GREMLIN Database
PSD5 - Protein of unknown function (DUF1595)
PFAM: PF07637 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 62 (62)
Sequences: 75101 (40565)
Seq/√Len: 5151.7
META: 0.992

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_S23_V2.4561.00
10_A51_V2.3831.00
6_L47_A2.3051.00
10_A18_V2.1811.00
46_L49_E2.0491.00
3_R27_L1.9571.00
10_A26_L1.5591.00
3_R7_S1.5501.00
30_Y47_A1.5211.00
19_T22_E1.5181.00
39_S42_A1.4771.00
20_D24_D1.4121.00
2_A30_Y1.3901.00
27_L31_R1.3351.00
25_R28_A1.3231.00
16_R56_E1.3051.00
5_I48_L1.2901.00
11_R18_V1.2861.00
45_R49_E1.2441.00
29_F50_A1.2281.00
31_R35_A1.2011.00
50_A54_S1.1981.00
30_Y34_R1.1831.00
33_G46_L1.1771.00
28_A32_A1.1691.00
5_I44_I1.1651.00
9_F13_A1.1621.00
4_R8_T1.1271.00
42_A45_R1.1221.00
3_R23_V1.0931.00
18_V23_V1.0851.00
26_L50_A1.0791.00
13_A51_V1.0761.00
32_A35_A1.0611.00
14_Y26_L1.0511.00
7_S20_D1.0391.00
32_A36_E1.0371.00
3_R20_D1.0361.00
28_A31_R1.0341.00
7_S11_R1.0271.00
40_F44_I1.0251.00
20_D23_V1.0151.00
24_D28_A0.9881.00
8_T12_R0.9861.00
26_L51_V0.9741.00
16_R22_E0.9491.00
46_L50_A0.9381.00
8_T11_R0.9341.00
2_A40_F0.9251.00
9_F51_V0.9061.00
42_A46_L0.9041.00
21_A24_D0.8911.00
38_G42_A0.8761.00
3_R24_D0.8451.00
33_G36_E0.8411.00
23_V27_L0.8401.00
56_E61_V0.8401.00
50_A53_V0.7951.00
34_R43_G0.7921.00
30_Y43_G0.7921.00
49_E53_V0.7891.00
14_Y54_S0.7711.00
33_G38_G0.7441.00
4_R7_S0.7111.00
37_G42_A0.7071.00
34_R38_G0.6821.00
24_D27_L0.6571.00
29_F46_L0.6531.00
33_G37_G0.6511.00
26_L47_A0.6411.00
46_L53_V0.6371.00
5_I9_F0.6341.00
30_Y40_F0.6161.00
31_R34_R0.6101.00
34_R37_G0.6091.00
22_E56_E0.6011.00
43_G47_A0.5981.00
6_L51_V0.5921.00
41_E45_R0.5911.00
5_I40_F0.5861.00
5_I8_T0.5691.00
27_L30_Y0.5641.00
58_L62_E0.5551.00
9_F48_L0.5531.00
22_E25_R0.5491.00
44_I48_L0.5451.00
29_F33_G0.5431.00
38_G43_G0.5421.00
33_G43_G0.5221.00
14_Y22_E0.5161.00
21_A25_R0.5071.00
14_Y56_E0.5071.00
36_E46_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1kblA 2 1 13.5 0.836 Contact Map
1vbgA 2 1 13.3 0.837 Contact Map
3gjxA 1 0.9839 10.9 0.843 Contact Map
2gq0A 1 0.8548 10.9 0.843 Contact Map
2qiaA 3 1 10.5 0.844 Contact Map
2x0sA 2 1 9.7 0.847 Contact Map
2xolA 2 0.9194 9.3 0.848 Contact Map
3hsqA 3 1 9.1 0.849 Contact Map
4eqyA 3 1 8.3 0.851 Contact Map
4fgvA 1 0.9839 8.3 0.851 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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