GREMLIN Database
DUF1638 - Protein of unknown function (DUF1638)
PFAM: PF07796 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 161 (155)
Sequences: 9467 (6503)
Seq/√Len: 522.4
META: 0.935

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
133_R149_E4.2301.00
62_E67_S2.7281.00
18_Q22_D2.5721.00
118_R148_E2.4821.00
16_A19_E2.3711.00
133_R147_F2.3131.00
137_R141_E2.2981.00
18_Q49_E2.2971.00
9_R12_K2.0461.00
20_A23_A1.9931.00
41_G44_G1.8911.00
81_T118_R1.8581.00
78_E117_T1.8391.00
102_P106_D1.7961.00
75_F83_Y1.7801.00
107_E110_G1.7791.00
135_K138_E1.7571.00
91_H94_R1.7541.00
80_G117_T1.7511.00
136_A147_F1.7301.00
101_G104_L1.7031.00
117_T146_P1.6431.00
133_R137_R1.6231.00
43_D54_R1.6111.00
6_L16_A1.5881.00
40_G43_D1.5761.00
30_R53_V1.5721.00
123_D151_P1.5681.00
64_F85_T1.5431.00
12_K15_A1.5381.00
120_V150_R1.5051.00
55_P63_F1.5001.00
155_G159_R1.4951.00
22_D50_E1.4881.00
122_L152_G1.4681.00
14_R45_L1.4621.00
73_E77_E1.4511.00
72_A76_E1.4471.00
107_E111_N1.4441.00
135_K139_A1.4411.00
125_G151_P1.4271.00
81_T120_V1.4261.00
18_Q50_E1.4191.00
70_F73_E1.4101.00
42_L54_R1.3731.00
134_E138_E1.3731.00
108_Y111_N1.3691.00
21_I31_I1.3591.00
21_I50_E1.3581.00
65_L122_L1.3431.00
15_A19_E1.3431.00
104_L107_E1.3431.00
19_E23_A1.3311.00
134_E137_R1.3241.00
97_G102_P1.3181.00
69_E73_E1.3091.00
78_E118_R1.3051.00
12_K16_A1.2991.00
58_H62_E1.2981.00
139_A143_L1.2831.00
138_E141_E1.2751.00
91_H95_L1.2691.00
89_V135_K1.2501.00
57_G62_E1.2481.00
125_G149_E1.2071.00
128_D133_R1.2031.00
34_G55_P1.1791.00
2_L35_Y1.1481.00
138_E142_R1.1471.00
17_L42_L1.1411.00
123_D149_E1.1401.00
24_A27_R1.1381.00
137_R147_F1.1321.00
84_L119_L1.1131.00
106_D110_G1.1041.00
74_L77_E1.0891.00
104_L111_N1.0861.00
16_A20_A1.0831.00
30_R51_G1.0801.00
101_G105_A1.0661.00
25_R50_E1.0621.00
36_G57_G1.0521.00
100_L108_Y1.0491.00
66_G69_E1.0441.00
93_D142_R1.0291.00
11_E14_R1.0251.00
97_G105_A1.0141.00
89_V132_L1.0141.00
33_V47_L1.0131.00
47_L50_E1.0001.00
21_I52_V0.9911.00
32_L53_V0.9911.00
104_L108_Y0.9901.00
36_G63_F0.9761.00
98_L101_G0.9731.00
74_L120_V0.9661.00
128_D151_P0.9591.00
24_A28_Y0.9471.00
39_G43_D0.9301.00
69_E150_R0.9291.00
20_A24_A0.9241.00
89_V139_A0.9131.00
25_R49_E0.9091.00
22_D48_A0.8941.00
46_K49_E0.8891.00
130_P134_E0.8841.00
21_I45_L0.8721.00
24_A31_I0.8701.00
100_L105_A0.8691.00
136_A140_A0.8661.00
14_R41_G0.8601.00
92_F95_L0.8591.00
123_D129_D0.8571.00
65_L74_L0.8571.00
121_Y129_D0.8411.00
92_F96_V0.8401.00
32_L160_L0.8391.00
119_L140_A0.8391.00
44_G48_A0.8321.00
84_L136_A0.8311.00
74_L78_E0.8281.00
98_L108_Y0.8201.00
57_G63_F0.8171.00
17_L33_V0.7961.00
128_D149_E0.7891.00
97_G101_G0.7841.00
120_V148_E0.7751.00
73_E76_E0.7741.00
14_R18_Q0.7631.00
118_R146_P0.7601.00
74_L118_R0.7511.00
62_E156_L0.7461.00
59_H62_E0.7451.00
3_P8_N0.7451.00
5_G8_N0.7401.00
105_A110_G0.7391.00
4_A8_N0.7381.00
128_D131_E0.7301.00
119_L136_A0.7291.00
105_A108_Y0.7191.00
68_E72_A0.7161.00
78_E146_P0.7161.00
37_D40_G0.7161.00
76_E79_P0.7121.00
67_S156_L0.7091.00
155_G158_E0.7081.00
93_D138_E0.7081.00
127_T130_P0.7071.00
41_G45_L0.7011.00
156_L159_R0.6861.00
3_P16_A0.6851.00
101_G108_Y0.6781.00
125_G128_D0.6751.00
45_L50_E0.6731.00
61_Y88_W0.6721.00
70_F83_Y0.6701.00
32_L36_G0.6691.00
98_L102_P0.6681.00
99_G108_Y0.6591.00
72_A75_F0.6571.00
102_P105_A0.6561.00
92_F97_G0.6561.00
62_E68_E0.6551.00
64_F124_T0.6551.00
103_E107_E0.6551.00
130_P133_R0.6541.00
18_Q45_L0.6531.00
39_G44_G0.6511.00
84_L139_A0.6491.00
55_P160_L0.6491.00
75_F79_P0.6471.00
84_L89_V0.6451.00
47_L52_V0.6431.00
154_L158_E0.6401.00
104_L109_F0.6391.00
39_G42_L0.6381.00
154_L157_L0.6311.00
131_E134_E0.6291.00
70_F74_L0.6261.00
136_A139_A0.6231.00
31_I52_V0.6191.00
81_T116_Y0.6191.00
22_D25_R0.6141.00
131_E135_K0.6121.00
39_G45_L0.6051.00
126_Q130_P0.6051.00
119_L145_L0.6031.00
17_L45_L0.5981.00
31_I50_E0.5950.99
126_Q129_D0.5940.99
125_G133_R0.5880.99
81_T117_T0.5860.99
23_A26_G0.5860.99
74_L150_R0.5810.99
105_A142_R0.5730.99
93_D96_V0.5690.99
123_D126_Q0.5660.99
33_V52_V0.5660.99
121_Y133_R0.5640.99
77_E80_G0.5640.99
21_I47_L0.5610.99
140_A147_F0.5520.99
128_D132_L0.5500.99
102_P110_G0.5490.99
92_F105_A0.5490.99
132_L135_K0.5470.99
19_E22_D0.5450.99
13_L41_G0.5440.99
97_G100_L0.5410.99
2_L6_L0.5360.99
102_P108_Y0.5360.99
21_I24_A0.5350.99
121_Y147_F0.5340.99
21_I25_R0.5300.99
45_L52_V0.5270.99
127_T151_P0.5250.99
129_D132_L0.5240.99
5_G94_R0.5240.99
75_F80_G0.5230.99
5_G9_R0.5220.99
67_S70_F0.5190.99
124_T154_L0.5170.99
99_G102_P0.5170.99
106_D109_F0.5170.99
34_G157_L0.5170.99
82_F89_V0.5160.99
85_T88_W0.5100.98
141_E144_G0.5100.98
39_G59_H0.5100.98
100_L107_E0.5020.98
121_Y132_L0.5020.98
48_A51_G0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bnlA 2 0.5528 42 0.919 Contact Map
2goyA 3 0.5714 21.4 0.93 Contact Map
4u9bA 1 0.4658 17.6 0.933 Contact Map
3tfgA 1 0.4658 15.3 0.935 Contact Map
3sj5A 1 0.472 15.3 0.935 Contact Map
4z0nA 1 0.8509 15.2 0.935 Contact Map
4r0gA 2 0.5217 13.7 0.936 Contact Map
4pe6A 1 0.8075 11.7 0.938 Contact Map
2fvyA 1 0.8509 11.2 0.939 Contact Map
3l49A 2 0.8012 11 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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