GREMLIN Database
DUF1676 - Protein of unknown function (DUF1676)
PFAM: PF07898 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 120 (117)
Sequences: 635 (466)
Seq/√Len: 43.1
META: 0.076

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
92_R95_L3.8581.00
116_L120_L2.7251.00
37_G40_P2.6731.00
7_D68_K2.2661.00
106_G109_K2.1821.00
85_F88_E2.1220.99
72_F83_P2.0570.99
41_L46_I1.9920.99
15_I23_L1.8530.99
35_R38_K1.8450.99
70_A91_A1.8380.98
113_K118_P1.8310.98
34_A38_K1.8060.98
97_L100_G1.7910.98
25_R49_S1.7400.98
32_R35_R1.6280.97
2_A80_V1.6150.97
30_D34_A1.6090.96
90_I119_L1.5850.96
65_L119_L1.5650.96
26_T81_K1.5650.96
20_G76_H1.5350.95
12_K78_L1.5280.95
89_E93_S1.5160.95
2_A9_A1.4520.94
57_R71_R1.4450.94
76_H94_L1.4410.93
30_D33_S1.4170.93
111_L114_M1.3930.92
101_V105_R1.3640.91
112_K118_P1.3470.91
31_E34_A1.3390.91
24_V79_Q1.3360.91
14_E24_V1.3330.90
23_L72_F1.3320.90
42_S46_I1.3300.90
36_S39_E1.3280.90
9_A83_P1.3210.90
107_K111_L1.3060.89
34_A37_G1.2920.89
2_A6_L1.2770.88
89_E92_R1.2470.87
109_K112_K1.2370.87
106_G111_L1.2320.87
33_S36_S1.2280.86
72_F115_L1.1970.85
73_L76_H1.1950.85
72_F76_H1.1900.85
112_K116_L1.1880.84
86_S89_E1.1870.84
97_L103_E1.1630.83
115_L118_P1.1620.83
40_P43_E1.1400.82
38_K41_L1.1370.82
111_L116_L1.0990.79
88_E95_L1.0960.79
10_L68_K1.0800.78
64_L91_A1.0700.78
56_S59_E1.0440.76
27_P30_D1.0300.75
31_E35_R1.0250.74
19_D80_V1.0130.74
1_K19_D0.9980.72
47_E51_P0.9840.71
108_K111_L0.9810.71
74_K82_L0.9720.70
45_E48_A0.9590.69
17_L71_R0.9490.69
11_R83_P0.9450.68
21_V49_S0.9260.67
109_K119_L0.9260.67
100_G105_R0.9230.66
34_A40_P0.9190.66
69_V73_L0.9190.66
72_F79_Q0.9060.65
14_E17_L0.9020.65
111_L115_L0.9020.65
14_E72_F0.8880.63
57_R82_L0.8720.62
11_R64_L0.8720.62
24_V28_D0.8710.62
69_V92_R0.8630.61
74_K84_D0.8590.61
58_E62_D0.8550.60
31_E40_P0.8550.60
9_A18_T0.8530.60
6_L60_E0.8520.60
86_S94_L0.8510.60
91_A94_L0.8500.60
97_L101_V0.8460.60
68_K120_L0.8410.59
70_A104_G0.8390.59
10_L76_H0.8350.59
19_D36_S0.8290.58
45_E50_L0.8250.58
106_G110_K0.8190.57
43_E51_P0.8150.57
50_L53_D0.8120.56
36_S40_P0.8110.56
5_F8_R0.8070.56
93_S96_E0.8050.56
33_S38_K0.7960.55
111_L118_P0.7920.55
57_R64_L0.7910.55
61_L109_K0.7820.54
30_D36_S0.7790.53
102_V105_R0.7770.53
2_A82_L0.7710.53
112_K120_L0.7700.53
3_L62_D0.7670.52
100_G103_E0.7640.52
73_L82_L0.7620.52
108_K112_K0.7520.51
77_S82_L0.7480.50
7_D11_R0.7450.50
73_L78_L0.7450.50
108_K116_L0.7410.50
109_K113_K0.7390.50
21_V59_E0.7180.48
68_K114_M0.7180.48
8_R50_L0.7140.47
44_S48_A0.7100.47
90_I95_L0.7070.47
17_L90_I0.7060.46
39_E42_S0.6960.46
62_D72_F0.6780.44
115_L120_L0.6770.44
106_G112_K0.6760.44
6_L10_L0.6740.43
70_A83_P0.6630.42
82_L92_R0.6590.42
55_E67_D0.6580.42
108_K113_K0.6570.42
48_A51_P0.6570.42
21_V102_V0.6490.41
58_E68_K0.6410.40
69_V78_L0.6370.40
102_V106_G0.6300.39
83_P96_E0.6280.39
24_V76_H0.6280.39
16_E76_H0.6230.39
22_S73_L0.6170.38
22_S64_L0.6160.38
63_N90_I0.6140.38
5_F20_G0.6110.38
3_L60_E0.6080.37
25_R73_L0.6010.37
41_L44_S0.6000.37
7_D71_R0.5990.37
114_M118_P0.5950.36
14_E61_L0.5830.35
25_R48_A0.5780.35
29_A88_E0.5770.35
92_R96_E0.5760.35
8_R83_P0.5710.34
66_L76_H0.5680.34
34_A54_L0.5640.34
47_E78_L0.5630.33
55_E86_S0.5590.33
12_K81_K0.5520.33
59_E87_G0.5470.32
66_L80_V0.5390.31
31_E38_K0.5300.31
20_G73_L0.5290.31
6_L86_S0.5280.31
87_G91_A0.5260.30
87_G93_S0.5250.30
18_T55_E0.5230.30
4_S40_P0.5220.30
96_E107_K0.5210.30
51_P54_L0.5190.30
44_S47_E0.5180.30
31_E41_L0.5110.29
17_L27_P0.5060.29
6_L87_G0.5040.29
88_E94_L0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2f6mA 1 0.3833 4.2 0.921 Contact Map
2p22A 1 0.3833 4.2 0.921 Contact Map
1vr7A 2 0.2583 3 0.927 Contact Map
4l3uA 1 0.3 2.5 0.93 Contact Map
1tdpA 1 0.7417 2.4 0.93 Contact Map
3bonA 1 0.4417 1.5 0.938 Contact Map
2kxeA 1 0.4583 1.4 0.939 Contact Map
3kv0A 2 0.575 1.3 0.941 Contact Map
2qsfA 1 0.2917 1.3 0.941 Contact Map
2jz1A 2 0.2583 1.2 0.941 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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