GREMLIN Database
PSCyt3 - Protein of unknown function (DUF1588)
PFAM: PF07627 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 98 (97)
Sequences: 45340 (21385)
Seq/√Len: 2171.3
META: 0.988

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
87_N94_W4.3181.00
89_D93_R2.7801.00
30_L36_T2.5901.00
27_K31_E2.3971.00
16_Y24_L2.3611.00
2_G7_Q2.2511.00
27_K78_M2.0471.00
72_A76_A1.9841.00
60_E63_E1.9721.00
64_Q67_A1.9511.00
70_A73_S1.8231.00
81_L84_A1.7471.00
87_N96_T1.7291.00
56_L64_Q1.6751.00
31_E37_P1.6551.00
2_G6_T1.6501.00
21_S24_L1.6161.00
57_T60_E1.5921.00
63_E66_R1.5811.00
64_Q68_N1.5401.00
20_T86_E1.4911.00
10_V28_W1.4781.00
63_E67_A1.4141.00
69_P72_A1.3561.00
10_V14_T1.3391.00
49_P52_A1.3071.00
30_L81_L1.3051.00
56_L60_E1.2931.00
16_Y19_R1.2901.00
52_A55_A1.2671.00
65_H79_D1.2631.00
22_P58_L1.2381.00
58_L62_L1.2341.00
30_L38_P1.2141.00
29_V81_L1.2131.00
66_R79_D1.2021.00
59_R63_E1.2011.00
86_E95_R1.1921.00
16_Y21_S1.1921.00
42_P45_V1.1791.00
78_M81_L1.1721.00
25_R85_L1.0911.00
51_D54_G1.0831.00
36_T77_R1.0711.00
59_R83_F1.0701.00
22_P83_F1.0631.00
28_W32_N1.0441.00
77_R80_P1.0431.00
51_D55_A1.0421.00
20_T58_L1.0341.00
58_L61_R1.0261.00
23_V62_L1.0071.00
23_V79_D0.9841.00
66_R76_A0.9831.00
30_L77_R0.9811.00
73_S76_A0.9711.00
35_G77_R0.9491.00
4_L10_V0.9391.00
31_E38_P0.9361.00
53_A56_L0.9281.00
7_Q10_V0.9161.00
62_L66_R0.9131.00
4_L7_Q0.9131.00
46_P49_P0.8971.00
28_W33_L0.8961.00
89_D95_R0.8861.00
67_A72_A0.8741.00
38_P41_P0.8651.00
26_G82_G0.8621.00
71_C74_C0.8541.00
22_P62_L0.8511.00
49_P54_G0.8171.00
11_L14_T0.8101.00
26_G78_M0.8041.00
8_G12_T0.8021.00
47_A50_P0.7961.00
88_F94_W0.7941.00
29_V33_L0.7941.00
5_L33_L0.7931.00
19_R58_L0.7911.00
19_R61_R0.7891.00
27_K38_P0.7891.00
79_D83_F0.7841.00
62_L83_F0.7801.00
52_A56_L0.7741.00
62_L65_H0.7741.00
24_L27_K0.7581.00
66_R72_A0.7511.00
49_P53_A0.7481.00
44_N70_A0.7411.00
90_A93_R0.7361.00
68_N72_A0.7281.00
71_C75_H0.7281.00
12_T15_S0.7231.00
38_P78_M0.7201.00
67_A70_A0.7101.00
37_P40_P0.7101.00
61_R65_H0.7091.00
40_P43_P0.7081.00
84_A87_N0.6871.00
50_P53_A0.6841.00
7_Q12_T0.6631.00
27_K32_N0.6561.00
13_V32_N0.6491.00
48_L52_A0.6471.00
3_G75_H0.6431.00
93_R97_T0.6421.00
50_P54_G0.6381.00
23_V78_M0.6361.00
63_E83_F0.6341.00
49_P64_Q0.6301.00
23_V27_K0.6281.00
6_T88_F0.6261.00
14_T28_W0.6201.00
66_R83_F0.6151.00
50_P55_A0.6071.00
6_T11_L0.6041.00
11_L88_F0.6021.00
14_T24_L0.5991.00
30_L34_L0.5981.00
15_S20_T0.5961.00
41_P45_V0.5891.00
77_R81_L0.5831.00
50_P61_R0.5831.00
73_S77_R0.5821.00
3_G74_C0.5771.00
2_G8_G0.5741.00
5_L29_V0.5711.00
12_T91_I0.5691.00
65_H68_N0.5671.00
47_A52_A0.5661.00
7_Q17_P0.5651.00
56_L61_R0.5551.00
20_T95_R0.5531.00
29_V32_N0.5481.00
10_V13_V0.5421.00
13_V17_P0.5351.00
39_P45_V0.5291.00
51_D64_Q0.5241.00
11_L15_S0.5141.00
27_K40_P0.5131.00
69_P76_A0.5121.00
39_P42_P0.5121.00
60_E64_Q0.5031.00
24_L31_E0.5021.00
38_P77_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3m97X 1 0.5918 27.9 0.891 Contact Map
4wqdA 1 0.6224 22.2 0.896 Contact Map
2zxyA 2 0.3878 20.7 0.898 Contact Map
3u99A 1 0.3878 19.8 0.899 Contact Map
4xxlA 1 0.4286 19.8 0.899 Contact Map
1iqcA 2 0.6327 18.8 0.9 Contact Map
3cp5A 1 0.5714 17.5 0.901 Contact Map
1cchA 1 0.3776 16 0.903 Contact Map
3mk7B 1 0.8061 15.1 0.904 Contact Map
1i8oA 2 0.3776 12.9 0.907 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0057 seconds.