GREMLIN Database
DoxX - DoxX
PFAM: PF07681 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 85 (82)
Sequences: 85565 (51706)
Seq/√Len: 5710.0
META: 0.883

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
58_L68_A3.2251.00
18_L22_F2.3881.00
55_G72_L2.2441.00
25_G28_G1.9531.00
10_G56_G1.9311.00
64_L67_L1.9191.00
75_F79_A1.9151.00
42_A46_Y1.8241.00
20_K52_E1.8221.00
26_L46_Y1.7571.00
14_L56_G1.6031.00
50_L54_V1.5911.00
10_G60_L1.5911.00
18_L53_L1.5771.00
43_L46_Y1.5311.00
67_L71_L1.4911.00
46_Y50_L1.4701.00
29_T32_F1.4511.00
13_F72_L1.4301.00
48_A75_F1.3911.00
27_A31_G1.3891.00
26_L30_A1.3761.00
30_A34_A1.3591.00
21_L49_G1.3281.00
11_L15_A1.2931.00
32_F35_S1.2911.00
21_L50_L1.2821.00
55_G68_A1.2741.00
28_G31_G1.2471.00
29_T33_F1.2461.00
74_G78_V1.2341.00
17_G53_L1.2181.00
51_A75_F1.2171.00
31_G34_A1.2071.00
70_L74_G1.1831.00
13_F76_M1.1811.00
14_L57_L1.1761.00
57_L61_L1.1511.00
54_V58_L1.1391.00
65_T69_A1.1371.00
76_M80_I1.1371.00
47_L51_A1.1001.00
55_G71_L1.0811.00
14_L18_L1.0601.00
32_F36_L1.0311.00
11_L60_L1.0091.00
51_A68_A1.0071.00
5_L9_L0.9951.00
26_L49_G0.9931.00
26_L29_T0.9891.00
30_A42_A0.9851.00
68_A71_L0.9361.00
21_L53_L0.9311.00
76_M79_A0.9201.00
78_V82_T0.9131.00
20_K49_G0.8881.00
3_L7_L0.8811.00
43_L47_L0.8791.00
40_P44_L0.8731.00
27_A30_A0.8721.00
28_G32_F0.8631.00
15_A19_Q0.8581.00
51_A71_L0.8491.00
29_T34_A0.8381.00
10_G14_L0.8261.00
77_L81_F0.8171.00
15_A18_L0.8041.00
59_L69_A0.8001.00
19_Q22_F0.7941.00
68_A72_L0.7891.00
64_L68_A0.7841.00
37_G40_P0.7811.00
8_L11_L0.7811.00
59_L72_L0.7711.00
14_L53_L0.7681.00
69_A73_A0.7641.00
44_L82_T0.7541.00
25_G29_T0.7431.00
14_L60_L0.7391.00
71_L75_F0.7371.00
12_V16_H0.7351.00
33_F36_L0.7331.00
61_L65_T0.7301.00
53_L56_G0.7111.00
30_A41_P0.7111.00
16_H19_Q0.7091.00
59_L68_A0.7011.00
34_A37_G0.6971.00
20_K48_A0.6951.00
31_G35_S0.6931.00
8_L12_V0.6861.00
73_A77_L0.6781.00
71_L74_G0.6761.00
12_V15_A0.6711.00
26_L32_F0.6581.00
38_L44_L0.6531.00
34_A41_P0.6441.00
67_L70_L0.6411.00
51_A55_G0.6301.00
65_T68_A0.6271.00
35_S40_P0.6241.00
16_H20_K0.6231.00
58_L63_L0.6081.00
40_P43_L0.6081.00
44_L78_V0.6011.00
6_R62_G0.6001.00
78_V81_F0.5841.00
59_L65_T0.5811.00
17_G49_G0.5811.00
61_L64_L0.5791.00
26_L45_A0.5751.00
22_F25_G0.5711.00
17_G56_G0.5591.00
30_A45_A0.5551.00
41_P45_A0.5501.00
19_Q23_G0.5341.00
79_A84_H0.5321.00
25_G31_G0.5271.00
7_L11_L0.5181.00
29_T45_A0.5151.00
30_A33_F0.5151.00
73_A76_M0.5081.00
7_L60_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ux4A 3 0.8471 1.3 0.889 Contact Map
4ytpC 1 0.6824 1 0.898 Contact Map
2wzlA 1 0.4353 0.9 0.901 Contact Map
4ezcA 3 0.7765 0.7 0.906 Contact Map
1ofdA 1 0.3647 0.7 0.908 Contact Map
1ea0A 1 0.3647 0.7 0.909 Contact Map
3hc7A 1 0.3882 0.6 0.911 Contact Map
3oa1A 1 0.3882 0.6 0.912 Contact Map
4qi1A 3 0.5882 0.6 0.913 Contact Map
1v54C 1 0.6235 0.6 0.913 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0048 seconds.