GREMLIN Database
DM4_12 - DM4/DM12 family
PFAM: PF07841 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 80 (80)
Sequences: 744 (550)
Seq/√Len: 61.5
META: 0.083

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_S64_E4.2541.00
63_A67_G3.4011.00
18_D21_A2.6291.00
39_N43_G2.4471.00
40_G43_G2.4191.00
20_R59_E2.2311.00
1_R5_Y2.2041.00
62_E66_A2.1831.00
25_R74_A1.6760.99
15_Y42_L1.6340.99
20_R37_H1.6000.99
73_C80_C1.5960.99
72_D75_R1.5660.99
37_H43_G1.4420.98
9_E20_R1.4180.97
68_R77_Y1.3960.97
22_C28_C1.3850.97
25_R29_E1.3660.97
30_A47_H1.3580.97
32_Q42_L1.3530.97
16_G19_G1.3280.96
63_A77_Y1.3280.96
52_P60_Y1.3240.96
10_D15_Y1.2970.96
25_R65_R1.2870.95
31_A34_P1.2730.95
19_G44_E1.2650.95
69_S72_D1.2650.95
12_L49_I1.2390.94
29_E52_P1.2390.94
28_C73_C1.2310.94
24_L59_E1.2180.94
47_H66_A1.2140.94
31_A51_T1.1660.92
44_E47_H1.1590.92
31_A44_E1.1170.91
23_L30_A1.1060.90
22_C73_C1.0990.90
7_K10_D1.0580.88
10_D14_R1.0440.88
27_I53_S1.0240.86
23_L44_E1.0150.86
2_R62_E1.0010.85
21_A32_Q0.9730.84
54_S57_D0.9710.83
9_E60_Y0.9650.83
49_I75_R0.9610.83
24_L60_Y0.9490.82
19_G23_L0.9380.81
3_D10_D0.9300.81
50_F70_G0.9280.81
21_A79_E0.9080.79
3_D77_Y0.8890.78
41_L47_H0.8830.77
3_D11_L0.8800.77
19_G24_L0.8180.72
56_E68_R0.8100.71
32_Q49_I0.8070.70
51_T67_G0.8070.70
45_L49_I0.8050.70
17_F29_E0.7990.70
13_E36_H0.7990.70
12_L33_R0.7910.69
65_R69_S0.7870.69
56_E71_G0.7720.67
48_I56_E0.7630.66
4_L78_P0.7620.66
3_D68_R0.7550.65
44_E60_Y0.7530.65
34_P52_P0.7430.64
42_L49_I0.7400.64
21_A69_S0.7300.63
71_G74_A0.7260.62
6_R9_E0.7150.61
1_R11_L0.7140.61
27_I56_E0.7050.60
4_L11_L0.6740.57
46_L79_E0.6680.56
28_C80_C0.6630.55
42_L79_E0.6600.55
8_L24_L0.6590.55
10_D13_E0.6580.55
23_L58_E0.6580.55
36_H46_L0.6370.52
40_G48_I0.6360.52
15_Y59_E0.6340.52
3_D62_E0.6330.52
53_S71_G0.6270.51
7_K18_D0.6260.51
35_L39_N0.6220.51
62_E72_D0.6220.51
17_F21_A0.6200.51
18_D78_P0.6170.50
19_G64_E0.6170.50
65_R77_Y0.6150.50
17_F74_A0.6140.50
29_E47_H0.6130.50
8_L74_A0.6040.49
39_N44_E0.5920.47
31_A47_H0.5860.47
6_R14_R0.5770.46
13_E56_E0.5710.45
31_A64_E0.5700.45
13_E55_S0.5650.44
5_Y9_E0.5580.43
43_G77_Y0.5580.43
26_A71_G0.5530.43
19_G30_A0.5470.42
55_S76_L0.5460.42
2_R65_R0.5390.41
46_L50_F0.5240.40
55_S58_E0.5210.39
5_Y64_E0.5200.39
19_G27_I0.5180.39
3_D54_S0.5180.39
38_H78_P0.5160.39
27_I48_I0.5060.38
2_R61_D0.5050.38
46_L71_G0.5050.38
25_R52_P0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2knjA 1 0.775 8.9 0.882 Contact Map
4e8uA 4 0.7875 4.1 0.9 Contact Map
3ec8A 2 0.8375 3.6 0.902 Contact Map
1yqfA 3 0.6 3.3 0.904 Contact Map
2vmlB 3 0.7625 2.8 0.907 Contact Map
1p32A 3 0.625 2.7 0.909 Contact Map
3l0fB 3 0.7625 2.7 0.909 Contact Map
3qv0A 3 0.6 2.6 0.909 Contact Map
3jv1A 3 0.6 2.6 0.909 Contact Map
2c7lB 3 0.7625 2.5 0.91 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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