GREMLIN Database
YibE_F - YibE/F-like protein
PFAM: PF07907 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 241 (239)
Sequences: 5482 (3964)
Seq/√Len: 256.4
META: 0.738

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_Y75_L4.8651.00
38_L55_G3.8671.00
148_A171_V3.7021.00
9_A24_L3.6961.00
47_N50_L3.0571.00
80_G235_T3.0191.00
41_A46_Y2.9921.00
88_T227_G2.8681.00
52_A128_A2.8101.00
162_K166_R2.6031.00
13_I21_L2.5991.00
41_A51_V2.5541.00
2_L6_A2.5461.00
160_S163_E2.4731.00
149_V168_G2.4721.00
32_L36_K2.3801.00
83_L234_I2.3481.00
151_E170_N2.3151.00
147_S174_D2.3021.00
146_A235_T2.1391.00
64_L74_T2.1311.00
150_W154_E2.0841.00
61_F78_I2.0191.00
33_V55_G1.9781.00
163_E167_S1.9541.00
142_A231_A1.9391.00
47_N124_G1.9351.00
29_F62_V1.9341.00
18_W22_R1.9341.00
156_N159_L1.9121.00
76_A238_I1.8671.00
99_A219_V1.8541.00
79_L238_I1.8271.00
205_L209_L1.7991.00
90_L94_L1.7931.00
11_L226_I1.7831.00
19_K22_R1.7701.00
176_I232_V1.7641.00
6_A10_L1.7561.00
76_A239_A1.7251.00
153_K159_L1.7011.00
76_A146_A1.6951.00
60_T78_I1.6941.00
87_L230_L1.6641.00
53_L89_G1.6531.00
149_V239_A1.6451.00
46_Y51_V1.6371.00
151_E167_S1.6261.00
57_A82_L1.6231.00
104_L122_L1.6201.00
217_E220_R1.6121.00
94_L98_L1.6111.00
121_D124_G1.5761.00
161_R240_A1.5621.00
156_N163_E1.5611.00
165_F237_L1.5111.00
68_H143_I1.5061.00
161_R165_F1.4691.00
3_L7_L1.4661.00
68_H74_T1.4591.00
188_A195_L1.4161.00
84_G231_A1.4011.00
5_A222_L1.4001.00
93_L97_K1.3911.00
133_G220_R1.3911.00
91_L223_V1.3791.00
133_G187_Y1.3761.00
155_A159_L1.3451.00
165_F240_A1.3391.00
73_K150_W1.3381.00
152_L155_A1.3301.00
145_Q236_T1.3261.00
97_K100_H1.3151.00
26_G67_V1.3101.00
33_V37_F1.2741.00
39_L195_L1.2681.00
161_R237_L1.2551.00
70_F75_L1.2551.00
155_A163_E1.2481.00
204_P207_Q1.2331.00
41_A44_A1.2331.00
168_G236_T1.2291.00
159_L163_E1.2291.00
37_F41_A1.2211.00
155_A167_S1.2171.00
65_Y78_I1.2141.00
39_L199_S1.2111.00
55_G59_I1.2051.00
34_I188_A1.1641.00
65_Y70_F1.1601.00
9_A13_I1.1571.00
73_K174_D1.1501.00
170_N173_R1.1451.00
203_T207_Q1.1451.00
12_L180_V1.1441.00
97_K123_R1.1361.00
10_L14_L1.1341.00
2_L205_L1.1231.00
37_F55_G1.1221.00
152_L168_G1.1221.00
84_G88_T1.1141.00
81_T142_A1.1071.00
184_V221_T1.1051.00
71_N74_T1.0961.00
83_L238_I1.0771.00
37_F51_V1.0731.00
152_L171_V1.0731.00
4_L95_F1.0611.00
92_A130_I1.0611.00
237_L240_A1.0591.00
77_A142_A1.0511.00
75_L78_I1.0371.00
139_M181_N1.0361.00
143_I178_T1.0321.00
165_F236_T1.0281.00
149_V236_T1.0251.00
50_L54_V1.0241.00
163_E166_R1.0231.00
7_L95_F1.0221.00
149_V159_L1.0131.00
102_T212_E1.0111.00
12_L24_L1.0081.00
133_G186_A1.0081.00
190_A193_P0.9921.00
105_G216_E0.9881.00
17_G173_R0.9701.00
4_L219_V0.9701.00
137_A177_G0.9681.00
80_G84_G0.9571.00
168_G240_A0.9411.00
56_S60_T0.9391.00
62_V66_L0.9371.00
54_V58_L0.9351.00
126_L130_I0.9241.00
145_Q175_H0.9231.00
101_L126_L0.9201.00
8_F225_S0.9161.00
96_V127_L0.9141.00
165_F169_M0.9101.00
223_V227_G0.8861.00
20_G23_A0.8841.00
74_T78_I0.8831.00
57_A61_F0.8801.00
59_I63_T0.8741.00
60_T64_L0.8691.00
38_L51_V0.8661.00
37_F54_V0.8601.00
153_K157_P0.8570.99
64_L143_I0.8490.99
86_L90_L0.8480.99
29_F66_L0.8470.99
2_L5_A0.8410.99
141_V179_M0.8390.99
13_I24_L0.8270.99
95_F99_A0.8270.99
202_G206_G0.8260.99
17_G21_L0.8220.99
61_F65_Y0.8210.99
15_V169_M0.8170.99
139_M178_T0.8170.99
167_S170_N0.8160.99
209_L218_I0.8140.99
226_I230_L0.8140.99
101_L216_E0.8110.99
4_L222_L0.8090.99
12_L229_V0.8080.99
16_G23_A0.8080.99
89_G131_I0.8060.99
83_L87_L0.8050.99
146_A150_W0.8030.99
38_L132_I0.8020.99
30_T185_L0.8010.99
3_L6_A0.7980.99
33_V58_L0.7950.99
150_W153_K0.7930.99
108_E112_L0.7890.99
64_L81_T0.7840.99
56_S135_L0.7820.99
152_L167_S0.7800.99
154_E157_P0.7760.99
124_G224_G0.7710.99
127_L224_G0.7690.99
187_Y224_G0.7620.99
166_R170_N0.7590.99
218_I222_L0.7530.99
154_E166_R0.7510.99
141_V175_H0.7470.99
148_A152_L0.7460.99
106_S109_A0.7440.99
38_L42_I0.7420.99
127_L133_G0.7390.98
64_L78_I0.7350.98
153_K164_L0.7330.98
7_L10_L0.7330.98
38_L128_A0.7330.98
225_S229_V0.7300.98
39_L196_L0.7220.98
56_S131_I0.7170.98
38_L52_A0.7170.98
80_G146_A0.7150.98
94_L97_K0.7100.98
184_V225_S0.7100.98
33_V59_I0.7090.98
207_Q211_S0.7060.98
60_T81_T0.7020.98
7_L11_L0.7010.98
221_T225_S0.7000.98
37_F46_Y0.6970.98
22_R25_L0.6950.98
53_L56_S0.6930.98
129_G133_G0.6900.98
26_G66_L0.6890.98
51_V59_I0.6840.98
49_L93_L0.6820.97
53_L131_I0.6780.97
63_T181_N0.6770.97
17_G22_R0.6770.97
92_A127_L0.6750.97
16_G177_G0.6740.97
149_V164_L0.6740.97
73_K147_S0.6720.97
90_L93_L0.6710.97
164_L168_G0.6690.97
78_I82_L0.6680.97
172_G232_V0.6670.97
190_A220_R0.6660.97
88_T92_A0.6640.97
18_W21_L0.6640.97
197_L208_I0.6610.97
31_F188_A0.6580.97
75_L79_L0.6580.97
25_L66_L0.6570.97
15_V176_I0.6550.97
169_M236_T0.6530.97
105_G212_E0.6520.97
147_S150_W0.6480.97
208_I214_I0.6460.97
21_L25_L0.6450.96
79_L83_L0.6410.96
144_S148_A0.6410.96
129_G220_R0.6370.96
185_L188_A0.6370.96
111_F197_L0.6360.96
68_H178_T0.6340.96
68_H71_N0.6290.96
27_L195_L0.6250.96
65_Y74_T0.6240.96
203_T211_S0.6230.96
128_A171_V0.6230.96
96_V130_I0.6210.96
143_I174_D0.6190.96
134_A185_L0.6180.96
152_L164_L0.6150.95
141_V144_S0.6150.95
188_A191_S0.6120.95
8_F222_L0.6110.95
193_P208_I0.6100.95
188_A228_L0.6090.95
68_H174_D0.6090.95
149_V171_V0.6040.95
124_G128_A0.6020.95
7_L91_L0.6020.95
90_L97_K0.6010.95
135_L174_D0.6010.95
216_E228_L0.6000.95
76_A150_W0.5990.95
30_T176_I0.5980.95
215_A218_I0.5970.95
83_L86_L0.5970.95
153_K156_N0.5940.94
154_E167_S0.5940.94
105_G109_A0.5880.94
144_S179_M0.5870.94
107_E111_F0.5860.94
11_L14_L0.5860.94
84_G234_I0.5820.94
101_L212_E0.5790.94
117_Q120_I0.5780.94
77_A143_I0.5760.94
104_L116_G0.5750.93
30_T34_I0.5730.93
137_A179_M0.5710.93
148_A168_G0.5680.93
122_L125_L0.5670.93
46_Y50_L0.5660.93
174_D185_L0.5660.93
121_D187_Y0.5650.93
34_I39_L0.5640.93
127_L130_I0.5630.93
154_E170_N0.5620.93
143_I179_M0.5620.93
43_L196_L0.5610.93
159_L167_S0.5610.93
40_P45_G0.5600.93
23_A180_V0.5600.93
109_A122_L0.5590.92
47_N51_V0.5540.92
4_L221_T0.5530.92
77_A146_A0.5530.92
3_L98_L0.5520.92
29_F32_L0.5520.92
72_K76_A0.5510.92
186_A224_G0.5470.92
159_L164_L0.5470.92
168_G172_G0.5460.92
60_T82_L0.5460.92
32_L35_F0.5460.92
110_E114_Y0.5450.92
174_D179_M0.5440.91
4_L91_L0.5410.91
49_L127_L0.5410.91
56_S132_I0.5390.91
198_F208_I0.5380.91
30_T59_I0.5380.91
49_L131_I0.5380.91
38_L50_L0.5340.91
76_A80_G0.5340.91
56_S59_I0.5340.91
45_G48_P0.5330.91
203_T208_I0.5330.91
183_L187_Y0.5300.90
175_H178_T0.5300.90
119_G123_R0.5300.90
19_K173_R0.5300.90
51_V54_V0.5280.90
175_H236_T0.5250.90
63_T151_E0.5240.90
83_L90_L0.5230.90
87_L234_I0.5230.90
183_L224_G0.5220.90
141_V232_V0.5180.89
91_L226_I0.5180.89
115_L200_A0.5160.89
106_S110_E0.5160.89
60_T139_M0.5160.89
230_L234_I0.5150.89
152_L159_L0.5150.89
130_I219_V0.5140.89
134_A137_A0.5140.89
8_F232_V0.5120.89
3_L10_L0.5110.89
72_K75_L0.5100.89
48_P52_A0.5100.89
153_K161_R0.5100.89
144_S175_H0.5070.88
133_G193_P0.5070.88
151_E155_A0.5060.88
81_T141_V0.5060.88
8_F24_L0.5050.88
102_T105_G0.5050.88
236_T240_A0.5050.88
198_F214_I0.5040.88
64_L139_M0.5040.88
59_I135_L0.5040.88
104_L109_A0.5030.88
53_L57_A0.5020.88
157_P160_S0.5020.88
15_V165_F0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3aqpA 1 0.7635 14.4 0.95 Contact Map
4mt1A 3 0.7676 13 0.951 Contact Map
3w9iA 3 0.7801 11.9 0.952 Contact Map
4k0jA 3 0.7178 8.2 0.956 Contact Map
4dx5A 3 0.7801 7 0.957 Contact Map
3ne5A 3 0.7676 6.2 0.958 Contact Map
3d31C 2 0.2822 3.8 0.962 Contact Map
3tuiA 2 0.2905 2.8 0.964 Contact Map
2onkC 2 0.2905 2.5 0.966 Contact Map
3qe7A 2 0.9087 2.4 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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