GREMLIN Database
DUF1624 - Protein of unknown function (DUF1624)
PFAM: PF07786 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 223 (194)
Sequences: 20693 (16105)
Seq/√Len: 1156.2
META: 0.884

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_A51_L3.2301.00
54_F181_L3.2071.00
71_R75_R2.8441.00
56_A175_M2.7921.00
42_R46_H2.7691.00
122_P125_A2.5201.00
88_T91_T2.4531.00
151_L154_G2.4231.00
53_L107_A2.3611.00
137_H141_D2.3451.00
138_N141_D2.3431.00
53_L108_I2.0471.00
115_L175_M1.9251.00
56_A108_I1.9111.00
107_A111_S1.8941.00
149_W153_L1.8691.00
149_W152_W1.8541.00
77_G113_L1.8181.00
32_P35_L1.7791.00
172_I176_L1.7671.00
81_F84_G1.7491.00
123_R183_R1.7451.00
8_L51_L1.6831.00
75_R79_W1.6521.00
115_L179_Y1.6431.00
43_W46_H1.6251.00
81_F109_G1.6171.00
144_L147_P1.6101.00
150_L154_G1.6041.00
60_A115_L1.5851.00
149_W154_G1.5791.00
34_D37_T1.5741.00
53_L175_M1.5641.00
77_G109_G1.5631.00
22_R25_L1.5291.00
29_G32_P1.5101.00
123_R180_A1.5031.00
73_L77_G1.4931.00
58_V182_G1.4841.00
86_L89_L1.4761.00
80_L84_G1.4751.00
28_F31_R1.4741.00
118_L176_L1.4521.00
97_D100_I1.4281.00
61_A182_G1.4261.00
31_R34_D1.4211.00
65_R186_L1.4201.00
42_R45_T1.4131.00
146_D149_W1.4071.00
111_S175_M1.3991.00
162_P165_Y1.3981.00
24_D27_A1.3891.00
138_N142_G1.3761.00
79_W83_L1.3591.00
82_L86_L1.3561.00
23_D26_G1.3501.00
85_L89_L1.3341.00
121_L125_A1.3321.00
86_L90_F1.3191.00
49_A166_Y1.3191.00
127_L180_A1.3141.00
58_V185_L1.3101.00
152_W156_H1.2801.00
114_L172_I1.2791.00
65_R68_R1.2781.00
150_L153_L1.2701.00
74_L116_A1.2661.00
145_F148_P1.2481.00
95_F98_S1.2481.00
35_L38_T1.2451.00
153_L156_H1.2341.00
152_W155_L1.2231.00
122_P126_L1.2161.00
61_A179_Y1.2151.00
123_R127_L1.2101.00
111_S172_I1.2091.00
83_L86_L1.2001.00
161_D164_D1.2001.00
132_A136_G1.1981.00
148_P154_G1.1961.00
78_L82_L1.1871.00
89_L92_W1.1821.00
15_L48_C1.1541.00
67_R70_K1.1371.00
41_T44_I1.1351.00
8_L55_L1.1321.00
76_R83_L1.1161.00
130_G176_L1.1141.00
93_F96_P1.1071.00
124_R128_A1.1011.00
139_L142_G1.0961.00
180_A184_L1.0921.00
64_L68_R1.0841.00
41_T45_T1.0801.00
125_A128_A1.0681.00
61_A186_L1.0671.00
137_H140_L1.0541.00
121_L126_L1.0481.00
30_G37_T1.0431.00
189_G193_R1.0401.00
120_R123_R1.0371.00
33_T36_A1.0361.00
151_L156_H1.0341.00
63_S67_R1.0221.00
137_H142_G1.0181.00
72_F75_R1.0151.00
67_R72_F1.0131.00
183_R186_L1.0131.00
31_R35_L1.0121.00
133_I136_G1.0081.00
147_P152_W1.0071.00
88_T92_W1.0051.00
79_W82_L1.0041.00
61_A183_R0.9941.00
84_G88_T0.9861.00
25_L28_F0.9831.00
51_L55_L0.9751.00
53_L104_V0.9721.00
183_R187_R0.9661.00
40_F43_W0.9561.00
27_A30_G0.9561.00
153_L157_P0.9481.00
28_F33_T0.9481.00
30_G33_T0.9461.00
123_R126_L0.9451.00
84_G91_T0.9421.00
144_L148_P0.9351.00
147_P150_L0.9351.00
45_T48_C0.9311.00
131_L135_A0.9281.00
130_G173_G0.9151.00
126_L129_L0.9121.00
32_P36_A0.9091.00
119_L122_P0.8991.00
110_L168_L0.8941.00
120_R124_R0.8921.00
24_D28_F0.8911.00
190_A193_R0.8881.00
66_R69_R0.8821.00
81_F85_L0.8801.00
134_L137_H0.8791.00
191_R194_R0.8741.00
151_L155_L0.8711.00
125_A129_L0.8711.00
21_V24_D0.8691.00
3_A7_L0.8681.00
147_P153_L0.8571.00
41_T46_H0.8551.00
61_A65_R0.8491.00
111_S115_L0.8471.00
30_G35_L0.8471.00
74_L77_G0.8371.00
179_Y183_R0.8311.00
124_R127_L0.8281.00
71_R74_L0.8261.00
159_G162_P0.8241.00
34_D38_T0.8141.00
132_A135_A0.8111.00
146_D153_L0.8101.00
30_G34_D0.7991.00
149_W157_P0.7991.00
38_T41_T0.7991.00
154_G157_P0.7961.00
22_R26_G0.7951.00
145_F150_L0.7881.00
106_H109_G0.7841.00
14_V18_L0.7811.00
26_G29_G0.7681.00
110_L114_L0.7681.00
58_V181_L0.7681.00
29_G33_T0.7681.00
146_D151_L0.7651.00
36_A39_F0.7641.00
74_L113_L0.7621.00
133_I169_L0.7521.00
126_L176_L0.7511.00
77_G81_F0.7501.00
112_M116_A0.7491.00
184_L187_R0.7451.00
31_R36_A0.7431.00
148_P152_W0.7431.00
144_L149_W0.7421.00
29_G34_D0.7411.00
94_F98_S0.7391.00
39_F42_R0.7391.00
60_A175_M0.7371.00
147_P151_L0.7341.00
104_V108_I0.7341.00
129_L132_A0.7331.00
121_L124_R0.7311.00
119_L126_L0.7271.00
100_I103_G0.7201.00
86_L91_T0.7131.00
2_L62_L0.7121.00
5_I59_S0.7081.00
152_W157_P0.7011.00
96_P99_F0.7011.00
27_A31_R0.6841.00
77_G80_L0.6841.00
135_A138_N0.6841.00
145_F154_G0.6801.00
77_G84_G0.6751.00
126_L130_G0.6741.00
13_I16_M0.6731.00
15_L44_I0.6701.00
130_G180_A0.6651.00
40_F46_H0.6641.00
189_G192_R0.6631.00
59_S63_S0.6611.00
15_L19_D0.6591.00
149_W155_L0.6581.00
110_L113_L0.6551.00
50_P174_V0.6491.00
170_P173_G0.6461.00
49_A104_V0.6461.00
26_G30_G0.6461.00
63_S66_R0.6441.00
87_L91_T0.6431.00
59_S62_L0.6421.00
40_F44_I0.6371.00
26_G31_R0.6361.00
188_D191_R0.6331.00
146_D154_G0.6321.00
98_S101_I0.6291.00
11_L15_L0.6281.00
18_L44_I0.6251.00
81_F110_L0.6241.00
55_L58_V0.6221.00
108_I111_S0.6221.00
84_G106_H0.6191.00
117_L120_R0.6131.00
180_A183_R0.6121.00
160_F164_D0.6091.00
128_A132_A0.6061.00
94_F97_D0.6051.00
74_L78_L0.6031.00
130_G134_L0.6011.00
96_P100_I0.6011.00
44_I48_C0.6001.00
121_L129_L0.5991.00
84_G89_L0.5941.00
144_L154_G0.5941.00
113_L117_L0.5931.00
126_L183_R0.5881.00
76_R79_W0.5881.00
85_L88_T0.5841.00
145_F149_W0.5841.00
84_G109_G0.5751.00
16_M48_C0.5721.00
30_G36_A0.5721.00
75_R78_L0.5701.00
151_L157_P0.5641.00
15_L51_L0.5621.00
87_L90_F0.5611.00
171_W174_V0.5601.00
108_I112_M0.5601.00
13_I17_I0.5591.00
48_C51_L0.5571.00
47_L50_P0.5541.00
26_G33_T0.5531.00
64_L67_R0.5521.00
145_F152_W0.5521.00
62_L186_L0.5521.00
187_R191_R0.5491.00
162_P166_Y0.5481.00
146_D150_L0.5461.00
19_D45_T0.5421.00
50_P54_F0.5391.00
80_L112_M0.5361.00
65_R70_K0.5351.00
129_L133_I0.5331.00
9_R55_L0.5311.00
168_L172_I0.5311.00
133_I137_H0.5301.00
23_D27_A0.5281.00
158_G163_E0.5261.00
80_L83_L0.5231.00
35_L39_F0.5231.00
28_F32_P0.5211.00
33_T37_T0.5191.00
148_P153_L0.5171.00
63_S72_F0.5171.00
25_L29_G0.5161.00
120_R125_A0.5121.00
25_L31_R0.5111.00
63_S68_R0.5101.00
127_L130_G0.5091.00
12_A48_C0.5071.00
190_A194_R0.5061.00
113_L116_A0.5021.00
77_G83_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1cmxA 2 0.2646 3.1 0.946 Contact Map
4w252 1 0.2422 1.3 0.957 Contact Map
3mp7B 1 0.2242 1.1 0.958 Contact Map
3rqwA 4 0.3901 1 0.959 Contact Map
2jwaA 2 0.1973 0.8 0.961 Contact Map
4hfiA 3 0.4036 0.8 0.961 Contact Map
4tp9C 1 0.009 0.8 0.962 Contact Map
2mgyA 1 0.713 0.8 0.962 Contact Map
2losA 1 0.2646 0.7 0.962 Contact Map
2yvtA 1 0.2691 0.7 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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