GREMLIN Database
DUF1643 - Protein of unknown function (DUF1643)
PFAM: PF07799 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 135 (133)
Sequences: 7115 (5894)
Seq/√Len: 511.1
META: 0.881

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
124_G132_R3.5861.00
16_L52_V3.2041.00
19_M51_V2.6441.00
59_A64_D2.4631.00
77_D105_R2.4411.00
122_C125_L2.4221.00
52_V83_A2.3891.00
17_F41_A2.2781.00
126_T130_H2.2601.00
19_M93_A2.1001.00
57_Y68_A2.0781.00
15_V46_Y1.9901.00
34_I51_V1.9331.00
14_R48_G1.8991.00
37_C51_V1.8121.00
50_I83_A1.6531.00
30_D34_I1.6401.00
56_A73_G1.6301.00
56_A76_N1.6151.00
52_V80_I1.5981.00
17_F91_V1.5981.00
30_D38_I1.5901.00
9_D12_G1.5721.00
8_W48_G1.5701.00
39_G43_R1.5521.00
38_I42_R1.5511.00
92_A120_L1.5451.00
35_R39_G1.5401.00
14_R50_I1.5391.00
89_L121_Y1.5381.00
16_L83_A1.5261.00
36_R39_G1.4941.00
16_L87_A1.4751.00
30_D35_R1.4661.00
37_C49_L1.4621.00
7_R48_G1.4501.00
126_T132_R1.4501.00
75_E79_A1.4021.00
106_G130_H1.3931.00
81_L112_L1.3751.00
13_P47_G1.3201.00
40_F44_W1.3111.00
38_I49_L1.2751.00
15_V91_V1.2591.00
50_I86_E1.2441.00
32_P35_R1.2331.00
98_N128_D1.2281.00
3_L79_A1.2171.00
3_L83_A1.2121.00
16_L90_V1.1961.00
24_T58_R1.1771.00
84_A90_V1.1651.00
59_A62_P1.1561.00
15_V41_A1.1391.00
25_A31_D1.1321.00
66_K102_L1.1311.00
3_L50_I1.1301.00
36_R40_F1.1231.00
18_I52_V1.1151.00
17_F37_C1.1071.00
46_Y89_L1.0991.00
84_A113_L1.0821.00
15_V44_W1.0761.00
68_A71_P1.0711.00
19_M37_C1.0561.00
9_D47_G1.0541.00
12_G47_G1.0471.00
15_V89_L1.0401.00
16_L84_A1.0251.00
34_I49_L1.0001.00
7_R14_R0.9981.00
5_W50_I0.9941.00
32_P60_T0.9831.00
5_W48_G0.9811.00
78_A82_E0.9791.00
61_D64_D0.9781.00
18_I90_V0.9761.00
55_F102_L0.9741.00
106_G110_L0.9691.00
41_A49_L0.9621.00
105_R108_E0.9531.00
52_V84_A0.9501.00
79_A83_A0.9451.00
100_G106_G0.9441.00
6_R30_D0.9401.00
80_I109_V0.9361.00
20_L62_P0.9341.00
105_R109_V0.9331.00
66_K99_H0.9251.00
75_E78_A0.9211.00
64_D67_A0.9181.00
101_A130_H0.9071.00
24_T60_T0.9041.00
57_Y66_K0.8851.00
14_R88_D0.8771.00
9_D13_P0.8701.00
41_A46_Y0.8691.00
79_A82_E0.8561.00
2_Y73_G0.8551.00
26_D58_R0.8511.00
2_Y56_A0.8331.00
59_A65_L0.8161.00
11_S47_G0.8031.00
117_G120_L0.8021.00
100_G103_L0.8011.00
77_D109_V0.8001.00
7_R10_P0.7951.00
37_C93_A0.7891.00
24_T29_K0.7831.00
91_V123_L0.7801.00
99_H102_L0.7781.00
54_L109_V0.7651.00
35_R40_F0.7641.00
34_I37_C0.7641.00
84_A109_V0.7591.00
17_F93_A0.7581.00
76_N80_I0.7571.00
40_F43_R0.7541.00
20_L54_L0.7451.00
3_L52_V0.7371.00
109_V112_L0.7321.00
108_E112_L0.7291.00
54_L106_G0.7261.00
17_F49_L0.7241.00
110_L114_R0.7231.00
77_D112_L0.7191.00
107_R110_L0.7141.00
60_T64_D0.7111.00
55_F105_R0.6951.00
16_L50_I0.6951.00
36_R43_R0.6941.00
101_A106_G0.6941.00
39_G42_R0.6911.00
13_P88_D0.6841.00
57_Y64_D0.6811.00
52_V87_A0.6801.00
32_P36_R0.6791.00
7_R47_G0.6781.00
104_G107_R0.6721.00
23_S31_D0.6711.00
100_G104_G0.6641.00
98_N130_H0.6631.00
77_D80_I0.6621.00
108_E111_A0.6601.00
17_F44_W0.6591.00
57_Y65_L0.6501.00
36_R44_W0.6481.00
37_C41_A0.6421.00
8_W47_G0.6421.00
84_A87_A0.6411.00
109_V113_L0.6191.00
65_L102_L0.6141.00
14_R87_A0.6121.00
4_L25_A0.6101.00
2_Y74_P0.6091.00
99_H103_L0.5990.99
113_L120_L0.5970.99
103_L106_G0.5950.99
81_L116_A0.5910.99
85_K116_A0.5860.99
6_R49_L0.5850.99
17_F123_L0.5830.99
8_W42_R0.5830.99
92_A113_L0.5820.99
98_N126_T0.5800.99
56_A72_V0.5790.99
104_G108_E0.5780.99
66_K71_P0.5770.99
90_V118_V0.5770.99
72_V77_D0.5740.99
102_L106_G0.5730.99
56_A75_E0.5720.99
55_F66_K0.5720.99
27_E30_D0.5590.99
107_R111_A0.5580.99
23_S60_T0.5570.99
55_F73_G0.5540.99
26_D29_K0.5500.99
54_L100_G0.5490.99
14_R86_E0.5460.99
77_D108_E0.5420.99
72_V105_R0.5380.99
90_V120_L0.5310.99
19_M49_L0.5300.99
35_R38_I0.5260.99
56_A71_P0.5260.99
7_R12_G0.5260.99
6_R38_I0.5220.99
92_A110_L0.5210.99
117_G121_Y0.5190.98
20_L65_L0.5160.98
21_N25_A0.5150.98
81_L85_K0.5150.98
81_L115_A0.5120.98
24_T59_A0.5090.98
121_Y125_L0.5070.98
70_D73_G0.5050.98
17_F51_V0.5040.98
80_I84_A0.5010.98
78_A81_L0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2d3yA 1 0.9407 51.5 0.886 Contact Map
1ui0A 1 0.9481 29.7 0.901 Contact Map
3kv1A 2 0.6296 28.3 0.902 Contact Map
4r9nA 1 0.637 26.8 0.903 Contact Map
1vk2A 1 0.9259 25 0.904 Contact Map
1oe4A 2 0.8741 21.4 0.907 Contact Map
2gnpA 1 0.7037 16.4 0.912 Contact Map
2j8xA 1 0.8815 15.9 0.912 Contact Map
4oqpA 2 0.6815 15.5 0.913 Contact Map
2okgA 2 0.7111 15.3 0.913 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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