GREMLIN Database
Secretin_N_2 - Secretin N-terminal domain
PFAM: PF07655 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 95 (93)
Sequences: 4878 (4012)
Seq/√Len: 416.0
META: 0.886

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
74_E78_K5.8381.00
68_D71_K3.8831.00
12_Q66_E3.3311.00
12_Q68_D2.6641.00
14_S66_E2.6191.00
16_T62_S2.3991.00
14_S62_S2.1231.00
23_S26_V1.9721.00
18_D60_R1.9571.00
6_V73_L1.8981.00
8_Y13_R1.7581.00
82_G87_R1.7091.00
17_S21_V1.6401.00
6_V69_F1.5871.00
12_Q64_T1.5731.00
10_N67_S1.5621.00
40_G43_S1.5301.00
71_K75_K1.3981.00
37_G40_G1.3841.00
36_G39_G1.3771.00
33_G36_G1.3571.00
16_T60_R1.3481.00
88_S91_V1.2951.00
5_Q11_G1.2871.00
75_K78_K1.2521.00
72_E76_A1.2241.00
20_R23_S1.2231.00
71_K74_E1.1821.00
53_S56_S1.1441.00
11_G65_S1.1251.00
7_N13_R1.1241.00
7_N11_G1.0981.00
47_G51_G1.0941.00
79_A82_G1.0901.00
57_S60_R1.0851.00
5_Q67_S1.0671.00
21_V24_G1.0581.00
13_R61_I1.0461.00
74_E91_V1.0351.00
25_S57_S1.0321.00
3_T19_T1.0281.00
41_G49_S1.0271.00
77_L82_G1.0261.00
11_G19_T1.0251.00
19_T61_I1.0211.00
58_G63_T0.9971.00
10_N66_E0.9551.00
78_K83_S0.9501.00
39_G43_S0.9481.00
31_S35_G0.9251.00
35_G38_G0.9251.00
49_S52_G0.9221.00
45_S52_G0.9191.00
34_G40_G0.9151.00
32_G38_G0.9111.00
43_S47_G0.9061.00
38_G43_S0.8921.00
69_F73_L0.8871.00
49_S54_N0.8811.00
38_G41_G0.8761.00
76_A79_A0.8511.00
8_Y69_F0.8461.00
84_G87_R0.8461.00
66_E71_K0.8451.00
11_G76_A0.8381.00
59_S63_T0.8341.00
45_S50_G0.8301.00
46_S49_S0.8301.00
65_S76_A0.8241.00
50_G53_S0.8231.00
34_G39_G0.8211.00
39_G44_G0.8141.00
14_S64_T0.8141.00
83_S87_R0.8041.00
31_S34_G0.8031.00
19_T63_T0.8021.00
16_T64_T0.7951.00
39_G42_S0.7931.00
38_G48_G0.7741.00
72_E92_S0.7701.00
15_G77_L0.7661.00
18_D21_V0.7581.00
33_G37_G0.7551.00
20_R60_R0.7461.00
13_R17_S0.7401.00
59_S76_A0.7311.00
7_N17_S0.7171.00
40_G46_S0.7111.00
70_W90_V0.7081.00
51_G54_N0.7021.00
6_V10_N0.6931.00
44_G50_G0.6901.00
45_S49_S0.6771.00
13_R70_W0.6731.00
48_G51_G0.6670.99
42_S45_S0.6640.99
39_G50_G0.6610.99
14_S68_D0.6600.99
46_S50_G0.6570.99
52_G55_S0.6560.99
25_S28_S0.6460.99
36_G49_S0.6430.99
57_S62_S0.6400.99
23_S59_S0.6390.99
10_N65_S0.6380.99
19_T58_G0.6340.99
35_G49_S0.6300.99
19_T24_G0.6280.99
36_G40_G0.6220.99
35_G39_G0.6160.99
7_N19_T0.6150.99
48_G52_G0.6150.99
58_G67_S0.6150.99
25_S59_S0.6130.99
69_F92_S0.6120.99
41_G48_G0.6090.99
59_S67_S0.6080.99
30_G33_G0.6000.99
4_F10_N0.5940.99
82_G86_G0.5870.99
42_S50_G0.5860.99
24_G27_S0.5740.98
13_R59_S0.5670.98
32_G36_G0.5660.98
88_S92_S0.5650.98
45_S53_S0.5630.98
41_G46_S0.5610.98
15_G21_V0.5580.98
2_R5_Q0.5570.98
10_N25_S0.5470.98
67_S76_A0.5440.98
61_I70_W0.5440.98
4_F67_S0.5430.98
37_G42_S0.5320.97
37_G43_S0.5250.97
25_S58_G0.5230.97
8_Y61_I0.5220.97
10_N80_I0.5190.97
51_G56_S0.5120.97
47_G50_G0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ossD 1 0.5053 38.7 0.837 Contact Map
4kblA 2 0.3474 13.4 0.869 Contact Map
4e9jA 2 0.7474 11.7 0.873 Contact Map
4ladB 1 0.2947 8.3 0.881 Contact Map
3gr5A 2 0.6947 6.2 0.888 Contact Map
4av2A 3 0.7789 6.1 0.889 Contact Map
4g08A 1 0.6842 4.2 0.897 Contact Map
1o4yA 1 0.1789 2.9 0.905 Contact Map
4rxuA 1 0.4316 2.7 0.906 Contact Map
1wj6A 1 0.5368 2.6 0.907 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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