GREMLIN Database
HCNGP - HCNGP-like protein
PFAM: PF07818 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 94 (92)
Sequences: 539 (409)
Seq/√Len: 42.7
META: 0.382

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_F34_L2.8001.00
86_K90_E2.7951.00
80_E83_K2.5971.00
82_A85_Q2.5361.00
74_E80_E2.3731.00
35_Q76_A2.3141.00
56_D70_H2.2281.00
22_E26_Q2.2241.00
64_K68_D2.1140.99
48_K52_F1.9570.99
17_F21_L1.8840.99
63_P66_V1.8170.98
5_P9_C1.8140.98
24_K29_H1.7690.98
47_E51_E1.6240.97
73_P76_A1.6150.96
39_A48_K1.6060.96
19_R22_E1.5480.95
33_K40_F1.5450.95
4_S9_C1.5440.95
50_V57_E1.4890.94
29_H35_Q1.4860.94
40_F61_N1.4360.93
84_A87_R1.4010.92
42_N45_L1.3630.91
78_Y82_A1.3060.89
14_Q59_G1.2920.89
20_F30_F1.2920.89
45_L61_N1.2660.88
9_C14_Q1.2640.88
49_L53_V1.2550.87
72_F76_A1.2510.87
20_F29_H1.2370.86
69_P72_F1.2240.86
7_G81_L1.2230.86
45_L49_L1.2210.86
71_G74_E1.2210.86
46_L61_N1.2200.86
31_N49_L1.1690.83
39_A52_F1.1030.79
44_S49_L1.0710.77
18_A84_A1.0690.77
46_L50_V1.0690.77
19_R52_F1.0330.75
32_E71_G1.0290.74
86_K89_M1.0200.74
24_K30_F1.0190.74
5_P66_V1.0190.74
17_F30_F1.0160.73
29_H53_V1.0110.73
33_K37_S0.9880.71
20_F60_T0.9820.71
27_G91_K0.9790.71
83_K87_R0.9560.69
4_S17_F0.9470.68
15_A90_E0.9440.68
3_P79_E0.9400.68
49_L52_F0.9310.67
41_R45_L0.9190.66
29_H34_L0.9170.66
18_A22_E0.8920.63
23_L29_H0.8790.62
23_L58_Y0.8710.62
47_E82_A0.8560.60
13_L59_G0.8540.60
20_F23_L0.8520.60
67_W71_G0.8390.59
47_E80_E0.8330.58
16_K49_L0.8300.58
15_A47_E0.8220.57
47_E61_N0.8200.57
58_Y62_L0.8080.56
10_D36_S0.8030.55
53_V91_K0.7750.53
24_K60_T0.7730.52
4_S8_S0.7730.52
58_Y77_Y0.7670.52
41_R49_L0.7550.51
55_I59_G0.7440.50
82_A86_K0.7430.50
6_P25_K0.7400.49
13_L16_K0.7290.48
60_T69_P0.7290.48
30_F53_V0.7290.48
29_H49_L0.7280.48
49_L76_A0.7250.48
4_S64_K0.7120.47
39_A45_L0.7080.46
38_K59_G0.7070.46
56_D59_G0.6910.45
2_P13_L0.6790.44
7_G51_E0.6770.43
89_M92_R0.6740.43
45_L50_V0.6700.43
1_I18_A0.6680.43
19_R51_E0.6640.42
30_F33_K0.6630.42
40_F85_Q0.6560.41
28_V87_R0.6440.40
50_V53_V0.6420.40
60_T67_W0.6410.40
80_E84_A0.6380.40
87_R90_E0.6360.40
64_K70_H0.6330.39
37_S59_G0.6300.39
32_E57_E0.6250.39
12_A58_Y0.6230.38
8_S13_L0.6180.38
34_L53_V0.6070.37
87_R91_K0.6050.37
46_L60_T0.6050.37
27_G38_K0.5990.36
1_I37_S0.5960.36
15_A82_A0.5940.36
20_F34_L0.5900.36
16_K52_F0.5800.35
31_N34_L0.5730.34
16_K21_L0.5690.34
84_A88_E0.5680.34
50_V67_W0.5620.33
57_E78_Y0.5580.33
36_S74_E0.5470.32
59_G66_V0.5440.32
51_E64_K0.5430.32
1_I71_G0.5420.32
46_L57_E0.5360.31
39_A49_L0.5330.31
18_A91_K0.5330.31
83_K86_K0.5300.31
66_V69_P0.5290.30
28_V33_K0.5250.30
30_F77_Y0.5240.30
7_G60_T0.5200.30
64_K92_R0.5160.29
11_P45_L0.5150.29
41_R46_L0.5050.29
67_W92_R0.5020.28
38_K50_V0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ux5A 2 0.9043 23.4 0.899 Contact Map
1v9dA 3 0.883 10.6 0.914 Contact Map
3obvE 2 0.9255 8.8 0.917 Contact Map
3p1aA 1 0.4574 7.5 0.919 Contact Map
4u4cA 1 0.383 6.9 0.921 Contact Map
4yodA 1 0.8723 5.7 0.924 Contact Map
4qu4A 1 0.3191 5.6 0.924 Contact Map
4a4zA 1 0.383 5.5 0.924 Contact Map
2j1dG 2 0.9255 5.3 0.925 Contact Map
1ry2A 1 0.3511 5.2 0.925 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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