GREMLIN Database
DUF1628 - Protein of unknown function (DUF1628)
PFAM: PF07790 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 80 (75)
Sequences: 8376 (6222)
Seq/√Len: 718.5
META: 0.912

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_G28_L4.5121.00
61_H67_I2.9971.00
23_I27_V2.7911.00
61_H64_G2.7021.00
9_V16_T2.2201.00
10_I14_A2.0941.00
61_H65_D2.0721.00
43_S62_E1.9871.00
7_I10_I1.7921.00
72_L75_T1.7061.00
13_V16_T1.6861.00
42_F59_I1.6311.00
57_V61_H1.6281.00
68_D71_D1.6251.00
44_V59_I1.5081.00
21_A25_A1.3851.00
16_T20_A1.3761.00
14_A18_I1.3631.00
42_F67_I1.3491.00
73_K76_V1.3181.00
25_A29_G1.2881.00
52_T55_N1.2621.00
42_F61_H1.2481.00
69_A72_L1.2351.00
27_V30_L1.2141.00
68_D72_L1.2101.00
48_S52_T1.2091.00
50_G55_N1.2051.00
33_S37_A1.1691.00
5_P8_G1.1571.00
26_F30_L1.1341.00
66_T69_A1.1311.00
15_I19_L1.1231.00
31_G34_P1.1161.00
52_T56_T1.0481.00
8_G26_F1.0271.00
12_M26_F1.0221.00
22_V25_A1.0181.00
5_P20_A1.0121.00
46_V50_G0.9821.00
6_V24_G0.9661.00
6_V20_A0.9281.00
33_S36_T0.9271.00
67_I72_L0.9231.00
46_V49_S0.9161.00
49_S52_T0.9061.00
9_V19_L0.9011.00
46_V51_G0.8871.00
10_I16_T0.8831.00
40_A44_V0.8761.00
68_D76_V0.8721.00
51_G56_T0.8591.00
9_V20_A0.8511.00
5_P16_T0.8391.00
48_S56_T0.8241.00
34_P37_A0.8161.00
9_V12_M0.7941.00
18_I24_G0.7911.00
15_I24_G0.7771.00
31_G35_E0.7721.00
70_S73_K0.7681.00
13_V21_A0.7441.00
19_L30_L0.7431.00
47_D55_N0.7361.00
35_E38_P0.7341.00
46_V55_N0.7311.00
48_S55_N0.7311.00
37_A41_S0.7301.00
49_S55_N0.7281.00
5_P12_M0.7241.00
10_I13_V0.7151.00
19_L22_V0.7061.00
49_S56_T0.6991.00
40_A61_H0.6951.00
36_T40_A0.6891.00
18_I23_I0.6871.00
36_T39_Q0.6841.00
43_S60_T0.6761.00
58_T62_E0.6741.00
13_V20_A0.6731.00
16_T30_L0.6681.00
57_V60_T0.6641.00
57_V63_G0.6371.00
47_D50_G0.6331.00
22_V28_L0.6321.00
44_V57_V0.6161.00
17_V26_F0.6001.00
50_G56_T0.5961.00
9_V23_I0.5911.00
4_S8_G0.5861.00
26_F41_S0.5831.00
10_I24_G0.5751.00
72_L76_V0.5651.00
4_S12_M0.5551.00
11_L19_L0.5491.00
1_R5_P0.5481.00
19_L29_G0.5381.00
23_I26_F0.5371.00
31_G36_T0.5341.00
5_P18_I0.5311.00
24_G27_V0.5301.00
51_G57_V0.5251.00
16_T19_L0.5251.00
5_P26_F0.5191.00
31_G38_P0.5171.00
25_A32_G0.5131.00
35_E39_Q0.5020.99
3_V7_I0.5010.99
1_R25_A0.5010.99
47_D52_T0.5010.99
18_I22_V0.5010.99
8_G16_T0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j1rA 5 0.325 86.2 0.712 Contact Map
2wnxA 2 0.575 26.5 0.813 Contact Map
2xbtA 1 0.6 19.5 0.824 Contact Map
1g43A 1 0.55 10.8 0.843 Contact Map
4b9pA 1 0.5625 9.4 0.847 Contact Map
1h2sB 2 0.3 6.9 0.857 Contact Map
3zqxA 1 0.5125 6.9 0.857 Contact Map
3zucA 1 0.55 6.6 0.858 Contact Map
4b9cA 1 0.575 6.2 0.86 Contact Map
4b9fA 1 0.5 5.9 0.861 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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