GREMLIN Database
DC_STAMP - DC-STAMP-like protein
PFAM: PF07782 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 191 (191)
Sequences: 567 (356)
Seq/√Len: 25.7
META: 0.092

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_R191_Y4.7941.00
176_A183_E3.6281.00
27_P32_E3.1501.00
186_R190_L2.9251.00
166_Y169_R2.9161.00
172_R183_E2.8981.00
182_R185_E2.8861.00
13_I191_Y2.7090.99
15_A18_K2.5710.99
110_A114_R2.5460.99
183_E187_I2.4970.99
180_P184_K2.2280.98
14_D32_E2.1760.97
5_Y183_E2.0550.96
10_F26_L1.9760.95
174_I181_S1.9740.95
176_A187_I1.9540.95
67_L152_L1.9490.95
1_F29_K1.9370.94
105_G114_R1.9150.94
73_D139_P1.8630.93
6_I26_L1.7800.91
2_D5_Y1.7770.91
105_G110_A1.7700.91
86_H99_L1.7640.91
83_V173_V1.7230.90
25_V36_Y1.7150.90
122_P131_S1.6410.88
13_I17_R1.5690.85
7_T28_L1.5660.85
148_L152_L1.5540.85
178_F189_Y1.5440.84
63_L71_A1.5240.83
103_V114_R1.5190.83
63_L154_Y1.4970.82
14_D26_L1.4820.82
113_L127_N1.4550.80
182_R191_Y1.4400.80
28_L32_E1.4350.79
141_P163_L1.4280.79
102_K179_Y1.4190.79
26_L32_E1.3940.77
2_D171_R1.3940.77
99_L103_V1.3930.77
67_L157_L1.3880.77
38_R174_I1.3860.77
8_K19_K1.3760.76
9_Y13_I1.3660.76
25_V32_E1.3380.74
36_Y41_S1.3240.74
66_L154_Y1.3090.73
55_G72_L1.3070.73
188_L191_Y1.2790.71
1_F114_R1.2730.71
55_G66_L1.2690.70
172_R176_A1.2650.70
14_D33_R1.2620.70
117_V121_N1.2480.69
80_L139_P1.2450.69
80_L107_G1.2430.69
12_Q16_R1.2380.68
59_L161_V1.2270.68
83_V88_Q1.2180.67
107_G114_R1.2070.66
70_V147_Y1.2010.66
160_L185_E1.1900.65
2_D166_Y1.1710.64
112_L120_F1.1660.64
52_L170_L1.1650.64
69_L74_Y1.1610.63
79_L151_G1.1570.63
156_L159_L1.1530.63
14_D27_P1.1420.62
64_L189_Y1.1320.61
29_K36_Y1.1270.61
105_G111_D1.1220.61
35_K41_S1.1180.60
63_L67_L1.1150.60
41_S74_Y1.1110.60
28_L170_L1.1090.60
110_A116_L1.1000.59
58_L150_I1.0950.59
58_L66_L1.0920.58
21_G90_E1.0850.58
94_P166_Y1.0750.57
24_T39_P1.0710.57
14_D105_G1.0630.56
10_F14_D1.0600.56
79_L130_L1.0490.55
66_L70_V1.0480.55
80_L159_L1.0450.55
21_G133_A1.0420.55
1_F100_S1.0360.54
31_K179_Y1.0360.54
1_F42_L1.0340.54
41_S150_I1.0290.54
69_L161_V1.0190.53
114_R120_F1.0160.53
172_R175_A1.0150.53
39_P55_G1.0140.53
156_L162_L1.0080.52
46_R67_L1.0070.52
168_L171_R1.0020.52
16_R181_S0.9980.52
49_R70_V0.9970.52
71_A151_G0.9950.51
10_F25_V0.9910.51
6_I112_L0.9800.50
52_L150_I0.9750.50
99_L152_L0.9720.50
34_K49_R0.9710.50
33_R50_K0.9700.50
184_K191_Y0.9510.48
48_E73_D0.9500.48
60_L118_S0.9450.48
11_R15_A0.9420.47
2_D183_E0.9380.47
36_Y130_L0.9380.47
32_E105_G0.9320.47
42_L148_L0.9290.47
4_I183_E0.9240.46
89_G132_S0.9190.46
94_P108_Y0.9030.45
67_L81_D0.8950.44
21_G128_L0.8950.44
7_T37_I0.8910.44
78_W142_P0.8900.44
108_Y116_L0.8900.44
57_L68_L0.8880.44
16_R25_V0.8850.43
127_N130_L0.8830.43
140_S155_L0.8800.43
107_G120_F0.8790.43
110_A113_L0.8720.42
74_Y78_W0.8710.42
34_K138_Q0.8650.42
48_E103_V0.8650.42
19_K156_L0.8620.42
17_R105_G0.8540.41
119_A178_F0.8480.41
29_K38_R0.8420.40
144_S160_L0.8400.40
136_L139_P0.8390.40
19_K45_S0.8380.40
131_S191_Y0.8370.40
152_L156_L0.8370.40
27_P137_P0.8190.39
30_K41_S0.8180.39
89_G95_V0.8160.38
38_R61_L0.8130.38
68_L76_L0.8100.38
44_L117_V0.8100.38
175_A183_E0.8040.38
137_P165_A0.8020.37
146_T158_L0.8010.37
8_K15_A0.8010.37
14_D25_V0.8000.37
71_A177_S0.7950.37
120_F125_Y0.7940.37
9_Y17_R0.7930.37
42_L185_E0.7910.37
113_L116_L0.7870.36
103_V169_R0.7840.36
43_R47_K0.7740.36
12_Q95_V0.7730.35
40_T58_L0.7670.35
9_Y184_K0.7660.35
1_F48_E0.7600.35
152_L181_S0.7570.34
100_S138_Q0.7550.34
124_S127_N0.7450.34
4_I161_V0.7360.33
110_A115_D0.7350.33
43_R64_L0.7320.33
97_L142_P0.7310.33
33_R121_N0.7260.32
110_A189_Y0.7260.32
22_K126_G0.7250.32
66_L93_V0.7210.32
76_L138_Q0.7160.32
6_I176_A0.7150.32
3_N7_T0.7150.32
103_V117_V0.7150.32
101_V117_V0.7130.32
5_Y130_L0.7130.32
27_P36_Y0.7070.31
113_L121_N0.7060.31
110_A119_A0.7040.31
79_L149_V0.7030.31
81_D85_R0.6940.30
169_R186_R0.6890.30
14_D17_R0.6830.30
170_L189_Y0.6820.30
143_D159_L0.6800.29
6_I25_V0.6740.29
1_F155_L0.6700.29
49_R150_I0.6660.29
15_A29_K0.6640.29
10_F167_A0.6580.28
14_D37_I0.6570.28
17_R24_T0.6540.28
169_R182_R0.6540.28
50_K120_F0.6530.28
5_Y172_R0.6510.28
28_L137_P0.6510.28
135_C186_R0.6490.28
157_L172_R0.6480.28
52_L166_Y0.6470.28
44_L52_L0.6470.28
1_F16_R0.6390.27
11_R37_I0.6380.27
15_A159_L0.6350.27
117_V124_S0.6340.27
42_L71_A0.6320.27
123_L179_Y0.6320.27
129_S152_L0.6240.26
123_L175_A0.6170.26
97_L132_S0.6140.26
44_L165_A0.6140.26
11_R88_Q0.6090.25
22_K102_K0.6080.25
78_W151_G0.6060.25
83_V137_P0.6040.25
121_N185_E0.6030.25
36_Y165_A0.6020.25
23_P189_Y0.6010.25
57_L161_V0.6010.25
111_D114_R0.6010.25
7_T139_P0.5990.25
57_L116_L0.5980.25
105_G112_L0.5950.25
93_V126_G0.5910.24
56_L140_S0.5910.24
59_L150_I0.5860.24
22_K170_L0.5850.24
86_H91_P0.5820.24
48_E169_R0.5800.24
34_K117_V0.5800.24
186_R191_Y0.5800.24
16_R171_R0.5750.23
44_L59_L0.5730.23
107_G110_A0.5730.23
89_G97_L0.5730.23
101_V111_D0.5710.23
54_L167_A0.5690.23
69_L164_E0.5690.23
3_N135_C0.5690.23
107_G121_N0.5620.23
88_Q187_I0.5620.23
2_D172_R0.5600.23
64_L71_A0.5590.23
47_K156_L0.5590.23
112_L117_V0.5580.23
10_F187_I0.5560.22
25_V76_L0.5540.22
164_E175_A0.5520.22
174_I182_R0.5490.22
37_I183_E0.5480.22
146_T166_Y0.5480.22
37_I191_Y0.5470.22
87_A97_L0.5450.22
10_F91_P0.5450.22
3_N10_F0.5430.22
82_T142_P0.5400.22
72_L93_V0.5370.22
34_K64_L0.5360.21
114_R117_V0.5330.21
77_Y126_G0.5300.21
127_N134_R0.5250.21
19_K70_V0.5240.21
21_G81_D0.5210.21
63_L139_P0.5200.21
63_L77_Y0.5200.21
145_S170_L0.5180.21
41_S44_L0.5160.21
96_P134_R0.5160.21
25_V31_K0.5140.20
145_S185_E0.5130.20
179_Y186_R0.5120.20
10_F39_P0.5110.20
177_S187_I0.5110.20
140_S154_Y0.5080.20
1_F86_H0.5050.20
39_P110_A0.5020.20
153_L179_Y0.5010.20
37_I120_F0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zjsE 1 0.2408 17.2 0.947 Contact Map
3bo0B 1 0.3298 11.2 0.951 Contact Map
3dinD 1 0.2932 10.8 0.951 Contact Map
3dl8C 1 0.1832 10.5 0.952 Contact Map
3nkgA 1 0.2932 5.2 0.958 Contact Map
3j01B 1 0.4241 4.1 0.96 Contact Map
4ib4A 1 0.2304 3.7 0.961 Contact Map
2mfrA 1 0.2775 3.1 0.962 Contact Map
4mqsA 1 0.2199 2.6 0.964 Contact Map
3w1oA 2 0.5497 2.6 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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