GREMLIN Database
DUF1642 - Protein of unknown function (DUF1642)
PFAM: PF07852 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 138 (131)
Sequences: 1685 (1502)
Seq/√Len: 131.2
META: 0.665

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
131_W135_I5.8071.00
58_R62_D4.8491.00
58_R61_L4.1641.00
131_W134_D3.9331.00
8_Q12_D2.3861.00
99_Y103_N2.0941.00
5_V65_E2.0891.00
79_V82_Y2.0521.00
103_N106_D2.0161.00
96_G100_L1.7821.00
52_N56_F1.7741.00
102_Y105_F1.7331.00
73_L76_L1.7111.00
54_E60_W1.6721.00
102_Y106_D1.6201.00
11_A15_E1.6061.00
120_R124_E1.5911.00
13_W17_C1.5901.00
78_G118_H1.5801.00
78_G81_G1.5611.00
28_A31_A1.5421.00
50_E53_Q1.5251.00
79_V118_H1.4901.00
81_G116_T1.4861.00
97_N100_L1.4701.00
88_L91_L1.4441.00
102_Y107_G1.4421.00
101_F104_N1.3761.00
26_F30_T1.3491.00
95_N99_Y1.3441.00
98_I103_N1.3321.00
97_N101_F1.3011.00
57_A60_W1.2841.00
76_L79_V1.2841.00
121_K125_E1.2711.00
28_A32_I1.2331.00
131_W137_V1.2151.00
44_K50_E1.2070.99
7_P10_V1.2070.99
30_T35_A1.2000.99
93_N96_G1.1960.99
14_I59_A1.1750.99
99_Y107_G1.1560.99
129_F132_V1.1560.99
99_Y102_Y1.1530.99
54_E61_L1.1530.99
104_N107_G1.1300.99
76_L113_N1.1220.99
26_F29_L1.1220.99
80_N116_T1.1100.99
33_N37_D1.0910.99
94_G97_N1.0890.99
33_N36_E1.0870.99
25_L28_A1.0780.99
96_G101_F1.0540.99
100_L103_N1.0440.99
99_Y106_D1.0430.99
81_G115_E1.0390.98
94_G99_Y1.0380.98
89_L92_K1.0380.98
104_N108_K1.0100.98
98_I104_N1.0060.98
31_A36_E1.0030.98
98_I102_Y0.9930.98
26_F32_I0.9850.98
70_K73_L0.9810.98
105_F108_K0.9670.98
98_I101_F0.9480.97
78_G82_Y0.9480.97
112_S115_E0.9470.97
21_G25_L0.9470.97
101_F106_D0.9470.97
98_I106_D0.9360.97
65_E68_K0.9330.97
30_T44_K0.9170.97
88_L92_K0.9120.97
44_K49_E0.9110.97
96_G99_Y0.9040.96
54_E58_R0.8930.96
99_Y108_K0.8910.96
97_N102_Y0.8830.96
76_L82_Y0.8790.96
98_I107_G0.8730.96
117_K120_R0.8700.95
103_N108_K0.8670.95
30_T33_N0.8630.95
52_N59_A0.8620.95
95_N98_I0.8610.95
81_G106_D0.8600.95
14_I60_W0.8500.95
27_D33_N0.8460.95
106_D110_F0.8440.95
92_K95_N0.8420.95
92_K96_G0.8410.95
107_G110_F0.8360.94
130_G134_D0.8310.94
34_Y37_D0.8260.94
30_T49_E0.8170.94
31_A45_E0.8150.94
41_D50_E0.8130.93
104_N110_F0.8110.93
89_L96_G0.8080.93
81_G117_K0.8080.93
76_L80_N0.8050.93
101_F105_F0.8010.93
31_A35_A0.7980.93
27_D32_I0.7950.93
42_E50_E0.7880.92
101_F108_K0.7880.92
79_V116_T0.7850.92
108_K112_S0.7840.92
105_F109_W0.7780.92
97_N104_N0.7750.92
128_G134_D0.7720.92
97_N106_D0.7690.91
56_F60_W0.7680.91
27_D34_Y0.7620.91
32_I36_E0.7600.91
22_E50_E0.7600.91
80_N99_Y0.7560.91
91_L100_L0.7540.91
90_V95_N0.7500.90
110_F113_N0.7470.90
13_W43_V0.7460.90
22_E52_N0.7410.90
31_A34_Y0.7410.90
100_L106_D0.7390.90
82_Y106_D0.7330.89
23_T27_D0.7330.89
88_L96_G0.7290.89
16_E30_T0.7260.89
11_A64_Y0.7210.89
14_I56_F0.7180.88
49_E53_Q0.7170.88
36_E44_K0.7170.88
19_D43_V0.7160.88
135_I138_E0.7110.88
13_W53_Q0.7060.88
31_A37_D0.6990.87
88_L93_N0.6980.87
27_D31_A0.6950.87
27_D30_T0.6950.87
97_N103_N0.6910.86
37_D41_D0.6840.86
89_L93_N0.6830.86
75_K78_G0.6710.85
29_L35_A0.6700.85
82_Y116_T0.6680.85
103_N107_G0.6660.84
75_K116_T0.6620.84
94_G98_I0.6590.84
17_C53_Q0.6570.84
128_G131_W0.6500.83
124_E130_G0.6490.83
23_T26_F0.6470.83
29_L32_I0.6460.83
75_K118_H0.6420.82
90_V93_N0.6410.82
45_E49_E0.6400.82
73_L78_G0.6360.82
92_K98_I0.6320.81
27_D44_K0.6290.81
109_W112_S0.6240.80
99_Y104_N0.6230.80
100_L116_T0.6050.78
23_T47_L0.5940.77
101_F107_G0.5940.77
16_E20_N0.5820.76
30_T34_Y0.5790.75
106_D112_S0.5790.75
90_V96_G0.5760.75
6_V9_F0.5720.74
128_G132_V0.5700.74
44_K53_Q0.5630.73
41_D44_K0.5630.73
25_L50_E0.5560.72
29_L33_N0.5440.71
91_L97_N0.5410.70
103_N113_N0.5390.70
105_F110_F0.5370.70
107_G115_E0.5360.70
91_L99_Y0.5330.69
5_V67_E0.5280.68
33_N42_E0.5270.68
91_L94_G0.5260.68
94_G100_L0.5240.68
82_Y117_K0.5220.68
95_N105_F0.5190.67
104_N109_W0.5190.67
99_Y105_F0.5170.67
101_F116_T0.5140.66
37_D50_E0.5080.65
82_Y108_K0.5050.65
127_A131_W0.5050.65
36_E49_E0.5030.65
82_Y97_N0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1yb3A 2 0.6087 2.2 0.945 Contact Map
3p0cA 2 0.3768 2.1 0.945 Contact Map
3cnqP 1 0.4565 2.1 0.945 Contact Map
4fxsA 3 0.4058 2 0.946 Contact Map
1kmdA 1 0.3623 1.8 0.947 Contact Map
3ostA 1 0.5797 1.7 0.948 Contact Map
2mhdA 1 0.6594 1.5 0.95 Contact Map
2vdwB 1 0.3986 1.5 0.95 Contact Map
2l14B 1 0.1522 1.4 0.951 Contact Map
2p22D 1 0.3188 1.4 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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