DUF1625 - PFAM28P - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

DUF1625 - Protein of unknown function (DUF1625)

PFAM:	PF07787	Sequences: MYQWVEESKSETKKKLGGGEETVTTYTYEKEWSSSPIDSSSFKDPEGHENPVAMPYESKTFTASNVTLGAFRLPPSLISQISGFEPLPLDASAAAALAAASLGAGVHVSGGYLYLGADPSSPQIGDVRISFTVVPPGTVSVVAKQSGNTFEPYTTKNGKTILLLEMGTVSAEEMFAAAQSENTMLTWILRLVGFLLMFIGLSLIFGPLSVLADVIPFLGSIVGAGTGLVAFLLALVLSLLTIAIAWLFYRP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	251 (250)
Sequences:	1732 (1510)
Seq/√Len:	95.5
META:	0.856

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
188_I	192_V	4.443	1.00
15_K	21_E	4.081	1.00
5_V	31_E	3.865	1.00
143_A	150_F	3.562	1.00
10_S	22_T	3.387	1.00
15_K	19_G	3.238	1.00
77_L	164_L	2.940	1.00
198_F	234_A	2.889	1.00
163_L	181_E	2.769	1.00
215_I	218_L	2.747	1.00
5_V	37_I	2.717	1.00
14_K	213_D	2.577	1.00
142_V	175_F	2.485	1.00
8_S	24_T	2.449	1.00
71_F	145_Q	2.431	1.00
30_K	124_I	2.377	1.00
210_V	213_D	2.361	1.00
12_T	20_E	2.350	1.00
7_E	29_E	2.344	1.00
38_D	41_S	2.337	1.00
195_L	199_I	2.242	1.00
201_L	233_L	2.221	1.00
16_L	215_I	2.187	1.00
138_T	168_T	2.180	1.00
140_S	174_M	2.119	1.00
14_K	20_E	2.032	1.00
33_S	37_I	2.021	1.00
212_A	222_V	2.002	1.00
189_L	192_V	1.991	1.00
146_S	151_E	1.987	1.00
194_F	238_S	1.987	1.00
74_P	77_L	1.978	1.00
77_L	162_L	1.966	1.00
238_S	242_I	1.942	1.00
197_M	238_S	1.940	1.00
5_V	33_S	1.918	1.00
142_V	163_L	1.916	1.00
72_R	148_N	1.884	1.00
176_A	180_S	1.849	1.00
165_E	177_A	1.847	1.00
169_V	173_E	1.838	1.00
144_K	151_E	1.837	1.00
55_P	127_V	1.811	1.00
170_S	173_E	1.778	1.00
143_A	162_L	1.773	1.00
139_V	164_L	1.749	1.00
65_N	72_R	1.747	1.00
31_E	37_I	1.740	1.00
163_L	178_A	1.706	1.00
194_F	234_A	1.702	1.00
197_M	234_A	1.646	1.00
85_E	135_P	1.638	1.00
197_M	237_L	1.630	1.00
12_T	22_T	1.610	1.00
154_T	157_N	1.608	1.00
63_A	66_V	1.573	1.00
180_S	184_M	1.530	1.00
13_K	23_V	1.505	1.00
118_D	121_S	1.485	1.00
155_T	161_I	1.483	1.00
1_M	51_P	1.440	1.00
13_K	21_E	1.420	0.99
246_W	250_R	1.397	0.99
165_E	169_V	1.393	0.99
112_Y	130_S	1.389	0.99
187_W	190_R	1.388	0.99
39_S	42_F	1.387	0.99
163_L	174_M	1.385	0.99
87_L	133_V	1.381	0.99
1_M	54_M	1.378	0.99
77_L	143_A	1.334	0.99
36_P	52_V	1.331	0.99
44_D	47_G	1.318	0.99
185_L	189_L	1.313	0.99
231_F	235_L	1.305	0.99
234_A	238_S	1.301	0.99
185_L	188_I	1.293	0.99
209_S	223_G	1.267	0.99
213_D	219_G	1.263	0.99
33_S	36_P	1.250	0.99
44_D	48_H	1.243	0.99
191_L	195_L	1.233	0.99
151_E	170_S	1.232	0.99
74_P	143_A	1.232	0.99
165_E	174_M	1.215	0.98
34_S	58_S	1.209	0.98
198_F	231_F	1.206	0.98
84_F	132_T	1.199	0.98
106_V	115_L	1.183	0.98
137_G	166_M	1.177	0.98
66_V	78_I	1.176	0.98
18_G	22_T	1.174	0.98
9_K	27_T	1.164	0.98
11_E	23_V	1.157	0.98
84_F	134_V	1.154	0.98
171_A	175_F	1.153	0.98
236_V	239_L	1.148	0.98
9_K	13_K	1.138	0.98
7_E	31_E	1.134	0.98
116_G	119_P	1.113	0.97
198_F	202_S	1.108	0.97
177_A	181_E	1.106	0.97
86_P	132_T	1.103	0.97
48_H	51_P	1.092	0.97
141_V	150_F	1.082	0.97
19_G	23_V	1.077	0.97
13_K	19_G	1.073	0.97
5_V	29_E	1.071	0.96
174_M	178_A	1.071	0.96
184_M	188_I	1.065	0.96
154_T	160_T	1.049	0.96
204_I	207_P	1.046	0.96
45_P	49_E	1.037	0.96
140_S	171_A	1.007	0.95
74_P	149_T	0.997	0.95
30_K	123_Q	0.996	0.95
2_Y	30_K	0.994	0.95
227_G	231_F	0.994	0.95
14_K	210_V	0.992	0.95
221_I	224_A	0.983	0.94
73_L	164_L	0.982	0.94
116_G	122_P	0.980	0.94
115_L	127_V	0.977	0.94
193_G	242_I	0.973	0.94
155_T	158_G	0.973	0.94
16_L	19_G	0.971	0.94
68_L	139_V	0.971	0.94
188_I	191_L	0.970	0.94
207_P	213_D	0.963	0.94
53_A	57_E	0.955	0.93
206_G	210_V	0.951	0.93
106_V	113_L	0.951	0.93
54_M	58_S	0.945	0.93
209_S	212_A	0.942	0.93
196_L	201_L	0.940	0.93
243_A	246_W	0.939	0.93
76_S	162_L	0.938	0.93
3_Q	37_I	0.932	0.93
206_G	209_S	0.931	0.93
201_L	230_A	0.926	0.92
142_V	174_M	0.924	0.92
83_G	134_V	0.918	0.92
7_E	27_T	0.914	0.92
81_I	164_L	0.913	0.92
226_T	230_A	0.903	0.91
201_L	205_F	0.902	0.91
237_L	241_T	0.901	0.91
207_P	210_V	0.897	0.91
226_T	233_L	0.892	0.91
221_I	225_G	0.885	0.91
212_A	218_L	0.882	0.90
192_V	196_L	0.874	0.90
245_A	249_Y	0.869	0.90
74_P	162_L	0.863	0.89
222_V	225_G	0.862	0.89
246_W	251_P	0.861	0.89
77_L	150_F	0.859	0.89
178_A	181_E	0.849	0.89
151_E	173_E	0.844	0.88
209_S	222_V	0.844	0.88
207_P	219_G	0.834	0.88
10_S	20_E	0.832	0.88
81_I	139_V	0.832	0.88
169_V	177_A	0.828	0.87
205_F	229_V	0.822	0.87
66_V	77_L	0.819	0.87
243_A	249_Y	0.818	0.87
3_Q	33_S	0.818	0.87
28_Y	42_F	0.812	0.86
6_E	42_F	0.811	0.86
183_T	186_T	0.811	0.86
165_E	178_A	0.806	0.86
63_A	136_P	0.805	0.86
219_G	224_A	0.798	0.85
210_V	214_V	0.796	0.85
199_I	202_S	0.795	0.85
175_F	182_N	0.790	0.85
203_L	207_P	0.787	0.85
95_A	98_A	0.782	0.84
4_W	48_H	0.773	0.83
14_K	220_S	0.770	0.83
234_A	239_L	0.768	0.83
194_F	235_L	0.767	0.83
1_M	33_S	0.763	0.83
7_E	11_E	0.759	0.82
11_E	21_E	0.758	0.82
54_M	57_E	0.757	0.82
178_A	182_N	0.755	0.82
83_G	166_M	0.754	0.82
210_V	219_G	0.754	0.82
82_S	166_M	0.746	0.81
87_L	131_F	0.742	0.81
81_I	166_M	0.741	0.81
109_S	112_Y	0.739	0.81
238_S	241_T	0.737	0.80
171_A	174_M	0.735	0.80
194_F	198_F	0.733	0.80
28_Y	39_S	0.729	0.80
228_L	231_F	0.728	0.80
33_S	51_P	0.726	0.79
198_F	230_A	0.726	0.79
108_V	111_G	0.726	0.79
202_S	226_T	0.721	0.79
87_L	90_D	0.719	0.79
142_V	171_A	0.719	0.79
89_L	111_G	0.713	0.78
2_Y	130_S	0.713	0.78
201_L	234_A	0.712	0.78
142_V	249_Y	0.711	0.78
208_L	222_V	0.707	0.78
90_D	93_A	0.706	0.78
12_T	18_G	0.701	0.77
216_P	219_G	0.700	0.77
105_G	115_L	0.699	0.77
17_G	214_V	0.698	0.77
75_P	79_S	0.696	0.77
77_L	141_V	0.693	0.76
18_G	21_E	0.692	0.76
36_P	53_A	0.689	0.76
8_S	44_D	0.689	0.76
134_V	137_G	0.686	0.76
154_T	159_K	0.683	0.75
223_G	227_G	0.682	0.75
129_I	137_G	0.677	0.75
16_L	21_E	0.675	0.74
133_V	136_P	0.672	0.74
129_I	159_K	0.672	0.74
182_N	186_T	0.666	0.73
197_M	242_I	0.666	0.73
198_F	227_G	0.665	0.73
74_P	164_L	0.664	0.73
15_K	23_V	0.661	0.73
140_S	167_G	0.654	0.72
209_S	213_D	0.653	0.72
113_L	131_F	0.651	0.72
110_G	180_S	0.649	0.71
80_Q	162_L	0.647	0.71
150_F	249_Y	0.643	0.71
217_F	220_S	0.643	0.71
10_S	24_T	0.643	0.71
14_K	18_G	0.642	0.71
209_S	226_T	0.642	0.71
77_L	139_V	0.640	0.70
34_S	57_E	0.640	0.70
76_S	152_P	0.638	0.70
174_M	246_W	0.637	0.70
9_K	23_V	0.635	0.70
144_K	155_T	0.632	0.69
193_G	238_S	0.631	0.69
194_F	241_T	0.630	0.69
20_E	210_V	0.630	0.69
202_S	209_S	0.627	0.69
113_L	129_I	0.627	0.69
118_D	123_Q	0.627	0.69
205_F	230_A	0.624	0.68
4_W	30_K	0.621	0.68
144_K	173_E	0.620	0.68
210_V	226_T	0.620	0.68
86_P	89_L	0.619	0.68
72_R	149_T	0.617	0.68
91_A	108_V	0.617	0.68
51_P	55_P	0.615	0.67
61_F	131_F	0.613	0.67
134_V	139_V	0.613	0.67
16_L	20_E	0.612	0.67
193_G	197_M	0.612	0.67
139_V	166_M	0.611	0.67
26_Y	39_S	0.610	0.67
225_G	228_L	0.609	0.67
106_V	129_I	0.608	0.66
202_S	206_G	0.608	0.66
137_G	164_L	0.608	0.66
208_L	224_A	0.607	0.66
46_E	49_E	0.607	0.66
176_A	179_Q	0.601	0.66
209_S	227_G	0.600	0.65
219_G	223_G	0.597	0.65
214_V	225_G	0.596	0.65
12_T	17_G	0.594	0.65
205_F	248_F	0.593	0.65
67_T	72_R	0.591	0.64
70_A	150_F	0.591	0.64
154_T	158_G	0.590	0.64
150_F	162_L	0.589	0.64
108_V	113_L	0.589	0.64
240_L	244_I	0.588	0.64
81_I	136_P	0.588	0.64
14_K	19_G	0.587	0.64
186_T	250_R	0.587	0.64
117_A	123_Q	0.583	0.63
36_P	54_M	0.583	0.63
95_A	195_L	0.581	0.63
244_I	247_L	0.580	0.63
201_L	237_L	0.579	0.63
84_F	172_E	0.577	0.62
246_W	249_Y	0.576	0.62
23_V	247_L	0.575	0.62
174_M	182_N	0.574	0.62
89_L	113_L	0.573	0.62
62_T	79_S	0.572	0.62
201_L	229_V	0.571	0.62
66_V	237_L	0.569	0.61
222_V	226_T	0.568	0.61
175_F	179_Q	0.567	0.61
186_T	189_L	0.565	0.61
85_E	133_V	0.564	0.61
28_Y	32_W	0.564	0.61
3_Q	246_W	0.563	0.61
17_G	21_E	0.562	0.60
211_L	214_V	0.561	0.60
18_G	24_T	0.561	0.60
17_G	22_T	0.559	0.60
143_A	152_P	0.558	0.60
211_L	223_G	0.556	0.60
19_G	22_T	0.556	0.60
66_V	164_L	0.555	0.59
182_N	249_Y	0.554	0.59
101_S	104_A	0.553	0.59
191_L	194_F	0.552	0.59
51_P	54_M	0.552	0.59
76_S	81_I	0.549	0.59
17_G	20_E	0.547	0.58
62_T	78_I	0.546	0.58
86_P	130_S	0.545	0.58
12_T	19_G	0.542	0.58
146_S	149_T	0.542	0.58
192_V	195_L	0.541	0.58
171_A	178_A	0.540	0.57
210_V	232_L	0.540	0.57
175_F	178_A	0.538	0.57
86_P	91_A	0.538	0.57
67_T	92_S	0.537	0.57
37_I	42_F	0.536	0.57
10_S	23_V	0.536	0.57
30_K	48_H	0.535	0.57
156_K	160_T	0.535	0.57
212_A	230_A	0.534	0.57
168_T	172_E	0.532	0.56
3_Q	174_M	0.528	0.56
201_L	241_T	0.527	0.56
214_V	217_F	0.526	0.55
203_L	219_G	0.526	0.55
225_G	229_V	0.525	0.55
172_E	179_Q	0.524	0.55
73_L	81_I	0.524	0.55
45_P	48_H	0.523	0.55
42_F	50_N	0.523	0.55
17_G	23_V	0.521	0.55
80_Q	164_L	0.520	0.55
206_G	223_G	0.519	0.54
143_A	148_N	0.516	0.54
241_T	248_F	0.515	0.54
199_I	203_L	0.515	0.54
215_I	219_G	0.512	0.53
14_K	22_T	0.512	0.53
208_L	211_L	0.512	0.53
26_Y	42_F	0.511	0.53
31_E	34_S	0.510	0.53
1_M	4_W	0.509	0.53
8_S	12_T	0.507	0.53
217_F	221_I	0.506	0.53
194_F	197_M	0.506	0.53
213_D	225_G	0.506	0.53
233_L	238_S	0.505	0.53
129_I	168_T	0.504	0.52
10_S	13_K	0.504	0.52
47_G	50_N	0.503	0.52
177_A	180_S	0.503	0.52
124_I	128_R	0.503	0.52
73_L	141_V	0.503	0.52
80_Q	139_V	0.503	0.52
108_V	112_Y	0.502	0.52
29_E	38_D	0.501	0.52
64_S	146_S	0.500	0.52
9_K	25_T	0.500	0.52

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1fftB	1	0.1633	26.2	0.948	Contact Map
3pjzA	2	0.239	10.2	0.957	Contact Map
2yevB	1	0.1873	9.3	0.958	Contact Map
2f95B	2	0.1952	7.1	0.96	Contact Map
3ux4A	3	0.2351	6.2	0.961	Contact Map
4p02A	1	0.2629	5.4	0.962	Contact Map
3zdqA	2	0.3187	4.7	0.963	Contact Map
1kqfC	3	0.3108	4.3	0.964	Contact Map
2m20A	2	0.1116	3.7	0.965	Contact Map
2l9uA	2	0.1394	3.4	0.965	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0085 seconds.