GREMLIN Database
7TMR-HDED - 7TM-HD extracellular
PFAM: PF07697 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 211 (207)
Sequences: 13143 (11518)
Seq/√Len: 800.6
META: 0.901

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_D161_D3.5751.00
32_A173_R3.5521.00
170_E174_E2.7381.00
188_V191_R2.6751.00
162_E166_E2.6061.00
29_E33_A2.4511.00
197_T200_Q2.3271.00
25_E28_R2.2861.00
25_E29_E2.2841.00
164_A167_A2.1651.00
191_R194_E2.1001.00
124_A128_L2.0981.00
161_D164_A2.0041.00
125_R129_R1.9981.00
20_D23_A1.8661.00
26_A30_E1.8551.00
123_E127_A1.8351.00
32_A169_R1.8221.00
183_V203_K1.8081.00
15_D184_K1.7811.00
190_V200_Q1.7401.00
190_V196_V1.7351.00
166_E169_R1.7151.00
27_E30_E1.7141.00
167_A171_E1.7071.00
166_E170_E1.6961.00
164_A168_A1.6961.00
125_R128_L1.6931.00
9_D191_R1.6861.00
17_P182_T1.6841.00
201_L205_E1.6471.00
184_K187_E1.5991.00
56_F153_L1.5601.00
23_A26_A1.5561.00
171_E175_A1.5531.00
21_E25_E1.5421.00
168_A171_E1.5111.00
29_E32_A1.5101.00
205_E208_G1.4941.00
80_L83_Y1.4911.00
124_A127_A1.4831.00
11_I188_V1.4801.00
19_K24_T1.4711.00
20_D24_T1.4631.00
199_E203_K1.4541.00
38_V168_A1.4501.00
28_R173_R1.4271.00
196_V201_L1.4231.00
198_E202_E1.4141.00
88_E148_E1.4121.00
49_Q52_R1.4061.00
200_Q203_K1.4011.00
187_E203_K1.3941.00
127_A131_Q1.3881.00
187_E195_I1.3741.00
9_D188_V1.3431.00
15_D182_T1.3411.00
160_Y165_T1.3331.00
30_E33_A1.3041.00
45_V49_Q1.2951.00
170_E173_R1.2951.00
28_R32_A1.2941.00
128_L131_Q1.2891.00
9_D192_K1.2891.00
111_L115_L1.2881.00
85_S88_E1.2881.00
35_V165_T1.2831.00
42_D45_V1.2801.00
2_V201_L1.2791.00
5_V195_I1.2731.00
127_A130_E1.2591.00
171_E174_E1.2561.00
88_E91_A1.2551.00
194_E200_Q1.2541.00
2_V198_E1.2411.00
123_E128_L1.2301.00
35_V172_A1.2301.00
77_K81_G1.2221.00
46_A50_L1.2191.00
17_P180_R1.2061.00
39_Y160_Y1.2051.00
19_K180_R1.2041.00
61_D104_E1.1971.00
24_T28_R1.1951.00
50_L112_E1.1871.00
54_R108_L1.1811.00
188_V194_E1.1701.00
75_E78_E1.1671.00
96_S99_E1.1581.00
50_L54_R1.1561.00
172_A175_A1.1511.00
142_L145_L1.1341.00
37_P160_Y1.1261.00
22_E26_A1.1141.00
68_S71_E1.1051.00
6_A190_V1.0971.00
52_R155_R1.0931.00
26_A29_E1.0891.00
19_K178_P1.0791.00
15_D185_K1.0771.00
51_E55_A1.0751.00
163_E167_A1.0511.00
71_E74_E1.0481.00
69_L73_L1.0441.00
12_A183_V1.0391.00
106_E109_R1.0371.00
73_L77_K1.0351.00
79_A83_Y1.0311.00
126_E129_R1.0291.00
169_R173_R1.0131.00
18_I181_G1.0101.00
30_E34_A1.0061.00
19_K27_E1.0031.00
31_A34_A1.0001.00
73_L76_L0.9991.00
13_P207_L0.9981.00
24_T178_P0.9941.00
11_I192_K0.9931.00
126_E130_E0.9931.00
71_E75_E0.9931.00
72_K75_E0.9921.00
74_E77_K0.9721.00
129_R133_S0.9711.00
32_A170_E0.9661.00
77_K80_L0.9661.00
101_E105_D0.9651.00
139_S142_L0.9631.00
76_L80_L0.9571.00
31_A176_V0.9471.00
48_E155_R0.9441.00
168_A172_A0.9411.00
20_D181_G0.9391.00
123_E126_E0.9351.00
16_F207_L0.9311.00
144_E147_A0.9301.00
48_E52_R0.9291.00
20_D202_E0.9201.00
84_L89_L0.9201.00
109_R113_R0.9191.00
87_E91_A0.9181.00
67_A71_E0.9171.00
202_E205_E0.9171.00
78_E81_G0.9151.00
72_K80_L0.9131.00
147_A151_S0.9131.00
84_L88_E0.9131.00
69_L72_K0.9071.00
107_L111_L0.8971.00
16_F183_V0.8971.00
47_E51_E0.8941.00
42_D159_F0.8901.00
75_E79_A0.8851.00
130_E134_A0.8851.00
105_D109_R0.8791.00
143_R146_V0.8781.00
131_Q134_A0.8781.00
68_S72_K0.8761.00
167_A170_E0.8661.00
29_E173_R0.8661.00
24_T27_E0.8651.00
74_E78_E0.8651.00
150_L153_L0.8581.00
110_V114_I0.8571.00
31_A172_A0.8541.00
54_R104_E0.8501.00
22_E25_E0.8481.00
104_E108_L0.8411.00
23_A27_E0.8331.00
53_L57_F0.8201.00
144_E148_E0.8191.00
54_R58_D0.8151.00
91_A94_S0.8121.00
49_Q153_L0.8111.00
61_D64_R0.8071.00
189_I207_L0.8041.00
31_A173_R0.8031.00
124_A131_Q0.8021.00
57_F104_E0.7971.00
28_R178_P0.7951.00
100_L104_E0.7931.00
55_A59_A0.7861.00
131_Q135_L0.7831.00
27_E179_V0.7821.00
108_L114_I0.7791.00
37_P169_R0.7761.00
142_L146_V0.7761.00
143_R147_A0.7701.00
125_R130_E0.7701.00
102_A106_E0.7671.00
20_D27_E0.7651.00
203_K206_S0.7641.00
84_L87_E0.7641.00
46_A157_N0.7581.00
72_K76_L0.7541.00
24_T179_V0.7491.00
38_V164_A0.7481.00
112_E116_R0.7471.00
108_L112_E0.7461.00
44_E48_E0.7431.00
48_E51_E0.7401.00
60_I63_V0.7361.00
70_E74_E0.7331.00
85_S89_L0.7301.00
86_D90_A0.7291.00
87_E90_A0.7281.00
124_A129_R0.7281.00
32_A172_A0.7281.00
197_T201_L0.7261.00
32_A35_V0.7191.00
6_A196_V0.7191.00
58_D62_E0.7181.00
49_Q155_R0.7121.00
45_V48_E0.7071.00
132_L135_L0.7061.00
72_K79_A0.6991.00
31_A35_V0.6931.00
99_E102_A0.6921.00
105_D108_L0.6821.00
99_E142_L0.6811.00
20_D25_E0.6771.00
110_V113_R0.6761.00
173_R176_V0.6741.00
6_A9_D0.6721.00
41_Y158_L0.6721.00
72_K81_G0.6701.00
77_K83_Y0.6691.00
27_E31_A0.6661.00
123_E131_Q0.6631.00
199_E202_E0.6601.00
53_L107_L0.6591.00
46_A49_Q0.6561.00
51_E54_R0.6551.00
2_V5_V0.6511.00
4_D7_P0.6501.00
31_A169_R0.6481.00
125_R131_Q0.6431.00
95_L99_E0.6381.00
19_K23_A0.6381.00
16_F206_S0.6351.00
70_E73_L0.6321.00
140_E143_R0.6321.00
79_A82_L0.6321.00
106_E110_V0.6271.00
90_A94_S0.6261.00
77_K82_L0.6251.00
67_A72_K0.6231.00
99_E104_E0.6211.00
59_A62_E0.6211.00
163_E166_E0.6161.00
67_A70_E0.6141.00
111_L118_G0.6121.00
12_A207_L0.6121.00
118_G122_D0.6121.00
180_R202_E0.6041.00
115_L118_G0.6041.00
23_A180_R0.5941.00
128_L132_L0.5921.00
129_R151_S0.5881.00
202_E206_S0.5841.00
95_L100_L0.5751.00
169_R172_A0.5751.00
57_F61_D0.5741.00
44_E47_E0.5741.00
35_V168_A0.5721.00
53_L56_F0.5711.00
179_V182_T0.5691.00
107_L150_L0.5681.00
11_I193_G0.5681.00
190_V204_L0.5681.00
52_R56_F0.5651.00
50_L108_L0.5641.00
113_R116_R0.5641.00
76_L81_G0.5621.00
35_V169_R0.5531.00
124_A132_L0.5521.00
153_L156_P0.5521.00
111_L114_I0.5521.00
107_L146_V0.5521.00
66_E69_L0.5521.00
72_K77_K0.5501.00
165_T169_R0.5491.00
76_L83_Y0.5471.00
14_F207_L0.5461.00
40_D159_F0.5441.00
145_L148_E0.5441.00
40_D164_A0.5421.00
106_E111_L0.5421.00
67_A75_E0.5411.00
47_E50_L0.5411.00
73_L80_L0.5381.00
149_L153_L0.5341.00
124_A130_E0.5331.00
43_P47_E0.5321.00
16_F189_I0.5311.00
181_G206_S0.5251.00
138_L142_L0.5211.00
118_G158_L0.5171.00
69_L75_E0.5171.00
73_L79_A0.5171.00
129_R147_A0.5171.00
129_R135_L0.5111.00
52_R55_A0.5071.00
183_V187_E0.5071.00
111_L153_L0.5041.00
45_V155_R0.5031.00
69_L76_L0.5011.00
75_E83_Y0.5011.00
38_V165_T0.5011.00
65_S68_S0.5001.00
196_V200_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3uknA 2 0.5545 14.6 0.923 Contact Map
3e6cC 2 0.2559 12.5 0.925 Contact Map
4ollA 1 0.2986 11.9 0.926 Contact Map
4d7sA 3 0.5592 11.9 0.926 Contact Map
3bpzA 3 0.564 11.2 0.927 Contact Map
4rz7A 2 0.4171 11.2 0.927 Contact Map
2ptmA 3 0.564 9.2 0.929 Contact Map
1o7fA 1 0.3649 8 0.931 Contact Map
3dn7A 2 0.2844 7.9 0.931 Contact Map
4l11A 1 0.5498 7.5 0.932 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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