GREMLIN Database
PSD4 - Protein of unknown function (DUF1592)
PFAM: PF07631 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 128 (127)
Sequences: 54660 (32664)
Seq/√Len: 2898.4
META: 0.988

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
91_R95_L2.7341.00
99_S103_E2.6631.00
52_R98_E2.5991.00
3_D33_R2.5361.00
25_A29_A2.4851.00
41_Q44_R2.2821.00
26_L41_Q2.1831.00
34_D37_V2.1431.00
22_E41_Q1.9961.00
88_A119_N1.9931.00
31_K37_V1.9911.00
31_K34_D1.9671.00
4_Y28_A1.9251.00
99_S115_Y1.9011.00
39_E43_R1.8841.00
105_R109_D1.8671.00
98_E102_R1.8521.00
12_Y18_M1.8471.00
26_L37_V1.8371.00
59_A97_F1.8291.00
26_L31_K1.8241.00
37_V40_A1.8081.00
91_R94_E1.7511.00
64_G67_N1.7141.00
21_D25_A1.6841.00
60_G94_E1.6461.00
99_S117_F1.6201.00
56_T94_E1.5721.00
25_A28_A1.5521.00
46_L51_A1.5291.00
18_M24_L1.5271.00
2_S5_E1.5141.00
20_D44_R1.4681.00
69_D90_R1.4621.00
39_E42_V1.4481.00
90_R94_E1.4431.00
96_F113_A1.4401.00
22_E26_L1.4251.00
88_A121_R1.4161.00
120_E124_R1.4111.00
52_R56_T1.3421.00
4_Y24_L1.3411.00
33_R37_V1.3191.00
15_W50_R1.3101.00
15_W48_D1.2861.00
95_L98_E1.2681.00
84_N88_A1.2611.00
82_D121_R1.2241.00
74_D77_L1.2221.00
3_D30_G1.2141.00
24_L28_A1.1911.00
35_P39_E1.1711.00
92_E116_T1.1661.00
16_S57_N1.1621.00
81_F86_R1.1621.00
16_S54_L1.1551.00
15_W45_M1.1511.00
22_E25_A1.1351.00
99_S102_R1.1271.00
95_L99_S1.1061.00
67_N70_S1.0961.00
60_G65_L1.0901.00
43_R47_A1.0771.00
65_L93_T1.0711.00
95_L117_F1.0641.00
84_N121_R1.0521.00
37_V41_Q1.0451.00
118_V128_I1.0341.00
60_G66_R1.0331.00
83_D86_R1.0121.00
56_T98_E1.0111.00
109_D115_Y0.9901.00
85_L125_H0.9801.00
55_V98_E0.9781.00
52_R102_R0.9651.00
30_G33_R0.9641.00
92_E126_Y0.9601.00
109_D112_T0.9511.00
4_Y8_S0.9481.00
36_A39_E0.9331.00
89_M122_L0.9151.00
57_N61_Q0.9001.00
97_F110_L0.8981.00
87_Q91_R0.8951.00
3_D6_L0.8761.00
83_D87_Q0.8661.00
36_A40_A0.8481.00
3_D29_A0.8361.00
6_L38_L0.8251.00
74_D78_F0.8241.00
49_P52_R0.8231.00
106_S109_D0.8121.00
8_S12_Y0.8111.00
53_A56_T0.8091.00
4_Y27_A0.8061.00
105_R115_Y0.8031.00
86_R90_R0.7991.00
20_D41_Q0.7841.00
9_R13_F0.7721.00
69_D86_R0.7701.00
100_V110_L0.7631.00
14_L42_V0.7621.00
89_M125_H0.7571.00
29_A33_R0.7541.00
60_G90_R0.7521.00
121_R124_R0.7401.00
121_R125_H0.7401.00
69_D72_T0.7371.00
38_L42_V0.7371.00
55_V59_A0.7301.00
8_S18_M0.7161.00
88_A122_L0.7161.00
84_N87_Q0.7101.00
52_R55_V0.7091.00
99_S105_R0.7071.00
108_L112_T0.7051.00
82_D85_L0.7031.00
55_V97_F0.6921.00
22_E40_A0.6861.00
11_S15_W0.6851.00
93_T96_F0.6821.00
69_D87_Q0.6811.00
72_T75_P0.6711.00
99_S109_D0.6681.00
73_P77_L0.6641.00
73_P81_F0.6621.00
8_S11_S0.6541.00
27_A32_L0.6521.00
51_A101_L0.6491.00
59_A100_V0.6481.00
82_D88_A0.6461.00
97_F101_L0.6461.00
56_T60_G0.6441.00
68_L71_V0.6431.00
98_E101_L0.6391.00
10_L38_L0.6381.00
26_L29_A0.6301.00
14_L45_M0.6281.00
85_L89_M0.6271.00
109_D113_A0.6271.00
21_D24_L0.6161.00
10_L42_V0.6101.00
97_F100_V0.6021.00
3_D27_A0.5981.00
33_R36_A0.5971.00
104_D109_D0.5891.00
118_V125_H0.5871.00
17_S50_R0.5851.00
26_L40_A0.5851.00
48_D51_A0.5841.00
68_L90_R0.5821.00
72_T83_D0.5771.00
89_M92_E0.5751.00
72_T86_R0.5741.00
41_Q45_M0.5721.00
87_Q90_R0.5721.00
35_P38_L0.5711.00
74_D79_P0.5711.00
107_V111_L0.5701.00
3_D37_V0.5651.00
54_L59_A0.5641.00
42_V45_M0.5591.00
77_L80_D0.5551.00
6_L9_R0.5461.00
59_A101_L0.5461.00
7_A32_L0.5451.00
64_G70_S0.5441.00
89_M93_T0.5411.00
20_D23_L0.5391.00
65_L68_L0.5391.00
16_S53_A0.5391.00
61_Q66_R0.5331.00
81_F89_M0.5251.00
40_A43_R0.5241.00
22_E44_R0.5241.00
101_L104_D0.5231.00
75_P84_N0.5231.00
55_V101_L0.5231.00
45_M48_D0.5181.00
100_V109_D0.5171.00
92_E96_F0.5171.00
80_D84_N0.5161.00
67_N71_V0.5151.00
72_T76_K0.5141.00
6_L33_R0.5071.00
80_D125_H0.5071.00
55_V94_E0.5071.00
7_A11_S0.5031.00
76_K79_P0.5011.00
57_N66_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lloB 1 0.2656 13.3 0.918 Contact Map
2ce7A 3 0.8594 6.6 0.928 Contact Map
1whrA 1 0.5781 6.4 0.929 Contact Map
2hjeA 1 0.6094 6.4 0.929 Contact Map
3r8rA 5 0.4688 6.2 0.929 Contact Map
3c38A 1 0.6094 5.6 0.931 Contact Map
2krxA 1 0.5547 5 0.932 Contact Map
1l6wA 6 0.5234 4.7 0.933 Contact Map
4dduA 1 0.9141 4.5 0.934 Contact Map
3uq8A 1 0.6797 4.4 0.934 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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