GREMLIN Database
DUF1620 - Protein of unknown function (DUF1620)
PFAM: PF07774 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 202 (202)
Sequences: 545 (428)
Seq/√Len: 30.1
META: 0.29

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_T157_V5.9691.00
49_F53_I3.8001.00
21_V84_R3.5161.00
184_V188_V3.4151.00
11_N18_E2.8691.00
8_S56_L2.8681.00
69_Q81_G2.7131.00
67_S160_S2.6111.00
22_V42_V2.4950.99
49_F84_R2.4810.99
8_S17_Y2.4450.99
116_P171_N2.3980.99
158_A162_T2.3530.99
88_D103_E2.2530.99
55_A73_A2.2450.99
52_P75_E2.1760.98
92_P105_L2.1420.98
146_F154_G2.1170.98
25_Y45_Q2.0760.98
189_T192_L1.9880.97
73_A129_V1.9280.96
8_S49_F1.8680.96
79_I147_A1.8410.95
181_A185_G1.8340.95
95_D107_P1.8170.95
128_G148_Y1.8150.95
20_V46_S1.7520.94
91_R108_Y1.7030.93
56_L190_R1.6930.93
9_Y18_E1.6580.92
8_S53_I1.6370.91
79_I126_V1.6130.91
5_F22_V1.6060.91
23_E47_Y1.6020.90
78_Q121_T1.5960.90
6_V87_L1.5710.90
49_F80_V1.5610.89
56_L71_L1.5540.89
91_R105_L1.5300.88
177_L181_A1.5280.88
71_L81_G1.5150.88
72_V132_I1.5150.88
178_T182_L1.4600.86
82_I200_A1.4530.85
90_R108_Y1.4510.85
23_E102_E1.4170.84
86_L106_I1.3980.83
145_V157_V1.3920.83
86_L112_L1.3870.83
79_I146_F1.3780.82
176_L180_V1.3630.81
24_L42_V1.3550.81
46_S137_A1.3540.81
94_R97_T1.3360.80
48_I120_L1.3340.80
160_S178_T1.3290.80
18_E172_K1.3270.80
120_L145_V1.3210.79
71_L158_A1.3100.79
51_E114_I1.3050.79
5_F21_V1.3050.79
197_Q200_A1.2930.78
144_L154_G1.2850.77
72_V82_I1.2830.77
179_V183_A1.2760.77
23_E113_P1.2720.77
134_T143_S1.2460.75
32_D36_L1.2370.75
13_K16_R1.2360.75
9_Y22_V1.2330.74
109_D121_T1.2320.74
71_L180_V1.2290.74
24_L177_L1.2230.74
156_R163_F1.1810.71
196_K202_W1.1750.71
49_F120_L1.1720.71
164_D170_F1.1720.71
78_Q83_P1.1620.70
90_R103_E1.1580.70
54_S77_G1.1560.69
24_L54_S1.1470.69
27_S34_G1.1410.68
15_K27_S1.1400.68
179_V182_L1.1270.67
24_L39_L1.1240.67
21_V134_T1.1170.67
129_V147_A1.1080.66
70_L168_E1.0940.65
176_L179_V1.0920.65
23_E174_Q1.0800.64
47_Y88_D1.0560.62
170_F175_L1.0500.62
120_L157_V1.0460.62
26_E40_P1.0380.61
90_R105_L1.0270.60
134_T147_A1.0080.59
82_I136_P0.9940.58
160_S202_W0.9940.58
6_V70_L0.9930.58
136_P184_V0.9920.57
194_R197_Q0.9800.56
125_E129_V0.9800.56
126_V187_L0.9710.56
45_Q112_L0.9700.56
167_G178_T0.9620.55
5_F24_L0.9620.55
172_K193_V0.9560.55
88_D160_S0.9560.55
88_D147_A0.9530.54
46_S158_A0.9490.54
58_V201_R0.9420.54
97_T100_E0.9400.53
19_L87_L0.9350.53
13_K18_E0.9340.53
70_L86_L0.9320.53
115_D172_K0.9260.52
24_L184_V0.9240.52
1_S4_W0.9230.52
107_P168_E0.9080.51
16_R174_Q0.9070.51
19_L85_R0.9030.50
156_R159_P0.9030.50
125_E179_V0.9030.50
198_L202_W0.8970.50
97_T103_E0.8940.50
127_A176_L0.8940.50
59_T81_G0.8930.50
11_N183_A0.8920.50
6_V21_V0.8890.49
49_F82_I0.8850.49
198_L201_R0.8830.49
23_E45_Q0.8820.49
195_R199_N0.8800.49
21_V89_P0.8760.48
173_V184_V0.8750.48
177_L194_R0.8720.48
178_T191_P0.8710.48
19_L53_I0.8700.48
43_L102_E0.8660.47
131_G187_L0.8620.47
1_S40_P0.8580.47
120_L132_I0.8410.45
98_P101_K0.8360.45
44_S121_T0.8260.44
11_N68_K0.8240.44
48_I119_V0.8210.44
62_R117_K0.8190.44
55_A132_I0.8020.42
47_Y91_R0.7970.42
130_R147_A0.7950.42
4_W64_G0.7930.42
55_A72_V0.7910.42
1_S67_S0.7900.41
173_V180_V0.7900.41
27_S31_N0.7880.41
67_S145_V0.7840.41
5_F174_Q0.7750.40
66_T153_F0.7710.40
21_V58_V0.7640.39
125_E137_A0.7630.39
7_Y11_N0.7630.39
59_T180_V0.7590.39
171_N175_L0.7550.39
64_G182_L0.7550.39
21_V101_K0.7460.38
51_E76_S0.7450.38
2_E66_T0.7440.38
152_L192_L0.7410.38
48_I110_P0.7410.38
190_R194_R0.7380.38
42_V189_T0.7350.37
25_Y169_D0.7340.37
174_Q178_T0.7330.37
146_F152_L0.7330.37
167_G175_L0.7260.37
71_L128_G0.7230.36
81_G120_L0.7220.36
142_T196_K0.7190.36
19_L192_L0.7160.36
131_G148_Y0.7140.36
174_Q191_P0.7100.35
96_P100_E0.7080.35
87_L182_L0.7040.35
168_E189_T0.7010.35
1_S74_T0.7000.35
102_E151_D0.6990.35
97_T102_E0.6990.35
100_E186_V0.6940.34
48_I184_V0.6920.34
132_I154_G0.6920.34
86_L99_A0.6910.34
13_K123_N0.6890.34
5_F177_L0.6880.34
22_V161_K0.6850.34
134_T148_Y0.6740.33
42_V76_S0.6720.33
2_E65_I0.6720.33
22_V25_Y0.6680.32
152_L165_V0.6670.32
77_G125_E0.6660.32
99_A150_L0.6560.32
180_V184_V0.6530.31
52_P89_P0.6510.31
130_R152_L0.6490.31
12_D176_L0.6450.31
97_T101_K0.6440.31
78_Q175_L0.6440.31
62_R102_E0.6420.31
92_P126_V0.6390.30
13_K52_P0.6380.30
7_Y14_A0.6370.30
177_L184_V0.6340.30
8_S19_L0.6340.30
27_S163_F0.6340.30
69_Q157_V0.6320.30
44_S137_A0.6310.30
140_E149_G0.6310.30
111_V171_N0.6290.30
56_L185_G0.6250.30
134_T201_R0.6210.29
91_R103_E0.6200.29
21_V177_L0.6200.29
84_R101_K0.6190.29
50_P142_T0.6180.29
24_L158_A0.6170.29
57_A121_T0.6160.29
25_Y30_P0.6160.29
57_A131_G0.6150.29
184_V187_L0.6140.29
40_P151_D0.6100.29
162_T190_R0.6090.28
7_Y53_I0.6070.28
70_L196_K0.6060.28
12_D75_E0.6040.28
51_E55_A0.6040.28
94_R100_E0.6010.28
29_I52_P0.6000.28
14_A17_Y0.5990.28
84_R173_V0.5970.28
150_L156_R0.5960.28
34_G39_L0.5950.28
139_L160_S0.5940.28
46_S112_L0.5910.27
184_V196_K0.5900.27
112_L138_L0.5890.27
64_G185_G0.5880.27
27_S107_P0.5870.27
62_R192_L0.5870.27
138_L175_L0.5850.27
162_T178_T0.5840.27
162_T169_D0.5820.27
79_I97_T0.5820.27
3_N14_A0.5790.27
95_D195_R0.5770.26
53_I145_V0.5760.26
7_Y120_L0.5730.26
7_Y20_V0.5710.26
56_L135_S0.5700.26
172_K191_P0.5670.26
6_V78_Q0.5670.26
82_I106_I0.5660.26
19_L70_L0.5650.26
113_P168_E0.5640.26
110_P142_T0.5620.26
68_K155_T0.5610.25
101_K130_R0.5600.25
83_P121_T0.5550.25
107_P112_L0.5550.25
20_V165_V0.5510.25
76_S82_I0.5510.25
166_L171_N0.5510.25
21_V174_Q0.5490.25
39_L77_G0.5450.25
79_I179_V0.5450.25
70_L76_S0.5440.24
56_L136_P0.5440.24
22_V44_S0.5410.24
171_N201_R0.5410.24
180_V188_V0.5400.24
30_P191_P0.5390.24
3_N65_I0.5380.24
193_V201_R0.5370.24
61_T129_V0.5360.24
109_D114_I0.5340.24
45_Q190_R0.5330.24
159_P163_F0.5330.24
7_Y139_L0.5320.24
88_D126_V0.5320.24
33_R124_R0.5300.24
22_V72_V0.5280.24
121_T175_L0.5250.23
53_I70_L0.5230.23
87_L200_A0.5220.23
122_H161_K0.5170.23
5_F163_F0.5160.23
129_V169_D0.5130.23
87_L93_V0.5120.23
30_P33_R0.5120.23
20_V44_S0.5110.23
74_T183_A0.5090.22
75_E157_V0.5050.22
95_D100_E0.5030.22
24_L38_S0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2mofA 1 0.1881 3.1 0.97 Contact Map
1eo6A 2 0.2277 3.1 0.97 Contact Map
4jcwA 2 0.3911 2.9 0.97 Contact Map
4eoyA 1 0.2178 2.8 0.971 Contact Map
2oajA 1 0.3564 2.7 0.971 Contact Map
2zjdA 1 0.2327 2.5 0.972 Contact Map
3h9dA 2 0.2228 2.3 0.972 Contact Map
5cxdA 3 0.302 2.2 0.972 Contact Map
4hwkA 3 0.1683 2.1 0.973 Contact Map
2ls4A 1 0.1188 2 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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