GREMLIN Database
DUF1625 - Protein of unknown function (DUF1625)
PFAM: PF07787 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 251 (250)
Sequences: 1732 (1510)
Seq/√Len: 95.5
META: 0.856

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
188_I192_V4.4431.00
15_K21_E4.0811.00
5_V31_E3.8651.00
143_A150_F3.5621.00
10_S22_T3.3871.00
15_K19_G3.2381.00
77_L164_L2.9401.00
198_F234_A2.8891.00
163_L181_E2.7691.00
215_I218_L2.7471.00
5_V37_I2.7171.00
14_K213_D2.5771.00
142_V175_F2.4851.00
8_S24_T2.4491.00
71_F145_Q2.4311.00
30_K124_I2.3771.00
210_V213_D2.3611.00
12_T20_E2.3501.00
7_E29_E2.3441.00
38_D41_S2.3371.00
195_L199_I2.2421.00
201_L233_L2.2211.00
16_L215_I2.1871.00
138_T168_T2.1801.00
140_S174_M2.1191.00
14_K20_E2.0321.00
33_S37_I2.0211.00
212_A222_V2.0021.00
189_L192_V1.9911.00
146_S151_E1.9871.00
194_F238_S1.9871.00
74_P77_L1.9781.00
77_L162_L1.9661.00
238_S242_I1.9421.00
197_M238_S1.9401.00
5_V33_S1.9181.00
142_V163_L1.9161.00
72_R148_N1.8841.00
176_A180_S1.8491.00
165_E177_A1.8471.00
169_V173_E1.8381.00
144_K151_E1.8371.00
55_P127_V1.8111.00
170_S173_E1.7781.00
143_A162_L1.7731.00
139_V164_L1.7491.00
65_N72_R1.7471.00
31_E37_I1.7401.00
163_L178_A1.7061.00
194_F234_A1.7021.00
197_M234_A1.6461.00
85_E135_P1.6381.00
197_M237_L1.6301.00
12_T22_T1.6101.00
154_T157_N1.6081.00
63_A66_V1.5731.00
180_S184_M1.5301.00
13_K23_V1.5051.00
118_D121_S1.4851.00
155_T161_I1.4831.00
1_M51_P1.4401.00
13_K21_E1.4200.99
246_W250_R1.3970.99
165_E169_V1.3930.99
112_Y130_S1.3890.99
187_W190_R1.3880.99
39_S42_F1.3870.99
163_L174_M1.3850.99
87_L133_V1.3810.99
1_M54_M1.3780.99
77_L143_A1.3340.99
36_P52_V1.3310.99
44_D47_G1.3180.99
185_L189_L1.3130.99
231_F235_L1.3050.99
234_A238_S1.3010.99
185_L188_I1.2930.99
209_S223_G1.2670.99
213_D219_G1.2630.99
33_S36_P1.2500.99
44_D48_H1.2430.99
191_L195_L1.2330.99
151_E170_S1.2320.99
74_P143_A1.2320.99
165_E174_M1.2150.98
34_S58_S1.2090.98
198_F231_F1.2060.98
84_F132_T1.1990.98
106_V115_L1.1830.98
137_G166_M1.1770.98
66_V78_I1.1760.98
18_G22_T1.1740.98
9_K27_T1.1640.98
11_E23_V1.1570.98
84_F134_V1.1540.98
171_A175_F1.1530.98
236_V239_L1.1480.98
9_K13_K1.1380.98
7_E31_E1.1340.98
116_G119_P1.1130.97
198_F202_S1.1080.97
177_A181_E1.1060.97
86_P132_T1.1030.97
48_H51_P1.0920.97
141_V150_F1.0820.97
19_G23_V1.0770.97
13_K19_G1.0730.97
5_V29_E1.0710.96
174_M178_A1.0710.96
184_M188_I1.0650.96
154_T160_T1.0490.96
204_I207_P1.0460.96
45_P49_E1.0370.96
140_S171_A1.0070.95
74_P149_T0.9970.95
30_K123_Q0.9960.95
2_Y30_K0.9940.95
227_G231_F0.9940.95
14_K210_V0.9920.95
221_I224_A0.9830.94
73_L164_L0.9820.94
116_G122_P0.9800.94
115_L127_V0.9770.94
193_G242_I0.9730.94
155_T158_G0.9730.94
16_L19_G0.9710.94
68_L139_V0.9710.94
188_I191_L0.9700.94
207_P213_D0.9630.94
53_A57_E0.9550.93
206_G210_V0.9510.93
106_V113_L0.9510.93
54_M58_S0.9450.93
209_S212_A0.9420.93
196_L201_L0.9400.93
243_A246_W0.9390.93
76_S162_L0.9380.93
3_Q37_I0.9320.93
206_G209_S0.9310.93
201_L230_A0.9260.92
142_V174_M0.9240.92
83_G134_V0.9180.92
7_E27_T0.9140.92
81_I164_L0.9130.92
226_T230_A0.9030.91
201_L205_F0.9020.91
237_L241_T0.9010.91
207_P210_V0.8970.91
226_T233_L0.8920.91
221_I225_G0.8850.91
212_A218_L0.8820.90
192_V196_L0.8740.90
245_A249_Y0.8690.90
74_P162_L0.8630.89
222_V225_G0.8620.89
246_W251_P0.8610.89
77_L150_F0.8590.89
178_A181_E0.8490.89
151_E173_E0.8440.88
209_S222_V0.8440.88
207_P219_G0.8340.88
10_S20_E0.8320.88
81_I139_V0.8320.88
169_V177_A0.8280.87
205_F229_V0.8220.87
66_V77_L0.8190.87
243_A249_Y0.8180.87
3_Q33_S0.8180.87
28_Y42_F0.8120.86
6_E42_F0.8110.86
183_T186_T0.8110.86
165_E178_A0.8060.86
63_A136_P0.8050.86
219_G224_A0.7980.85
210_V214_V0.7960.85
199_I202_S0.7950.85
175_F182_N0.7900.85
203_L207_P0.7870.85
95_A98_A0.7820.84
4_W48_H0.7730.83
14_K220_S0.7700.83
234_A239_L0.7680.83
194_F235_L0.7670.83
1_M33_S0.7630.83
7_E11_E0.7590.82
11_E21_E0.7580.82
54_M57_E0.7570.82
178_A182_N0.7550.82
83_G166_M0.7540.82
210_V219_G0.7540.82
82_S166_M0.7460.81
87_L131_F0.7420.81
81_I166_M0.7410.81
109_S112_Y0.7390.81
238_S241_T0.7370.80
171_A174_M0.7350.80
194_F198_F0.7330.80
28_Y39_S0.7290.80
228_L231_F0.7280.80
33_S51_P0.7260.79
198_F230_A0.7260.79
108_V111_G0.7260.79
202_S226_T0.7210.79
87_L90_D0.7190.79
142_V171_A0.7190.79
89_L111_G0.7130.78
2_Y130_S0.7130.78
201_L234_A0.7120.78
142_V249_Y0.7110.78
208_L222_V0.7070.78
90_D93_A0.7060.78
12_T18_G0.7010.77
216_P219_G0.7000.77
105_G115_L0.6990.77
17_G214_V0.6980.77
75_P79_S0.6960.77
77_L141_V0.6930.76
18_G21_E0.6920.76
36_P53_A0.6890.76
8_S44_D0.6890.76
134_V137_G0.6860.76
154_T159_K0.6830.75
223_G227_G0.6820.75
129_I137_G0.6770.75
16_L21_E0.6750.74
133_V136_P0.6720.74
129_I159_K0.6720.74
182_N186_T0.6660.73
197_M242_I0.6660.73
198_F227_G0.6650.73
74_P164_L0.6640.73
15_K23_V0.6610.73
140_S167_G0.6540.72
209_S213_D0.6530.72
113_L131_F0.6510.72
110_G180_S0.6490.71
80_Q162_L0.6470.71
150_F249_Y0.6430.71
217_F220_S0.6430.71
10_S24_T0.6430.71
14_K18_G0.6420.71
209_S226_T0.6420.71
77_L139_V0.6400.70
34_S57_E0.6400.70
76_S152_P0.6380.70
174_M246_W0.6370.70
9_K23_V0.6350.70
144_K155_T0.6320.69
193_G238_S0.6310.69
194_F241_T0.6300.69
20_E210_V0.6300.69
202_S209_S0.6270.69
113_L129_I0.6270.69
118_D123_Q0.6270.69
205_F230_A0.6240.68
4_W30_K0.6210.68
144_K173_E0.6200.68
210_V226_T0.6200.68
86_P89_L0.6190.68
72_R149_T0.6170.68
91_A108_V0.6170.68
51_P55_P0.6150.67
61_F131_F0.6130.67
134_V139_V0.6130.67
16_L20_E0.6120.67
193_G197_M0.6120.67
139_V166_M0.6110.67
26_Y39_S0.6100.67
225_G228_L0.6090.67
106_V129_I0.6080.66
202_S206_G0.6080.66
137_G164_L0.6080.66
208_L224_A0.6070.66
46_E49_E0.6070.66
176_A179_Q0.6010.66
209_S227_G0.6000.65
219_G223_G0.5970.65
214_V225_G0.5960.65
12_T17_G0.5940.65
205_F248_F0.5930.65
67_T72_R0.5910.64
70_A150_F0.5910.64
154_T158_G0.5900.64
150_F162_L0.5890.64
108_V113_L0.5890.64
240_L244_I0.5880.64
81_I136_P0.5880.64
14_K19_G0.5870.64
186_T250_R0.5870.64
117_A123_Q0.5830.63
36_P54_M0.5830.63
95_A195_L0.5810.63
244_I247_L0.5800.63
201_L237_L0.5790.63
84_F172_E0.5770.62
246_W249_Y0.5760.62
23_V247_L0.5750.62
174_M182_N0.5740.62
89_L113_L0.5730.62
62_T79_S0.5720.62
201_L229_V0.5710.62
66_V237_L0.5690.61
222_V226_T0.5680.61
175_F179_Q0.5670.61
186_T189_L0.5650.61
85_E133_V0.5640.61
28_Y32_W0.5640.61
3_Q246_W0.5630.61
17_G21_E0.5620.60
211_L214_V0.5610.60
18_G24_T0.5610.60
17_G22_T0.5590.60
143_A152_P0.5580.60
211_L223_G0.5560.60
19_G22_T0.5560.60
66_V164_L0.5550.59
182_N249_Y0.5540.59
101_S104_A0.5530.59
191_L194_F0.5520.59
51_P54_M0.5520.59
76_S81_I0.5490.59
17_G20_E0.5470.58
62_T78_I0.5460.58
86_P130_S0.5450.58
12_T19_G0.5420.58
146_S149_T0.5420.58
192_V195_L0.5410.58
171_A178_A0.5400.57
210_V232_L0.5400.57
175_F178_A0.5380.57
86_P91_A0.5380.57
67_T92_S0.5370.57
37_I42_F0.5360.57
10_S23_V0.5360.57
30_K48_H0.5350.57
156_K160_T0.5350.57
212_A230_A0.5340.57
168_T172_E0.5320.56
3_Q174_M0.5280.56
201_L241_T0.5270.56
214_V217_F0.5260.55
203_L219_G0.5260.55
225_G229_V0.5250.55
172_E179_Q0.5240.55
73_L81_I0.5240.55
45_P48_H0.5230.55
42_F50_N0.5230.55
17_G23_V0.5210.55
80_Q164_L0.5200.55
206_G223_G0.5190.54
143_A148_N0.5160.54
241_T248_F0.5150.54
199_I203_L0.5150.54
215_I219_G0.5120.53
14_K22_T0.5120.53
208_L211_L0.5120.53
26_Y42_F0.5110.53
31_E34_S0.5100.53
1_M4_W0.5090.53
8_S12_T0.5070.53
217_F221_I0.5060.53
194_F197_M0.5060.53
213_D225_G0.5060.53
233_L238_S0.5050.53
129_I168_T0.5040.52
10_S13_K0.5040.52
47_G50_N0.5030.52
177_A180_S0.5030.52
124_I128_R0.5030.52
73_L141_V0.5030.52
80_Q139_V0.5030.52
108_V112_Y0.5020.52
29_E38_D0.5010.52
64_S146_S0.5000.52
9_K25_T0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1fftB 1 0.1633 26.2 0.948 Contact Map
3pjzA 2 0.239 10.2 0.957 Contact Map
2yevB 1 0.1873 9.3 0.958 Contact Map
2f95B 2 0.1952 7.1 0.96 Contact Map
3ux4A 3 0.2351 6.2 0.961 Contact Map
4p02A 1 0.2629 5.4 0.962 Contact Map
3zdqA 2 0.3187 4.7 0.963 Contact Map
1kqfC 3 0.3108 4.3 0.964 Contact Map
2m20A 2 0.1116 3.7 0.965 Contact Map
2l9uA 2 0.1394 3.4 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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