GREMLIN Database
DUF1599 - Domain of Unknown Function (DUF1599)
PFAM: PF07659 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 61 (61)
Sequences: 7401 (2592)
Seq/√Len: 331.8
META: 0.952

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
2_N7_E2.9141.00
31_I37_T2.4591.00
42_G45_D2.4481.00
44_E48_I2.3841.00
20_Q23_I2.2081.00
51_I55_I2.0441.00
37_T40_S2.0421.00
52_N56_M1.8941.00
16_S19_D1.8371.00
47_F57_A1.7561.00
28_I46_E1.7451.00
13_R57_A1.6991.00
13_R32_E1.6091.00
28_I43_I1.5781.00
42_G46_E1.4981.00
41_E45_D1.4421.00
45_D49_D1.4161.00
21_I50_I1.3651.00
34_K37_T1.3561.00
32_E47_F1.3281.00
30_S34_K1.2971.00
17_L57_A1.2831.00
29_R33_E1.2601.00
2_N56_M1.2381.00
4_D39_V1.2141.00
19_D23_I1.1781.00
51_I54_A1.1751.00
15_S18_T1.1661.00
18_T26_Q1.1381.00
22_L26_Q1.1071.00
44_E58_L1.0641.00
54_A57_A1.0241.00
11_I18_T0.9841.00
26_Q29_R0.9801.00
9_W57_A0.9601.00
37_T41_E0.9491.00
15_S33_E0.9171.00
25_A50_I0.9141.00
17_L50_I0.8861.00
10_R60_Q0.8531.00
24_K27_R0.8391.00
32_E43_I0.8321.00
50_I54_A0.8191.00
9_W56_M0.8071.00
1_K5_Y0.7961.00
18_T25_A0.7861.00
3_H7_E0.7831.00
46_E49_D0.7741.00
31_I35_G0.7731.00
48_I58_L0.7711.00
34_K38_K0.7360.99
28_I32_E0.7260.99
17_L25_A0.7170.99
12_M15_S0.6990.99
18_T29_R0.6840.99
41_E49_D0.6810.99
16_S24_K0.6730.99
12_M16_S0.6720.99
8_A26_Q0.6710.99
14_L28_I0.6700.99
20_Q24_K0.6680.99
41_E46_E0.6670.99
31_I43_I0.6530.99
13_R16_S0.6430.98
29_R32_E0.6400.98
43_I47_F0.6370.98
3_H38_K0.6340.98
11_I14_L0.6250.98
25_A29_R0.6230.98
14_L18_T0.6140.98
25_A28_I0.6110.98
16_S20_Q0.6080.98
6_G9_W0.6000.98
4_D37_T0.5960.97
11_I29_R0.5910.97
6_G20_Q0.5720.97
16_S21_I0.5630.96
19_D22_L0.5590.96
34_K39_V0.5580.96
13_R18_T0.5530.96
13_R17_L0.5520.96
10_R13_R0.5430.96
47_F51_I0.5400.95
49_D56_M0.5330.95
52_N59_I0.5300.95
24_K45_D0.5200.94
27_R31_I0.5150.94
14_L61_L0.5140.94
11_I33_E0.5090.94
47_F54_A0.5060.94
7_E56_M0.5040.93
12_M57_A0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2p06A 4 0.9508 55.1 0.808 Contact Map
4wsrA 5 1 8.3 0.873 Contact Map
4rvqA 1 0.9672 7.3 0.876 Contact Map
4mc5A 3 1 5.4 0.883 Contact Map
2wr1A 3 1 5.4 0.883 Contact Map
2yp5A 3 1 5 0.885 Contact Map
4o5nB 3 1 4.3 0.889 Contact Map
4f23A 3 0.9672 4 0.891 Contact Map
4bsgB 3 1 3.9 0.891 Contact Map
4lvhA 3 0.2295 3.6 0.893 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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