GREMLIN Database
GCFC - GC-rich sequence DNA-binding factor-like protein
PFAM: PF07842 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 276 (269)
Sequences: 636 (432)
Seq/√Len: 26.4
META: 0.159

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_I109_M5.0821.00
237_P240_Q4.7681.00
245_L249_L4.6811.00
231_R267_E3.5741.00
214_W218_L3.3871.00
83_S87_E3.3811.00
105_D108_P2.8421.00
193_H247_W2.7831.00
48_D51_Y2.6980.99
163_F166_L2.6300.99
235_I240_Q2.4930.99
236_N240_Q2.4370.99
180_D183_R2.4350.99
255_L260_L2.4290.99
93_V112_L2.4180.99
97_I132_L2.3950.99
89_W116_W2.3170.98
127_N131_Q2.2550.98
222_I225_K2.2520.98
93_V206_K2.2120.98
194_P225_K2.1960.98
264_L268_F2.1040.97
128_I132_L2.1020.97
233_F236_N1.9640.95
107_D110_L1.9500.95
116_W121_P1.9380.95
189_L226_L1.9100.94
101_W121_P1.9030.94
33_A84_L1.9010.94
164_P222_I1.8760.94
89_W93_V1.8710.94
59_W225_K1.8310.93
162_L176_P1.8280.93
79_T82_E1.8080.93
144_W184_K1.7490.91
10_E14_K1.7270.91
189_L225_K1.7240.91
104_R149_D1.7210.90
253_G257_P1.6750.89
127_N132_L1.6720.89
63_L146_P1.6640.89
34_P46_L1.6460.88
40_L52_G1.6280.88
202_L217_L1.6200.88
72_S76_K1.6200.88
243_D247_W1.6130.87
186_R221_H1.6030.87
194_P204_P1.5420.85
111_A115_A1.5220.84
42_G235_I1.5020.83
86_W127_N1.4920.83
9_E58_R1.4900.83
69_L72_S1.4770.82
106_P222_I1.4690.82
4_I32_L1.4660.82
212_G216_K1.4620.81
124_I203_S1.4550.81
206_K271_K1.4350.80
134_L209_F1.4230.80
43_W141_V1.4020.79
120_L133_I1.4000.79
176_P180_D1.3930.78
129_L133_I1.3850.78
12_Q19_Y1.3830.78
195_S247_W1.3700.77
94_R99_N1.3600.76
214_W217_L1.3520.76
260_L271_K1.3480.76
7_K14_K1.3460.76
165_W272_W1.3290.75
141_V198_A1.3220.74
181_I185_L1.3170.74
177_L244_P1.2990.73
81_Y112_L1.2970.73
272_W276_L1.2900.73
105_D140_A1.2890.72
248_V260_L1.2760.72
71_S74_R1.2740.72
123_F131_Q1.2680.71
194_P247_W1.2650.71
12_Q271_K1.2610.71
183_R186_R1.2440.70
201_G204_P1.2230.68
187_S248_V1.2170.68
96_A108_P1.2170.68
49_P133_I1.2130.68
35_L44_D1.2110.68
59_W94_R1.2080.67
128_I233_F1.2040.67
48_D245_L1.1990.67
61_S81_Y1.1930.66
94_R132_L1.1920.66
88_V103_P1.1880.66
237_P242_L1.1800.66
247_W250_A1.1730.65
233_F271_K1.1730.65
239_Q255_L1.1720.65
68_D73_R1.1630.64
129_L157_P1.1610.64
3_E10_E1.1590.64
50_S115_A1.1580.64
103_P162_L1.1570.64
214_W255_L1.1550.64
42_G51_Y1.1540.64
213_E233_F1.1460.63
186_R197_S1.1360.63
165_W205_W1.1350.62
93_V115_A1.1230.62
165_W226_L1.1230.62
164_P202_L1.1210.61
53_V56_L1.1200.61
149_D182_R1.1140.61
264_L267_E1.1110.61
70_S74_R1.1070.60
230_L248_V1.0980.60
211_P215_D1.0910.59
158_I204_P1.0910.59
124_I133_I1.0910.59
197_S201_G1.0840.59
225_K268_F1.0800.59
10_E17_E1.0700.58
182_R209_F1.0670.58
6_L14_K1.0600.57
31_L163_F1.0600.57
9_E15_Y1.0570.57
81_Y85_L1.0560.57
8_F130_D1.0440.56
90_L126_D1.0160.54
147_L188_A1.0140.54
44_D47_E1.0130.54
4_I10_E1.0090.53
67_Q70_S1.0060.53
223_L255_L1.0040.53
76_K145_D1.0030.53
213_E216_K0.9960.52
97_I218_L0.9930.52
123_F245_L0.9920.52
59_W134_L0.9880.52
110_L213_E0.9860.52
169_L269_F0.9820.51
17_E20_K0.9790.51
226_L230_L0.9790.51
86_W123_F0.9730.51
225_K247_W0.9680.50
163_F178_Y0.9640.50
29_V116_W0.9570.49
63_L141_V0.9530.49
128_I236_N0.9510.49
149_D197_S0.9510.49
62_L193_H0.9480.49
160_T178_Y0.9430.48
197_S204_P0.9380.48
90_L113_L0.9370.48
92_K97_I0.9350.48
17_E83_S0.9330.48
188_A194_P0.9320.48
164_P205_W0.9300.47
269_F272_W0.9250.47
11_L199_L0.9190.47
262_E266_K0.9140.46
240_Q276_L0.9000.45
98_N139_A0.8990.45
163_F197_S0.8970.45
151_V189_L0.8950.45
203_S253_G0.8940.45
158_I181_I0.8940.45
189_L268_F0.8920.45
22_Y29_V0.8870.44
42_G255_L0.8860.44
134_L167_P0.8850.44
42_G85_L0.8850.44
256_P260_L0.8850.44
65_L206_K0.8830.44
254_L258_S0.8810.44
6_L10_E0.8790.44
178_Y181_I0.8770.44
163_F201_G0.8760.43
63_L109_M0.8740.43
198_A204_P0.8700.43
44_D112_L0.8690.43
264_L269_F0.8560.42
90_L249_L0.8550.42
25_S28_A0.8500.42
14_K235_I0.8490.42
65_L69_L0.8470.41
226_L268_F0.8470.41
119_L207_D0.8430.41
164_P226_L0.8410.41
146_P184_K0.8400.41
78_M162_L0.8390.41
147_L190_D0.8390.41
45_P263_L0.8380.41
66_D69_L0.8370.41
35_L129_L0.8320.40
141_V252_K0.8240.40
29_V201_G0.8240.40
209_F265_E0.8210.40
158_I161_W0.8200.39
38_R47_E0.8130.39
183_R231_R0.8110.39
49_P224_P0.8090.39
164_P217_L0.8080.39
170_G173_R0.8040.38
86_W90_L0.8040.38
133_I137_L0.8040.38
65_L198_A0.8020.38
229_F232_E0.8020.38
40_L249_L0.8000.38
80_P84_L0.7930.38
113_L136_K0.7920.37
233_F240_Q0.7920.37
54_E257_P0.7910.37
57_K211_P0.7890.37
15_Y18_E0.7870.37
158_I244_P0.7850.37
40_L134_L0.7840.37
242_L276_L0.7840.37
146_P161_W0.7830.37
161_W181_I0.7830.37
85_L89_W0.7810.37
192_W225_K0.7800.37
128_I133_I0.7770.36
125_L128_I0.7770.36
108_P140_A0.7760.36
99_N231_R0.7700.36
50_S133_I0.7610.35
80_P222_I0.7580.35
89_W132_L0.7570.35
112_L118_P0.7570.35
30_A90_L0.7510.35
81_Y121_P0.7470.34
44_D100_E0.7460.34
132_L217_L0.7460.34
84_L103_P0.7450.34
38_R122_P0.7400.34
114_E164_P0.7390.34
8_F19_Y0.7380.34
37_R245_L0.7330.33
252_K255_L0.7320.33
32_L37_R0.7310.33
68_D72_S0.7270.33
22_Y215_D0.7260.33
45_P141_V0.7250.33
84_L87_E0.7250.33
81_Y118_P0.7220.33
181_I199_L0.7220.33
118_P206_K0.7200.33
151_V197_S0.7170.32
40_L88_V0.7160.32
207_D211_P0.7130.32
75_Q211_P0.7110.32
130_D209_F0.7100.32
51_Y208_V0.7080.32
10_E13_E0.7080.32
94_R135_P0.7070.32
19_Y119_L0.7050.32
61_S77_S0.7040.32
240_Q248_V0.7030.31
137_L161_W0.7030.31
52_G56_L0.7010.31
6_L85_L0.7010.31
52_G60_K0.6990.31
149_D225_K0.6970.31
161_W185_L0.6960.31
234_E271_K0.6900.31
138_T188_A0.6890.31
98_N262_E0.6890.31
56_L273_L0.6880.31
20_K113_L0.6850.30
169_L262_E0.6850.30
240_Q271_K0.6850.30
43_W46_L0.6840.30
159_H164_P0.6830.30
167_P195_S0.6800.30
186_R262_E0.6780.30
101_W106_P0.6770.30
65_L275_V0.6730.30
180_D267_E0.6730.30
93_V136_K0.6720.30
11_L22_Y0.6710.29
206_K245_L0.6700.29
37_R41_A0.6680.29
119_L130_D0.6670.29
24_L213_E0.6620.29
248_V271_K0.6620.29
141_V144_W0.6610.29
188_A216_K0.6610.29
23_G38_R0.6550.28
124_I148_S0.6540.28
8_F12_Q0.6460.28
181_I197_S0.6460.28
84_L187_S0.6450.28
61_S206_K0.6440.28
53_V197_S0.6440.28
218_L229_F0.6440.28
74_R77_S0.6430.28
206_K214_W0.6420.28
27_L147_L0.6410.28
91_P94_R0.6410.28
233_F237_P0.6320.27
91_P165_W0.6310.27
145_D188_A0.6270.27
98_N238_R0.6260.27
133_I248_V0.6250.27
14_K38_R0.6240.27
23_G114_E0.6230.27
30_A145_D0.6220.27
32_L229_F0.6210.26
13_E102_D0.6190.26
5_L12_Q0.6180.26
23_G228_K0.6160.26
35_L45_P0.6150.26
28_A250_A0.6130.26
127_N173_R0.6120.26
101_W165_W0.6080.26
13_E16_P0.6080.26
52_G275_V0.6060.26
63_L85_L0.6050.26
41_A133_I0.6040.25
237_P276_L0.6010.25
204_P256_P0.6010.25
115_A176_P0.5990.25
184_K237_P0.5990.25
151_V200_A0.5990.25
99_N136_K0.5970.25
43_W121_P0.5950.25
143_S182_R0.5900.25
19_Y86_W0.5880.25
163_F256_P0.5850.24
2_D150_T0.5830.24
86_W188_A0.5830.24
4_I7_K0.5830.24
27_L207_D0.5800.24
11_L91_P0.5780.24
230_L263_L0.5700.24
5_L112_L0.5690.24
88_V207_D0.5670.23
192_W202_L0.5660.23
40_L95_S0.5640.23
28_A149_D0.5630.23
80_P121_P0.5610.23
121_P192_W0.5600.23
195_S243_D0.5580.23
122_P148_S0.5570.23
36_L74_R0.5570.23
86_W199_L0.5560.23
166_L240_Q0.5550.23
92_K250_A0.5550.23
15_Y50_S0.5540.23
89_W127_N0.5520.23
61_S68_D0.5500.23
167_P209_F0.5500.23
128_I230_L0.5500.23
57_K62_L0.5490.23
36_L219_V0.5490.23
62_L100_E0.5480.22
35_L109_M0.5460.22
68_D207_D0.5450.22
29_V223_L0.5450.22
167_P215_D0.5440.22
165_W222_I0.5430.22
16_P208_V0.5430.22
20_K70_S0.5420.22
116_W266_K0.5410.22
235_I271_K0.5390.22
4_I28_A0.5390.22
60_K81_Y0.5360.22
227_A266_K0.5360.22
24_L131_Q0.5350.22
166_L224_P0.5350.22
210_D213_E0.5330.22
194_P229_F0.5330.22
118_P207_D0.5320.22
161_W165_W0.5300.22
207_D235_I0.5300.22
20_K180_D0.5290.21
51_Y206_K0.5280.21
84_L165_W0.5270.21
71_S97_I0.5270.21
89_W123_F0.5250.21
145_D184_K0.5250.21
103_P218_L0.5230.21
163_F182_R0.5220.21
135_P263_L0.5200.21
109_M116_W0.5180.21
53_V162_L0.5170.21
4_I214_W0.5160.21
110_L168_L0.5120.21
102_D113_L0.5120.21
30_A213_E0.5110.21
9_E12_Q0.5080.20
234_E241_D0.5060.20
168_L175_E0.5060.20
133_I162_L0.5060.20
41_A162_L0.5040.20
100_E257_P0.5040.20
149_D158_I0.5030.20
94_R240_Q0.5020.20
163_F221_H0.5020.20
94_R226_L0.5010.20
63_L157_P0.5010.20
168_L173_R0.5010.20
36_L264_L0.5000.20
159_H251_W0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ibrB 1 0.8768 12.3 0.961 Contact Map
4qmiA 1 0.4746 7.4 0.964 Contact Map
3hr0A 2 0.7138 6.9 0.965 Contact Map
1svdM 3 0.1486 5.4 0.967 Contact Map
4rs6A 1 0.2174 4.9 0.967 Contact Map
4qmhA 1 0.7971 4.5 0.968 Contact Map
4a5pA 3 0.6087 4.5 0.968 Contact Map
2qk2A 1 0.8188 4.4 0.968 Contact Map
4wzxE 1 0.0471 4 0.969 Contact Map
2qk1A 1 0.8478 3.8 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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