GREMLIN Database
DUF1634 - Protein of unknown function (DUF1634)
PFAM: PF07843 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 102 (101)
Sequences: 6571 (5042)
Seq/√Len: 501.7
META: 0.94

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_V62_L3.5491.00
22_L52_P3.4611.00
46_G54_A3.1771.00
75_L91_L3.1281.00
74_S90_T2.6911.00
76_V80_R2.6851.00
3_R6_R2.3031.00
39_S42_G2.1481.00
79_A87_V2.0871.00
88_A92_I1.9781.00
85_L89_I1.9321.00
95_A99_Y1.9001.00
3_R7_A1.7671.00
10_L14_A1.7011.00
92_I96_V1.6261.00
72_A94_L1.6221.00
4_L73_F1.6071.00
46_G51_R1.5171.00
91_L95_A1.4731.00
45_R49_A1.4661.00
22_L55_I1.4581.00
7_A11_L1.4511.00
9_V13_A1.4301.00
85_L88_A1.3871.00
14_A18_A1.3711.00
75_L90_T1.3281.00
18_A55_I1.3211.00
22_L26_R1.3181.00
79_A84_R1.3121.00
83_D86_Y1.3011.00
2_G6_R1.2971.00
27_H30_S1.2851.00
73_F77_A1.2531.00
71_V97_L1.2461.00
84_R88_A1.2191.00
43_I47_A1.2011.00
94_L98_L1.1981.00
69_A73_F1.1791.00
4_L69_A1.1741.00
44_L48_L1.1561.00
16_V56_I1.1491.00
74_S78_F1.1281.00
75_L79_A1.0951.00
16_V59_G1.0781.00
47_A58_L1.0701.00
8_G66_T1.0691.00
75_L87_V1.0661.00
15_V55_I1.0471.00
90_T93_V1.0431.00
41_S45_R1.0241.00
51_R54_A1.0211.00
33_E37_L1.0061.00
7_A10_L0.9961.00
20_G23_Y0.9691.00
45_R48_L0.9651.00
26_R52_P0.9611.00
71_V78_F0.9561.00
47_A50_L0.9511.00
60_L63_L0.9351.00
74_S77_A0.9271.00
78_F86_Y0.9261.00
27_H52_P0.9251.00
97_L101_L0.9201.00
34_P37_L0.9191.00
15_V58_L0.9191.00
84_R87_V0.8971.00
33_E38_R0.8921.00
40_L44_L0.8801.00
17_L21_V0.8751.00
16_V20_G0.8661.00
44_L47_A0.8481.00
12_S66_T0.8451.00
18_A22_L0.8421.00
21_V25_A0.8151.00
64_I67_P0.8061.00
23_Y56_I0.8001.00
20_G27_H0.7921.00
36_F46_G0.7861.00
67_P93_V0.7851.00
64_I101_L0.7841.00
42_G46_G0.7801.00
64_I70_R0.7751.00
12_S63_L0.7741.00
48_L51_R0.7631.00
19_G52_P0.7541.00
35_A38_R0.7451.00
72_A76_V0.7421.00
12_S62_L0.7401.00
33_E36_F0.7281.00
27_H53_R0.7191.00
86_Y89_I0.7131.00
74_S86_Y0.7131.00
70_R74_S0.7131.00
68_V97_L0.7011.00
11_L62_L0.6961.00
46_G49_A0.6911.00
61_L65_A0.6881.00
70_R93_V0.6871.00
16_V60_L0.6861.00
41_S44_L0.6831.00
35_A39_S0.6761.00
13_A97_L0.6711.00
68_V98_L0.6661.00
87_V91_L0.6611.00
46_G50_L0.6581.00
47_A55_I0.6551.00
5_L8_G0.6471.00
98_L101_L0.6361.00
75_L94_L0.6341.00
83_D89_I0.6341.00
36_F51_R0.6231.00
66_T86_Y0.6211.00
79_A82_R0.6191.00
86_Y90_T0.6181.00
23_Y28_G0.6171.00
42_G45_R0.6161.00
18_A50_L0.6161.00
1_I74_S0.6111.00
64_I68_V0.6030.99
43_I57_Q0.5950.99
37_L42_G0.5920.99
96_V100_S0.5890.99
80_R89_I0.5890.99
66_T70_R0.5880.99
84_R95_A0.5870.99
11_L14_A0.5780.99
43_I54_A0.5760.99
71_V94_L0.5750.99
12_S20_G0.5730.99
5_L70_R0.5720.99
19_G56_I0.5680.99
36_F57_Q0.5670.99
30_S33_E0.5640.99
26_R53_R0.5630.99
19_G55_I0.5490.99
64_I93_V0.5470.99
2_G9_V0.5410.99
47_A54_A0.5380.99
8_G71_V0.5380.99
53_R57_Q0.5370.99
71_V90_T0.5370.99
74_S89_I0.5340.99
32_G35_A0.5250.99
77_A80_R0.5240.98
43_I58_L0.5240.98
32_G39_S0.5180.98
73_F100_S0.5150.98
50_L55_I0.5150.98
39_S43_I0.5150.98
22_L25_A0.5130.98
63_L86_Y0.5030.98
69_A72_A0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3giaA 1 1 7 0.882 Contact Map
2vpzC 2 0.8627 5 0.89 Contact Map
1v54C 1 0.9314 4.8 0.891 Contact Map
4ev6A 3 0.6275 4 0.895 Contact Map
1qleC 1 0.9314 3.1 0.9 Contact Map
4b19A 1 0.2745 2.6 0.903 Contact Map
4i0uA 4 0.6078 2.5 0.905 Contact Map
4xtlA 1 0.7059 2.1 0.909 Contact Map
1m56C 2 0.9314 2 0.91 Contact Map
3j1zP 8 0.9608 1.9 0.911 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0052 seconds.