GREMLIN Database
Spb1_C - Spb1 C-terminal domain
PFAM: PF07780 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 210 (207)
Sequences: 597 (431)
Seq/√Len: 29.9
META: 0.296

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
204_A208_K5.3351.00
198_M201_D3.0221.00
113_A134_A3.0211.00
201_D208_K2.9881.00
87_L98_K2.8881.00
122_R125_K2.8171.00
202_L205_Q2.7821.00
40_A45_L2.7461.00
121_R125_K2.6071.00
137_I155_L2.5580.99
25_D28_D2.4770.99
204_A207_R2.1740.98
35_T38_A2.1600.98
197_R201_D2.1570.98
7_F10_V2.1540.98
200_K204_A2.1130.98
19_D22_D2.1030.98
201_D204_A2.0830.98
113_A117_A2.0680.98
154_K158_K2.0160.97
197_R200_K1.9300.96
135_E139_D1.9180.96
198_M202_L1.8210.95
83_S147_E1.7990.95
44_Q93_A1.7950.94
200_K206_K1.7940.94
95_A99_E1.7270.93
31_D34_L1.7110.93
170_Y202_L1.7010.93
44_Q51_T1.6910.92
7_F11_P1.6880.92
43_H93_A1.6780.92
31_D36_A1.6720.92
89_I188_K1.6630.92
89_I94_V1.6570.92
45_L60_F1.6480.91
43_H46_A1.6450.91
90_T93_A1.6320.91
196_P200_K1.6280.91
122_R150_K1.5760.89
20_D23_D1.5720.89
179_G191_Y1.5540.89
50_K54_D1.5230.88
96_A99_E1.5160.88
45_L51_T1.5000.87
205_Q208_K1.4710.86
194_V199_K1.4480.85
62_R157_K1.4400.85
26_E29_E1.4370.85
45_L55_L1.4300.84
66_N71_L1.4280.84
44_Q49_K1.4070.83
17_D20_D1.4050.83
39_L100_K1.3960.83
178_R181_K1.3920.83
15_D22_D1.3530.81
130_A155_L1.3320.80
99_E103_A1.3260.79
8_E14_E1.3210.79
169_K193_M1.3160.79
22_D25_D1.3140.79
102_R137_I1.3090.78
18_S21_D1.2990.78
173_A184_P1.2830.77
23_D56_I1.2740.77
184_P191_Y1.2690.76
167_E170_Y1.2680.76
78_D81_K1.2550.75
15_D18_S1.2260.74
88_P108_P1.2250.74
23_D28_D1.2190.73
192_K202_L1.2180.73
187_V191_Y1.1990.72
202_L209_A1.1930.72
90_T107_R1.1920.72
117_A154_K1.1920.72
159_A201_D1.1910.71
62_R66_N1.1870.71
24_D28_D1.1760.70
196_P199_K1.1670.70
32_D45_L1.1340.68
6_D9_I1.1300.67
178_R191_Y1.1180.67
81_K205_Q1.1080.66
195_D201_D1.1030.65
138_A152_I1.1020.65
94_V97_I1.0920.65
20_D24_D1.0890.64
13_E25_D1.0750.63
107_R155_L1.0670.63
7_F16_D1.0430.61
13_E16_D1.0390.61
144_S147_E1.0380.61
55_L156_Y1.0360.61
135_E201_D1.0350.60
140_D147_E1.0300.60
15_D20_D1.0250.60
13_E17_D1.0220.59
51_T55_L1.0180.59
16_D27_D1.0170.59
13_E19_D1.0110.59
23_D27_D0.9960.57
173_A183_R0.9890.57
17_D22_D0.9820.56
93_A96_A0.9810.56
23_D26_E0.9810.56
52_K63_Y0.9800.56
49_K56_I0.9760.56
47_T52_K0.9700.55
56_I160_A0.9630.55
94_V112_V0.9600.55
178_R196_P0.9470.54
42_A97_I0.9450.53
123_A182_G0.9440.53
173_A193_M0.9430.53
113_A142_D0.9400.53
65_F125_K0.9350.53
173_A186_G0.9340.53
37_E81_K0.9290.52
128_E131_K0.9250.52
42_A96_A0.9150.51
63_Y83_S0.9130.51
9_I15_D0.9090.51
10_V15_D0.9030.50
45_L50_K0.8900.49
14_E18_S0.8900.49
11_P14_E0.8820.48
193_M201_D0.8730.48
153_E192_K0.8720.48
142_D162_K0.8710.48
6_D10_V0.8630.47
140_D153_E0.8620.47
9_I18_S0.8610.47
186_G191_Y0.8580.47
100_K152_I0.8560.46
183_R187_V0.8530.46
21_D26_E0.8440.45
71_L76_L0.8410.45
178_R182_G0.8400.45
84_K102_R0.8390.45
36_A58_D0.8380.45
12_A16_D0.8350.45
66_N83_S0.8340.45
56_I59_G0.8290.44
24_D163_K0.8260.44
183_R186_G0.8220.44
87_L167_E0.8210.44
63_Y66_N0.8190.44
64_A164_K0.8170.43
174_K182_G0.8160.43
107_R119_K0.8150.43
173_A189_G0.8140.43
16_D21_D0.8130.43
32_D98_K0.8120.43
59_G65_F0.8070.43
131_K139_D0.8040.42
176_G201_D0.8010.42
99_E102_R0.7970.42
5_D16_D0.7930.41
143_M197_R0.7890.41
73_D85_P0.7880.41
48_R85_P0.7880.41
112_V138_A0.7840.41
59_G166_P0.7840.41
190_R193_M0.7820.41
43_H151_Q0.7820.41
43_H47_T0.7790.40
156_Y181_K0.7760.40
48_R97_I0.7750.40
56_I60_F0.7740.40
66_N134_A0.7700.40
162_K205_Q0.7680.40
40_A170_Y0.7680.40
55_L104_L0.7610.39
41_L141_E0.7600.39
151_Q156_Y0.7540.39
95_A129_K0.7530.38
39_L175_G0.7530.38
97_I130_A0.7500.38
24_D27_D0.7470.38
23_D155_L0.7450.38
183_R191_Y0.7420.38
184_P187_V0.7420.38
106_A113_A0.7390.37
206_K210_K0.7350.37
82_H145_E0.7280.37
19_D25_D0.7280.37
126_R143_M0.7240.36
197_R202_L0.7240.36
138_A201_D0.7210.36
15_D21_D0.7200.36
42_A175_G0.7170.36
33_I36_A0.7150.36
9_I12_A0.7120.35
30_D34_L0.7120.35
143_M150_K0.7080.35
16_D26_E0.7080.35
16_D22_D0.7060.35
11_P21_D0.7020.35
91_K104_L0.7020.35
83_S87_L0.7010.35
90_T102_R0.6980.34
165_K170_Y0.6940.34
4_D15_D0.6920.34
116_K174_K0.6920.34
116_K151_Q0.6920.34
33_I47_T0.6910.34
95_A141_E0.6890.34
21_D25_D0.6870.34
196_P202_L0.6820.33
60_F116_K0.6780.33
65_F83_S0.6770.33
16_D24_D0.6770.33
174_K178_R0.6760.33
68_K87_L0.6730.33
64_A83_S0.6730.33
154_K190_R0.6700.32
113_A130_A0.6680.32
64_A108_P0.6660.32
32_D35_T0.6640.32
91_K129_K0.6620.32
7_F15_D0.6620.32
104_L131_K0.6600.32
53_R57_D0.6560.31
69_D199_K0.6550.31
10_V18_S0.6540.31
59_G86_Q0.6540.31
49_K64_A0.6480.31
12_A17_D0.6460.31
46_A59_G0.6460.31
40_A50_K0.6440.31
17_D23_D0.6440.31
18_S28_D0.6430.31
9_I62_R0.6410.30
13_E24_D0.6410.30
57_D60_F0.6410.30
16_D19_D0.6340.30
101_L149_A0.6330.30
74_W115_A0.6320.30
20_D26_E0.6310.30
13_E29_E0.6300.30
204_A210_K0.6290.30
54_D65_F0.6280.30
151_Q155_L0.6280.30
55_L122_R0.6280.30
117_A121_R0.6250.29
27_D78_D0.6220.29
103_A108_P0.6220.29
13_E22_D0.6220.29
161_K192_K0.6180.29
65_F131_K0.6170.29
44_Q50_K0.6150.29
131_K155_L0.6120.29
146_R150_K0.6100.28
32_D47_T0.6100.28
184_P189_G0.6090.28
89_I142_D0.6090.28
39_L43_H0.6080.28
37_E159_A0.6080.28
175_G178_R0.6060.28
45_L167_E0.6030.28
16_D20_D0.5960.28
143_M151_Q0.5950.27
96_A185_K0.5950.27
100_K109_I0.5940.27
202_L206_K0.5860.27
40_A43_H0.5850.27
101_L139_D0.5820.27
173_A191_Y0.5770.26
63_Y167_E0.5750.26
50_K152_I0.5690.26
20_D25_D0.5670.26
73_D156_Y0.5620.25
176_G202_L0.5590.25
131_K138_A0.5550.25
144_S174_K0.5540.25
136_A142_D0.5530.25
7_F12_A0.5520.25
56_I62_R0.5500.25
18_S26_E0.5490.25
21_D28_D0.5470.25
173_A187_V0.5460.24
55_L135_E0.5450.24
165_K168_V0.5450.24
54_D129_K0.5410.24
120_K136_A0.5390.24
49_K59_G0.5340.24
170_Y193_M0.5320.24
84_K129_K0.5310.24
110_K175_G0.5260.23
120_K198_M0.5240.23
99_E145_E0.5230.23
91_K102_R0.5230.23
48_R94_V0.5180.23
8_E15_D0.5180.23
8_E11_P0.5180.23
48_R140_D0.5180.23
64_A85_P0.5150.23
101_L174_K0.5150.23
141_E198_M0.5130.23
54_D99_E0.5130.23
177_N204_A0.5100.22
22_D26_E0.5090.22
177_N192_K0.5080.22
55_L200_K0.5070.22
169_K186_G0.5070.22
95_A185_K0.5060.22
65_F137_I0.5050.22
177_N186_G0.5000.22
169_K187_V0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gyiA 1 0.0286 15.4 0.96 Contact Map
4fp9B 2 0.0286 10.8 0.962 Contact Map
2marA 1 0.5286 5.4 0.967 Contact Map
1ya0A 1 0.2857 2.2 0.973 Contact Map
3e1kB 1 0.0667 2.1 0.973 Contact Map
4ui9I 1 0.1095 1.9 0.974 Contact Map
1i27A 1 0.3429 1.9 0.974 Contact Map
1wglA 1 0.281 1.9 0.974 Contact Map
2n0pA 1 0.3667 1.8 0.974 Contact Map
1a0cA 4 0.3048 1.8 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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