GREMLIN Database
DUF1651 - Protein of unknown function (DUF1651)
PFAM: PF07864 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 74 (72)
Sequences: 1317 (549)
Seq/√Len: 64.7
META: 0.917

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_S25_S2.6771.00
38_G41_P2.4521.00
70_T73_Q2.3971.00
2_G56_R2.2421.00
13_K32_S2.0671.00
20_K24_N1.8971.00
6_N10_S1.7651.00
51_S54_E1.7120.99
30_I33_G1.6910.99
17_K20_K1.6810.99
39_G45_K1.6580.99
16_E29_F1.5820.99
61_E65_E1.5190.99
37_P40_E1.5190.99
52_I69_K1.4950.98
8_N12_V1.4680.98
58_E61_E1.4350.98
13_K48_R1.4240.98
22_S26_P1.3800.97
48_R58_E1.3470.97
36_V43_L1.3420.97
48_R54_E1.3030.96
39_G43_L1.3000.96
3_W14_R1.2990.96
28_V33_G1.2710.96
31_D34_G1.2700.96
6_N13_K1.2370.95
60_K63_L1.2330.95
16_E31_D1.2270.95
6_N11_R1.2160.95
50_L58_E1.2020.94
31_D47_R1.1910.94
21_S24_N1.1210.92
33_G43_L1.1150.92
7_P35_I1.1090.92
60_K68_R1.0930.91
55_A59_W1.0460.89
37_P42_P1.0380.89
33_G42_P1.0340.88
35_I73_Q1.0330.88
21_S25_S1.0310.88
3_W50_L1.0220.88
60_K64_S0.9830.86
45_K57_E0.9780.85
15_F55_A0.9770.85
61_E68_R0.9590.84
7_P19_E0.9300.82
14_R31_D0.9180.82
43_L72_P0.9130.81
52_I56_R0.9030.81
18_D26_P0.9030.81
11_R32_S0.8880.79
32_S46_T0.8650.78
33_G36_V0.8600.77
18_D31_D0.8600.77
9_R13_K0.8330.75
65_E68_R0.8050.72
5_I12_V0.7940.71
16_E20_K0.7820.70
18_D22_S0.7800.70
44_M47_R0.7760.70
34_G45_K0.7740.69
30_I64_S0.7710.69
26_P49_V0.7660.69
17_K25_S0.7630.68
6_N9_R0.7580.68
3_W59_W0.7570.68
3_W7_P0.7540.67
27_Y51_S0.7540.67
65_E72_P0.7490.67
21_S29_F0.7340.65
14_R43_L0.7270.65
14_R23_D0.7260.64
16_E54_E0.7150.63
5_I10_S0.7050.62
52_I64_S0.7040.62
18_D28_V0.6850.60
17_K24_N0.6840.60
30_I50_L0.6750.59
13_K58_E0.6720.58
23_D53_E0.6590.57
5_I11_R0.6570.57
64_S72_P0.6530.56
65_E73_Q0.6500.56
13_K19_E0.6490.56
5_I9_R0.6400.55
68_R73_Q0.6280.53
17_K23_D0.6240.53
8_N11_R0.6210.53
52_I59_W0.6130.52
14_R17_K0.6110.51
53_E71_E0.6030.50
63_L72_P0.6010.50
69_K72_P0.5830.48
31_D35_I0.5800.48
34_G43_L0.5610.46
43_L47_R0.5590.45
39_G42_P0.5470.44
7_P12_V0.5460.44
14_R61_E0.5460.44
37_P43_L0.5420.43
27_Y54_E0.5320.42
27_Y35_I0.5280.42
12_V35_I0.5210.41
49_V54_E0.5180.41
19_E32_S0.5010.39
9_R12_V0.5010.39
23_D29_F0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wdjA 3 0.6351 10.6 0.883 Contact Map
3bq3A 2 0.9189 10.1 0.884 Contact Map
4gbaA 1 0.9459 8.4 0.888 Contact Map
3ecqA 1 0.8649 8.2 0.888 Contact Map
3ot2A 2 0.7027 5.4 0.897 Contact Map
3tduA 1 0.9054 5.3 0.898 Contact Map
2b7eA 1 0.2973 5 0.899 Contact Map
2zxqA 1 0.8649 4.2 0.903 Contact Map
1uzcA 1 0.4324 3.6 0.906 Contact Map
3kevA 1 0.9054 3.4 0.906 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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