DUF1624 - PFAM28P - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

DUF1624 - Protein of unknown function (DUF1624)

PFAM:	PF07786	Sequences: RLASIDLLRGLAIVLMILDHVRDDLGAFGGRPTDLATTFFTRWITHLCAPLFLFLAGVSAALSLRRRRRKRFLLRRGLWLFLLGLLLTLFTWFFFPDSFIIFGVLHAIGLSMLLLALLLRLPRRALLALGLAILAGHNLLDGPLFDPPWLLWLGLHPGGFDPEDYYPLLPWIGVMLLGYALGRLLLRDGARRRRLLALALGRAVRPLAFLGRHSLLIYLLHQP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	223 (194)
Sequences:	20693 (16105)
Seq/√Len:	1156.2
META:	0.884

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
12_A	51_L	3.230	1.00
54_F	181_L	3.207	1.00
71_R	75_R	2.844	1.00
56_A	175_M	2.792	1.00
42_R	46_H	2.769	1.00
122_P	125_A	2.520	1.00
88_T	91_T	2.453	1.00
151_L	154_G	2.423	1.00
53_L	107_A	2.361	1.00
137_H	141_D	2.345	1.00
138_N	141_D	2.343	1.00
53_L	108_I	2.047	1.00
115_L	175_M	1.925	1.00
56_A	108_I	1.911	1.00
107_A	111_S	1.894	1.00
149_W	153_L	1.869	1.00
149_W	152_W	1.854	1.00
77_G	113_L	1.818	1.00
32_P	35_L	1.779	1.00
172_I	176_L	1.767	1.00
81_F	84_G	1.749	1.00
123_R	183_R	1.745	1.00
8_L	51_L	1.683	1.00
75_R	79_W	1.652	1.00
115_L	179_Y	1.643	1.00
43_W	46_H	1.625	1.00
81_F	109_G	1.617	1.00
144_L	147_P	1.610	1.00
150_L	154_G	1.604	1.00
60_A	115_L	1.585	1.00
149_W	154_G	1.579	1.00
34_D	37_T	1.574	1.00
53_L	175_M	1.564	1.00
77_G	109_G	1.563	1.00
22_R	25_L	1.529	1.00
29_G	32_P	1.510	1.00
123_R	180_A	1.503	1.00
73_L	77_G	1.493	1.00
58_V	182_G	1.484	1.00
86_L	89_L	1.476	1.00
80_L	84_G	1.475	1.00
28_F	31_R	1.474	1.00
118_L	176_L	1.452	1.00
97_D	100_I	1.428	1.00
61_A	182_G	1.426	1.00
31_R	34_D	1.421	1.00
65_R	186_L	1.420	1.00
42_R	45_T	1.413	1.00
146_D	149_W	1.407	1.00
111_S	175_M	1.399	1.00
162_P	165_Y	1.398	1.00
24_D	27_A	1.389	1.00
138_N	142_G	1.376	1.00
79_W	83_L	1.359	1.00
82_L	86_L	1.356	1.00
23_D	26_G	1.350	1.00
85_L	89_L	1.334	1.00
121_L	125_A	1.332	1.00
86_L	90_F	1.319	1.00
49_A	166_Y	1.319	1.00
127_L	180_A	1.314	1.00
58_V	185_L	1.310	1.00
152_W	156_H	1.280	1.00
114_L	172_I	1.279	1.00
65_R	68_R	1.278	1.00
150_L	153_L	1.270	1.00
74_L	116_A	1.266	1.00
145_F	148_P	1.248	1.00
95_F	98_S	1.248	1.00
35_L	38_T	1.245	1.00
153_L	156_H	1.234	1.00
152_W	155_L	1.223	1.00
122_P	126_L	1.216	1.00
61_A	179_Y	1.215	1.00
123_R	127_L	1.210	1.00
111_S	172_I	1.209	1.00
83_L	86_L	1.200	1.00
161_D	164_D	1.200	1.00
132_A	136_G	1.198	1.00
148_P	154_G	1.196	1.00
78_L	82_L	1.187	1.00
89_L	92_W	1.182	1.00
15_L	48_C	1.154	1.00
67_R	70_K	1.137	1.00
41_T	44_I	1.135	1.00
8_L	55_L	1.132	1.00
76_R	83_L	1.116	1.00
130_G	176_L	1.114	1.00
93_F	96_P	1.107	1.00
124_R	128_A	1.101	1.00
139_L	142_G	1.096	1.00
180_A	184_L	1.092	1.00
64_L	68_R	1.084	1.00
41_T	45_T	1.080	1.00
125_A	128_A	1.068	1.00
61_A	186_L	1.067	1.00
137_H	140_L	1.054	1.00
121_L	126_L	1.048	1.00
30_G	37_T	1.043	1.00
189_G	193_R	1.040	1.00
120_R	123_R	1.037	1.00
33_T	36_A	1.036	1.00
151_L	156_H	1.034	1.00
63_S	67_R	1.022	1.00
137_H	142_G	1.018	1.00
72_F	75_R	1.015	1.00
67_R	72_F	1.013	1.00
183_R	186_L	1.013	1.00
31_R	35_L	1.012	1.00
133_I	136_G	1.008	1.00
147_P	152_W	1.007	1.00
88_T	92_W	1.005	1.00
79_W	82_L	1.004	1.00
61_A	183_R	0.994	1.00
84_G	88_T	0.986	1.00
25_L	28_F	0.983	1.00
51_L	55_L	0.975	1.00
53_L	104_V	0.972	1.00
183_R	187_R	0.966	1.00
40_F	43_W	0.956	1.00
27_A	30_G	0.956	1.00
153_L	157_P	0.948	1.00
28_F	33_T	0.948	1.00
30_G	33_T	0.946	1.00
123_R	126_L	0.945	1.00
84_G	91_T	0.942	1.00
144_L	148_P	0.935	1.00
147_P	150_L	0.935	1.00
45_T	48_C	0.931	1.00
131_L	135_A	0.928	1.00
130_G	173_G	0.915	1.00
126_L	129_L	0.912	1.00
32_P	36_A	0.909	1.00
119_L	122_P	0.899	1.00
110_L	168_L	0.894	1.00
120_R	124_R	0.892	1.00
24_D	28_F	0.891	1.00
190_A	193_R	0.888	1.00
66_R	69_R	0.882	1.00
81_F	85_L	0.880	1.00
134_L	137_H	0.879	1.00
191_R	194_R	0.874	1.00
151_L	155_L	0.871	1.00
125_A	129_L	0.871	1.00
21_V	24_D	0.869	1.00
3_A	7_L	0.868	1.00
147_P	153_L	0.857	1.00
41_T	46_H	0.855	1.00
61_A	65_R	0.849	1.00
111_S	115_L	0.847	1.00
30_G	35_L	0.847	1.00
74_L	77_G	0.837	1.00
179_Y	183_R	0.831	1.00
124_R	127_L	0.828	1.00
71_R	74_L	0.826	1.00
159_G	162_P	0.824	1.00
34_D	38_T	0.814	1.00
132_A	135_A	0.811	1.00
146_D	153_L	0.810	1.00
30_G	34_D	0.799	1.00
149_W	157_P	0.799	1.00
38_T	41_T	0.799	1.00
154_G	157_P	0.796	1.00
22_R	26_G	0.795	1.00
145_F	150_L	0.788	1.00
106_H	109_G	0.784	1.00
14_V	18_L	0.781	1.00
26_G	29_G	0.768	1.00
110_L	114_L	0.768	1.00
58_V	181_L	0.768	1.00
29_G	33_T	0.768	1.00
146_D	151_L	0.765	1.00
36_A	39_F	0.764	1.00
74_L	113_L	0.762	1.00
133_I	169_L	0.752	1.00
126_L	176_L	0.751	1.00
77_G	81_F	0.750	1.00
112_M	116_A	0.749	1.00
184_L	187_R	0.745	1.00
31_R	36_A	0.743	1.00
148_P	152_W	0.743	1.00
144_L	149_W	0.742	1.00
29_G	34_D	0.741	1.00
94_F	98_S	0.739	1.00
39_F	42_R	0.739	1.00
60_A	175_M	0.737	1.00
147_P	151_L	0.734	1.00
104_V	108_I	0.734	1.00
129_L	132_A	0.733	1.00
121_L	124_R	0.731	1.00
119_L	126_L	0.727	1.00
100_I	103_G	0.720	1.00
86_L	91_T	0.713	1.00
2_L	62_L	0.712	1.00
5_I	59_S	0.708	1.00
152_W	157_P	0.701	1.00
96_P	99_F	0.701	1.00
27_A	31_R	0.684	1.00
77_G	80_L	0.684	1.00
135_A	138_N	0.684	1.00
145_F	154_G	0.680	1.00
77_G	84_G	0.675	1.00
126_L	130_G	0.674	1.00
13_I	16_M	0.673	1.00
15_L	44_I	0.670	1.00
130_G	180_A	0.665	1.00
40_F	46_H	0.664	1.00
189_G	192_R	0.663	1.00
59_S	63_S	0.661	1.00
15_L	19_D	0.659	1.00
149_W	155_L	0.658	1.00
110_L	113_L	0.655	1.00
50_P	174_V	0.649	1.00
170_P	173_G	0.646	1.00
49_A	104_V	0.646	1.00
26_G	30_G	0.646	1.00
63_S	66_R	0.644	1.00
87_L	91_T	0.643	1.00
59_S	62_L	0.642	1.00
40_F	44_I	0.637	1.00
26_G	31_R	0.636	1.00
188_D	191_R	0.633	1.00
146_D	154_G	0.632	1.00
98_S	101_I	0.629	1.00
11_L	15_L	0.628	1.00
18_L	44_I	0.625	1.00
81_F	110_L	0.624	1.00
55_L	58_V	0.622	1.00
108_I	111_S	0.622	1.00
84_G	106_H	0.619	1.00
117_L	120_R	0.613	1.00
180_A	183_R	0.612	1.00
160_F	164_D	0.609	1.00
128_A	132_A	0.606	1.00
94_F	97_D	0.605	1.00
74_L	78_L	0.603	1.00
130_G	134_L	0.601	1.00
96_P	100_I	0.601	1.00
44_I	48_C	0.600	1.00
121_L	129_L	0.599	1.00
84_G	89_L	0.594	1.00
144_L	154_G	0.594	1.00
113_L	117_L	0.593	1.00
126_L	183_R	0.588	1.00
76_R	79_W	0.588	1.00
85_L	88_T	0.584	1.00
145_F	149_W	0.584	1.00
84_G	109_G	0.575	1.00
16_M	48_C	0.572	1.00
30_G	36_A	0.572	1.00
75_R	78_L	0.570	1.00
151_L	157_P	0.564	1.00
15_L	51_L	0.562	1.00
87_L	90_F	0.561	1.00
171_W	174_V	0.560	1.00
108_I	112_M	0.560	1.00
13_I	17_I	0.559	1.00
48_C	51_L	0.557	1.00
47_L	50_P	0.554	1.00
26_G	33_T	0.553	1.00
64_L	67_R	0.552	1.00
145_F	152_W	0.552	1.00
62_L	186_L	0.552	1.00
187_R	191_R	0.549	1.00
162_P	166_Y	0.548	1.00
146_D	150_L	0.546	1.00
19_D	45_T	0.542	1.00
50_P	54_F	0.539	1.00
80_L	112_M	0.536	1.00
65_R	70_K	0.535	1.00
129_L	133_I	0.533	1.00
9_R	55_L	0.531	1.00
168_L	172_I	0.531	1.00
133_I	137_H	0.530	1.00
23_D	27_A	0.528	1.00
158_G	163_E	0.526	1.00
80_L	83_L	0.523	1.00
35_L	39_F	0.523	1.00
28_F	32_P	0.521	1.00
33_T	37_T	0.519	1.00
148_P	153_L	0.517	1.00
63_S	72_F	0.517	1.00
25_L	29_G	0.516	1.00
120_R	125_A	0.512	1.00
25_L	31_R	0.511	1.00
63_S	68_R	0.510	1.00
127_L	130_G	0.509	1.00
12_A	48_C	0.507	1.00
190_A	194_R	0.506	1.00
113_L	116_A	0.502	1.00
77_G	83_L	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1cmxA	2	0.2646	3.1	0.946	Contact Map
4w252	1	0.2422	1.3	0.957	Contact Map
3mp7B	1	0.2242	1.1	0.958	Contact Map
3rqwA	4	0.3901	1	0.959	Contact Map
2jwaA	2	0.1973	0.8	0.961	Contact Map
4hfiA	3	0.4036	0.8	0.961	Contact Map
4tp9C	1	0.009	0.8	0.962	Contact Map
2mgyA	1	0.713	0.8	0.962	Contact Map
2losA	1	0.2646	0.7	0.962	Contact Map
2yvtA	1	0.2691	0.7	0.963	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.007 seconds.