GREMLIN Database
FBA_2 - F-box associated
PFAM: PF07735 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 64 (61)
Sequences: 1229 (1012)
Seq/√Len: 129.5
META: 0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_N49_K5.1591.00
50_H55_S2.8051.00
54_G57_P2.7531.00
47_F56_N2.4621.00
24_L47_F2.3211.00
4_K7_I2.0371.00
30_K58_R1.8061.00
8_Q13_L1.7991.00
46_R50_H1.7741.00
52_I56_N1.6691.00
29_C32_I1.6141.00
27_M32_I1.6061.00
17_S37_S1.5881.00
43_D46_R1.3421.00
33_E61_Y1.3181.00
23_D41_N1.3081.00
13_L27_M1.2941.00
31_T61_Y1.2351.00
28_N64_I1.2201.00
47_F55_S1.2171.00
41_N48_L1.2130.99
19_I27_M1.2040.99
5_I17_S1.2030.99
30_K60_E1.1470.99
12_S33_E1.1180.99
37_S64_I1.0920.99
19_I40_T1.0860.99
14_S33_E1.0550.99
31_T52_I1.0360.98
38_S42_K1.0240.98
9_N28_N1.0080.98
30_K49_K1.0030.98
18_F35_E0.9540.97
6_L26_L0.9370.97
28_N47_F0.9090.96
16_G35_E0.8860.96
23_D28_N0.8470.95
51_W61_Y0.8430.94
21_L25_L0.8270.94
53_A57_P0.8260.94
32_I36_N0.8250.94
5_I43_D0.8180.93
24_L36_N0.8170.93
43_D64_I0.8170.93
16_G38_S0.8060.93
21_L30_K0.7930.92
45_N56_N0.7800.92
12_S30_K0.7750.92
15_I32_I0.7620.91
26_L31_T0.7510.90
49_K56_N0.7410.90
44_L63_S0.7330.89
41_N55_S0.7260.89
9_N26_L0.7200.88
28_N58_R0.7180.88
10_F13_L0.7090.87
50_H58_R0.7020.87
5_I48_L0.7000.87
4_K34_L0.7000.87
26_L38_S0.6750.85
15_I59_L0.6610.84
11_D58_R0.6550.83
32_I54_G0.6540.83
18_F38_S0.6470.82
22_D46_R0.6370.81
7_I46_R0.6340.81
12_S15_I0.6220.80
19_I39_L0.6200.80
24_L62_L0.6190.79
39_L43_D0.6120.79
10_F29_C0.6070.78
46_R61_Y0.6040.78
18_F33_E0.6010.77
30_K46_R0.5910.76
30_K62_L0.5750.74
6_L27_M0.5670.73
8_Q42_K0.5620.73
21_L38_S0.5570.72
12_S52_I0.5530.71
41_N46_R0.5430.70
19_I46_R0.5420.70
20_T23_D0.5410.70
11_D14_S0.5380.69
21_L59_L0.5350.69
31_T63_S0.5340.69
42_K60_E0.5260.68
4_K48_L0.5190.67
60_E63_S0.5150.66
16_G36_N0.5080.65
35_E64_I0.5040.64
26_L60_E0.5040.64
35_E38_S0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4kxfK 4 1 8.1 0.856 Contact Map
4pq8A 1 0.9688 7.6 0.858 Contact Map
2ra8A 2 1 6.9 0.861 Contact Map
1m9sA 1 0.8438 6.3 0.863 Contact Map
4r5cA 1 0.9375 5.8 0.866 Contact Map
4r6gA 1 0.9688 5.2 0.868 Contact Map
4r5dA 1 0.9375 4.8 0.87 Contact Map
1h6tA 1 0.8438 4.5 0.873 Contact Map
4fkeA 1 0.9688 4.2 0.874 Contact Map
4wz9A 2 0.9844 4.2 0.874 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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