GREMLIN Database
DUF1598 - Protein of unknown function (DUF1598)
PFAM: PF07643 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 84 (84)
Sequences: 3029 (2246)
Seq/√Len: 245.1
META: 0.987

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_F35_G3.8191.00
4_D46_T3.5111.00
47_V61_V2.8961.00
6_T9_G2.7921.00
35_G39_A2.5041.00
34_A38_E2.2361.00
14_Q18_R2.2251.00
6_T44_D2.1801.00
45_I61_V1.9831.00
34_A37_R1.9111.00
50_V56_F1.8361.00
8_E12_R1.7631.00
15_Q19_Q1.7551.00
16_F39_A1.7071.00
20_L32_W1.6511.00
62_E66_R1.6041.00
29_R33_L1.5931.00
24_L27_G1.5431.00
11_A15_Q1.5261.00
69_L75_E1.4741.00
13_L17_L1.4711.00
17_L36_L1.4691.00
66_R75_E1.4531.00
70_I77_P1.4161.00
1_C61_V1.4101.00
17_L20_L1.3361.00
78_P81_L1.2681.00
28_Q31_A1.2431.00
25_T28_Q1.2281.00
16_F20_L1.2251.00
77_P80_G1.2221.00
13_L40_L1.2141.00
55_H59_V1.2131.00
31_A35_G1.2051.00
12_R15_Q1.1391.00
12_R39_A1.1371.00
7_P10_L1.1001.00
9_G12_R1.0981.00
7_P11_A1.0901.00
10_L14_Q1.0841.00
55_H58_R1.0811.00
25_T29_R1.0501.00
35_G38_E1.0101.00
19_Q22_G1.0031.00
14_Q17_L0.9801.00
62_E72_M0.9741.00
15_Q18_R0.9421.00
17_L22_G0.9141.00
2_S46_T0.9091.00
3_I43_Q0.9061.00
13_L36_L0.8630.99
36_L39_A0.8560.99
47_V52_P0.8510.99
50_V60_L0.8040.99
70_I81_L0.8010.99
26_P29_R0.7740.99
30_Q34_A0.7730.99
78_P82_P0.7710.99
21_G32_W0.7610.99
9_G41_G0.7500.98
26_P32_W0.7460.98
72_M83_S0.7420.98
10_L55_H0.7370.98
77_P81_L0.7270.98
64_D68_K0.7260.98
30_Q33_L0.7250.98
72_M77_P0.7250.98
9_G39_A0.7160.98
47_V60_L0.7150.98
17_L33_L0.7150.98
50_V54_S0.7140.98
20_L35_G0.7090.98
77_P82_P0.7060.98
17_L21_G0.6980.97
22_G34_A0.6940.97
51_P54_S0.6850.97
31_A34_A0.6840.97
11_A18_R0.6820.97
56_F60_L0.6730.97
79_V82_P0.6650.97
10_L63_A0.6600.96
59_V65_Y0.6540.96
57_A65_Y0.6540.96
36_L40_L0.6490.96
19_Q35_G0.6480.96
19_Q39_A0.6450.96
37_R74_L0.6390.96
13_L39_A0.6360.96
9_G40_L0.6350.96
6_T12_R0.6350.96
21_G29_R0.6270.95
54_S60_L0.6250.95
49_G61_V0.6160.95
33_L37_R0.6050.94
67_M71_G0.6010.94
15_Q39_A0.5890.93
24_L32_W0.5860.93
29_R32_W0.5840.93
26_P33_L0.5780.93
6_T39_A0.5770.93
27_G30_Q0.5770.93
9_G13_L0.5750.93
37_R54_S0.5730.93
76_P80_G0.5720.92
32_W36_L0.5700.92
3_I67_M0.5670.92
72_M80_G0.5620.92
10_L40_L0.5620.92
71_G84_Y0.5490.91
3_I72_M0.5430.90
24_L29_R0.5430.90
27_G31_A0.5410.90
7_P44_D0.5400.90
1_C47_V0.5380.90
21_G43_Q0.5360.90
42_P51_P0.5340.90
63_A73_G0.5320.90
70_I78_P0.5310.89
9_G71_G0.5290.89
40_L43_Q0.5280.89
19_Q31_A0.5270.89
33_L38_E0.5180.88
65_Y75_E0.5140.88
79_V83_S0.5080.87
46_T61_V0.5010.87
65_Y69_L0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gfjA 1 0.75 47.4 0.882 Contact Map
2csbA 1 0.75 37.1 0.889 Contact Map
3m6zA 1 0.75 36.4 0.89 Contact Map
4bjtA 1 0.9405 22.6 0.9 Contact Map
2r5rA 4 0.8333 16.9 0.906 Contact Map
3d2oA 4 0.8333 16.4 0.907 Contact Map
1hjrA 2 0.4524 13.2 0.91 Contact Map
2lcqA 1 0.8095 12.7 0.911 Contact Map
1pq4A 1 0.8333 12.6 0.911 Contact Map
4ep4A 2 0.4762 12.2 0.912 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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