GREMLIN Database
Rrp15p - Rrp15p
PFAM: PF07890 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 128 (128)
Sequences: 558 (405)
Seq/√Len: 35.8
META: 0.242

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_A87_V2.7691.00
61_D64_G2.6511.00
38_L42_A2.5931.00
39_E43_K2.5641.00
61_D78_R2.4061.00
77_T82_K2.2580.99
2_A17_K2.1340.99
14_P118_M2.0430.99
86_A124_L2.0400.99
8_I13_L1.9290.98
8_I11_T1.9110.98
119_S124_L1.8920.98
31_K34_E1.8890.98
5_M9_L1.8730.97
28_K32_K1.8610.97
77_T81_V1.8330.97
4_A8_I1.7200.96
44_K47_R1.6960.95
15_T18_R1.6880.95
96_E99_K1.6670.95
5_M88_R1.6450.95
114_V122_G1.5980.94
26_S31_K1.5960.94
27_K34_E1.5600.93
67_E70_R1.5410.92
3_D10_S1.5250.92
86_A91_Q1.4810.91
115_V124_L1.4670.90
11_T16_S1.4480.90
36_E40_A1.4430.90
109_K116_K1.4410.90
102_G105_E1.3820.88
118_M124_L1.3690.87
70_R125_D1.3660.87
107_G127_L1.3560.87
5_M8_I1.3520.86
98_L114_V1.3420.86
61_D65_D1.3330.86
3_D7_K1.3240.85
102_G127_L1.3230.85
58_R82_K1.3180.85
21_P24_S1.2880.84
13_L18_R1.2760.83
53_A56_K1.2660.82
23_L80_V1.2380.81
14_P19_A1.2370.81
63_L77_T1.2170.80
120_K123_F1.2030.79
114_V119_S1.2000.79
41_K56_K1.1970.79
64_G77_T1.1810.78
41_K50_K1.1800.78
69_E76_A1.1750.77
95_E99_K1.1720.77
93_K117_E1.1580.76
95_E100_E1.1470.76
18_R25_R1.1470.76
113_K117_E1.1360.75
113_K118_M1.1350.75
2_A87_V1.1340.75
54_E71_R1.1280.74
52_E70_R1.1180.74
87_V91_Q1.1140.74
75_I95_E1.1080.73
28_K62_V1.1060.73
3_D9_L1.1050.73
93_K96_E1.1050.73
22_I53_A1.0940.72
12_K18_R1.0920.72
50_K117_E1.0790.71
97_A100_E1.0700.70
89_K92_K1.0620.70
66_L73_R1.0570.70
46_L74_K1.0490.69
94_A97_A1.0430.68
95_E98_L1.0300.68
3_D87_V1.0250.67
44_K50_K1.0180.67
66_L106_G1.0060.66
11_T14_P1.0000.65
44_K68_R0.9730.63
17_K120_K0.9620.62
2_A110_K0.9600.62
80_V85_N0.9430.61
22_I35_D0.9420.60
15_T99_K0.9340.60
90_A94_A0.9150.58
8_I14_P0.9090.58
65_D110_K0.9030.57
63_L67_E0.8910.56
52_E56_K0.8900.56
50_K56_K0.8740.55
40_A93_K0.8690.54
33_L37_K0.8590.53
85_N123_F0.8370.52
81_V84_F0.8330.51
123_F127_L0.8310.51
77_T83_L0.8230.50
40_A109_K0.8220.50
69_E74_K0.8180.50
48_A68_R0.8170.50
112_E116_K0.8050.49
1_F21_P0.8030.49
69_E72_L0.7970.48
114_V118_M0.7930.48
28_K37_K0.7800.47
18_R21_P0.7780.46
45_K74_K0.7740.46
22_I32_K0.7680.46
13_L21_P0.7640.45
12_K101_A0.7600.45
113_K116_K0.7500.44
9_L25_R0.7450.44
28_K31_K0.7450.44
13_L32_K0.7440.43
121_E125_D0.7370.43
97_A101_A0.7360.43
83_L123_F0.7360.43
26_S81_V0.7250.42
55_E106_G0.7250.42
27_K51_K0.7170.41
30_A70_R0.7160.41
45_K49_E0.7110.41
35_D57_G0.7100.41
43_K47_R0.7100.41
121_E128_K0.6970.40
34_E58_R0.6890.39
15_T20_D0.6890.39
51_K122_G0.6850.39
8_I28_K0.6850.39
101_A104_S0.6770.38
67_E71_R0.6700.37
40_A83_L0.6670.37
15_T22_I0.6560.36
29_A33_L0.6530.36
77_T127_L0.6490.36
17_K34_E0.6480.36
55_E121_E0.6470.35
12_K20_D0.6450.35
104_S109_K0.6430.35
84_F91_Q0.6380.35
8_I29_A0.6360.35
4_A11_T0.6360.35
48_A99_K0.6350.35
47_R90_A0.6350.35
69_E79_G0.6320.34
95_E114_V0.6300.34
25_R33_L0.6290.34
36_E46_L0.6260.34
28_K82_K0.6210.33
94_A102_G0.6190.33
4_A25_R0.6150.33
39_E60_K0.6100.33
66_L98_L0.6100.33
55_E59_V0.6070.32
113_K124_L0.6060.32
32_K44_K0.6050.32
5_M10_S0.6040.32
102_G107_G0.5920.31
58_R67_E0.5910.31
77_T92_K0.5840.31
70_R113_K0.5820.30
64_G90_A0.5820.30
50_K73_R0.5820.30
70_R101_A0.5820.30
25_R97_A0.5800.30
30_A97_A0.5660.29
22_I44_K0.5590.29
6_S14_P0.5580.29
72_L76_A0.5530.28
66_L70_R0.5510.28
56_K97_A0.5490.28
79_G123_F0.5480.28
33_L110_K0.5460.28
50_K74_K0.5450.28
81_V123_F0.5450.28
49_E120_K0.5430.28
13_L71_R0.5370.27
49_E100_E0.5280.27
42_A51_K0.5250.26
100_E103_K0.5230.26
7_K17_K0.5200.26
32_K86_A0.5140.26
48_A52_E0.5130.26
72_L82_K0.5110.26
56_K104_S0.5110.26
70_R85_N0.5100.25
6_S31_K0.5100.25
42_A46_L0.5060.25
116_K120_K0.5020.25
36_E43_K0.5010.25
98_L112_E0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2dodA 1 0.2188 4.4 0.934 Contact Map
2doeA 1 0.2188 3.3 0.937 Contact Map
4oydB 1 0.6797 3.2 0.938 Contact Map
1tt5E 1 0.1016 2.6 0.941 Contact Map
4q9vA 2 0.5 2.3 0.942 Contact Map
1sn9A 2 0.1016 2.2 0.943 Contact Map
2oy9A 2 0.3203 1.9 0.945 Contact Map
2ibfB 1 0.1172 1.8 0.946 Contact Map
2kpaA 1 0.0859 1.7 0.947 Contact Map
1syqB 1 0.1328 1.6 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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