GREMLIN Database
DUF1618 - Protein of unknown function (DUF1618)
PFAM: PF07762 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 96 (92)
Sequences: 904 (752)
Seq/√Len: 78.4
META: 0.046

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
73_L77_L3.5601.00
71_A74_P3.1351.00
84_P88_S2.8791.00
73_L76_L2.5601.00
25_V28_S2.5271.00
30_I63_V2.3501.00
73_L78_P2.2581.00
72_G75_R2.2001.00
74_P77_L1.8781.00
6_R11_C1.8661.00
12_E36_S1.7831.00
46_T59_D1.7611.00
15_F21_P1.7471.00
69_W81_P1.7361.00
76_L79_L1.6891.00
24_D85_T1.6591.00
27_V32_F1.6121.00
4_L45_W1.5710.99
20_P51_P1.5610.99
42_V45_W1.5420.99
70_A75_R1.5350.99
48_S59_D1.4950.99
58_K62_T1.4900.99
36_S39_E1.4810.99
5_W8_I1.4650.99
40_W44_T1.4470.99
6_R13_L1.3750.99
10_L14_R1.3450.98
31_K92_P1.2980.98
44_T60_C1.2400.97
41_T46_T1.2370.97
27_V31_K1.2170.97
24_D34_E1.1640.96
30_I34_E1.1580.96
5_W96_Y1.1530.96
82_A85_T1.1490.96
85_T88_S1.1360.96
18_L95_V1.1300.95
42_V47_L1.1120.95
63_V68_I1.0880.94
2_V25_V1.0870.94
31_K59_D1.0850.94
71_A75_R1.0830.94
53_S57_R1.0650.94
62_T66_A1.0620.94
33_V39_E1.0560.93
41_T66_A1.0550.93
85_T96_Y1.0550.93
78_P81_P1.0490.93
7_G15_F1.0380.93
25_V83_F1.0340.93
2_V8_I0.9890.91
48_S60_C0.9820.91
40_W43_T0.9690.90
74_P78_P0.9640.90
55_E86_L0.9430.89
3_D83_F0.9320.88
42_V92_P0.8920.86
58_K93_D0.8900.86
17_P44_T0.8860.85
59_D93_D0.8550.83
46_T90_D0.8470.83
63_V67_D0.8450.83
29_D96_Y0.8300.82
28_S34_E0.8280.81
18_L35_I0.8270.81
4_L83_F0.8230.81
86_L92_P0.8190.81
27_V86_L0.8090.80
27_V91_D0.7980.79
15_F47_L0.7970.79
25_V34_E0.7900.78
30_I92_P0.7890.78
3_D7_G0.7830.78
47_L54_G0.7620.76
10_L35_I0.7480.74
35_I40_W0.7270.72
11_C94_V0.7250.72
41_T67_D0.7150.71
5_W15_F0.7080.70
72_G76_L0.7000.69
1_W31_K0.6990.69
6_R12_E0.6910.68
71_A80_V0.6900.68
39_E64_D0.6850.68
4_L66_A0.6840.68
26_A29_D0.6800.67
4_L8_I0.6800.67
45_W56_W0.6780.67
13_L60_C0.6720.66
33_V86_L0.6710.66
8_I44_T0.6680.66
8_I82_A0.6640.65
14_R67_D0.6590.65
28_S31_K0.6450.63
8_I39_E0.6450.63
11_C89_L0.6400.62
23_R34_E0.6400.62
15_F30_I0.6380.62
65_V81_P0.6290.61
68_I83_F0.6270.61
4_L11_C0.6130.59
12_E51_P0.6110.59
52_S70_A0.6100.59
5_W21_P0.6090.59
39_E47_L0.5980.57
82_A90_D0.5980.57
14_R54_G0.5930.57
16_V65_V0.5930.57
4_L92_P0.5900.56
71_A76_L0.5790.55
69_W82_A0.5770.55
32_F42_V0.5750.54
36_S82_A0.5740.54
41_T47_L0.5640.53
22_Y84_P0.5600.52
68_I94_V0.5570.52
43_T62_T0.5560.52
20_P43_T0.5550.52
8_I52_S0.5550.52
48_S57_R0.5530.52
66_A70_A0.5520.51
75_R78_P0.5430.50
20_P41_T0.5390.50
20_P65_V0.5320.49
24_D35_I0.5320.49
6_R10_L0.5300.49
8_I25_V0.5260.48
82_A91_D0.5250.48
12_E69_W0.5240.48
4_L13_L0.5230.48
39_E66_A0.5180.47
3_D23_R0.5150.47
15_F26_A0.5030.45
79_L95_V0.5030.45
26_A66_A0.5010.45
57_R64_D0.5010.45
67_D75_R0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2olmA 2 0.7812 7 0.915 Contact Map
3ljuX 1 0.7708 5 0.921 Contact Map
2iqjA 1 0.8021 4.6 0.922 Contact Map
3jueA 1 0.8125 4.5 0.922 Contact Map
2crrA 1 0.7917 4.1 0.924 Contact Map
4fg0A 3 0.7396 3.3 0.927 Contact Map
3p54A 3 0.75 3.1 0.928 Contact Map
3lvqE 1 0.8125 2.6 0.931 Contact Map
3hy0A 1 0.3958 2.5 0.932 Contact Map
4ohxA 1 0.3125 2.1 0.935 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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