GREMLIN Database
DUF1614 - Protein of unknown function (DUF1614)
PFAM: PF07758 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 171 (170)
Sequences: 2994 (2151)
Seq/√Len: 165.0
META: 0.923

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
83_V97_V4.5781.00
12_R41_G4.4711.00
138_N141_K4.4611.00
75_A125_S4.3951.00
82_V105_V3.3131.00
132_I136_L2.9161.00
62_L72_A2.8511.00
48_V52_V2.8341.00
80_A137_L2.7431.00
84_Y138_N2.5721.00
78_I109_V2.4151.00
11_A44_I2.2931.00
46_V51_A2.2841.00
13_L42_T2.2551.00
46_V55_V2.2531.00
97_V102_P2.2511.00
13_L44_I2.2191.00
90_V96_A2.0951.00
81_A85_L2.0571.00
141_K144_G1.9941.00
142_I150_A1.8351.00
79_V109_V1.8281.00
76_T80_A1.8221.00
128_L132_I1.8151.00
84_Y137_L1.8131.00
45_A149_V1.7551.00
104_L108_L1.7021.00
58_S61_L1.6871.00
135_D159_D1.6201.00
6_I48_V1.6081.00
3_G9_P1.5791.00
87_A95_I1.5021.00
117_Y120_P1.4961.00
80_A132_I1.4891.00
86_L97_V1.4871.00
24_S29_R1.4781.00
52_V56_L1.4371.00
86_L101_I1.4341.00
58_S123_Y1.4301.00
110_A125_S1.4201.00
76_T132_I1.3891.00
114_S117_Y1.3461.00
87_A138_N1.3231.00
75_A110_A1.3061.00
42_T150_A1.3041.00
58_S127_T1.3041.00
89_P95_I1.3001.00
81_A137_L1.2941.00
62_L124_I1.2781.00
103_P163_L1.2621.00
10_L44_I1.2511.00
22_E29_R1.2401.00
135_D138_N1.2381.00
10_L46_V1.2221.00
23_V27_G1.2211.00
51_A161_I1.2171.00
83_V130_T1.2011.00
159_D165_G1.1941.00
80_A84_Y1.1851.00
55_V58_S1.1621.00
35_V39_W1.1521.00
61_L64_R1.1471.00
25_F28_M1.1451.00
103_P106_A1.1331.00
164_T168_A1.1321.00
123_Y127_T1.1131.00
44_I150_A1.0971.00
126_G164_T1.0901.00
87_A134_A1.0891.00
23_V29_R1.0851.00
107_A118_A1.0851.00
110_A114_S1.0821.00
106_A110_A1.0821.00
17_R21_E1.0811.00
82_V101_I1.0600.99
72_A76_T1.0470.99
76_T128_L1.0360.99
62_L69_L1.0360.99
67_L121_L1.0320.99
57_L103_P1.0140.99
72_A124_I1.0000.99
71_R114_S0.9970.99
6_I57_L0.9930.99
2_L5_Y0.9890.99
6_I103_P0.9840.99
73_L77_A0.9820.99
108_L111_L0.9780.99
145_L148_P0.9770.99
79_V130_T0.9650.99
85_L89_P0.9650.99
27_G33_P0.9610.99
110_A113_L0.9460.99
121_L124_I0.9410.99
11_A15_S0.9290.99
58_S128_L0.9270.99
71_R121_L0.9140.98
1_L5_Y0.9140.98
55_V131_L0.9110.98
79_V83_V0.8840.98
106_A168_A0.8800.98
82_V86_L0.8790.98
61_L65_N0.8730.98
27_G32_V0.8710.98
130_T161_I0.8490.97
14_P41_G0.8480.97
93_V96_A0.8440.97
123_Y162_F0.8430.97
76_T125_S0.8400.97
23_V26_F0.8340.97
113_L116_E0.8250.97
16_E20_G0.8200.97
23_V32_V0.8160.97
134_A151_S0.8090.96
69_L73_L0.8090.96
72_A121_L0.8090.96
95_I134_A0.8060.96
69_L72_A0.8050.96
112_L115_R0.7990.96
61_L124_I0.7900.96
99_V163_L0.7810.96
48_V53_I0.7770.96
21_E25_F0.7770.96
34_V74_I0.7760.96
8_I48_V0.7700.95
94_G133_G0.7660.95
6_I59_L0.7590.95
139_L142_I0.7570.95
108_L112_L0.7560.95
45_A151_S0.7500.95
78_I105_V0.7460.94
166_I169_V0.7450.94
49_G158_F0.7380.94
75_A113_L0.7350.94
127_T165_G0.7350.94
140_G143_R0.7340.94
31_V34_V0.7290.94
32_V35_V0.7280.94
17_R40_P0.7190.93
27_G30_Y0.7160.93
2_L13_L0.7080.93
104_L107_A0.6980.92
44_I60_Y0.6970.92
22_E25_F0.6930.92
14_P18_P0.6900.92
103_P107_A0.6880.92
110_A115_R0.6880.92
20_G36_R0.6830.91
96_A99_V0.6830.91
156_G160_G0.6800.91
3_G126_G0.6790.91
20_G34_V0.6760.91
89_P93_V0.6760.91
165_G169_V0.6740.91
94_G102_P0.6650.90
25_F29_R0.6650.90
88_R140_G0.6650.90
19_V22_E0.6640.90
25_F30_Y0.6620.90
60_Y64_R0.6610.90
81_A116_E0.6590.90
107_A110_A0.6560.90
155_A168_A0.6540.90
23_V28_M0.6520.89
72_A75_A0.6520.89
83_V105_V0.6510.89
77_A81_A0.6510.89
126_G155_A0.6490.89
153_G156_G0.6450.89
120_P124_I0.6420.89
103_P164_T0.6420.89
5_Y127_T0.6410.89
97_V160_G0.6400.89
23_V31_V0.6400.89
162_F166_I0.6380.88
87_A97_V0.6370.88
84_Y140_G0.6350.88
18_P21_E0.6340.88
105_V109_V0.6310.88
22_E31_V0.6300.88
89_P169_V0.6290.88
115_R118_A0.6210.87
84_Y141_K0.6190.87
165_G168_A0.6160.87
155_A159_D0.6130.86
126_G160_G0.6130.86
111_L115_R0.6120.86
58_S124_I0.6100.86
34_V37_E0.6050.86
75_A126_G0.6040.86
95_I131_L0.6000.85
80_A83_V0.5990.85
70_L74_I0.5990.85
125_S129_G0.5970.85
11_A14_P0.5950.85
109_V125_S0.5900.84
127_T164_T0.5870.84
65_N117_Y0.5860.84
12_R15_S0.5830.84
24_S27_G0.5830.84
77_A132_I0.5820.83
89_P158_F0.5790.83
149_V167_L0.5780.83
84_Y88_R0.5760.83
53_I57_L0.5730.83
150_A168_A0.5680.82
75_A160_G0.5670.82
111_L118_A0.5670.82
98_P160_G0.5620.81
9_P60_Y0.5620.81
106_A164_T0.5600.81
83_V137_L0.5600.81
133_G139_L0.5590.81
36_R40_P0.5580.81
39_W81_A0.5550.80
2_L6_I0.5550.80
88_R103_P0.5540.80
24_S34_V0.5540.80
12_R116_E0.5540.80
157_T167_L0.5530.80
114_S118_A0.5530.80
18_P36_R0.5510.80
148_P164_T0.5500.80
63_L69_L0.5490.80
5_Y20_G0.5480.80
66_P88_R0.5470.80
85_L105_V0.5430.79
12_R16_E0.5420.79
29_R32_V0.5410.79
42_T157_T0.5390.79
100_F115_R0.5380.78
71_R74_I0.5370.78
94_G152_I0.5340.78
13_L17_R0.5310.78
122_A125_S0.5300.77
13_L16_E0.5280.77
14_P17_R0.5240.77
83_V87_A0.5230.76
15_S42_T0.5220.76
94_G131_L0.5180.76
51_A152_I0.5180.76
79_V129_G0.5170.76
12_R25_F0.5170.76
86_L102_P0.5160.76
33_P147_A0.5150.75
32_V36_R0.5150.75
16_E143_R0.5140.75
167_L170_L0.5110.75
37_E41_G0.5110.75
123_Y148_P0.5100.75
24_S31_V0.5100.75
29_R34_V0.5100.75
113_L118_A0.5090.75
20_G23_V0.5030.74
35_V40_P0.5020.74
162_F169_V0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4uzzA 1 0.2047 2 0.956 Contact Map
1y32A 1 0.0819 1.8 0.957 Contact Map
1rq8A 1 0.2339 1.5 0.959 Contact Map
2ksfA 1 0.5614 1.1 0.962 Contact Map
2nnuB 2 0.0936 0.9 0.964 Contact Map
3p5nA 2 0.5088 0.8 0.965 Contact Map
2k1kA 2 0.2222 0.8 0.965 Contact Map
2kncB 1 0.1813 0.8 0.965 Contact Map
4hzuS 1 0.5497 0.8 0.965 Contact Map
2k3cA 1 0.1287 0.8 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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