GREMLIN Database
DUF1622 - Protein of unknown function (DUF1622)
PFAM: PF07784 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 78 (77)
Sequences: 10364 (6374)
Seq/√Len: 726.4
META: 0.936

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_L25_L4.3311.00
54_L58_G4.3191.00
2_A29_L2.4751.00
11_R15_R2.3271.00
72_F75_E2.2851.00
8_R11_R2.2031.00
55_E59_V1.8051.00
57_V62_A1.7861.00
41_V64_V1.7571.00
72_F76_V1.7551.00
73_F76_V1.7241.00
54_L62_A1.7011.00
55_E58_G1.6571.00
8_R28_R1.5371.00
9_F13_L1.4761.00
58_G62_A1.4261.00
26_R77_E1.4071.00
48_T60_L1.4011.00
64_V69_F1.3941.00
4_V8_R1.3931.00
53_T56_S1.3821.00
13_L16_R1.3791.00
51_V56_S1.3681.00
23_R27_L1.3591.00
4_V28_R1.3161.00
59_V62_A1.2751.00
40_L49_V1.2131.00
61_G65_L1.2071.00
68_T73_F1.2001.00
33_L40_L1.1731.00
9_F32_A1.1451.00
7_V11_R1.1371.00
14_L17_R1.1151.00
65_L69_F1.1091.00
24_R28_R1.0381.00
12_R17_R1.0001.00
47_R56_S0.9801.00
50_A56_S0.9801.00
11_R14_L0.9691.00
2_A39_F0.9541.00
54_L59_V0.9391.00
33_L44_D0.9271.00
52_P59_V0.9241.00
35_L38_E0.9101.00
8_R12_R0.9071.00
52_P56_S0.8981.00
26_R30_G0.8811.00
22_Y31_R0.8801.00
18_R21_A0.8741.00
11_R17_R0.8731.00
20_D24_R0.8691.00
25_L35_L0.8681.00
32_A42_A0.8591.00
41_V44_D0.8581.00
22_Y26_R0.8421.00
47_R52_P0.8301.00
12_R21_A0.8281.00
39_F42_A0.8191.00
30_G38_E0.8131.00
9_F25_L0.7811.00
12_R24_R0.7761.00
47_R51_V0.7681.00
9_F21_A0.7651.00
12_R16_R0.7611.00
13_L17_R0.7561.00
4_V7_V0.7381.00
16_R20_D0.7371.00
17_R20_D0.7371.00
27_L78_I0.7361.00
21_A24_R0.7261.00
23_R26_R0.7111.00
63_I72_F0.6981.00
7_V14_L0.6921.00
33_L71_S0.6861.00
40_L45_I0.6841.00
36_G46_I0.6821.00
47_R59_V0.6771.00
10_L14_L0.6721.00
28_R31_R0.6681.00
23_R31_R0.6671.00
12_R15_R0.6671.00
30_G78_I0.6671.00
3_L7_V0.6631.00
36_G40_L0.6601.00
38_E44_D0.6421.00
13_L18_R0.6191.00
4_V13_L0.6151.00
7_V10_L0.6131.00
51_V63_I0.6131.00
19_G24_R0.6121.00
21_A28_R0.6121.00
34_L71_S0.6101.00
15_R18_R0.6081.00
62_A65_L0.6061.00
2_A42_A0.5961.00
4_V9_F0.5841.00
11_R16_R0.5781.00
61_G66_I0.5771.00
7_V17_R0.5711.00
4_V11_R0.5651.00
64_V70_L0.5601.00
22_Y35_L0.5601.00
32_A39_F0.5561.00
37_L45_I0.5561.00
46_I56_S0.5551.00
6_L9_F0.5401.00
28_R32_A0.5361.00
6_L10_L0.5361.00
68_T71_S0.5341.00
57_V63_I0.5311.00
15_R21_A0.5301.00
34_L38_E0.5181.00
40_L48_T0.5131.00
44_D63_I0.5131.00
16_R19_G0.5040.99
5_A32_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mk7A 1 0.3077 1.6 0.913 Contact Map
2rpaA 1 0.5385 1.6 0.913 Contact Map
4acoA 1 0 1.4 0.916 Contact Map
1oaoC 1 0.7949 1.4 0.917 Contact Map
4g1uA 2 0.9231 1.2 0.919 Contact Map
1odkA 3 0.5513 1.2 0.92 Contact Map
2nq2A 2 0.8846 1.1 0.92 Contact Map
1rh5A 1 0.1923 1.1 0.921 Contact Map
4b19A 1 0.2179 1.1 0.921 Contact Map
2kv5A 1 0.2436 1 0.923 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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