GREMLIN Database
FBA_1 - F-box associated
PFAM: PF07734 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 164 (163)
Sequences: 1403 (1192)
Seq/√Len: 93.4
META: 0.073

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
117_K139_E4.2021.00
7_N28_F3.4571.00
26_F33_F3.3141.00
8_T28_F2.8011.00
149_G152_S2.7401.00
89_K92_T2.5621.00
23_L26_F2.5311.00
14_D36_R2.4121.00
9_Y80_I2.2501.00
79_K84_A2.2481.00
102_F105_F2.2481.00
3_S9_Y2.0241.00
77_T85_V2.0051.00
40_P75_W1.9691.00
59_K114_E1.9411.00
9_Y85_V1.8191.00
10_W131_R1.8161.00
142_Y145_E1.7901.00
17_T20_E1.7681.00
155_W162_V1.7391.00
140_D144_K1.7141.00
145_E148_L1.7121.00
56_R80_I1.7091.00
118_V127_G1.6851.00
161_Y164_S1.6451.00
23_L146_V1.6381.00
72_I93_V1.6191.00
141_G144_K1.6181.00
5_K9_Y1.6051.00
154_C158_V1.5951.00
73_E89_K1.5791.00
16_E20_E1.5521.00
10_W124_K1.5331.00
3_S7_N1.5331.00
139_E144_K1.5301.00
5_K77_T1.5291.00
12_A24_L1.5011.00
90_F112_I1.4861.00
89_K162_V1.4811.00
5_K8_T1.4601.00
4_L61_A1.4541.00
157_L160_S1.4411.00
145_E152_S1.4160.99
128_K153_Y1.4140.99
54_V137_I1.4030.99
1_G81_E1.3340.99
11_F16_E1.3020.99
3_S39_L1.2890.99
55_V93_V1.2770.99
110_F113_D1.2770.99
3_S6_G1.2730.99
159_C162_V1.2650.99
46_S129_D1.2630.99
131_R145_E1.2610.99
146_V158_V1.2590.99
63_L109_S1.2430.99
74_I134_A1.2350.98
51_T122_F1.2300.98
5_K58_E1.2110.98
132_N148_L1.2090.98
82_P134_A1.1970.98
154_C157_L1.1930.98
91_L94_D1.1910.98
110_F114_E1.1560.98
53_S117_K1.1360.97
132_N145_E1.1360.97
156_P163_P1.1320.97
32_R92_T1.1230.97
12_A50_V1.1130.97
53_S110_F1.1130.97
25_C84_A1.0970.97
151_S155_W1.0840.96
75_W136_I1.0770.96
140_D143_F1.0770.96
149_G153_Y1.0650.96
10_W83_N1.0290.95
141_G145_E1.0260.95
7_N25_C1.0220.95
127_G130_T1.0010.95
22_F36_R0.9980.94
82_P85_V0.9950.94
4_L36_R0.9880.94
10_W147_D0.9860.94
58_E61_A0.9820.94
34_G37_L0.9710.94
10_W14_D0.9700.94
55_V81_E0.9640.93
28_F77_T0.9500.93
9_Y77_T0.9380.92
24_L29_T0.9360.92
21_G69_T0.9330.92
2_V25_C0.9320.92
55_V58_E0.9230.92
153_Y156_P0.9170.91
61_A134_A0.9170.91
4_L12_A0.9150.91
59_K62_V0.9090.91
148_L159_C0.9080.91
90_F138_G0.9070.91
144_K147_D0.9040.91
130_T143_F0.8970.91
156_P160_S0.8970.91
54_V133_T0.8940.90
53_S56_R0.8790.90
29_T110_F0.8770.90
94_D119_A0.8770.90
35_P38_P0.8770.90
155_W160_S0.8740.89
48_D123_D0.8710.89
136_I140_D0.8710.89
152_S155_W0.8650.89
69_T72_I0.8620.89
51_T84_A0.8620.89
32_R147_D0.8480.88
124_K132_N0.8450.88
2_V10_W0.8440.88
55_V114_E0.8420.88
9_Y33_F0.8390.87
56_R113_D0.8360.87
53_S114_E0.8350.87
75_W89_K0.8340.87
7_N53_S0.8260.87
24_L124_K0.8210.86
74_I109_S0.8210.86
10_W145_E0.8190.86
59_K77_T0.8170.86
35_P64_F0.8130.86
142_Y147_D0.8120.86
13_S18_E0.8100.86
6_G9_Y0.8040.85
5_K37_L0.7980.85
113_D117_K0.7970.85
147_D150_E0.7970.85
7_N61_A0.7950.84
114_E128_K0.7870.84
24_L73_E0.7860.84
38_P86_S0.7810.83
76_V85_V0.7770.83
58_E115_E0.7680.82
148_L151_S0.7630.82
73_E112_I0.7600.82
98_L112_I0.7550.81
15_K104_D0.7530.81
125_D159_C0.7530.81
60_L63_L0.7510.81
3_S63_L0.7450.80
43_S98_L0.7440.80
41_F62_V0.7430.80
1_G88_S0.7420.80
22_F64_F0.7380.80
126_T129_D0.7370.80
90_F93_V0.7370.80
97_P100_G0.7350.79
46_S66_R0.7290.79
119_A133_T0.7280.79
9_Y82_P0.7210.78
61_A135_Y0.7060.77
121_C124_K0.7020.76
94_D97_P0.7010.76
15_K50_V0.6990.76
22_F42_H0.6990.76
77_T135_Y0.6980.76
48_D64_F0.6940.75
58_E136_I0.6930.75
66_R101_L0.6890.75
79_K162_V0.6860.75
26_F31_E0.6820.74
69_T99_P0.6790.74
17_T21_G0.6720.73
84_A92_T0.6720.73
153_Y158_V0.6690.73
143_F146_V0.6680.73
101_L107_G0.6670.73
4_L77_T0.6650.72
44_D47_Y0.6610.72
132_N135_Y0.6580.72
76_V135_Y0.6550.71
35_P50_V0.6540.71
155_W164_S0.6520.71
92_T131_R0.6490.71
10_W26_F0.6460.70
7_N24_L0.6420.70
26_F163_P0.6420.70
15_K46_S0.6400.69
141_G146_V0.6340.69
16_E21_G0.6330.69
71_K107_G0.6290.68
10_W75_W0.6290.68
11_F36_R0.6290.68
11_F140_D0.6290.68
29_T34_G0.6230.67
35_P83_N0.6160.67
24_L84_A0.6080.66
4_L141_G0.6060.65
132_N139_E0.6030.65
96_P99_P0.6020.65
118_V121_C0.6010.65
75_W87_W0.6000.65
137_I144_K0.5990.64
33_F72_I0.5990.64
49_T147_D0.5950.64
30_T133_T0.5910.63
15_K137_I0.5900.63
11_F32_R0.5840.62
86_S91_L0.5840.62
23_L50_V0.5840.62
63_L76_V0.5800.62
35_P59_K0.5780.62
148_L158_V0.5770.62
12_A36_R0.5720.61
152_S156_P0.5720.61
97_P101_L0.5710.61
56_R162_V0.5700.61
119_A129_D0.5690.60
77_T80_I0.5580.59
23_L133_T0.5570.59
4_L71_K0.5490.58
88_S115_E0.5480.58
111_F119_A0.5480.58
53_S58_E0.5470.57
147_D155_W0.5450.57
81_E115_E0.5430.57
78_T90_F0.5410.57
28_F109_S0.5380.56
146_V151_S0.5370.56
39_L87_W0.5280.55
144_K160_S0.5280.55
28_F80_I0.5280.55
59_K82_P0.5240.54
44_D68_D0.5230.54
151_S154_C0.5190.54
74_I154_C0.5190.54
93_V96_P0.5170.53
150_E156_P0.5170.53
16_E19_E0.5140.53
7_N12_A0.5110.52
85_V90_F0.5100.52
58_E77_T0.5090.52
138_G162_V0.5070.52
109_S113_D0.5060.52
15_K65_Q0.5050.52
106_S129_D0.5040.52
9_Y86_S0.5020.51
113_D119_A0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wozA 2 0.6524 68.3 0.895 Contact Map
2uvkA 2 0.5061 49 0.906 Contact Map
4ascA 1 0.6463 44.6 0.909 Contact Map
3ii7A 1 0.6159 42 0.91 Contact Map
2vpjA 1 0.6037 38.9 0.912 Contact Map
4unmA 1 0.9451 27.6 0.918 Contact Map
1zgkA 1 0.5915 23.9 0.921 Contact Map
4yy8A 2 0.6037 22.8 0.922 Contact Map
4chbA 1 0.3171 16.2 0.927 Contact Map
1a7gE 2 0.3171 12.2 0.931 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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