180.66
290_L298_V0.8180.66
157_A190_G0.8180.66
364_A381_A0.8160.66
136_F149_L0.8150.66
362_R366_L0.8130.66
151_V193_L0.8100.65
97_A289_P0.8020.65
170_V175_P0.7920.64
77_A80_L0.7900.63
138_A166_R0.7900.63
79_R349_V0.7890.63
81_A84_L0.7870.63
230_I298_V0.7840.63
48_R394_E0.7800.62
200_F207_G0.7780.62
7_A11_R0.7760.62
115_E130_V0.7750.62
90_A211_D0.7730.62
231_L279_S0.7730.62
13_H17_A0.7690.61
365_P383_V0.7690.61
163_D166_R0.7680.61
164_L183_A0.7680.61
85_D88_E0.7680.61
213_L233_A0.7670.61
61_R64_H0.7650.61
139_G142_S0.7640.61
90_A94_I0.7630.61
42_A373_L0.7630.61
275_F322_L0.7620.61
234_L328_A0.7600.60
171_S175_P0.7600.60
98_I239_G0.7580.60
316_F363_L0.7570.60
41_V387_G0.7560.60
14_R264_G0.7560.60
19_A272_L0.7560.60
254_L257_C0.7560.60
365_P369_A0.7530.60
275_F354_A0.7520.60
258_W345_G0.7500.59
209_L233_A0.7480.59
397_A405_G0.7480.59
164_L304_L0.7460.59
208_G212_Y0.7460.59
67_A122_F0.7460.59
325_R342_H0.7440.59
405_G409_K0.7420.59
145_P148_P0.7400.58
122_F257_C0.7370.58
181_G258_W0.7370.58
4_S8_V0.7340.58
76_L80_L0.7300.57
283_T287_I0.7300.57
76_L133_L0.7290.57
16_L20_L0.7270.57
140_A159_L0.7220.56
158_R196_R0.7210.56
15_V258_W0.7210.56
115_E122_F0.7170.56
116_P134_R0.7150.56
72_R75_E0.7140.56
5_A303_G0.7120.55
44_V48_R0.7090.55
15_V19_A0.7080.55
88_E208_G0.7040.55
77_A89_R0.7010.54
16_L19_A0.6990.54
325_R370_R0.6990.54
196_R240_P0.6980.54
2_L7_A0.6970.54
214_A217_A0.6960.54
213_L225_L0.6930.53
351_E355_L0.6880.53
92_A206_P0.6870.53
366_L383_V0.6870.53
60_S382_K0.6870.53
45_T257_C0.6870.53
6_A228_P0.6870.53
3_L8_V0.6870.53
358_A362_R0.6860.53
207_G211_D0.6850.53
153_A194_A0.6850.53
8_V12_A0.6850.53
110_A403_D0.6840.52
258_W412_S0.6820.52
89_R292_W0.6820.52
118_T202_R0.6820.52
195_A215_A0.6820.52
228_P299_T0.6820.52
45_T367_V0.6770.52
386_G390_A0.6760.52
291_E301_L0.6760.52
378_L382_K0.6750.52
275_F351_E0.6740.51
94_I233_A0.6700.51
2_L11_R0.6700.51
76_L99_V0.6680.51
246_R412_S0.6650.50
136_F206_P0.6650.50
350_V408_I0.6640.50
378_L388_T0.6620.50
280_Q305_T0.6610.50
191_E296_I0.6600.50
412_S415_T0.6590.50
66_E73_W0.6590.50
100_S132_S0.6580.50
232_S236_D0.6580.50
65_F133_L0.6560.50
45_T60_S0.6540.49
200_F212_Y0.6520.49
15_V260_H0.6520.49
206_P237_G0.6500.49
26_H351_E0.6500.49
7_A239_G0.6480.49
265_G269_T0.6470.49
106_G309_E0.6470.49
16_L316_F0.6470.49
73_W97_A0.6470.49
53_L282_L0.6460.48
29_V359_L0.6450.48
62_W288_E0.6450.48
138_A141_F0.6450.48
94_I230_I0.6430.48
49_Y58_F0.6430.48
90_A207_G0.6430.48
210_F214_A0.6430.48
68_G122_F0.6430.48
177_V308_P0.6420.48
283_T304_L0.6410.48
290_L301_L0.6400.48
49_Y53_L0.6400.48
15_V24_L0.6370.47
90_A294_A0.6360.47
181_G412_S0.6330.47
113_Y322_L0.6330.47
231_L239_G0.6300.47
66_E130_V0.6300.47
147_D155_A0.6300.47
217_A222_G0.6280.47
386_G391_A0.6280.47
125_S309_E0.6240.46
80_L93_L0.6210.46
134_R138_A0.6200.46
56_I308_P0.6190.46
26_H347_E0.6180.45
187_R191_E0.6170.45
190_G194_A0.6160.45
364_A379_P0.6160.45
33_R319_T0.6130.45
279_S288_E0.6120.45
151_V155_A0.6110.45
37_A70_V0.6070.44
358_A363_L0.6070.44
62_W289_P0.6060.44
375_A379_P0.6050.44
325_R351_E0.6040.44
263_L271_G0.6040.44
206_P225_L0.6040.44
158_R195_A0.6030.44
191_E195_A0.6030.44
259_R269_T0.6020.44
316_F360_L0.6020.44
12_A18_L0.6020.44
70_V130_V0.6000.44
129_A385_E0.5980.43
47_R85_D0.5980.43
13_H322_L0.5950.43
227_A235_L0.5950.43
277_K309_E0.5950.43
80_L88_E0.5930.43
264_G269_T0.5920.43
213_L234_L0.5920.43
327_P346_S0.5920.43
259_R267_D0.5910.43
15_V263_L0.5900.43
308_P390_A0.5890.42
326_D330_A0.5890.42
24_L60_S0.5870.42
112_R173_D0.5870.42
65_F280_Q0.5860.42
291_E382_K0.5840.42
144_D150_R0.5840.42
135_M140_A0.5820.42
106_G277_K0.5810.42
201_G205_R0.5790.41
22_G48_R0.5750.41
129_A409_K0.5740.41
158_R191_E0.5730.41
365_P368_R0.5720.41
22_G31_L0.5720.41
392_G396_A0.5720.41
99_V135_M0.5720.41
207_G212_Y0.5720.41
99_V155_A0.5710.41
34_L121_T0.5710.41
321_V359_L0.5710.41
155_A160_T0.5670.40
227_A260_H0.5670.40
97_A151_V0.5670.40
350_V410_I0.5660.40
16_L359_L0.5640.40
58_F385_E0.5630.40
42_A46_R0.5630.40
130_V134_R0.5620.40
346_S363_L0.5620.40
80_L92_A0.5620.40
210_F230_I0.5600.39
217_A296_I0.5600.39
192_A195_A0.5600.39
217_A225_L0.5580.39
374_D378_L0.5560.39
42_A378_L0.5550.39
320_G323_V0.5550.39
339_A394_E0.5550.39
108_G125_S0.5540.39
64_H310_Y0.5540.39
288_E388_T0.5520.39
43_A394_E0.5520.39
348_L408_I0.5520.39
308_P317_V0.5520.39
196_R237_G0.5510.39
89_R147_D0.5510.39
70_V120_Q0.5510.39
74_A78_A0.5510.39
106_G125_S0.5510.39
106_G310_Y0.5500.38
31_L316_F0.5490.38
215_A249_L0.5490.38
277_K312_N0.5480.38
113_Y369_A0.5470.38
115_E137_A0.5470.38
188_R203_E0.5460.38
18_L271_G0.5450.38
109_P319_T0.5440.38
236_D239_G0.5440.38
109_P129_A0.5430.38
76_L136_F0.5430.38
213_L230_I0.5420.38
15_V22_G0.5420.38
134_R252_V0.5410.38
8_V303_G0.5390.37
171_S248_T0.5390.37
155_A167_G0.5380.37
2_L9_R0.5360.37
192_A246_R0.5360.37
60_S66_E0.5350.37
289_P295_G0.5350.37
389_W393_R0.5340.37
17_A56_I0.5340.37
189_L241_I0.5340.37
117_E120_Q0.5340.37
100_S106_G0.5340.37
147_D238_L0.5330.37
63_R364_A0.5330.37
45_T385_E0.5320.37
33_R323_V0.5320.37
241_I416_V0.5310.37
257_C385_E0.5310.37
278_L310_Y0.5310.37
151_V223_G0.5290.36
259_R347_E0.5290.36
166_R171_S0.5280.36
400_R407_P0.5280.36
60_S63_R0.5270.36
322_L374_D0.5270.36
368_R375_A0.5260.36
58_F94_I0.5260.36
67_A115_E0.5260.36
364_A382_K0.5250.36
18_L21_A0.5240.36
58_F382_K0.5230.36
326_D348_L0.5230.36
74_A179_L0.5230.36
167_G316_F0.5230.36
216_R224_R0.5220.36
123_G404_G0.5200.35
20_L24_L0.5200.35
355_L359_L0.5190.35
85_D211_D0.5180.35
40_Y44_V0.5170.35
108_G311_R0.5160.35
73_W83_W0.5160.35
75_E79_R0.5150.35
113_Y375_A0.5140.35
58_F162_A0.5140.35
45_T187_R0.5130.35
181_G246_R0.5130.35
379_P387_G0.5110.35
193_L237_G0.5090.34
107_A243_P0.5080.34
165_A270_D0.5080.34
10_E13_H0.5070.34
132_S279_S0.5070.34
49_Y346_S0.5070.34
233_A257_C0.5070.34
233_A236_D0.5060.34
42_A45_T0.5060.34
21_A36_A0.5060.34
62_W152_D0.5060.34
94_I234_L0.5050.34
110_A317_V0.5050.34
84_L349_V0.5050.34
402_P405_G0.5050.34
245_S308_P0.5030.34
164_L383_V0.5020.34
261_P264_G0.5010.34
393_R400_R0.5000.34
344_V349_V0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ts7A 2 0.1295 34.6 0.981 Contact Map
4f62A 2 0.1007 31.4 0.981 Contact Map
2c4bA 2 0.1271 29.4 0.982 Contact Map
1tizA 1 0.1559 14.6 0.984 Contact Map
3h4mA 1 0.1103 14.1 0.984 Contact Map
2ycuA 1 0.1511 14 0.984 Contact Map
1mbaA 1 0.223 14 0.984 Contact Map
4uz0A 1 0.1079 13.5 0.984 Contact Map
1bm9A 2 0.1175 12.3 0.985 Contact Map
1c3pA 1 0.2038 10.8 0.985 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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