GREMLIN Database
TfuA - TfuA-like protein
PFAM: PF07812 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 120 (120)
Sequences: 4174 (3107)
Seq/√Len: 283.7
META: 0.897

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_A51_F3.2981.00
64_E87_R2.9301.00
46_G51_F2.9161.00
94_V104_A2.8831.00
24_H45_I2.6791.00
53_A58_V2.4161.00
70_G77_R2.3461.00
49_R53_A2.3151.00
70_G74_L2.2181.00
71_P74_L2.1961.00
90_L104_A2.1101.00
61_D112_K2.0851.00
40_A55_R2.0661.00
92_A96_A2.0211.00
26_F45_I1.9011.00
3_Y7_V1.7391.00
68_L80_S1.7081.00
86_I90_L1.6721.00
52_E56_D1.6211.00
5_E116_Y1.5981.00
49_R52_E1.5741.00
67_V82_A1.5551.00
49_R88_A1.5511.00
37_A40_A1.5151.00
100_S103_E1.5141.00
39_L44_M1.4881.00
74_L77_R1.4831.00
93_A98_V1.4371.00
5_E117_P1.4251.00
90_L108_L1.4071.00
19_L44_M1.3991.00
94_V101_A1.3461.00
83_L112_K1.3351.00
61_D83_L1.3141.00
54_Y59_L1.2721.00
104_A108_L1.2411.00
17_W20_S1.2391.00
68_L117_P1.2361.00
63_D112_K1.2271.00
68_L79_L1.2241.00
13_K16_L1.2181.00
59_L84_V1.1881.00
3_Y69_H1.1861.00
106_A110_A1.1761.00
15_I25_V1.1741.00
82_A85_N1.1721.00
3_Y6_Q1.1691.00
90_L107_L1.1531.00
70_G75_G1.1381.00
81_E85_N1.1361.00
26_F47_V1.1331.00
17_W21_R1.1331.00
67_V78_P1.1291.00
101_A105_A1.1181.00
80_S117_P1.1141.00
110_A114_L1.1031.00
111_A114_L1.0761.00
83_L111_A1.0661.00
86_I89_T1.0541.00
11_W18_A1.0521.00
88_A92_A1.0481.00
92_A95_R1.0441.00
9_A31_M1.0421.00
70_G79_L1.0211.00
84_V88_A1.0111.00
99_I103_E1.0031.00
53_A88_A0.9861.00
51_F55_R0.9801.00
99_I104_A0.9601.00
59_L87_R0.9561.00
61_D64_E0.9561.00
109_A113_A0.9551.00
69_H76_Y0.9511.00
18_A25_V0.9441.00
5_E11_W0.9361.00
53_A59_L0.9341.00
81_E86_I0.9211.00
64_E108_L0.9101.00
28_A47_V0.9001.00
59_L64_E0.8881.00
88_A91_A0.8871.00
83_L108_L0.8811.00
53_A91_A0.8531.00
13_K17_W0.8471.00
89_T92_A0.8471.00
8_P12_H0.8431.00
16_L42_F0.8321.00
105_A109_A0.8301.00
54_Y65_V0.8261.00
64_E83_L0.8231.00
115_F118_E0.8201.00
36_A46_G0.8191.00
31_M65_V0.8181.00
63_D83_L0.7880.99
94_V99_I0.7830.99
10_V31_M0.7760.99
111_A115_F0.7740.99
102_A105_A0.7720.99
15_I44_M0.7630.99
94_V105_A0.7590.99
87_R108_L0.7580.99
87_R112_K0.7550.99
91_A104_A0.7450.99
19_L24_H0.7450.99
8_P39_L0.7370.99
4_F10_V0.7340.99
8_P11_W0.7260.99
4_F66_A0.7260.99
5_E8_P0.7230.99
86_I111_A0.7160.99
105_A108_L0.7150.99
91_A95_R0.7020.98
45_I49_R0.7020.98
18_A23_V0.7000.98
53_A57_G0.6990.98
38_E62_D0.6940.98
46_G55_R0.6790.98
6_Q9_A0.6780.98
12_H17_W0.6770.98
114_L118_E0.6750.98
72_A76_Y0.6680.98
4_F9_A0.6660.98
31_M66_A0.6620.98
3_Y13_K0.6580.98
107_L110_A0.6570.98
55_R58_V0.6540.98
50_I84_V0.6540.98
94_V100_S0.6470.97
19_L25_V0.6400.97
12_H16_L0.6360.97
39_L42_F0.6350.97
97_G101_A0.6350.97
83_L86_I0.6350.97
110_A113_A0.6340.97
106_A109_A0.6120.96
70_G73_E0.6110.96
91_A108_L0.6040.96
93_A96_A0.6000.96
11_W17_W0.6000.96
18_A61_D0.5990.96
74_L79_L0.5950.96
54_Y64_E0.5900.96
86_I120_T0.5900.96
79_L82_A0.5870.96
106_A113_A0.5870.96
8_P13_K0.5860.95
96_A109_A0.5840.95
5_E13_K0.5830.95
53_A64_E0.5820.95
64_E112_K0.5800.95
28_A34_L0.5800.95
114_L117_P0.5780.95
108_L112_K0.5770.95
12_H15_I0.5740.95
63_D86_I0.5720.95
67_V81_E0.5700.95
49_R91_A0.5680.95
52_E55_R0.5660.95
16_L39_L0.5610.94
52_E95_R0.5570.94
103_E106_A0.5510.94
4_F29_A0.5510.94
6_Q82_A0.5490.94
35_R62_D0.5480.94
99_I107_L0.5480.94
76_Y82_A0.5480.94
18_A21_R0.5410.93
102_A106_A0.5350.93
101_A109_A0.5350.93
37_A55_R0.5340.93
19_L39_L0.5330.93
69_H82_A0.5310.93
85_N89_T0.5180.92
4_F8_P0.5110.91
5_E115_F0.5070.91
100_S106_A0.5060.91
110_A120_T0.5050.91
63_D93_A0.5050.91
53_A87_R0.5040.90
20_S24_H0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gq4A 1 0.7333 28.4 0.928 Contact Map
2lwjA 1 0.7167 17.7 0.935 Contact Map
1uj8A 1 0.6083 15.4 0.937 Contact Map
3ohsX 2 0.8167 14.8 0.937 Contact Map
4i5lC 1 0.3583 13.7 0.938 Contact Map
3c8tA 4 0.5167 11.4 0.94 Contact Map
4l5gA 1 0.6917 11.1 0.94 Contact Map
2ou3A 2 0.55 9.7 0.942 Contact Map
4n18A 2 0.9083 9 0.943 Contact Map
3ip3A 2 0.9167 7.7 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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