GREMLIN Database
Nop53 - Nop53 (60S ribosomal biogenesis)
PFAM: PF07767 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 381 (379)
Sequences: 577 (489)
Seq/√Len: 25.1
META: 0.125

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
189_S192_D3.7481.00
4_G11_N3.7061.00
3_K11_N3.5111.00
271_A274_N3.3381.00
208_L212_E3.2981.00
268_K276_E3.2901.00
274_N278_R3.2841.00
4_G7_A3.0921.00
268_K273_R3.0721.00
3_K7_A3.0301.00
282_E286_A3.0021.00
279_R282_E2.8641.00
355_Q361_S2.8591.00
273_R276_E2.7780.99
356_L359_E2.6600.99
355_Q370_E2.5720.99
7_A11_N2.5470.99
180_P184_A2.5040.99
295_K299_L2.4520.99
194_Q197_L2.4200.98
2_R11_N2.3540.98
107_K110_A2.3280.98
14_I17_V2.3160.98
232_E238_E2.2690.98
55_K58_L2.2620.98
377_R380_S2.2550.98
4_G9_R2.1090.96
5_K9_R2.0750.96
281_E284_R2.0700.96
202_E205_K2.0130.95
68_S72_L2.0100.95
20_F24_L1.9800.95
299_L302_L1.9760.95
215_E219_A1.9550.94
272_Q275_K1.9530.94
136_L182_A1.9230.94
249_E254_S1.9160.94
75_R79_P1.8910.93
5_K8_W1.8750.93
339_P347_F1.8740.93
3_K12_I1.8600.93
1_S11_N1.8370.92
22_E25_R1.8190.92
239_M274_N1.7800.91
2_R7_A1.7660.91
230_E233_E1.7650.91
342_L346_K1.7640.91
250_E255_E1.7640.91
301_R308_E1.7400.90
113_K116_G1.7390.90
247_E255_E1.7340.90
269_T272_Q1.7120.89
209_K213_K1.7010.89
118_K254_S1.6980.89
34_P37_E1.6890.88
360_L369_P1.6650.88
206_K210_E1.6600.88
291_A294_K1.6370.87
1_S4_G1.6140.86
245_E248_E1.6140.86
262_K265_P1.6140.86
10_K13_D1.6080.86
43_L46_V1.6080.86
193_H197_L1.5870.85
7_A274_N1.5840.85
200_A203_A1.5660.84
177_V377_R1.5620.84
21_L273_R1.5440.83
102_E107_K1.5430.83
98_V145_E1.5400.83
54_V58_L1.5390.83
35_L38_K1.5320.83
235_L238_E1.5190.82
234_E239_M1.5110.82
363_S366_T1.4960.81
212_E215_E1.4910.81
4_G12_I1.4800.81
110_A165_K1.4780.81
196_L370_E1.4710.80
254_S259_D1.4690.80
268_K370_E1.4640.80
71_I76_S1.4620.80
99_S106_L1.4580.80
237_E240_D1.4370.79
298_Q301_R1.4360.79
249_E252_E1.4330.78
232_E236_F1.4320.78
2_R9_R1.4310.78
21_L25_R1.4300.78
244_W247_E1.4220.78
173_A243_E1.4170.78
362_G365_R1.4150.78
227_T231_A1.4130.77
193_H339_P1.4130.77
301_R304_S1.4110.77
39_P42_E1.4030.77
94_K97_W1.3970.77
150_L153_T1.3950.77
203_A352_L1.3920.76
3_K9_R1.3900.76
235_L239_M1.3800.76
335_E340_R1.3710.75
67_K70_E1.3640.75
154_K159_K1.3620.75
192_D301_R1.3530.74
64_K67_K1.3510.74
281_E285_K1.3480.74
177_V291_A1.3420.74
353_E370_E1.3390.73
342_L347_F1.3350.73
170_S315_E1.3320.73
339_P342_L1.3270.73
367_L370_E1.3230.73
46_V64_K1.3200.72
27_E35_L1.3130.72
285_K289_E1.3100.72
227_T234_E1.3040.71
161_P369_P1.2980.71
223_P227_T1.2930.71
374_L379_K1.2920.71
200_A376_D1.2920.71
200_A354_V1.2900.71
17_V28_E1.2890.71
7_A12_I1.2830.70
196_L353_E1.2720.70
193_H200_A1.2690.69
33_G69_D1.2660.69
60_K164_L1.2540.68
296_L302_L1.2430.68
234_E237_E1.2410.68
161_P186_Y1.2400.67
9_R32_G1.2380.67
68_S71_I1.2370.67
3_K373_L1.2320.67
41_E138_A1.2310.67
1_S5_K1.2240.66
26_L29_R1.2200.66
213_K217_Q1.2030.65
111_K115_K1.1960.65
137_W188_P1.1950.65
184_A196_L1.1940.64
272_Q371_G1.1930.64
295_K305_I1.1820.64
198_A201_V1.1800.64
279_R283_E1.1780.63
1_S8_W1.1770.63
347_F379_K1.1770.63
102_E105_R1.1740.63
26_L31_T1.1720.63
21_L85_R1.1670.63
2_R12_I1.1670.63
39_P305_I1.1590.62
193_H196_L1.1510.62
227_T230_E1.1420.61
192_D354_V1.1360.61
314_E319_R1.1350.60
287_K293_K1.1200.59
320_R323_R1.1190.59
208_L211_E1.1170.59
254_S258_G1.1160.59
25_R76_S1.1090.59
196_L268_K1.1060.58
10_K14_I1.0970.58
8_W21_L1.0960.58
10_K186_Y1.0950.58
71_I161_P1.0900.57
46_V133_S1.0830.57
25_R29_R1.0810.57
234_E238_E1.0780.56
207_R337_L1.0770.56
65_P368_K1.0760.56
200_A211_E1.0730.56
66_L370_E1.0690.56
139_D255_E1.0660.56
312_E317_A1.0630.55
352_L355_Q1.0550.55
309_I315_E1.0550.55
47_D50_G1.0530.55
5_K32_G1.0520.55
21_L369_P1.0490.54
315_E319_R1.0470.54
139_D142_P1.0440.54
238_E242_S1.0430.54
49_T313_E1.0400.54
1_S10_K1.0320.53
160_A165_K1.0260.53
180_P268_K1.0260.53
11_N15_T1.0240.53
276_E280_K1.0230.52
233_E236_F1.0220.52
106_L275_K1.0210.52
236_F239_M1.0190.52
161_P371_G1.0190.52
6_K11_N1.0170.52
226_A234_E1.0140.52
266_K272_Q1.0110.52
5_K183_G1.0030.51
293_K303_K1.0000.51
67_K358_D0.9950.50
190_F194_Q0.9940.50
302_L306_K0.9890.50
284_R292_A0.9860.50
322_R328_R0.9830.50
65_P73_A0.9830.50
48_T52_E0.9810.49
104_A381_L0.9740.49
315_E332_R0.9740.49
3_K10_K0.9730.49
67_K101_K0.9640.48
185_S188_P0.9640.48
267_R362_G0.9630.48
226_A229_E0.9550.48
33_G38_K0.9530.47
198_A202_E0.9440.47
244_W248_E0.9400.46
10_K21_L0.9380.46
282_E293_K0.9360.46
247_E254_S0.9350.46
196_L216_R0.9340.46
60_K63_K0.9300.46
368_K376_D0.9280.46
6_K234_E0.9270.46
55_K99_S0.9250.45
156_K159_K0.9240.45
2_R8_W0.9220.45
274_N373_L0.9210.45
17_V21_L0.9160.45
150_L155_K0.9160.45
118_K123_Q0.9150.45
303_K307_K0.9140.45
3_K13_D0.9090.44
270_K274_N0.9070.44
17_V214_L0.9050.44
267_R343_G0.9040.44
312_E316_R0.9040.44
359_E367_L0.9030.44
24_L34_P0.9030.44
171_L379_K0.9030.44
290_K342_L0.8960.43
96_K105_R0.8950.43
103_L109_L0.8950.43
10_K360_L0.8930.43
179_V184_A0.8910.43
339_P379_K0.8890.43
41_E44_F0.8890.43
92_K99_S0.8850.43
40_D233_E0.8840.42
362_G366_T0.8840.42
25_R196_L0.8820.42
48_T136_L0.8780.42
270_K277_K0.8750.42
280_K352_L0.8730.42
219_A359_E0.8720.42
236_F240_D0.8710.42
108_K112_R0.8710.42
243_E251_E0.8670.41
6_K241_E0.8650.41
264_R361_S0.8650.41
110_A114_R0.8630.41
149_F156_K0.8540.40
38_K42_E0.8520.40
298_Q305_I0.8450.40
72_L311_K0.8440.40
1_S7_A0.8440.40
260_N265_P0.8430.40
138_A141_D0.8420.39
310_A313_E0.8410.39
254_S257_E0.8400.39
2_R15_T0.8390.39
133_S309_I0.8370.39
285_K288_E0.8350.39
43_L49_T0.8350.39
344_K360_L0.8340.39
32_G71_I0.8340.39
57_K64_K0.8340.39
195_E209_K0.8280.39
76_S196_L0.8270.38
8_W32_G0.8250.38
65_P70_E0.8230.38
144_K147_D0.8230.38
356_L363_S0.8220.38
103_L347_F0.8170.38
52_E56_K0.8170.38
41_E233_E0.8160.38
19_E145_E0.8130.38
212_E216_R0.8130.38
190_F302_L0.8130.38
21_L211_E0.8110.37
32_G81_V0.8090.37
105_R110_A0.8090.37
7_A278_R0.8080.37
190_F378_F0.8060.37
348_P378_F0.8040.37
99_S257_E0.8010.37
251_E256_D0.8010.37
355_Q359_E0.7990.37
51_D54_V0.7980.36
157_K239_M0.7980.36
138_A289_E0.7970.36
63_K159_K0.7970.36
228_A231_A0.7950.36
228_A380_S0.7930.36
18_E286_A0.7920.36
201_V205_K0.7910.36
138_A249_E0.7870.36
359_E368_K0.7860.36
21_L27_E0.7850.36
104_A109_L0.7850.36
33_G37_E0.7840.36
78_V196_L0.7840.36
169_I324_K0.7830.35
102_E106_L0.7820.35
105_R109_L0.7790.35
210_E302_L0.7780.35
286_A289_E0.7780.35
56_K145_E0.7750.35
33_G61_K0.7750.35
6_K13_D0.7710.35
10_K32_G0.7700.35
267_R360_L0.7700.35
283_E286_A0.7680.34
20_F23_E0.7670.34
21_L268_K0.7650.34
72_L147_D0.7650.34
243_E247_E0.7580.34
64_K212_E0.7580.34
195_E295_K0.7520.33
99_S103_L0.7480.33
197_L201_V0.7480.33
248_E253_G0.7470.33
47_D183_G0.7450.33
163_T182_A0.7430.33
100_K132_G0.7430.33
256_D259_D0.7390.33
1_S9_R0.7390.33
161_P356_L0.7380.33
143_E312_E0.7380.33
25_R32_G0.7360.32
8_W187_N0.7340.32
245_E317_A0.7330.32
153_T158_V0.7280.32
116_G374_L0.7260.32
230_E236_F0.7250.32
138_A246_E0.7250.32
260_N263_K0.7210.31
301_R313_E0.7200.31
183_G193_H0.7190.31
99_S381_L0.7160.31
76_S370_E0.7160.31
304_S308_E0.7140.31
203_A261_K0.7090.31
17_V23_E0.7060.31
245_E325_R0.7060.31
297_K300_D0.7050.30
161_P187_N0.7040.30
111_K127_A0.7030.30
232_E237_E0.7020.30
94_K103_L0.7010.30
32_G187_N0.7010.30
63_K200_A0.7000.30
111_K212_E0.7000.30
355_Q369_P0.6990.30
46_V52_E0.6990.30
136_L337_L0.6980.30
213_K381_L0.6980.30
229_E235_L0.6970.30
203_A349_E0.6960.30
361_S366_T0.6950.30
271_A278_R0.6930.30
270_K278_R0.6920.30
153_T159_K0.6920.30
110_A136_L0.6920.30
314_E318_E0.6900.30
116_G126_E0.6890.29
268_K272_Q0.6860.29
278_R300_D0.6850.29
292_A295_K0.6840.29
279_R286_A0.6840.29
162_K255_E0.6840.29
217_Q221_I0.6840.29
132_G258_G0.6830.29
275_K345_H0.6820.29
245_E255_E0.6810.29
341_R345_H0.6800.29
278_R354_V0.6790.29
48_T202_E0.6780.29
65_P148_T0.6780.29
110_A113_K0.6750.29
205_K212_E0.6740.29
243_E253_G0.6730.29
41_E202_E0.6680.28
284_R302_L0.6670.28
134_Y363_S0.6640.28
342_L351_D0.6630.28
201_V208_L0.6620.28
347_F350_P0.6610.28
247_E287_K0.6610.28
25_R28_E0.6610.28
17_V20_F0.6590.28
37_E104_A0.6580.28
178_E316_R0.6560.28
209_K222_A0.6560.28
50_G360_L0.6520.27
360_L372_N0.6520.27
192_D302_L0.6510.27
272_Q381_L0.6500.27
222_A317_A0.6490.27
18_E46_V0.6480.27
71_I367_L0.6460.27
221_I229_E0.6450.27
201_V272_Q0.6400.27
56_K66_L0.6380.27
10_K70_E0.6380.27
222_A226_A0.6370.26
308_E348_P0.6360.26
355_Q375_R0.6350.26
235_L240_D0.6350.26
79_P105_R0.6330.26
216_R352_L0.6300.26
169_I342_L0.6290.26
204_E275_K0.6290.26
107_K112_R0.6290.26
100_K136_L0.6290.26
114_R118_K0.6280.26
65_P309_I0.6280.26
351_D356_L0.6280.26
362_G379_K0.6270.26
14_I18_E0.6260.26
269_T359_E0.6250.26
87_R177_V0.6240.26
225_A230_E0.6240.26
303_K381_L0.6230.26
202_E219_A0.6230.26
241_E245_E0.6220.26
180_P372_N0.6190.25
18_E192_D0.6190.25
197_L346_K0.6150.25
83_S380_S0.6140.25
139_D342_L0.6120.25
345_H354_V0.6100.25
267_R372_N0.6090.25
45_F55_K0.6090.25
243_E248_E0.6080.25
51_D110_A0.6070.25
183_G188_P0.6060.25
262_K266_K0.6060.25
67_K359_E0.6060.25
320_R324_K0.6050.25
9_R17_V0.6040.25
2_R5_K0.6040.25
98_V252_E0.6030.25
172_S368_K0.6010.24
287_K291_A0.6000.24
12_I373_L0.6000.24
184_A193_H0.5980.24
231_A235_L0.5970.24
186_Y371_G0.5940.24
199_K254_S0.5940.24
197_L316_R0.5940.24
192_D198_A0.5930.24
97_W286_A0.5920.24
358_D368_K0.5890.24
92_K354_V0.5890.24
274_N351_D0.5890.24
99_S248_E0.5880.24
205_K209_K0.5880.24
229_E233_E0.5880.24
51_D212_E0.5880.24
27_E84_S0.5860.24
27_E85_R0.5860.24
106_L112_R0.5860.24
340_R343_G0.5860.24
46_V95_K0.5830.24
117_A124_D0.5800.23
114_R280_K0.5780.23
118_K130_K0.5770.23
71_I370_E0.5760.23
203_A206_K0.5760.23
277_K360_L0.5760.23
67_K311_K0.5750.23
19_E29_R0.5740.23
81_V260_N0.5740.23
285_K378_F0.5740.23
136_L308_E0.5740.23
7_A22_E0.5740.23
169_I334_A0.5720.23
22_E76_S0.5710.23
200_A352_L0.5690.23
12_I15_T0.5680.23
17_V24_L0.5650.23
373_L376_D0.5640.23
167_K342_L0.5640.23
12_I151_F0.5630.22
282_E380_S0.5620.22
97_W250_E0.5620.22
303_K311_K0.5610.22
77_A290_K0.5600.22
304_S307_K0.5590.22
263_K381_L0.5590.22
81_V86_K0.5580.22
35_L210_E0.5580.22
242_S277_K0.5570.22
78_V195_E0.5570.22
367_L371_G0.5560.22
272_Q286_A0.5550.22
32_G267_R0.5520.22
204_E377_R0.5520.22
8_W25_R0.5500.22
177_V380_S0.5500.22
302_L339_P0.5490.22
23_E26_L0.5470.22
47_D293_K0.5470.22
7_A13_D0.5440.22
167_K246_E0.5430.21
29_R193_H0.5420.21
137_W185_S0.5410.21
41_E53_K0.5400.21
9_R12_I0.5400.21
22_E255_E0.5400.21
194_Q201_V0.5390.21
176_A269_T0.5390.21
40_D226_A0.5370.21
158_V324_K0.5370.21
258_G338_R0.5360.21
252_E259_D0.5350.21
89_N255_E0.5340.21
218_L221_I0.5340.21
339_P349_E0.5330.21
205_K380_S0.5330.21
334_A372_N0.5320.21
88_P91_K0.5310.21
90_A166_K0.5310.21
6_K12_I0.5300.21
45_F134_Y0.5300.21
193_H352_L0.5250.21
249_E259_D0.5240.21
195_E312_E0.5240.21
66_L80_A0.5230.21
56_K254_S0.5230.21
250_E259_D0.5200.20
292_A299_L0.5200.20
66_L69_D0.5200.20
341_R349_E0.5200.20
327_K334_A0.5190.20
85_R211_E0.5190.20
286_A296_L0.5180.20
343_G377_R0.5170.20
87_R242_S0.5160.20
281_E373_L0.5150.20
213_K276_E0.5150.20
321_E342_L0.5140.20
155_K344_K0.5130.20
16_D53_K0.5100.20
264_R344_K0.5100.20
246_E250_E0.5090.20
64_K70_E0.5050.20
139_D251_E0.5050.20
182_A347_F0.5050.20
103_L111_K0.5040.20
46_V49_T0.5040.20
353_E371_G0.5040.20
79_P140_D0.5030.20
61_K65_P0.5030.20
38_K211_E0.5030.20
16_D279_R0.5020.20
79_P180_P0.5010.19
100_K106_L0.5010.19
242_S245_E0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xi4J 1 0.1102 7.1 0.973 Contact Map
4hdqC 1 0.0131 2.9 0.978 Contact Map
1pulA 1 0.1207 2.8 0.978 Contact Map
1hcwA 1 0.0577 2.2 0.979 Contact Map
4j2nA 4 0.0577 2.1 0.979 Contact Map
1z4hA 1 0.0709 2.1 0.98 Contact Map
1iojA 1 0.0656 1.9 0.98 Contact Map
4gf3B 1 0.0105 1.7 0.981 Contact Map
1ezeA 1 0.0656 1.6 0.981 Contact Map
2l5gB 1 0.1102 1.5 0.981 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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