GREMLIN Database
7TMR-DISM_7TM - 7TM diverse intracellular signalling
PFAM: PF07695 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 205 (200)
Sequences: 23451 (20405)
Seq/√Len: 1442.8
META: 0.837

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
85_R97_D4.2001.00
63_W67_R2.6881.00
33_Y86_S2.6671.00
97_D101_L2.5831.00
89_E92_R2.5491.00
145_W153_R2.4291.00
23_F32_L2.3951.00
98_R101_L2.3911.00
139_V143_R2.3511.00
16_A35_A2.3501.00
11_I14_A2.3421.00
29_R86_S2.3181.00
142_I146_R2.1921.00
7_L10_G2.1631.00
97_D100_L2.1231.00
161_L193_L2.1001.00
34_Y194_E2.0651.00
95_R99_L2.0561.00
40_S79_F1.9751.00
143_R147_R1.9681.00
95_R98_R1.9401.00
52_L57_W1.9331.00
194_E198_L1.9161.00
30_S86_S1.9041.00
84_A155_F1.8991.00
98_R102_A1.8781.00
38_L195_V1.8141.00
49_S188_Q1.8061.00
19_N199_S1.8031.00
16_A39_L1.7911.00
101_L105_L1.7381.00
11_I192_L1.7231.00
33_Y82_L1.7001.00
90_L97_D1.6971.00
118_P121_L1.6881.00
99_L102_A1.6861.00
36_L79_F1.6631.00
185_Y188_Q1.6471.00
85_R101_L1.6161.00
87_F201_A1.6111.00
37_Y194_E1.6081.00
135_L139_V1.5991.00
144_A149_R1.5681.00
19_N31_Y1.5581.00
144_A147_R1.5561.00
12_L42_A1.5361.00
148_G152_A1.5331.00
171_L176_L1.5311.00
5_L188_Q1.5041.00
9_F49_S1.4801.00
91_K97_D1.4751.00
20_L35_A1.4511.00
180_N183_T1.4251.00
8_F191_S1.4051.00
145_W156_L1.4041.00
143_R146_R1.3881.00
40_S75_L1.3721.00
74_A78_I1.3591.00
43_L72_S1.3371.00
102_A106_L1.3281.00
68_L72_S1.3271.00
102_A105_L1.3121.00
153_R157_L1.3071.00
40_S44_Y1.2771.00
101_L104_A1.2711.00
141_G156_L1.2681.00
121_L124_P1.2671.00
46_L52_L1.2581.00
182_F186_L1.2531.00
12_L195_V1.2461.00
105_L109_L1.2441.00
16_A42_A1.2361.00
148_G153_R1.2331.00
16_A38_L1.2331.00
120_S124_P1.2311.00
97_D104_A1.2261.00
9_F42_A1.2231.00
80_F159_W1.2201.00
6_G10_G1.2071.00
64_L68_L1.1991.00
85_R90_L1.1961.00
78_I82_L1.1591.00
128_L132_L1.1581.00
99_L103_L1.1581.00
96_L99_L1.1541.00
70_Y74_A1.1351.00
150_R153_R1.1281.00
79_F82_L1.1241.00
29_R33_Y1.1171.00
168_L172_R1.1061.00
172_R179_S1.1011.00
19_N34_Y1.0991.00
115_P118_P1.0971.00
5_L51_L1.0881.00
158_G201_A1.0851.00
19_N35_A1.0781.00
141_G155_F1.0721.00
21_F25_S1.0631.00
157_L161_L1.0611.00
33_Y79_F1.0561.00
15_L195_V1.0511.00
179_S184_E1.0221.00
40_S72_S1.0101.00
41_L191_S1.0071.00
61_P64_L0.9981.00
52_L56_L0.9981.00
124_P127_Q0.9911.00
34_Y38_L0.9881.00
67_R70_Y0.9871.00
28_D31_Y0.9791.00
194_E197_L0.9761.00
63_W66_N0.9641.00
82_L86_S0.9531.00
18_Y203_A0.9521.00
165_G190_G0.9431.00
11_I15_L0.9261.00
50_G54_Q0.9131.00
169_D173_L0.9091.00
197_L201_A0.9071.00
86_S89_E0.9021.00
149_R153_R0.8981.00
94_P98_R0.8961.00
165_G186_L0.8951.00
139_V142_I0.8941.00
158_G197_L0.8911.00
44_Y73_L0.8861.00
48_L51_L0.8851.00
183_T186_L0.8741.00
18_Y22_L0.8681.00
108_A112_L0.8631.00
104_A107_L0.8581.00
23_F29_R0.8551.00
129_L133_L0.8531.00
100_L104_A0.8521.00
193_L197_L0.8501.00
168_L179_S0.8501.00
37_Y80_F0.8371.00
136_L139_V0.8371.00
101_L108_A0.8311.00
84_A137_L0.8251.00
23_F35_A0.8251.00
66_N69_E0.8221.00
71_L75_L0.8201.00
70_Y73_L0.8201.00
106_L110_L0.8161.00
112_L115_P0.8161.00
9_F51_L0.8091.00
53_F65_N0.8021.00
154_Y201_A0.8001.00
149_R152_A0.8001.00
25_S200_L0.7901.00
19_N23_F0.7881.00
30_S33_Y0.7831.00
16_A19_N0.7741.00
134_L163_L0.7711.00
29_R32_L0.7671.00
9_F46_L0.7621.00
86_S91_K0.7571.00
10_G14_A0.7501.00
52_L55_Y0.7501.00
169_D187_L0.7481.00
145_W152_A0.7471.00
190_G194_E0.7461.00
9_F13_L0.7451.00
50_G55_Y0.7441.00
161_L165_G0.7431.00
169_D172_R0.7391.00
114_L117_L0.7391.00
87_F151_P0.7381.00
105_L108_A0.7371.00
82_L85_R0.7341.00
164_L168_L0.7331.00
19_N22_L0.7321.00
82_L101_L0.7311.00
108_A111_L0.7311.00
171_L177_L0.7271.00
91_K149_R0.7261.00
50_G53_F0.7251.00
6_G14_A0.7241.00
85_R89_E0.7211.00
45_L48_L0.7151.00
171_L175_G0.7151.00
65_N69_E0.7141.00
140_V144_A0.7121.00
142_I145_W0.7111.00
5_L49_S0.7101.00
35_A39_L0.7051.00
16_A20_L0.7051.00
156_L160_L0.7041.00
141_G152_A0.6991.00
191_S195_V0.6981.00
78_I81_L0.6981.00
60_L63_W0.6951.00
49_S52_L0.6951.00
160_L164_L0.6921.00
103_L107_L0.6911.00
51_L54_Q0.6891.00
5_L9_F0.6851.00
182_F185_Y0.6801.00
48_L52_L0.6781.00
127_Q173_L0.6771.00
44_Y48_L0.6731.00
124_P128_L0.6731.00
119_Y122_A0.6721.00
188_Q191_S0.6711.00
138_L160_L0.6691.00
69_E73_L0.6681.00
144_A152_A0.6671.00
104_A108_A0.6671.00
76_A79_F0.6671.00
144_A148_G0.6651.00
138_L142_I0.6641.00
32_L36_L0.6641.00
18_Y199_S0.6601.00
184_E188_Q0.6571.00
93_S144_A0.6571.00
111_L114_L0.6551.00
118_P122_A0.6541.00
72_S76_A0.6471.00
81_L137_L0.6471.00
60_L64_L0.6461.00
130_A133_L0.6451.00
73_L77_L0.6421.00
158_G194_E0.6371.00
66_N70_Y0.6371.00
192_L196_L0.6321.00
113_L117_L0.6321.00
162_L166_A0.6281.00
107_L111_L0.6261.00
7_L13_L0.6251.00
100_L103_L0.6221.00
49_S53_F0.6201.00
121_L125_L0.6181.00
194_E201_A0.6151.00
158_G198_L0.6121.00
142_I156_L0.6091.00
93_S143_R0.6081.00
136_L140_V0.6071.00
127_Q174_L0.6071.00
47_S52_L0.6041.00
15_L19_N0.6041.00
85_R91_K0.6021.00
23_F28_D0.6001.00
162_L165_G0.5971.00
30_S202_L0.5971.00
109_L113_L0.5951.00
67_R71_L0.5931.00
65_N68_L0.5881.00
122_A126_A0.5861.00
62_W66_N0.5801.00
132_L136_L0.5791.00
111_L115_P0.5771.00
94_P97_D0.5741.00
33_Y36_L0.5741.00
90_L93_S0.5711.00
131_L135_L0.5711.00
47_S69_E0.5671.00
25_S203_A0.5661.00
63_W68_L0.5641.00
6_G9_F0.5621.00
22_L203_A0.5601.00
56_L59_D0.5591.00
117_L121_L0.5591.00
40_S80_F0.5571.00
161_L164_L0.5561.00
137_L141_G0.5561.00
45_L191_S0.5561.00
72_S75_L0.5551.00
162_L191_S0.5531.00
181_F184_E0.5521.00
186_L190_G0.5491.00
22_L26_L0.5461.00
200_L203_A0.5451.00
41_L45_L0.5451.00
98_R105_L0.5451.00
33_Y37_Y0.5431.00
83_F202_L0.5431.00
70_Y77_L0.5411.00
188_Q192_L0.5401.00
185_Y189_I0.5371.00
157_L160_L0.5341.00
45_L188_Q0.5311.00
162_L194_E0.5311.00
36_L40_S0.5301.00
14_A22_L0.5291.00
151_P201_A0.5281.00
107_L129_L0.5271.00
6_G11_I0.5241.00
71_L74_A0.5241.00
161_L190_G0.5221.00
97_D102_A0.5211.00
123_L127_Q0.5181.00
94_P99_L0.5111.00
44_Y169_D0.5091.00
22_L25_S0.5081.00
59_D63_W0.5081.00
138_L163_L0.5051.00
44_Y72_S0.5051.00
132_L135_L0.5001.00
137_L140_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3m73A 3 0.8488 5.1 0.907 Contact Map
2k1kA 2 0.1415 4.3 0.911 Contact Map
4qncA 2 0.3854 4.1 0.912 Contact Map
1iijA 1 0.1415 3.2 0.916 Contact Map
3wu2X 1 0.1561 3.2 0.916 Contact Map
3bz1X 1 0.1512 3.2 0.916 Contact Map
4pypA 1 0.8634 2.7 0.919 Contact Map
2l6wA 2 0.1902 2.4 0.922 Contact Map
4x5mA 2 0.4098 2.1 0.924 Contact Map
4knfA 3 0.4488 2 0.925 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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