GREMLIN Database
DUF1656 - Protein of unknown function (DUF1656)
PFAM: PF07869 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 56 (55)
Sequences: 5305 (2921)
Seq/√Len: 393.9
META: 0.835

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_L53_L3.1031.00
39_V45_F2.8611.00
15_L54_L2.4931.00
50_Y54_L2.2051.00
3_D6_G2.1581.00
12_L54_L2.1271.00
30_L35_L1.9731.00
27_R46_D1.8321.00
22_L53_L1.8111.00
19_A54_L1.7371.00
16_A50_Y1.6091.00
36_Y46_D1.5851.00
10_P13_L1.5101.00
40_W45_F1.4921.00
24_L27_R1.4811.00
29_L33_L1.4771.00
2_I14_L1.4611.00
11_P15_L1.3831.00
19_A23_T1.2801.00
3_D8_Y1.2521.00
41_H44_L1.2381.00
28_R32_R1.2181.00
35_L39_V1.1951.00
45_F48_A1.1161.00
19_A50_Y1.0511.00
30_L49_L1.0451.00
1_E10_P1.0231.00
31_A42_P1.0151.00
46_D50_Y0.9881.00
16_A54_L0.9321.00
23_T46_D0.9131.00
16_A27_R0.8971.00
31_A36_Y0.8651.00
15_L19_A0.8591.00
42_P46_D0.8561.00
19_A53_L0.8511.00
12_L36_Y0.8271.00
1_E11_P0.8151.00
35_L38_Y0.8111.00
40_W44_L0.8081.00
9_V14_L0.7621.00
40_W48_A0.7551.00
20_L50_Y0.7411.00
25_L28_R0.7401.00
23_T27_R0.7401.00
22_L32_R0.7141.00
25_L39_V0.7111.00
7_V12_L0.6880.99
26_L49_L0.6870.99
29_L34_G0.6730.99
34_G37_R0.6690.99
13_L17_V0.6630.99
34_G45_F0.6610.99
33_L38_Y0.6550.99
17_V21_L0.6470.99
51_V55_G0.6200.99
10_P43_A0.6190.99
10_P54_L0.6150.99
42_P55_G0.6150.99
28_R31_A0.6140.99
8_Y52_I0.6120.99
33_L36_Y0.6120.99
25_L29_L0.6070.99
24_L31_A0.5980.99
15_L23_T0.5980.99
36_Y42_P0.5960.99
27_R31_A0.5950.99
21_L25_L0.5850.98
7_V11_P0.5760.98
8_Y14_L0.5700.98
3_D48_A0.5610.98
10_P15_L0.5490.98
36_Y47_L0.5440.97
15_L18_L0.5380.97
1_E8_Y0.5380.97
2_I5_G0.5250.97
5_G8_Y0.5210.97
8_Y54_L0.5170.96
12_L15_L0.5070.96
45_F51_V0.5030.96
18_L21_L0.5020.96
36_Y39_V0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wguB 1 0.5893 4.4 0.856 Contact Map
2zxeB 1 0.2321 4.3 0.856 Contact Map
2hi7B 1 0.3214 2.4 0.874 Contact Map
4wisA 2 0.75 2.2 0.876 Contact Map
2m3eA 1 0.8393 2.2 0.877 Contact Map
2lzpA 1 0.5179 2.1 0.878 Contact Map
3rqwA 4 0.9643 2 0.879 Contact Map
3w4tA 1 0.6429 1.9 0.881 Contact Map
3weoA 1 0 1.9 0.881 Contact Map
3orgA 2 0.8214 1.8 0.882 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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