GREMLIN Database
Abi_2 - Abi-like protein
PFAM: PF07751 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 179 (176)
Sequences: 8372 (6695)
Seq/√Len: 504.6
META: 0.798

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
2_Y35_L2.8821.00
62_K153_E2.8081.00
68_S123_I2.7821.00
30_T33_D2.6431.00
136_S165_N2.4141.00
20_K25_K2.2321.00
170_I175_S2.1021.00
170_I177_L2.0691.00
15_W26_F2.0581.00
140_S158_E2.0421.00
142_L146_D1.9951.00
59_L161_L1.9611.00
15_W34_I1.9321.00
35_L39_E1.8741.00
66_H149_A1.8481.00
2_Y6_I1.8481.00
58_A154_F1.8431.00
101_E104_R1.7921.00
46_L50_D1.7661.00
162_H165_N1.7481.00
42_R54_R1.7421.00
19_R24_H1.7201.00
60_R135_L1.6721.00
136_S162_H1.6611.00
113_Y125_V1.6541.00
42_R53_E1.6461.00
62_K66_H1.6251.00
5_N58_A1.6021.00
11_L15_W1.5781.00
48_L177_L1.5491.00
122_P125_V1.5351.00
97_K100_K1.5281.00
52_I164_L1.5231.00
64_A127_V1.5101.00
6_I35_L1.4971.00
64_A68_S1.4921.00
66_H153_E1.4721.00
147_K158_E1.4521.00
101_E134_T1.4381.00
49_L53_E1.4381.00
109_F129_V1.4301.00
139_Y147_K1.4271.00
130_L134_T1.4251.00
16_Y19_R1.4241.00
71_G77_D1.4121.00
49_L171_C1.4041.00
167_L177_L1.4011.00
139_Y161_L1.3941.00
111_K115_N1.3811.00
36_A39_E1.3811.00
33_D36_A1.3501.00
131_S134_T1.3431.00
162_H166_Y1.3371.00
29_T34_I1.3081.00
97_K134_T1.3071.00
4_S153_E1.2861.00
75_Y126_L1.2861.00
140_S162_H1.2811.00
74_W123_I1.2741.00
70_Y146_D1.2641.00
18_F29_T1.2631.00
42_R50_D1.2581.00
97_K101_E1.2551.00
63_I139_Y1.2451.00
127_V135_L1.2291.00
50_D54_R1.2111.00
7_N10_R1.2101.00
98_I126_L1.2101.00
166_Y170_I1.2091.00
136_S161_L1.2061.00
98_I102_I1.2001.00
2_Y11_L1.1981.00
39_E42_R1.1781.00
139_Y158_E1.1731.00
43_E50_D1.1661.00
96_E100_K1.1641.00
130_L135_L1.1631.00
10_R57_V1.1491.00
132_F165_N1.1431.00
127_V130_L1.1351.00
87_H90_N1.1301.00
57_V60_R1.1301.00
20_K23_D1.1201.00
73_F113_Y1.1141.00
126_L130_L1.1081.00
38_Y57_V1.1051.00
94_L98_I1.0901.00
100_K104_R1.0881.00
20_K27_K1.0881.00
53_E174_H1.0871.00
45_R171_C1.0861.00
76_L120_Y1.0831.00
13_G16_Y1.0581.00
71_G74_W1.0511.00
95_L99_K1.0491.00
52_I171_C1.0431.00
73_F76_L1.0401.00
74_W80_N1.0381.00
113_Y118_P1.0291.00
67_L123_I1.0161.00
137_K165_N1.0091.00
58_A62_K0.9961.00
59_L135_L0.9941.00
99_K103_K0.9761.00
49_L52_I0.9741.00
77_D80_N0.9721.00
110_I121_P0.9671.00
49_L172_A0.9621.00
137_K140_S0.9561.00
47_L51_A0.9551.00
32_E36_A0.9461.00
143_K146_D0.9431.00
110_I129_V0.9411.00
7_N127_V0.9401.00
63_I142_L0.9401.00
39_E43_E0.9341.00
76_L99_K0.9331.00
73_F120_Y0.9311.00
144_D148_K0.9171.00
124_W128_E0.9071.00
110_I113_Y0.9061.00
151_A157_L0.9051.00
51_A54_R0.9041.00
2_Y39_E0.9031.00
134_T137_K0.9001.00
136_S158_E0.8991.00
122_P128_E0.8981.00
66_H69_K0.8971.00
67_L146_D0.8921.00
109_F113_Y0.8911.00
96_E99_K0.8901.00
12_S19_R0.8861.00
139_Y150_I0.8811.00
163_S167_L0.8791.00
174_H178_W0.8771.00
61_T65_Y0.8731.00
67_L80_N0.8591.00
12_S16_Y0.8531.00
134_T138_L0.8531.00
7_N61_T0.8521.00
12_S15_W0.8511.00
48_L171_C0.8511.00
4_S62_K0.8511.00
18_F34_I0.8491.00
146_D149_A0.8461.00
99_K120_Y0.8451.00
62_K154_F0.8451.00
145_K149_A0.8421.00
147_K151_A0.8351.00
168_R173_H0.8301.00
64_A123_I0.8281.00
41_D45_R0.8281.00
85_F141_N0.8211.00
15_W19_R0.8201.00
65_Y68_S0.8121.00
59_L139_Y0.7931.00
69_K149_A0.7771.00
108_D111_K0.7731.00
13_G17_P0.7691.00
128_E175_S0.7691.00
60_R174_H0.7651.00
130_L138_L0.7651.00
83_N87_H0.7601.00
163_S166_Y0.7571.00
6_I11_L0.7571.00
33_D37_L0.7501.00
62_K65_Y0.7461.00
10_R128_E0.7381.00
66_H146_D0.7271.00
82_N85_F0.7221.00
169_N173_H0.7131.00
2_Y5_N0.7121.00
98_I130_L0.7111.00
159_S163_S0.7091.00
102_I110_I0.7051.00
12_S24_H0.7041.00
149_A153_E0.6981.00
102_I105_S0.6941.00
83_N86_K0.6931.00
42_R46_L0.6891.00
5_N62_K0.6821.00
4_S65_Y0.6821.00
160_W163_S0.6801.00
113_Y117_Y0.6781.00
112_H116_K0.6781.00
75_Y120_Y0.6761.00
136_S140_S0.6741.00
111_K114_K0.6711.00
142_L150_I0.6681.00
102_I114_K0.6661.00
113_Y122_P0.6651.00
9_Y13_G0.6611.00
144_D147_K0.6601.00
63_I138_L0.6571.00
11_L35_L0.6541.00
22_R25_K0.6531.00
19_R22_R0.6481.00
148_K152_K0.6461.00
47_L50_D0.6441.00
78_P84_K0.6431.00
109_F125_V0.6391.00
123_I128_E0.6351.00
63_I135_L0.6311.00
78_P88_K0.6311.00
99_K102_I0.6301.00
98_I101_E0.6261.00
90_N94_L0.6251.00
151_A154_F0.6201.00
32_E35_L0.6201.00
74_W81_F0.6181.00
128_E135_L0.6161.00
19_R23_D0.6161.00
74_W77_D0.6111.00
67_L138_L0.6081.00
101_E131_S0.6050.99
46_L53_E0.6040.99
139_Y151_A0.6030.99
176_R179_N0.5970.99
112_H124_W0.5970.99
18_F37_L0.5920.99
46_L49_L0.5900.99
55_I59_L0.5880.99
36_A40_F0.5880.99
97_K104_R0.5880.99
89_K93_K0.5820.99
6_I38_Y0.5810.99
110_I114_K0.5800.99
67_L142_L0.5740.99
125_V128_E0.5730.99
86_K90_N0.5720.99
67_L74_W0.5710.99
40_F178_W0.5690.99
4_S61_T0.5680.99
161_L165_N0.5620.99
19_R25_K0.5610.99
157_L161_L0.5600.99
69_K145_K0.5600.99
10_R38_Y0.5550.99
121_P126_L0.5540.99
105_S114_K0.5540.99
50_D53_E0.5460.99
6_I10_R0.5460.99
109_F128_E0.5450.99
131_S165_N0.5430.99
150_I154_F0.5410.99
99_K119_G0.5400.99
103_K106_K0.5350.99
123_I127_V0.5330.99
73_F118_P0.5300.99
95_L98_I0.5300.99
43_E47_L0.5290.99
135_L138_L0.5290.99
112_H117_Y0.5220.98
102_I126_L0.5210.98
40_F44_L0.5200.98
34_I37_L0.5190.98
85_F88_K0.5190.98
18_F33_D0.5170.98
126_L135_L0.5160.98
29_T33_D0.5110.98
93_K97_K0.5080.98
19_R26_F0.5040.98
16_Y108_D0.5030.98
88_K99_K0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2b6gA 1 0.3687 4.4 0.937 Contact Map
3hilA 1 0.2905 3.8 0.939 Contact Map
3kkaC 1 0.3184 3.8 0.939 Contact Map
1regX 2 0.4581 3.8 0.94 Contact Map
2es6A 1 0.3687 3.3 0.941 Contact Map
3h8mA 1 0.324 3.1 0.942 Contact Map
2ksoA 1 0.3296 3.1 0.942 Contact Map
1ucvA 1 0.3743 3.1 0.942 Contact Map
2d3dA 1 0.3687 2.7 0.944 Contact Map
2k4pA 1 0.2961 2.7 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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