GREMLIN Database
TraG_N - TraG-like protein, N-terminal region
PFAM: PF07916 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 467 (463)
Sequences: 1861 (1440)
Seq/√Len: 66.9
META: 0.673

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
80_V103_A4.5071.00
15_L82_I4.3571.00
79_T96_D4.3261.00
78_V103_A4.1911.00
160_E219_R3.8881.00
208_T211_E3.8571.00
190_D193_D3.5371.00
117_T121_E3.4941.00
2_I15_L3.4431.00
16_N19_A3.4341.00
16_N97_N3.3191.00
163_D167_D3.2951.00
346_A384_I3.2861.00
381_L441_A3.1501.00
157_L220_L3.1301.00
207_P211_E3.1001.00
363_K366_K3.0811.00
113_G376_Q3.0161.00
192_Y217_R2.8271.00
1_E83_E2.8091.00
207_P212_A2.7351.00
117_T380_P2.6941.00
198_P202_V2.6851.00
114_Y118_E2.6531.00
199_A202_V2.6281.00
102_L348_F2.6211.00
30_L112_I2.5771.00
12_Y16_N2.5691.00
198_P201_T2.5491.00
207_P215_G2.5151.00
181_S184_D2.4221.00
85_R114_Y2.4201.00
271_D274_R2.4101.00
160_E212_A2.3851.00
341_E345_Y2.3791.00
337_Q341_E2.3701.00
73_L101_G2.3571.00
331_Q425_D2.3301.00
16_N20_M2.2941.00
448_G452_G2.2941.00
17_A124_F2.2441.00
106_A345_Y2.2341.00
82_I95_V2.2271.00
371_A375_L2.1881.00
107_S111_G2.1801.00
448_G451_A2.1301.00
450_A453_S2.0851.00
81_T92_V2.0811.00
202_V212_A2.0611.00
326_G432_Y2.0381.00
188_S194_T2.0351.00
19_A97_N2.0191.00
449_G453_S2.0121.00
168_C209_C2.0071.00
35_L66_A1.9901.00
446_K450_A1.9871.00
12_Y82_I1.9861.00
382_A434_F1.9751.00
137_M140_G1.9441.00
381_L437_I1.9221.00
377_L441_A1.9171.00
329_A334_P1.9131.00
4_T7_G1.8911.00
14_V342_A1.8901.00
386_N390_L1.8771.00
192_Y213_W1.8651.00
319_R425_D1.8591.00
38_G42_A1.8201.00
4_T11_L1.8141.00
18_V102_L1.7781.00
106_A341_E1.7511.00
21_I119_A1.7381.00
374_W378_W1.7361.00
232_L236_A1.7341.00
161_L220_L1.7341.00
275_Q279_I1.7191.00
452_G456_A1.7131.00
2_I80_V1.7121.00
108_L350_L1.7000.99
341_E375_L1.7000.99
17_A20_M1.6970.99
128_D134_K1.6830.99
374_W441_A1.6740.99
341_E376_Q1.6540.99
446_K449_G1.6460.99
315_E331_Q1.6400.99
349_P353_L1.6260.99
385_L437_I1.6050.99
19_A96_D1.5900.99
105_V109_S1.5880.99
10_I342_A1.5840.99
455_L458_A1.5380.99
143_L147_V1.5180.99
197_S202_V1.4820.99
215_G219_R1.4770.99
114_Y133_S1.4770.99
270_Q274_R1.4710.99
412_T415_T1.4610.98
251_S255_D1.4590.98
154_D219_R1.4560.98
197_S201_T1.4350.98
316_A319_R1.4290.98
318_Q322_W1.4240.98
236_A239_F1.4230.98
19_A79_T1.4180.98
344_I372_L1.4100.98
157_L219_R1.4090.98
95_V98_V1.3990.98
112_I115_A1.3910.98
233_A237_G1.3880.98
15_L18_V1.3850.98
5_Y337_Q1.3830.98
197_S200_R1.3800.98
196_R217_R1.3640.98
138_L430_A1.3630.98
4_T372_L1.3400.97
14_V346_A1.3320.97
180_Y184_D1.3300.97
80_V98_V1.3210.97
372_L375_L1.3140.97
2_I345_Y1.3130.97
442_L446_K1.3090.97
205_T215_G1.3050.97
141_R423_A1.2990.97
329_A333_L1.2940.97
120_I387_S1.2910.97
337_Q379_P1.2860.96
131_S134_K1.2730.96
387_S391_D1.2630.96
115_A119_A1.2630.96
6_G10_I1.2570.96
423_A426_L1.2550.96
374_W456_A1.2520.96
217_R221_L1.2510.96
411_L415_T1.2490.96
375_L378_W1.2400.96
184_D194_T1.2400.96
257_Y276_A1.2380.96
370_F442_L1.2340.96
172_D200_R1.2290.95
280_N312_A1.2210.95
21_I350_L1.2210.95
379_P382_A1.2190.95
142_Q146_E1.2170.95
188_S192_Y1.2090.95
450_A456_A1.2060.95
263_A266_S1.2020.95
389_L430_A1.1980.95
447_G452_G1.1920.95
190_D194_T1.1890.95
159_Q163_D1.1880.95
193_D210_K1.1860.94
13_N387_S1.1850.94
173_I180_Y1.1810.94
120_I380_P1.1780.94
161_L216_L1.1770.94
15_L106_A1.1760.94
156_V160_E1.1640.94
261_T265_Q1.1640.94
213_W217_R1.1630.94
39_L43_L1.1600.94
113_G341_E1.1590.94
338_A426_L1.1580.94
105_V369_L1.1570.94
87_Q114_Y1.1480.93
374_W377_L1.1470.93
235_A239_F1.1440.93
397_L423_A1.1440.93
19_A22_F1.1380.93
348_F368_Y1.1360.93
232_L239_F1.1350.93
374_W380_P1.1340.93
263_A268_S1.1330.93
349_P438_P1.1310.93
193_D196_R1.1260.93
374_W445_L1.1080.92
90_G93_P1.1060.92
40_L64_L1.1030.92
234_A237_G1.0990.92
352_L355_S1.0900.92
266_S271_D1.0870.91
9_W12_Y1.0840.91
289_L292_A1.0770.91
297_A301_G1.0760.91
280_N283_R1.0730.91
338_A358_P1.0730.91
393_L407_G1.0700.91
121_E386_N1.0670.91
70_Y101_G1.0610.90
19_A122_T1.0590.90
335_M426_L1.0530.90
271_D275_Q1.0490.90
87_Q90_G1.0480.90
429_V434_F1.0460.90
337_Q376_Q1.0440.90
178_G181_S1.0400.89
11_L15_L1.0380.89
309_Y313_Q1.0340.89
68_L347_L1.0290.89
313_Q317_Q1.0280.89
248_L252_A1.0270.89
70_Y74_F1.0260.89
318_Q341_E1.0250.89
136_G139_F1.0250.89
2_I106_A1.0210.89
337_Q389_L1.0190.89
196_R213_W1.0190.89
3_Y83_E1.0170.88
458_A463_A1.0170.88
451_A455_L1.0150.88
132_Y135_T1.0130.88
347_L444_L1.0130.88
18_V98_V1.0080.88
18_V213_W1.0080.88
459_L462_A1.0070.88
195_L221_L1.0050.88
439_L454_S1.0020.88
443_A452_G1.0010.88
277_L312_A0.9990.88
428_A431_G0.9980.87
99_P209_C0.9970.87
98_V103_A0.9940.87
191_L279_I0.9940.87
172_D175_L0.9920.87
7_G106_A0.9890.87
339_V429_V0.9890.87
453_S456_A0.9800.87
172_D180_Y0.9790.86
339_V430_A0.9780.86
432_Y435_L0.9720.86
63_L333_L0.9700.86
154_D183_D0.9660.86
147_V276_A0.9650.86
231_R234_A0.9580.85
99_P168_C0.9520.85
21_I123_A0.9470.85
355_S377_L0.9450.84
89_T93_P0.9440.84
342_A345_Y0.9390.84
376_Q379_P0.9360.84
113_G322_W0.9350.84
19_A98_V0.9340.84
59_I347_L0.9330.84
191_L278_L0.9310.84
88_P93_P0.9310.84
29_S33_T0.9230.83
172_D178_G0.9200.83
314_A328_L0.9200.83
447_G455_L0.9150.82
165_V285_A0.9120.82
172_D177_N0.9090.82
188_S193_D0.9070.82
377_L380_P0.9060.82
169_V185_L0.9020.82
19_A123_A0.9010.81
80_V110_S0.9000.81
305_G308_A0.8960.81
113_G379_P0.8950.81
203_S218_A0.8940.81
123_A350_L0.8900.81
30_L353_L0.8900.81
188_S191_L0.8900.81
392_A426_L0.8870.80
1_E7_G0.8860.80
355_S365_L0.8850.80
279_I412_T0.8840.80
359_G382_A0.8820.80
234_A238_G0.8800.80
83_E90_G0.8770.80
432_Y442_L0.8740.79
336_L340_L0.8730.79
59_I354_L0.8700.79
218_A222_A0.8670.79
334_P431_G0.8660.79
235_A238_G0.8660.79
131_S138_L0.8660.79
450_A454_S0.8650.79
271_D411_L0.8620.79
343_L437_I0.8610.78
130_L137_M0.8550.78
317_Q321_S0.8520.78
12_Y93_P0.8510.78
430_A438_P0.8490.77
177_N185_L0.8490.77
216_L220_L0.8480.77
439_L446_K0.8480.77
290_A294_N0.8470.77
125_S132_Y0.8470.77
120_I352_L0.8470.77
310_A324_A0.8460.77
74_F101_G0.8450.77
455_L461_G0.8430.77
353_L452_G0.8420.77
273_L283_R0.8420.77
216_L368_Y0.8400.77
276_A279_I0.8400.77
380_P383_A0.8390.77
375_L379_P0.8390.77
29_S115_A0.8390.77
355_S444_L0.8380.77
448_G458_A0.8360.76
325_A431_G0.8330.76
456_A463_A0.8320.76
102_L107_S0.8300.76
192_Y278_L0.8290.76
218_A264_S0.8290.76
243_D247_A0.8280.76
185_L188_S0.8280.76
443_A453_S0.8250.75
258_Q460_G0.8250.75
160_E204_G0.8230.75
175_L197_S0.8210.75
403_H407_G0.8200.75
192_Y220_L0.8190.75
157_L161_L0.8180.75
232_L235_A0.8170.75
138_L167_D0.8160.75
121_E322_W0.8160.75
381_L385_L0.8140.74
238_G241_G0.8110.74
173_I181_S0.8080.74
117_T383_A0.8070.74
339_V433_L0.8020.73
102_L105_V0.8000.73
382_A386_N0.8000.73
102_L106_A0.8000.73
135_T138_L0.7990.73
173_I260_L0.7990.73
9_W334_P0.7970.73
107_S177_N0.7960.73
420_Y423_A0.7910.72
422_A429_V0.7900.72
384_I446_K0.7890.72
363_K367_G0.7890.72
7_G337_Q0.7880.72
364_V368_Y0.7880.72
17_A438_P0.7870.72
94_T97_N0.7860.72
172_D179_K0.7840.72
457_G462_A0.7840.72
156_V351_V0.7840.72
414_A417_D0.7830.72
116_L187_N0.7830.72
281_A285_A0.7800.71
24_S119_A0.7790.71
372_L445_L0.7760.71
231_R235_A0.7740.71
288_T291_N0.7730.71
75_V101_G0.7730.71
298_A301_G0.7700.70
144_L385_L0.7700.70
289_L293_V0.7690.70
147_V253_L0.7680.70
276_A280_N0.7680.70
347_L381_L0.7660.70
115_A184_D0.7650.70
458_A464_Q0.7630.70
23_G26_D0.7610.69
333_L378_W0.7610.69
38_G378_W0.7590.69
452_G460_G0.7580.69
164_F318_Q0.7550.69
65_V368_Y0.7550.69
452_G458_A0.7540.69
441_A449_G0.7510.68
437_I441_A0.7510.68
427_L430_A0.7500.68
330_R428_A0.7500.68
68_L117_T0.7490.68
402_A405_N0.7470.68
253_L281_A0.7430.68
441_A445_L0.7420.67
139_F379_P0.7420.67
164_F345_Y0.7390.67
141_R393_L0.7390.67
120_I350_L0.7390.67
297_A304_A0.7380.67
23_G29_S0.7370.67
3_Y17_A0.7330.67
216_L300_A0.7320.66
396_S431_G0.7320.66
268_S271_D0.7320.66
371_A445_L0.7310.66
211_E214_S0.7310.66
210_K214_S0.7310.66
437_I447_G0.7290.66
451_A454_S0.7280.66
31_V107_S0.7270.66
346_A383_A0.7270.66
354_L445_L0.7270.66
77_K310_A0.7250.66
319_R424_S0.7240.66
117_T386_N0.7240.66
79_T94_T0.7230.65
333_L442_L0.7230.65
458_A462_A0.7200.65
410_G415_T0.7200.65
12_Y193_D0.7200.65
324_A431_G0.7200.65
3_Y392_A0.7190.65
124_F383_A0.7190.65
38_G64_L0.7170.65
201_T206_Y0.7160.65
256_A263_A0.7160.65
112_I244_A0.7160.65
161_L213_W0.7150.65
366_K370_F0.7150.65
177_N184_D0.7140.64
175_L179_K0.7140.64
195_L350_L0.7130.64
156_V353_L0.7130.64
180_Y194_T0.7120.64
76_P381_L0.7120.64
19_A23_G0.7080.64
333_L338_A0.7070.64
128_D217_R0.7050.63
110_S379_P0.7040.63
369_L373_I0.7030.63
191_L275_Q0.7030.63
291_N295_D0.7020.63
228_L239_F0.7010.63
31_V36_L0.7010.63
62_W65_V0.7010.63
249_L440_L0.6990.63
428_A435_L0.6990.63
207_P407_G0.6980.63
446_K452_G0.6980.63
376_Q437_I0.6960.62
449_G452_G0.6940.62
337_Q382_A0.6940.62
106_A113_G0.6940.62
5_Y15_L0.6940.62
367_G446_K0.6940.62
380_P387_S0.6930.62
180_Y185_L0.6930.62
17_A249_L0.6920.62
257_Y265_Q0.6890.62
442_L449_G0.6890.62
406_L444_L0.6870.61
452_G455_L0.6860.61
419_I422_A0.6860.61
394_Y429_V0.6850.61
20_M123_A0.6840.61
152_I157_L0.6800.61
257_Y264_S0.6790.61
430_A447_G0.6790.61
10_I322_W0.6790.61
162_Q429_V0.6780.60
63_L350_L0.6770.60
123_A333_L0.6750.60
138_L213_W0.6750.60
164_F194_T0.6750.60
25_G181_S0.6750.60
25_G29_S0.6740.60
358_P388_I0.6690.59
322_W338_A0.6690.59
15_L97_N0.6680.59
207_P213_W0.6670.59
175_L180_Y0.6660.59
354_L365_L0.6640.59
31_V266_S0.6640.59
43_L55_S0.6630.59
190_D274_R0.6630.59
166_R218_A0.6610.59
24_S109_S0.6610.59
225_D229_A0.6610.59
217_R351_V0.6600.58
196_R218_A0.6600.58
349_P378_W0.6600.58
173_I177_N0.6590.58
210_K340_L0.6580.58
378_W441_A0.6580.58
450_A458_A0.6560.58
288_T292_A0.6520.57
257_Y272_I0.6520.57
406_L410_G0.6520.57
273_L380_P0.6520.57
37_L357_Y0.6510.57
24_S34_G0.6500.57
11_L341_E0.6480.57
17_A387_S0.6470.57
4_T387_S0.6470.57
177_N181_S0.6470.57
43_L111_G0.6460.57
456_A460_G0.6440.57
291_N296_A0.6430.56
232_L237_G0.6430.56
336_L457_G0.6410.56
321_S325_A0.6400.56
220_L224_V0.6390.56
451_A456_A0.6380.56
88_P91_S0.6380.56
4_T338_A0.6370.56
240_G271_D0.6360.56
164_F212_A0.6350.55
30_L33_T0.6330.55
7_G341_E0.6320.55
378_W438_P0.6310.55
329_A337_Q0.6310.55
157_L216_L0.6300.55
32_A43_L0.6300.55
11_L82_I0.6300.55
119_A457_G0.6300.55
375_L436_S0.6260.54
407_G412_T0.6260.54
355_S361_G0.6240.54
160_E215_G0.6230.54
373_I377_L0.6230.54
316_A435_L0.6230.54
21_I33_T0.6210.54
354_L411_L0.6200.54
294_N298_A0.6180.54
195_L278_L0.6180.54
74_F352_L0.6180.54
143_L448_G0.6160.53
454_S463_A0.6160.53
370_F447_G0.6160.53
322_W432_Y0.6150.53
67_L71_L0.6150.53
297_A307_L0.6140.53
454_S458_A0.6130.53
371_A374_W0.6130.53
322_W428_A0.6130.53
20_M126_L0.6120.53
344_I415_T0.6120.53
18_V22_F0.6120.53
213_W249_L0.6120.53
172_D181_S0.6110.53
117_T334_P0.6110.53
5_Y113_G0.6080.52
103_A341_E0.6060.52
323_A349_P0.6050.52
361_G447_G0.6030.52
244_A247_A0.6020.52
269_A273_L0.6000.51
339_V388_I0.5990.51
155_P159_Q0.5980.51
98_V106_A0.5970.51
8_G88_P0.5970.51
33_T369_L0.5960.51
183_D187_N0.5950.51
190_D238_G0.5940.51
182_L195_L0.5940.51
22_F122_T0.5940.51
88_P444_L0.5920.50
131_S191_L0.5920.50
214_S217_R0.5920.50
443_A446_K0.5920.50
332_A382_A0.5900.50
378_W387_S0.5900.50
338_A348_F0.5880.50
117_T133_S0.5870.50
247_A267_A0.5860.50
227_G230_T0.5860.50
67_L346_A0.5860.50
178_G234_A0.5850.50
438_P447_G0.5840.49
186_L190_D0.5840.49
47_A54_L0.5840.49
15_L345_Y0.5830.49
81_T84_D0.5820.49
36_L108_L0.5810.49
325_A334_P0.5800.49
6_G335_M0.5800.49
1_E386_N0.5790.49
291_N297_A0.5780.49
278_L350_L0.5770.49
291_N294_N0.5750.48
195_L213_W0.5750.48
275_Q280_N0.5750.48
287_Q411_L0.5750.48
40_L112_I0.5740.48
113_G337_Q0.5730.48
142_Q145_M0.5730.48
11_L14_V0.5730.48
10_I333_L0.5730.48
366_K441_A0.5720.48
413_L416_A0.5710.48
371_A442_L0.5700.48
295_D299_D0.5700.48
366_K445_L0.5700.48
264_S405_N0.5630.47
460_G463_A0.5620.47
213_W274_R0.5610.47
365_L408_L0.5570.46
9_W13_N0.5560.46
2_I11_L0.5560.46
191_L449_G0.5560.46
240_G300_A0.5550.46
185_L202_V0.5550.46
344_I375_L0.5550.46
314_A431_G0.5540.46
260_L275_Q0.5540.46
446_K459_L0.5540.46
104_L154_D0.5530.46
160_E216_L0.5530.46
79_T239_F0.5520.46
363_K435_L0.5520.46
98_V177_N0.5520.46
215_G218_A0.5510.46
366_K446_K0.5500.45
81_T89_T0.5500.45
439_L450_A0.5500.45
7_G15_L0.5490.45
21_I184_D0.5480.45
33_T258_Q0.5460.45
36_L353_L0.5460.45
351_V355_S0.5440.45
273_L309_Y0.5420.45
237_G240_G0.5410.44
214_S411_L0.5410.44
393_L423_A0.5390.44
144_L256_A0.5380.44
206_Y347_L0.5370.44
370_F446_K0.5370.44
125_S133_S0.5370.44
106_A110_S0.5370.44
310_A314_A0.5330.43
243_D246_A0.5320.43
453_S460_G0.5320.43
362_L365_L0.5320.43
194_T282_L0.5320.43
211_E406_L0.5310.43
140_G382_A0.5300.43
340_L393_L0.5290.43
315_E318_Q0.5290.43
259_Y262_G0.5280.43
161_L277_L0.5280.43
231_R240_G0.5280.43
453_S461_G0.5270.43
382_A385_L0.5260.43
274_R443_A0.5260.43
175_L184_D0.5250.43
223_E247_A0.5250.43
63_L76_P0.5250.43
77_K83_E0.5240.42
126_L355_S0.5240.42
138_L454_S0.5240.42
30_L425_D0.5230.42
188_S284_D0.5210.42
434_F437_I0.5210.42
38_G49_E0.5200.42
110_S380_P0.5200.42
48_R67_L0.5190.42
206_Y366_K0.5190.42
218_A221_L0.5190.42
392_A395_G0.5190.42
37_L344_I0.5190.42
171_P429_V0.5180.42
110_S345_Y0.5170.42
43_L164_F0.5170.42
30_L36_L0.5170.42
438_P441_A0.5160.41
17_A89_T0.5160.41
73_L129_L0.5160.41
323_A427_L0.5160.41
20_M24_S0.5150.41
141_R386_N0.5140.41
5_Y114_Y0.5140.41
68_L207_P0.5140.41
451_A463_A0.5130.41
14_V345_Y0.5130.41
340_L375_L0.5130.41
361_G368_Y0.5130.41
453_S458_A0.5120.41
100_L103_A0.5120.41
33_T36_L0.5120.41
197_S210_K0.5120.41
318_Q326_G0.5110.41
1_E431_G0.5100.41
313_Q320_S0.5090.41
14_V32_A0.5090.41
154_D263_A0.5090.41
177_N180_Y0.5090.41
327_D330_R0.5080.41
351_V387_S0.5080.41
112_I148_R0.5080.41
113_G345_Y0.5070.40
2_I110_S0.5070.40
166_R300_A0.5070.40
358_P385_L0.5060.40
320_S337_Q0.5050.40
314_A456_A0.5050.40
228_L232_L0.5050.40
314_A385_L0.5040.40
40_L281_A0.5040.40
363_K446_K0.5040.40
191_L309_Y0.5030.40
113_G377_L0.5030.40
11_L333_L0.5020.40
376_Q386_N0.5020.40
7_G358_P0.5010.40
8_G91_S0.5010.40
339_V458_A0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ccdA 2 0.1649 4.1 0.972 Contact Map
2mmuA 1 0.1071 3.4 0.973 Contact Map
4c48C 1 0.0942 2.7 0.974 Contact Map
4z35A 1 0.2591 2.6 0.975 Contact Map
4u15A 2 0.2762 1.9 0.977 Contact Map
4mqsA 1 0.2719 1.8 0.977 Contact Map
4ognA 1 0.2099 1.6 0.977 Contact Map
4ldeA 1 0.2612 1.6 0.978 Contact Map
4h33A 3 0.1949 1.5 0.978 Contact Map
3v2yA 1 0.2891 1.4 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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