7TMR-DISM_7TM - PFAM28P - GREMLIN Contacts

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7TMR-DISM_7TM - 7TM diverse intracellular signalling

PFAM:	PF07695	Sequences: ENLLLGLFFGILLALALYNLFLFLSLRDRSYLYYALYLLSLALYLLSLSGLLFQYLWPDLPWWLNNRLEYLSLALALIFFLLFARSFLELKRSPRLDRLLLALALLLALLLLLLPLLPYSLALPLAQLLALLLLLLLLVVGIRAWRRGRRPARYFLLGWLLLLLGALLDILRLLGLLPSNFFTEYLLQIGSLLEVLLLSLALADR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	205 (200)
Sequences:	23451 (20405)
Seq/√Len:	1442.8
META:	0.837

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
85_R	97_D	4.200	1.00
63_W	67_R	2.688	1.00
33_Y	86_S	2.667	1.00
97_D	101_L	2.583	1.00
89_E	92_R	2.549	1.00
145_W	153_R	2.429	1.00
23_F	32_L	2.395	1.00
98_R	101_L	2.391	1.00
139_V	143_R	2.351	1.00
16_A	35_A	2.350	1.00
11_I	14_A	2.342	1.00
29_R	86_S	2.318	1.00
142_I	146_R	2.192	1.00
7_L	10_G	2.163	1.00
97_D	100_L	2.123	1.00
161_L	193_L	2.100	1.00
34_Y	194_E	2.065	1.00
95_R	99_L	2.056	1.00
40_S	79_F	1.975	1.00
143_R	147_R	1.968	1.00
95_R	98_R	1.940	1.00
52_L	57_W	1.933	1.00
194_E	198_L	1.916	1.00
30_S	86_S	1.904	1.00
84_A	155_F	1.899	1.00
98_R	102_A	1.878	1.00
38_L	195_V	1.814	1.00
49_S	188_Q	1.806	1.00
19_N	199_S	1.803	1.00
16_A	39_L	1.791	1.00
101_L	105_L	1.738	1.00
11_I	192_L	1.723	1.00
33_Y	82_L	1.700	1.00
90_L	97_D	1.697	1.00
118_P	121_L	1.688	1.00
99_L	102_A	1.686	1.00
36_L	79_F	1.663	1.00
185_Y	188_Q	1.647	1.00
85_R	101_L	1.616	1.00
87_F	201_A	1.611	1.00
37_Y	194_E	1.608	1.00
135_L	139_V	1.599	1.00
144_A	149_R	1.568	1.00
19_N	31_Y	1.558	1.00
144_A	147_R	1.556	1.00
12_L	42_A	1.536	1.00
148_G	152_A	1.533	1.00
171_L	176_L	1.531	1.00
5_L	188_Q	1.504	1.00
9_F	49_S	1.480	1.00
91_K	97_D	1.475	1.00
20_L	35_A	1.451	1.00
180_N	183_T	1.425	1.00
8_F	191_S	1.405	1.00
145_W	156_L	1.404	1.00
143_R	146_R	1.388	1.00
40_S	75_L	1.372	1.00
74_A	78_I	1.359	1.00
43_L	72_S	1.337	1.00
102_A	106_L	1.328	1.00
68_L	72_S	1.327	1.00
102_A	105_L	1.312	1.00
153_R	157_L	1.307	1.00
40_S	44_Y	1.277	1.00
101_L	104_A	1.271	1.00
141_G	156_L	1.268	1.00
121_L	124_P	1.267	1.00
46_L	52_L	1.258	1.00
182_F	186_L	1.253	1.00
12_L	195_V	1.246	1.00
105_L	109_L	1.244	1.00
16_A	42_A	1.236	1.00
148_G	153_R	1.233	1.00
16_A	38_L	1.233	1.00
120_S	124_P	1.231	1.00
97_D	104_A	1.226	1.00
9_F	42_A	1.223	1.00
80_F	159_W	1.220	1.00
6_G	10_G	1.207	1.00
64_L	68_L	1.199	1.00
85_R	90_L	1.196	1.00
78_I	82_L	1.159	1.00
128_L	132_L	1.158	1.00
99_L	103_L	1.158	1.00
96_L	99_L	1.154	1.00
70_Y	74_A	1.135	1.00
150_R	153_R	1.128	1.00
79_F	82_L	1.124	1.00
29_R	33_Y	1.117	1.00
168_L	172_R	1.106	1.00
172_R	179_S	1.101	1.00
19_N	34_Y	1.099	1.00
115_P	118_P	1.097	1.00
5_L	51_L	1.088	1.00
158_G	201_A	1.085	1.00
19_N	35_A	1.078	1.00
141_G	155_F	1.072	1.00
21_F	25_S	1.063	1.00
157_L	161_L	1.061	1.00
33_Y	79_F	1.056	1.00
15_L	195_V	1.051	1.00
179_S	184_E	1.022	1.00
40_S	72_S	1.010	1.00
41_L	191_S	1.007	1.00
61_P	64_L	0.998	1.00
52_L	56_L	0.998	1.00
124_P	127_Q	0.991	1.00
34_Y	38_L	0.988	1.00
67_R	70_Y	0.987	1.00
28_D	31_Y	0.979	1.00
194_E	197_L	0.976	1.00
63_W	66_N	0.964	1.00
82_L	86_S	0.953	1.00
18_Y	203_A	0.952	1.00
165_G	190_G	0.943	1.00
11_I	15_L	0.926	1.00
50_G	54_Q	0.913	1.00
169_D	173_L	0.909	1.00
197_L	201_A	0.907	1.00
86_S	89_E	0.902	1.00
149_R	153_R	0.898	1.00
94_P	98_R	0.896	1.00
165_G	186_L	0.895	1.00
139_V	142_I	0.894	1.00
158_G	197_L	0.891	1.00
44_Y	73_L	0.886	1.00
48_L	51_L	0.885	1.00
183_T	186_L	0.874	1.00
18_Y	22_L	0.868	1.00
108_A	112_L	0.863	1.00
104_A	107_L	0.858	1.00
23_F	29_R	0.855	1.00
129_L	133_L	0.853	1.00
100_L	104_A	0.852	1.00
193_L	197_L	0.850	1.00
168_L	179_S	0.850	1.00
37_Y	80_F	0.837	1.00
136_L	139_V	0.837	1.00
101_L	108_A	0.831	1.00
84_A	137_L	0.825	1.00
23_F	35_A	0.825	1.00
66_N	69_E	0.822	1.00
71_L	75_L	0.820	1.00
70_Y	73_L	0.820	1.00
106_L	110_L	0.816	1.00
112_L	115_P	0.816	1.00
9_F	51_L	0.809	1.00
53_F	65_N	0.802	1.00
154_Y	201_A	0.800	1.00
149_R	152_A	0.800	1.00
25_S	200_L	0.790	1.00
19_N	23_F	0.788	1.00
30_S	33_Y	0.783	1.00
16_A	19_N	0.774	1.00
134_L	163_L	0.771	1.00
29_R	32_L	0.767	1.00
9_F	46_L	0.762	1.00
86_S	91_K	0.757	1.00
10_G	14_A	0.750	1.00
52_L	55_Y	0.750	1.00
169_D	187_L	0.748	1.00
145_W	152_A	0.747	1.00
190_G	194_E	0.746	1.00
9_F	13_L	0.745	1.00
50_G	55_Y	0.744	1.00
161_L	165_G	0.743	1.00
169_D	172_R	0.739	1.00
114_L	117_L	0.739	1.00
87_F	151_P	0.738	1.00
105_L	108_A	0.737	1.00
82_L	85_R	0.734	1.00
164_L	168_L	0.733	1.00
19_N	22_L	0.732	1.00
82_L	101_L	0.731	1.00
108_A	111_L	0.731	1.00
171_L	177_L	0.727	1.00
91_K	149_R	0.726	1.00
50_G	53_F	0.725	1.00
6_G	14_A	0.724	1.00
85_R	89_E	0.721	1.00
45_L	48_L	0.715	1.00
171_L	175_G	0.715	1.00
65_N	69_E	0.714	1.00
140_V	144_A	0.712	1.00
142_I	145_W	0.711	1.00
5_L	49_S	0.710	1.00
35_A	39_L	0.705	1.00
16_A	20_L	0.705	1.00
156_L	160_L	0.704	1.00
141_G	152_A	0.699	1.00
191_S	195_V	0.698	1.00
78_I	81_L	0.698	1.00
60_L	63_W	0.695	1.00
49_S	52_L	0.695	1.00
160_L	164_L	0.692	1.00
103_L	107_L	0.691	1.00
51_L	54_Q	0.689	1.00
5_L	9_F	0.685	1.00
182_F	185_Y	0.680	1.00
48_L	52_L	0.678	1.00
127_Q	173_L	0.677	1.00
44_Y	48_L	0.673	1.00
124_P	128_L	0.673	1.00
119_Y	122_A	0.672	1.00
188_Q	191_S	0.671	1.00
138_L	160_L	0.669	1.00
69_E	73_L	0.668	1.00
144_A	152_A	0.667	1.00
104_A	108_A	0.667	1.00
76_A	79_F	0.667	1.00
144_A	148_G	0.665	1.00
138_L	142_I	0.664	1.00
32_L	36_L	0.664	1.00
18_Y	199_S	0.660	1.00
184_E	188_Q	0.657	1.00
93_S	144_A	0.657	1.00
111_L	114_L	0.655	1.00
118_P	122_A	0.654	1.00
72_S	76_A	0.647	1.00
81_L	137_L	0.647	1.00
60_L	64_L	0.646	1.00
130_A	133_L	0.645	1.00
73_L	77_L	0.642	1.00
158_G	194_E	0.637	1.00
66_N	70_Y	0.637	1.00
192_L	196_L	0.632	1.00
113_L	117_L	0.632	1.00
162_L	166_A	0.628	1.00
107_L	111_L	0.626	1.00
7_L	13_L	0.625	1.00
100_L	103_L	0.622	1.00
49_S	53_F	0.620	1.00
121_L	125_L	0.618	1.00
194_E	201_A	0.615	1.00
158_G	198_L	0.612	1.00
142_I	156_L	0.609	1.00
93_S	143_R	0.608	1.00
136_L	140_V	0.607	1.00
127_Q	174_L	0.607	1.00
47_S	52_L	0.604	1.00
15_L	19_N	0.604	1.00
85_R	91_K	0.602	1.00
23_F	28_D	0.600	1.00
162_L	165_G	0.597	1.00
30_S	202_L	0.597	1.00
109_L	113_L	0.595	1.00
67_R	71_L	0.593	1.00
65_N	68_L	0.588	1.00
122_A	126_A	0.586	1.00
62_W	66_N	0.580	1.00
132_L	136_L	0.579	1.00
111_L	115_P	0.577	1.00
94_P	97_D	0.574	1.00
33_Y	36_L	0.574	1.00
90_L	93_S	0.571	1.00
131_L	135_L	0.571	1.00
47_S	69_E	0.567	1.00
25_S	203_A	0.566	1.00
63_W	68_L	0.564	1.00
6_G	9_F	0.562	1.00
22_L	203_A	0.560	1.00
56_L	59_D	0.559	1.00
117_L	121_L	0.559	1.00
40_S	80_F	0.557	1.00
161_L	164_L	0.556	1.00
137_L	141_G	0.556	1.00
45_L	191_S	0.556	1.00
72_S	75_L	0.555	1.00
162_L	191_S	0.553	1.00
181_F	184_E	0.552	1.00
186_L	190_G	0.549	1.00
22_L	26_L	0.546	1.00
200_L	203_A	0.545	1.00
41_L	45_L	0.545	1.00
98_R	105_L	0.545	1.00
33_Y	37_Y	0.543	1.00
83_F	202_L	0.543	1.00
70_Y	77_L	0.541	1.00
188_Q	192_L	0.540	1.00
185_Y	189_I	0.537	1.00
157_L	160_L	0.534	1.00
45_L	188_Q	0.531	1.00
162_L	194_E	0.531	1.00
36_L	40_S	0.530	1.00
14_A	22_L	0.529	1.00
151_P	201_A	0.528	1.00
107_L	129_L	0.527	1.00
6_G	11_I	0.524	1.00
71_L	74_A	0.524	1.00
161_L	190_G	0.522	1.00
97_D	102_A	0.521	1.00
123_L	127_Q	0.518	1.00
94_P	99_L	0.511	1.00
44_Y	169_D	0.509	1.00
22_L	25_S	0.508	1.00
59_D	63_W	0.508	1.00
138_L	163_L	0.505	1.00
44_Y	72_S	0.505	1.00
132_L	135_L	0.500	1.00
137_L	140_V	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3m73A	3	0.8488	5.1	0.907	Contact Map
2k1kA	2	0.1415	4.3	0.911	Contact Map
4qncA	2	0.3854	4.1	0.912	Contact Map
1iijA	1	0.1415	3.2	0.916	Contact Map
3wu2X	1	0.1561	3.2	0.916	Contact Map
3bz1X	1	0.1512	3.2	0.916	Contact Map
4pypA	1	0.8634	2.7	0.919	Contact Map
2l6wA	2	0.1902	2.4	0.922	Contact Map
4x5mA	2	0.4098	2.1	0.924	Contact Map
4knfA	3	0.4488	2	0.925	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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